Details of the Target

General Information of Target

Target ID LDTP03601
Target Name Transcription factor HIVEP2 (HIVEP2)
Gene Name HIVEP2
Gene ID 3097
Synonyms
Transcription factor HIVEP2; Human immunodeficiency virus type I enhancer-binding protein 2; HIV-EP2; MHC-binding protein 2; MBP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTGDTALGQKATSRSGETDKASGRWRQEQSAVIKMSTFGSHEGQRQPQIEPEQIGNTAS
AQLFGSGKLASPSEVVQQVAEKQYPPHRPSPYSCQHSLSFPQHSLPQGVMHSTKPHQSLE
GPPWLFPGPLPSVASEDLFPFPIHGHSGGYPRKKISSLNPAYSQYSQKSIEQAEEAHKKE
HKPKKPGKYICPYCSRACAKPSVLKKHIRSHTGERPYPCIPCGFSFKTKSNLYKHRKSHA
HAIKAGLVPFTESAVSKLDLEAGFIDVEAEIHSDGEQSTDTDEESSLFAEASDKMSPGPP
IPLDIASRGGYHGSLEESLGGPMKVPILIIPKSGIPLPNESSQYIGPDMLPNPSLNTKAD
DSHTVKQKLALRLSEKKGQDSEPSLNLLSPHSKGSTDSGYFSRSESAEQQISPPNTNAKS
YEEIIFGKYCRLSPRNALSVTTTSQERAAMGRKGIMEPLPHVNTRLDVKMFEDPVSQLIP
SKGDVDPSQTSMLKSTKFNSESRQPQIIPSSIRNEGKLYPANFQGSNPVLLEAPVDSSPL
IRSNSVPTSSATNLTIPPSLRGSHSFDERMTGSDDVFYPGTVGIPPQRMLRRQAAFELPS
VQEGHVEVEHHGRMLKGISSSSLKEKKLSPGDRVGYDYDVCRKPYKKWEDSETPKQNYRD
ISCLSSLKHGGEYFMDPVVPLQGVPSMFGTTCENRKRRKEKSVGDEEDTPMICSSIVSTP
VGIMASDYDPKLQMQEGVRSGFAMAGHENLSHGHTERFDPCRPQLQPGSPSLVSEESPSA
IDSDKMSDLGGRKPPGNVISVIQHTNSLSRPNSFERSESAELVACTQDKAPSPSETCDSE
ISEAPVSPEWAPPGDGAESGGKPSPSQQVQQQSYHTQPRLVRQHNIQVPEIRVTEEPDKP
EKEKEAQSKEPEKPVEEFQWPQRSETLSQLPAEKLPPKKKRLRLADMEHSSGESSFESTG
TGLSRSPSQESNLSHSSSFSMSFEREETSKLSALPKQDEFGKHSEFLTVPAGSYSLSVPG
HHHQKEMRRCSSEQMPCPHPAEVPEVRSKSFDYGNLSHAPVSGAAASTVSPSRERKKCFL
VRQASFSGSPEISQGEVGMDQSVKQEQLEHLHAGLRSGWHHGPPAVLPPLQQEDPGKQVA
GPCPPLSSGPLHLAQPQIMHMDSQESLRNPLIQPTSYMTSKHLPEQPHLFPHQETIPFSP
IQNALFQFQYPTVCMVHLPAQQPPWWQAHFPHPFAQHPQKSYGKPSFQTEIHSSYPLEHV
AEHTGKKPAEYAHTKEQTYPCYSGASGLHPKNLLPKFPSDQSSKSTETPSEQVLQEDFAS
ANAGSLQSLPGTVVPVRIQTHVPSYGSVMYTSISQILGQNSPAIVICKVDENMTQRTLVT
NAAMQGIGFNIAQVLGQHAGLEKYPIWKAPQTLPLGLESSIPLCLPSTSDSVATLGGSKR
MLSPASSLELFMETKQQKRVKEEKMYGQIVEELSAVELTNSDIKKDLSRPQKPQLVRQGC
ASEPKDGLQSGSSSFSSLSPSSSQDYPSVSPSSREPFLPSKEMLSGSRAPLPGQKSSGPS
ESKESSDELDIDETASDMSMSPQSSSLPAGDGQLEEEGKGHKRPVGMLVRMASAPSGNVA
DSTLLLTDMADFQQILQFPSLRTTTTVSWCFLNYTKPNYVQQATFKSSVYASWCISSCNP
NPSGLNTKTTLALLRSKQKITAEIYTLAAMHRPGTGKLTSSSAWKQFTQMKPDASFLFGS
KLERKLVGNILKERGKGDIHGDKDIGSKQTEPIRIKIFEGGYKSNEDYVYVRGRGRGKYI
CEECGIRCKKPSMLKKHIRTHTDVRPYVCKLCNFAFKTKGNLTKHMKSKAHMKKCLELGV
SMTSVDDTETEEAENLEDLHKAAEKHSMSSISTDHQFSDAEESDGEDGDDNDDDDEDEDD
FDDQGDLTPKTRSRSTSPQPPRFSSLPVNVGAVPHGVPSDSSLGHSSLISYLVTLPSIRV
TQLMTPSDSCEDTQMTEYQRLFQSKSTDSEPDKDRLDIPSCMDEECMLPSEPSSSPRDFS
PSSHHSSPGYDSSPCRDNSPKRYLIPKGDLSPRRHLSPRRDLSPMRHLSPRKEAALRREM
SQRDVSPRRHLSPRRPVSPGKDITARRDLSPRRERRYMTTIRAPSPRRALYHNPPLSMGQ
YLQAEPIVLGPPNLRRGLPQVPYFSLYGDQEGAYEHPGSSLFPEGPNDYVFSHLPLHSQQ
QVRAPIPMVPVGGIQMVHSMPPALSSLHPSPTLPLPMEGFEEKKGASGESFSKDPYVLSK
QHEKRGPHALQSSGPPSTPSSPRLLMKQSTSEDSLNATEREQEENIQTCTKAIASLRIAT
EEAALLGPDQPARVQEPHQNPLGSAHVSIRHFSRPEPGQPCTSATHPDLHDGEKDNFGTS
QTPLAHSTFYSKSCVDDKQLDFHSSKELSSSTEESKDPSSEKSQLH
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
Uniprot ID
P31629
Ensemble ID
ENST00000012134.7
HGNC ID
HGNC:4921
ChEMBL ID
CHEMBL4523214

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C641(6.09)  LDD1706  [1]
DBIA
 Probe Info  		C2021(1.06); C2026(1.06); C1030(0.96); C1037(0.96)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0072  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1500(0.91)  LDD1507  [7]
 LDCM0226  AC11 HEK-293T C1500(0.98)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C1500(0.95)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C1500(0.64)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C1500(1.02)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C1500(1.07)  LDD1515  [7]
 LDCM0278  AC19 HEK-293T C1500(1.01)  LDD1517  [7]
 LDCM0280  AC20 HEK-293T C1500(1.00)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C1500(1.37)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C1500(0.91)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C1500(0.97)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C1500(0.91)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C1500(0.99)  LDD1524  [7]
