Details of the Target

General Information of Target

Target ID LDTP03039
Target Name Cyclin-A2 (CCNA2)
Gene Name CCNA2
Gene ID 890
Synonyms
CCN1; CCNA; Cyclin-A2; Cyclin-A; Cyclin A
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRG
LAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKI
EREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHE
DIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYID
RFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK
VLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAF
HLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHG
VSLLNPPETLNL
Target Type
Literature-reported
Target Bioclass
Other
Family
Cyclin family, Cyclin AB subfamily
Subcellular location
Nucleus
Function
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
TTD ID
T58470
Uniprot ID
P20248
DrugMap ID
TTAMQ62
Ensemble ID
ENST00000274026.10
HGNC ID
HGNC:1578
ChEMBL ID
CHEMBL2582

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K201(1.18); K54(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C327(1.73)  LDD3397  [2]
AHL-Pu-1
 Probe Info  		C327(2.61)  LDD0169  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C390(0.00); C327(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C390(0.00); C327(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C327(0.00); C390(0.00)  LDD0037  [4]
IPM
 Probe Info  		C327(0.00); C390(0.00)  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C327(2.61)  LDD0169  [3]
 LDCM0214  AC1 PaTu 8988t C327(1.20)  LDD1093  [8]
 LDCM0215  AC10 PaTu 8988t C327(1.39)  LDD1094  [8]
 LDCM0226  AC11 PaTu 8988t C327(1.66)  LDD1105  [8]
 LDCM0237  AC12 PaTu 8988t C327(1.52)  LDD1116  [8]
 LDCM0259  AC14 PaTu 8988t C327(1.30)  LDD1138  [8]
 LDCM0270  AC15 PaTu 8988t C327(1.23)  LDD1149  [8]
 LDCM0276  AC17 HEK-293T C327(0.97); C390(1.18)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C327(0.97); C390(0.92)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C327(0.95); C390(0.98)  LDD1517  [9]
 LDCM0279  AC2 PaTu 8988t C327(1.24)  LDD1158  [8]
 LDCM0280  AC20 HEK-293T C327(0.91); C390(0.96)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C327(1.03); C390(0.97)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C327(1.00); C390(1.07)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C327(0.83); C390(1.10)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C327(0.94)  LDD1523  [9]
 LDCM0285  AC25 PaTu 8988t C327(1.32)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C327(1.08)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C327(1.41)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C327(1.71)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C327(1.26)  LDD1168  [8]
 LDCM0290  AC3 PaTu 8988t C327(1.00)  LDD1169  [8]
 LDCM0291  AC30 PaTu 8988t C327(1.04)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C327(1.15)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C327(1.40)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C327(1.60)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C327(1.13)  LDD1174  [8]
 LDCM0296  AC35 HEK-293T C327(1.06); C390(1.10)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C327(0.93); C390(1.13)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C327(0.98); C390(1.03)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C327(0.91); C390(1.08)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C327(0.79); C390(0.99)  LDD1539  [9]
 LDCM0301  AC4 PaTu 8988t C327(1.26)  LDD1180  [8]
 LDCM0302  AC40 HEK-293T C327(0.98)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C327(0.99); C390(1.01)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C327(1.05); C390(1.07)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C327(0.81); C390(1.20)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C327(0.96); C390(0.87)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C327(0.93); C390(1.03)  LDD1546  [9]
 LDCM0308  AC46 PaTu 8988t C327(1.04)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C327(0.94)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C327(0.98)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C327(1.14)  LDD1190  [8]
 LDCM0312  AC5 PaTu 8988t C327(1.37)  LDD1191  [8]
 LDCM0313  AC50 PaTu 8988t C327(1.18)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C327(1.24)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C327(1.12)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C327(1.12)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C327(1.15)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C327(0.97)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C327(1.45)  LDD1198  [8]
 LDCM0320  AC57 PaTu 8988t C327(1.02)  LDD1199  [8]
 LDCM0321  AC58 PaTu 8988t C327(0.87)  LDD1200  [8]
 LDCM0322  AC59 PaTu 8988t C327(0.96)  LDD1201  [8]
 LDCM0323  AC6 PaTu 8988t C327(1.19)  LDD1202  [8]
 LDCM0324  AC60 PaTu 8988t C327(0.81)  LDD1203  [8]
 LDCM0325  AC61 PaTu 8988t C327(1.08)  LDD1204  [8]
 LDCM0326  AC62 PaTu 8988t C327(1.17)  LDD1205  [8]
 LDCM0327  AC63 PaTu 8988t C327(1.04)  LDD1206  [8]
 LDCM0328  AC64 PaTu 8988t C327(0.99)  LDD1207  [8]
