Details of the Target

General Information of Target

Target ID LDTP03122
Target Name Transcription initiation factor TFIID subunit 1 (TAF1)
Gene Name TAF1
Gene ID 6872
Synonyms
BA2R; CCG1; CCGS; TAF2A; Transcription initiation factor TFIID subunit 1; EC 2.3.1.48; EC 2.7.11.1; Cell cycle gene 1 protein; TBP-associated factor 250 kDa; p250; Transcription initiation factor TFIID 250 kDa subunit; TAF(II)250; TAFII-250; TAFII250
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
RDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMS
EGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESM
MSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRS
GPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
Target Bioclass
Enzyme
Family
TAF1 family
Subcellular location
Nucleus
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly. TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.
Uniprot ID
P21675
Ensemble ID
ENST00000373790.9
HGNC ID
HGNC:11535
ChEMBL ID
CHEMBL3217390

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y110(10,589.02)  LDD3495  [1]
DBIA
 Probe Info  		C40(0.90)  LDD3316  [2]
AHL-Pu-1
 Probe Info  		C1364(5.42)  LDD0170  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1600(0.00); C725(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		C717(0.00); C1364(0.00); C1066(0.00); C280(0.00)  LDD2156  [6]
HHS-465
 Probe Info  		K1591(0.00); Y1589(0.00)  LDD2240  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1364(5.42)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C1364(5.79)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C717(1.00); C1364(1.05); C280(0.98); C786(1.09)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C717(1.03); C1364(1.00); C280(0.85); C786(0.94)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C717(1.05); C1364(0.98); C280(1.22); C786(1.04)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C717(1.20); C1364(1.01); C280(0.98); C786(0.97)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C1364(1.02); C280(1.26); C786(0.94)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C717(0.99); C1364(0.83); C786(0.98)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C717(0.94); C1364(1.01); C280(1.20); C786(1.01)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C717(0.94); C1364(1.06); C280(1.14); C786(0.95)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C717(1.12); C1364(1.18); C280(1.17); C786(0.97)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C717(1.03); C1364(1.06); C280(1.00); C786(1.10)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C717(1.03); C1364(0.98); C280(0.88); C786(0.95)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C717(0.94); C280(0.96); C786(1.07)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C1364(1.03); C280(0.89); C786(0.85)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C717(0.97); C1364(0.75); C786(1.01)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C717(1.07); C1364(1.08); C280(0.92); C786(1.08)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C717(0.92); C1364(1.06); C280(1.19); C786(1.10)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C717(0.98); C1364(1.04); C280(0.97); C786(1.03)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C717(1.02); C1364(1.04); C280(1.08); C786(1.06)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C717(0.96); C1364(0.96); C280(1.04); C786(0.97)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C717(1.02); C280(1.11); C786(1.12)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C717(1.07); C1364(0.98); C280(1.00); C786(0.91)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C1364(1.02); C280(1.18); C786(1.08)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C717(1.02); C1364(0.98); C786(1.09)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C717(1.00); C1364(1.08); C280(0.88); C786(1.13)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C717(1.00); C1364(1.04); C280(1.14); C786(1.07)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C717(0.96); C1364(1.01); C280(1.00); C786(0.96)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C717(1.10); C1364(1.00); C280(1.23); C786(1.12)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C717(1.06); C1364(0.93); C280(1.06); C786(0.93)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C717(1.00); C280(1.02); C786(1.01)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C1364(1.05); C280(1.15); C786(1.04)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C717(1.17); C1364(0.88); C786(1.02)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C717(0.95); C1364(1.01); C280(0.86); C786(0.99)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C717(0.99); C1364(1.01); C280(0.99); C786(1.07)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C717(1.07); C1364(1.01); C280(1.05); C786(1.03)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C717(1.02); C1364(1.10); C280(1.07); C786(1.12)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C717(1.09); C1364(1.02); C280(1.37); C786(0.97)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C717(1.12); C1364(1.00); C280(0.99); C786(0.90)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C717(1.04); C280(1.06); C786(1.06)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C1364(1.04); C280(0.96); C786(0.77)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C717(1.02); C1364(0.91); C786(0.91)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C717(1.05); C1364(1.04); C280(1.01); C786(1.02)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C717(1.01); C1364(1.04); C280(1.06); C786(1.01)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C717(1.01); C280(0.91); C786(1.11)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C717(1.11); C1364(0.99); C280(1.12); C786(0.98)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C717(1.13); C1364(0.99); C280(1.23); C786(1.00)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C717(1.11); C1364(0.99); C280(1.04); C786(1.02)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C717(1.10); C280(0.99); C786(1.09)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C1364(1.02); C280(1.14); C786(1.02)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C717(1.02); C1364(0.99); C786(0.93)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C717(0.98); C1364(1.03); C280(1.07); C786(0.98)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C717(0.96); C1364(1.05); C280(1.03); C786(1.04)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C717(1.01); C1364(1.01); C280(1.15); C786(1.18)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C717(1.14); C1364(0.96); C280(1.13); C786(1.02)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C1364(1.06); C280(1.30); C786(1.25)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C717(1.06); C1364(0.98); C280(0.88); C786(1.00)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C717(1.06); C280(1.11); C786(1.00)