 LDCM0287  AC27 HEK-293T C1500(0.89)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C1500(0.98)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C1500(0.90)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C1500(0.94)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C1500(0.79)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C1500(1.21)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C1500(0.96)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C1500(1.03)  LDD1533  [7]
 LDCM0296  AC35 HEK-293T C1500(0.97)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C1500(1.04)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C1500(1.10)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C1500(0.95)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C1500(1.09)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C1500(1.16)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C1500(1.00)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C1500(1.17)  LDD1542  [7]
 LDCM0305  AC43 HEK-293T C1500(0.93)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C1500(1.12)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C1500(1.09)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C1500(0.93)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C1500(0.85)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C1500(1.18)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C1500(0.93)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C1500(1.16)  LDD1551  [7]
 LDCM0314  AC51 HEK-293T C1500(0.96)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C1500(1.14)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C1500(1.03)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C1500(0.87)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C1500(1.02)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C1500(1.29)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C1500(0.96)  LDD1559  [7]
 LDCM0322  AC59 HEK-293T C1500(0.94)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C1500(0.97)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C1500(1.09)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C1500(1.24)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C1500(0.70)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C1500(1.24)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C1500(1.29)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C1500(1.15)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C1500(1.03)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C1500(1.23)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C1500(1.16)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C1500(1.00)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C2021(1.06); C2026(1.06); C1030(0.96); C1037(0.96)  LDD0078  [2]
 LDCM0368  CL10 HEK-293T C1500(0.77)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C1500(1.02)  LDD1573  [7]
 LDCM0371  CL102 HEK-293T C1500(0.89)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C1500(1.01)  LDD1577  [7]
 LDCM0375  CL106 HEK-293T C1500(0.89)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C1500(1.19)  LDD1581  [7]
 LDCM0379  CL11 HEK-293T C1500(1.14)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C1500(0.95)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C1500(1.20)  LDD1586  [7]
 LDCM0384  CL114 HEK-293T C1500(0.90)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C1500(1.21)  LDD1590  [7]
 LDCM0388  CL118 HEK-293T C1500(0.98)  LDD1592  [7]
 LDCM0390  CL12 HEK-293T C1500(0.88)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C1500(1.29)  LDD1595  [7]
 LDCM0393  CL122 HEK-293T C1500(1.03)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C1500(1.12)  LDD1599  [7]
 LDCM0397  CL126 HEK-293T C1500(0.89)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C1500(1.12)  LDD1603  [7]
 LDCM0401  CL14 HEK-293T C1500(0.98)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C1500(1.04)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C1500(0.91)  LDD1608  [7]