 LDCM0329  AC65 PaTu 8988t C327(1.04)  LDD1208  [8]
 LDCM0330  AC66 PaTu 8988t C327(0.84)  LDD1209  [8]
 LDCM0331  AC67 PaTu 8988t C327(0.88)  LDD1210  [8]
 LDCM0332  AC68 PaTu 8988t C327(0.85)  LDD1211  [8]
 LDCM0333  AC69 PaTu 8988t C327(0.93)  LDD1212  [8]
 LDCM0334  AC7 PaTu 8988t C327(1.03)  LDD1213  [8]
 LDCM0335  AC70 PaTu 8988t C327(0.85)  LDD1214  [8]
 LDCM0336  AC71 PaTu 8988t C327(0.84)  LDD1215  [8]
 LDCM0337  AC72 PaTu 8988t C327(0.99)  LDD1216  [8]
 LDCM0338  AC73 PaTu 8988t C327(0.71)  LDD1217  [8]
 LDCM0339  AC74 PaTu 8988t C327(0.72)  LDD1218  [8]
 LDCM0340  AC75 PaTu 8988t C327(0.93)  LDD1219  [8]
 LDCM0341  AC76 PaTu 8988t C327(0.80)  LDD1220  [8]
 LDCM0342  AC77 PaTu 8988t C327(0.83)  LDD1221  [8]
 LDCM0343  AC78 PaTu 8988t C327(0.75)  LDD1222  [8]
 LDCM0344  AC79 PaTu 8988t C327(0.70)  LDD1223  [8]
 LDCM0345  AC8 PaTu 8988t C327(1.02)  LDD1224  [8]
 LDCM0346  AC80 PaTu 8988t C327(0.77)  LDD1225  [8]
 LDCM0347  AC81 PaTu 8988t C327(0.81)  LDD1226  [8]
 LDCM0348  AC82 PaTu 8988t C327(0.74)  LDD1227  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C327(1.44)  LDD1127  [8]
 LDCM0356  AKOS034007680 PaTu 8988t C327(1.61)  LDD1235  [8]
 LDCM0275  AKOS034007705 PaTu 8988t C327(1.31)  LDD1154  [8]
 LDCM0367  CL1 HEK-293T C327(1.32); C390(1.21)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C327(1.48); C390(1.68)  LDD1572  [9]
 LDCM0369  CL100 PaTu 8988t C327(1.08)  LDD1248  [8]
 LDCM0370  CL101 PaTu 8988t C327(1.22)  LDD1249  [8]
 LDCM0371  CL102 PaTu 8988t C327(1.17)  LDD1250  [8]
 LDCM0372  CL103 PaTu 8988t C327(1.77)  LDD1251  [8]
 LDCM0373  CL104 PaTu 8988t C327(1.62)  LDD1252  [8]
 LDCM0374  CL105 HEK-293T C327(1.06); C390(1.14)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C327(0.99); C390(1.17)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C327(0.90); C390(1.09)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C327(0.96); C390(0.99)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C327(1.09); C390(1.14)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C327(1.45); C390(0.95)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C327(1.16); C390(1.56)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C327(0.95); C390(1.16)  LDD1585  [9]
 LDCM0382  CL112 PaTu 8988t C327(1.28)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C327(1.13)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C327(1.03)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C327(1.38)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C327(1.55)  LDD1265  [8]
 LDCM0387  CL117 HEK-293T C327(1.04); C390(1.09)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C327(0.96); C390(1.05)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C327(0.90); C390(1.13)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C327(1.48)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C327(0.93); C390(0.98)  LDD1595  [9]
 LDCM0392  CL121 PaTu 8988t C327(1.03)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C327(1.53)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C327(1.11)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C327(1.23)  LDD1274  [8]
 LDCM0396  CL125 PaTu 8988t C327(0.83)  LDD1275  [8]
 LDCM0397  CL126 PaTu 8988t C327(0.87)  LDD1276  [8]
 LDCM0398  CL127 PaTu 8988t C327(1.01)  LDD1277  [8]
 LDCM0399  CL128 PaTu 8988t C327(0.93)  LDD1278  [8]
 LDCM0400  CL13 HEK-293T C327(1.03); C390(0.96)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C327(0.94); C390(0.95)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C327(1.09); C390(1.42)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C327(1.01); C390(0.94)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C327(1.28); C390(1.08)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C327(1.01); C390(0.81)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C327(0.90); C390(0.84)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C327(0.98); C390(0.86)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C327(1.10); C390(0.75)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C327(1.30); C390(0.94)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C327(1.17); C390(1.03)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C327(1.09); C390(0.89)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C327(1.21)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C327(1.28); C390(1.03)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C327(0.93); C390(1.18)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C327(0.89); C390(1.05)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C327(1.05); C390(1.00)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C327(0.93); C390(1.01)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C327(1.03); C390(1.14)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C327(1.01); C390(0.90)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C327(0.87); C390(0.81)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C327(1.12); C390(0.78)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C327(1.27); C390(1.09)