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C1364(1.03); C280(1.24); C786(0.90)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C717(1.07); C1364(1.11); C786(1.06)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C717(0.91); C1364(0.99); C280(0.91); C786(1.07)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C717(1.05); C1364(0.80); C786(1.08)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C717(1.05); C1364(0.98); C280(1.13); C786(1.05)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C717(0.97); C280(1.03); C786(0.99)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C717(1.02); C1364(1.10); C280(1.15); C786(1.02)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C717(1.06); C1364(1.02); C280(0.99); C786(0.98)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C717(1.12); C1364(0.98); C280(1.20); C786(0.97)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C1364(1.02); C280(1.44); C786(0.88)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C717(0.97); C1364(1.07); C280(0.94); C786(1.04)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C717(1.03); C1364(1.04); C280(1.02); C786(1.07)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C717(1.08); C1364(1.05); C280(0.87); C786(0.94)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C717(1.14); C1364(0.99); C280(1.37); C786(0.97)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C717(1.01); C1364(1.00); C280(1.01); C786(1.03)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C717(1.02); C1364(0.97); C280(0.94); C786(1.01)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C717(0.96); C1364(1.05); C280(0.90); C786(1.30)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C717(1.09); C1364(0.99); C280(1.33); C786(0.86)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C717(0.98); C1364(1.00); C280(0.70); C786(0.99)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C717(1.01); C1364(1.00); C280(1.04); C786(1.00)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C717(1.24); C1364(0.76); C786(1.11)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C717(1.02); C1364(1.11); C280(0.91); C786(1.13)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C717(1.02); C1364(1.05); C280(1.21); C786(1.10)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C717(1.09); C1364(1.11); C280(0.83); C786(1.17)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C717(1.10); C1364(0.98); C280(1.02); C786(0.85)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C717(1.05); C1364(1.08); C280(0.83); C786(0.91)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C717(1.18); C1364(1.01); C280(1.02); C786(1.03)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C717(1.09); C1364(1.04); C280(1.06); C786(0.93)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C717(1.15); C1364(0.92); C280(1.04); C786(0.98)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C717(1.02); C1364(1.02); C280(0.94); C786(1.13)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C717(1.10); C1364(0.95); C280(1.07); C786(0.97)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C717(1.24); C1364(0.87); C280(1.01); C786(1.13)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C717(1.07); C1364(1.02); C280(0.91); C786(1.00)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C717(1.09); C1364(0.98); C280(1.01); C786(0.93)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C717(1.03); C1364(0.98); C280(0.90); C786(1.07)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C717(1.23); C1364(0.96); C280(0.97); C786(1.10)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C717(1.11); C1364(1.04); C280(1.11); C786(1.11)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C717(1.05); C1364(0.91); C280(0.98); C786(0.94)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C717(1.04); C1364(1.08); C280(1.02); C786(1.00)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C717(1.18); C1364(1.01); C280(1.19); C786(0.88)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C717(0.94); C1364(1.03); C280(0.94); C786(1.13)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C717(1.08); C1364(1.18); C280(1.12); C786(0.96)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C717(1.06); C1364(1.06); C280(1.00); C786(1.08)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C717(1.19); C1364(0.93); C280(0.87); C786(1.00)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C717(1.03); C1364(1.01); C280(0.92); C786(1.10)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C717(1.19); C1364(1.09); C280(1.10); C786(1.17)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C717(1.16); C1364(0.97); C280(0.90); C786(1.09)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C717(1.28); C1364(1.02); C280(1.14); C786(1.14)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C717(1.03); C1364(1.11); C280(1.05); C786(0.97)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C717(1.22); C1364(0.93); C280(1.17); C786(0.99)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C717(1.33); C280(1.11); C786(1.42)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C1364(0.91); C280(1.08); C786(1.03)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C717(1.29); C1364(0.85); C786(1.10)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C717(1.29); C1364(0.79); C280(1.73); C786(1.11)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C717(1.01); C1364(0.93); C280(0.99); C786(0.99)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C717(0.98); C1364(1.00); C280(1.09); C786(0.80)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C717(1.19); C1364(0.98); C280(0.90); C786(0.94)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C717(1.07); C1364(1.01); C280(0.82); C786(1.04)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C717(1.01); C1364(0.93); C280(0.98); C786(1.07)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C717(1.20); C1364(0.89); C280(1.01); C786(1.00)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C717(1.00); C1364(0.99); C280(0.90); C786(1.05)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C717(1.23); C1364(1.02); C280(0.82); C786(1.01)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C717(1.11); C1364(0.93); C280(1.24); C786(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C717(1.19); C280(1.13); C786(1.26)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C1364(0.86); C280(1.05); C786(1.01)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C717(1.09); C1364(0.93); C786(1.13)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C717(1.21); C1364(0.77); C280(1.39); C786(1.15)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C717(0.98); C1364(0.92); C280(0.89); C786(0.91)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C717(1.27); C1364(1.22); C280(1.11); C786(0.98)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C717(1.05); C1364(1.00); C280(1.10); C786(1.06)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