 LDCM0406  CL19 HEK-293T C1500(0.92)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C1500(0.92)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C1500(1.13)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C1500(0.94)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C1500(0.96)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C1500(1.14)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C1500(1.04)  LDD1616  [7]
 LDCM0414  CL26 HEK-293T C1500(0.95)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C1500(1.33)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C1500(0.92)  LDD1621  [7]
 LDCM0420  CL31 HEK-293T C1500(0.94)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C1500(1.07)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C1500(0.83)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C1500(0.91)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C1500(1.08)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C1500(0.96)  LDD1629  [7]
 LDCM0429  CL4 HEK-293T C1500(1.04)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C1500(1.08)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C1500(0.71)  LDD1635  [7]
 LDCM0433  CL43 HEK-293T C1500(1.06)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C1500(1.01)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C1500(1.13)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C1500(0.75)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C1500(1.12)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C1500(1.21)  LDD1642  [7]
 LDCM0440  CL5 HEK-293T C1500(1.13)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C1500(0.98)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C1500(1.06)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C1500(1.05)  LDD1647  [7]
 LDCM0446  CL55 HEK-293T C1500(1.00)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C1500(1.00)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C1500(1.21)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C1500(0.92)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C1500(1.29)  LDD1653  [7]
 LDCM0452  CL60 HEK-293T C1500(1.20)  LDD1655  [7]
 LDCM0454  CL62 HEK-293T C1500(0.98)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C1500(1.31)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C1500(1.07)  LDD1660  [7]
 LDCM0459  CL67 HEK-293T C1500(0.93)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C1500(1.21)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C1500(1.04)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C1500(0.89)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C1500(0.84)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C1500(1.14)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C1500(1.08)  LDD1668  [7]
 LDCM0467  CL74 HEK-293T C1500(1.03)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C1500(1.21)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C1500(0.94)  LDD1673  [7]
 LDCM0472  CL79 HEK-293T C1500(0.96)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C1500(0.98)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C1500(0.97)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C1500(0.97)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C1500(1.00)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C1500(0.95)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C1500(0.97)  LDD1681  [7]
 LDCM0480  CL86 HEK-293T C1500(0.99)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C1500(1.19)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C1500(1.23)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C1500(1.12)  LDD1687  [7]
 LDCM0486  CL91 HEK-293T C1500(1.11)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C1500(1.09)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C1500(1.00)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C1500(0.81)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C1500(0.95)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C1500(0.95)  LDD1694  [7]
 LDCM0493  CL98 HEK-293T C1500(0.96)  LDD1696  [7]
 LDCM0427  Fragment51 HEK-293T C1500(0.81)  LDD1631  [7]
 LDCM0022  KB02 HCT 116 C641(1.77)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C641(1.37)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C641(2.38)  LDD0082  [2]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402