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C327(1.51); C390(1.00)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C327(1.20); C390(0.82)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C327(1.25)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C327(1.08); C390(1.05)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C327(0.92); C390(1.08)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C327(1.14); C390(0.94)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C327(0.93); C390(1.05)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C327(1.12); C390(1.09)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C327(1.06); C390(0.72)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C327(1.02); C390(0.85)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C327(1.03); C390(0.76)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C327(1.10); C390(0.95)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C327(1.27); C390(0.96)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C327(1.09); C390(0.81)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C327(1.18)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C327(1.10); C390(0.86)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C327(1.11); C390(0.84)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C327(1.02); C390(1.04)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C327(0.91); C390(1.02)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C327(1.07); C390(1.27)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C327(1.37); C390(1.32)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C327(0.93); C390(0.78)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C327(1.08); C390(0.77)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C327(1.27); C390(0.99)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C327(1.25); C390(0.93)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C327(1.09); C390(0.86)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C327(1.35); C390(0.83)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C327(1.26)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C327(1.05); C390(0.99)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C327(0.91); C390(1.04)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C327(0.84); C390(1.03)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C327(1.04); C390(1.12)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C327(0.89); C390(1.02)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C327(1.09); C390(0.82)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C327(0.96); C390(0.88)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C327(1.11); C390(0.76)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C327(1.38); C390(0.80)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C327(0.95); C390(0.76)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C327(1.04); C390(0.99)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C327(0.93); C390(0.94)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C327(1.15)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C327(1.15); C390(1.00)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C327(0.97); C390(0.93)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C327(0.98); C390(0.91)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C327(1.22); C390(1.06)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C327(1.03); C390(0.86)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C327(0.89); C390(0.87)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C327(1.35); C390(1.40)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C327(0.99); C390(0.75)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C327(0.98); C390(0.80)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C327(1.07); C390(0.99)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C327(1.10); C390(0.91)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C327(1.20)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C327(1.16); C390(1.06)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C327(1.05); C390(0.96)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C327(1.05); C390(0.94)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C327(1.12); C390(0.82)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C327(0.98); C390(0.77)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C327(1.38); C390(0.84)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C327(1.26); C390(1.27)  LDD1688  [9]
 LDCM0486  CL91 PaTu 8988t C327(0.89)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C327(1.52)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C327(1.11)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C327(1.30)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C327(0.97)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C327(0.90)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C327(1.24)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C327(1.54)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C327(1.37)  LDD1373  [8]
 LDCM0495  E2913 HEK-293T C327(0.82); C390(1.18)  LDD1698  [9]