C717(1.10); C1364(1.02); C280(0.82); C786(1.03)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C717(1.06); C1364(1.07); C280(1.18); C786(1.27)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C717(0.95); C1364(0.96); C280(1.38); C786(1.04)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C717(1.24); C1364(0.97); C280(1.15); C786(1.07)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C717(1.11); C1364(0.93); C280(1.32); C786(1.11)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C717(1.19); C280(1.06); C786(1.13)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C1364(0.90); C280(1.64); C786(0.96)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C717(1.19); C1364(0.85); C786(1.06)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C717(1.17); C1364(0.70); C280(1.24); C786(0.99)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C717(1.06); C1364(0.87); C280(1.04); C786(0.96)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C717(1.13); C1364(1.06); C280(1.13); C786(0.98)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C717(1.05); C1364(1.04); C280(1.15); C786(1.08)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C717(1.10); C1364(1.02); C280(1.02); C786(1.02)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C717(1.19); C1364(1.10); C280(1.08); C786(1.14)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C717(1.21); C1364(0.96); C280(0.97); C786(1.20)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C717(1.39); C1364(0.97); C280(1.26); C786(0.98)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C717(1.28); C1364(0.94); C280(1.33); C786(1.09)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C717(1.29); C280(1.06); C786(0.88)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C1364(0.88); C280(1.03); C786(1.09)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C717(1.22); C1364(0.82); C786(1.05)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C717(1.25); C1364(1.01); C280(1.39); C786(1.17)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C717(1.32); C1364(0.71); C280(0.99); C786(1.08)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C717(1.07); C1364(0.91); C280(0.96); C786(1.17)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C717(1.04); C1364(1.04); C280(0.88); C786(0.92)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C717(1.01); C1364(0.98); C280(0.83); C786(0.94)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C717(1.08); C1364(1.05); C280(0.91); C786(1.24)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C717(1.06); C1364(1.02); C280(1.05); C786(1.03)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C717(1.17); C1364(1.01); C280(0.66); C786(1.02)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C717(1.24); C1364(1.01); C280(1.03); C786(1.08)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C717(1.25); C1364(0.93); C280(1.28); C786(1.05)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C717(1.13); C280(1.13); C786(1.18)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C717(1.37); C1364(1.00); C280(1.25); C786(1.09)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C1364(0.85); C280(1.13); C786(0.96)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C717(1.04); C1364(0.85); C786(1.13)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C717(1.23); C1364(0.78); C280(0.89); C786(1.08)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C717(1.17); C1364(0.99); C280(1.02); C786(1.01)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C717(1.00); C1364(1.05); C280(0.88); C786(0.96)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C717(1.08); C1364(1.04); C280(0.84); C786(1.03)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C717(1.10); C1364(1.11); C280(1.15); C786(1.35)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C717(1.10); C1364(0.95); C280(1.36); C786(1.09)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C717(1.24); C1364(0.96); C280(1.03); C786(1.17)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C717(1.41); C1364(1.03); C280(0.99); C786(1.63)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C717(1.23); C1364(0.92); C280(1.10); C786(0.98)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C717(1.09); C280(1.15); C786(1.05)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C1364(0.90); C280(1.73); C786(1.06)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C717(1.18); C1364(0.95); C786(1.08)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C717(1.19); C1364(0.82); C280(1.02); C786(1.27)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C717(0.99); C1364(0.96); C280(1.03); C786(0.92)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C717(1.02); C1364(1.03); C280(0.95); C786(0.96)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C717(1.15); C1364(0.97); C280(0.93); C786(0.97)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C717(1.05); C1364(1.03); C280(0.88); C786(1.07)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C717(0.95); C1364(1.01); C280(1.22); C786(0.98)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C717(1.23); C280(1.01); C786(1.15)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C717(1.26); C1364(1.02); C280(1.28); C786(1.43)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C717(1.22); C1364(0.97); C280(1.24); C786(1.11)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C717(1.27); C1364(0.93); C280(1.04); C786(1.09)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C717(1.12); C280(0.97); C786(1.05)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C1364(0.97); C280(0.86); C786(0.95)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C717(1.23); C1364(0.96); C786(1.15)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C717(1.10); C1364(0.80); C280(1.50); C786(1.32)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C717(1.12); C1364(0.97); C280(1.09); C786(1.01)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C717(1.02); C1364(1.04); C280(0.88); C786(0.92)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C717(1.06); C1364(1.08); C280(1.12); C786(0.95)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C717(1.18); C1364(1.12); C280(1.06); C786(1.07)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C717(1.26); C1364(0.94); C280(0.75); C786(1.06)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C717(0.96); C1364(1.05); C280(0.97); C786(1.02)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C1364(1.01); C280(0.88); C786(0.85)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C1364(1.09); C280(1.10); C786(1.08)  LDD1497  [8]
 LDCM0024  KB05 MEL167 C40(0.90)  LDD3316  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TATA-box-binding protein (TBP) TBP family P20226
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
General transcription factor IIF subunit 1 (GTF2F1) TFIIF alpha subunit family P35269

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402