 LDCM0625  F8 Ramos C390(1.82)  LDD2187  [10]
 LDCM0573  Fragment11 Ramos C390(2.11)  LDD2190  [10]
 LDCM0576  Fragment14 Ramos C390(0.67)  LDD2193  [10]
 LDCM0586  Fragment28 Ramos C390(1.92)  LDD2198  [10]
 LDCM0468  Fragment33 HEK-293T C327(0.95); C390(1.05)  LDD1671  [9]
 LDCM0566  Fragment4 Ramos C390(0.84)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C327(0.86); C390(1.10)  LDD1631  [9]
 LDCM0569  Fragment7 Ramos C390(1.17)  LDD2186  [10]
 LDCM0022  KB02 HEK-293T C390(0.98); C327(0.90)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C390(0.89); C327(0.88)  LDD1497  [9]
 LDCM0024  KB05 PF-382 C327(1.73)  LDD3397  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Cyclin-dependent kinase 2 (CDK2) CMGC Ser/Thr protein kinase family P24941
E3 ubiquitin-protein ligase UHRF2 (UHRF2) . Q96PU4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 54 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2,5-dichloro-n-p-tolylthiophene-3-sulfonamide Small molecular drug D06WUE
2-anilino-6-cyclohexylmethoxypurine Small molecular drug DB06948
3-((3,5-diamino-1h-pyrazol-4-yl)Diazenyl)Phenol Small molecular drug D0W0BL
4-(24-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine Small molecular drug DB02091
4-(4-methoxy-1h-pyrrolo[23-b]Pyridin-3-yl)Pyrimidin-2-amine Small molecular drug DB08178
4-(4-propoxy-1h-pyrrolo[23-b]Pyridin-3-yl)Pyrimidin-2-amine Small molecular drug DB08182
4-(Phenyldiazenyl)-1h-pyrazole-3,5-diamine Small molecular drug D04UNQ
4-[(3,5-diamino-1h-pyrazol-4-yl)Diazenyl]Phenol Small molecular drug D0A5RM
6-(3-amino-benzyloxy)-9h-purin-2-ylamine Small molecular drug D07JHG
6-(3-methyl-benzyloxy)-9h-purin-2-ylamine Small molecular drug D03XKK
6-(Cyclohex-3-enylmethoxy)-9h-purin-2-ylamine Small molecular drug D01FJB
6-cyclohexylmethoxy-2-(3'-chloroanilino) Purine Small molecular drug DB07203
6-cyclohexylmethoxy-pyrimidine-2,4,5-triamine Small molecular drug D02ZYA
6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)Purine Small molecular drug DB08233
6-o-cyclohexylmethyl Guanine Small molecular drug D0R1FT
Aloisine A Small molecular drug D02XHC
Gw-8510 Small molecular drug D04RBG
Meriolin 1 Small molecular drug D08KSQ
Meriolin 2 Small molecular drug D0U1WL
Meriolin 3 Small molecular drug D0S8VE
Meriolin 4 Small molecular drug D0B9YR
Meriolin 5 Small molecular drug D0H6CQ
Meriolin 6 Small molecular drug D0D0ZQ
Meriolin 7 Small molecular drug D0E3FK
Meriolin 8 Small molecular drug D01PEF
O6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) Purine Small molecular drug DB07126
Purvalanol A Small molecular drug D07OAT
Rescovitine Small molecular drug D07AEC
(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)Amino]-9h-purin-2-yl}Amino)Butan-1-ol . DB08463
(2r)-2-{[4-(Benzylamino)-8-(1-methylethyl)Pyrazolo[15-a][135]Triazin-2-yl]Amino}Butan-1-ol . DB08285
(2s)-n-[(3e)-5-cyclopropyl-3h-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)Phenyl]Propanamide . DB07137
1-(35-dichlorophenyl)-5-methyl-1h-124-triazole-3-carboxylic Acid . DB07852
1-methyl-8-(Phenylamino)-45-dihydro-1h-pyrazolo[43-h]Quinazoline-3-carboxylic Acid . DB08355
1-[4-(Aminosulfonyl)Phenyl]-16-dihydropyrazolo[34-e]Indazole-3-carboxamide . DB08527
3-(6-cyclohexylmethoxy-9h-purin-2-ylamino)-benzenesulfonamide . DB08248
3-({2-[(4-{[6-(Cyclohexylmethoxy)-9h-purin-2-yl]Amino}Phenyl)Sulfonyl]Ethyl}Amino)Propan-1-ol . DB08309
4-(24-dimethyl-13-thiazol-5-yl)-n-[4-(Trifluoromethyl)Phenyl]-2-pyrimidinamine . DB02915
4-(6-cyclohexylmethoxy-9h-purin-2-ylamino)--benzamide . DB08241
4-methyl-5-[(2z)-2-{[4-(4-morpholinyl)Phenyl]Imino}-25-dihydro-4-pyrimidinyl]-13-thiazol-2-amine . DB08219
4-[(7-oxo-7h-thiazolo[54-e]Indol-8-ylmethyl)-amino]-n-pyridin-2-yl-benzenesulfonamide . DB06844
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]-2-furyl}-n-methylbenzenesulfonamide . DB07533
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]Furan-2-yl}-2-(Trifluoromethyl)Benzenesulfonamide . DB07538
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]Furan-2-yl}Benzenesulfonamide . DB07534
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]Furan-2-yl}Benzoic Acid . DB07539
4-{[4-amino-6-(Cyclohexylmethoxy)-5-nitrosopyrimidin-2-yl]Amino}Benzamide . DB08572
4-{[5-(Cyclohexyloxy)[124]Triazolo[15-a]Pyrimidin-7-yl]Amino}Benzenesulfonamide . DB07688
5-[56-bis(Methyloxy)-1h-benzimidazol-1-yl]-3-{[1-(2-chlorophenyl)Ethyl]Oxy}-2-thiophenecarboxamide . DB07471
Hydroxy(Oxo)(3-{[(2z)-4-[3-(1h-124-triazol-1-ylmethyl)Phenyl]Pyrimidin-2(5h)-ylidene]Amino}Phenyl)Ammonium . DB08218
N-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)Acetamide . DB06944
N-cyclopropyl-4-pyrazolo[15-b]Pyridazin-3-ylpyrimidin-2-amine . DB07164
N-[4-(24-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n'n'-dimethyl-benzene-14-diamine . DB07562
Nu-6027 . D0U8YN
Variolin B . DB08694
[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine . DB02833
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pd-0183812 Small molecular drug D0Z0KD

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578