Details of the Target

General Information of Target

Target ID LDTP02668
Target Name Versican core protein (VCAN)
Gene Name VCAN
Gene ID 1462
Synonyms
CSPG2; Versican core protein; Chondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan 2; Glial hyaluronate-binding protein; GHAP; Large fibroblast proteoglycan; PG-M
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSE
FLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKL
LASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIA
TPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYD
VYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS
DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKPKEATTIDLSILA
ETASPSLSKEPQMVSDRTTPIIPLVDELPVIPTEFPPVGNIVSFEQKATVQPQAITDSLA
TKLPTPTGSTKKPWDMDDYSPSASGPLGKLDISEIKEEVLQSTTGVSHYATDSWDGVVED
KQTQESVTQIEQIEVGPLVTSMEILKHIPSKEFPVTETPLVTARMILESKTEKKMVSTVS
ELVTTGHYGFTLGEEDDEDRTLTVGSDESTLIFDQIPEVITVSKTSEDTIHTHLEDLESV
SASTTVSPLIMPDNNGSSMDDWEERQTSGRITEEFLGKYLSTTPFPSQHRTEIELFPYSG
DKILVEGISTVIYPSLQTEMTHRRERTETLIPEMRTDTYTDEIQEEITKSPFMGKTEEEV
FSGMKLSTSLSEPIHVTESSVEMTKSFDFPTLITKLSAEPTEVRDMEEDFTATPGTTKYD
ENITTVLLAHGTLSVEAATVSKWSWDEDNTTSKPLESTEPSASSKLPPALLTTVGMNGKD
KDIPSFTEDGADEFTLIPDSTQKQLEEVTDEDIAAHGKFTIRFQPTTSTGIAEKSTLRDS
TTEEKVPPITSTEGQVYATMEGSALGEVEDVDLSKPVSTVPQFAHTSEVEGLAFVSYSST
QEPTTYVDSSHTIPLSVIPKTDWGVLVPSVPSEDEVLGEPSQDILVIDQTRLEATISPET
MRTTKITEGTTQEEFPWKEQTAEKPVPALSSTAWTPKEAVTPLDEQEGDGSAYTVSEDEL
LTGSERVPVLETTPVGKIDHSVSYPPGAVTEHKVKTDEVVTLTPRIGPKVSLSPGPEQKY
ETEGSSTTGFTSSLSPFSTHITQLMEETTTEKTSLEDIDLGSGLFEKPKATELIEFSTIK
VTVPSDITTAFSSVDRLHTTSAFKPSSAITKKPPLIDREPGEETTSDMVIIGESTSHVPP
TTLEDIVAKETETDIDREYFTTSSPPATQPTRPPTVEDKEAFGPQALSTPQPPASTKFHP
DINVYIIEVRENKTGRMSDLSVIGHPIDSESKEDEPCSEETDPVHDLMAEILPEFPDIIE
IDLYHSEENEEEEEECANATDVTTTPSVQYINGKHLVTTVPKDPEAAEARRGQFESVAPS
QNFSDSSESDTHPFVIAKTELSTAVQPNESTETTESLEVTWKPETYPETSEHFSGGEPDV
FPTVPFHEEFESGTAKKGAESVTERDTEVGHQAHEHTEPVSLFPEESSGEIAIDQESQKI
AFARATEVTFGEEVEKSTSVTYTPTIVPSSASAYVSEEEAVTLIGNPWPDDLLSTKESWV
EATPRQVVELSGSSSIPITEGSGEAEEDEDTMFTMVTDLSQRNTTDTLITLDTSRIITES
FFEVPATTIYPVSEQPSAKVVPTKFVSETDTSEWISSTTVEEKKRKEEEGTTGTASTFEV
YSSTQRSDQLILPFELESPNVATSSDSGTRKSFMSLTTPTQSEREMTDSTPVFTETNTLE
NLGAQTTEHSSIHQPGVQEGLTTLPRSPASVFMEQGSGEAAADPETTTVSSFSLNVEYAI
QAEKEVAGTLSPHVETTFSTEPTGLVLSTVMDRVVAENITQTSREIVISERLGEPNYGAE
IRGFSTGFPLEEDFSGDFREYSTVSHPIAKEETVMMEGSGDAAFRDTQTSPSTVPTSVHI
SHISDSEGPSSTMVSTSAFPWEEFTSSAEGSGEQLVTVSSSVVPVLPSAVQKFSGTASSI
IDEGLGEVGTVNEIDRRSTILPTAEVEGTKAPVEKEEVKVSGTVSTNFPQTIEPAKLWSR
QEVNPVRQEIESETTSEEQIQEEKSFESPQNSPATEQTIFDSQTFTETELKTTDYSVLTT
KKTYSDDKEMKEEDTSLVNMSTPDPDANGLESYTTLPEATEKSHFFLATALVTESIPAEH
VVTDSPIKKEESTKHFPKGMRPTIQESDTELLFSGLGSGEEVLPTLPTESVNFTEVEQIN
NTLYPHTSQVESTSSDKIEDFNRMENVAKEVGPLVSQTDIFEGSGSVTSTTLIEILSDTG
AEGPTVAPLPFSTDIGHPQNQTVRWAEEIQTSRPQTITEQDSNKNSSTAEINETTTSSTD
FLARAYGFEMAKEFVTSAPKPSDLYYEPSGEGSGEVDIVDSFHTSATTQATRQESSTTFV
SDGSLEKHPEVPSAKAVTADGFPTVSVMLPLHSEQNKSSPDPTSTLSNTVSYERSTDGSF
QDRFREFEDSTLKPNRKKPTENIIIDLDKEDKDLILTITESTILEILPELTSDKNTIIDI
DHTKPVYEDILGMQTDIDTEVPSEPHDSNDESNDDSTQVQEIYEAAVNLSLTEETFEGSA
DVLASYTQATHDESMTYEDRSQLDHMGFHFTTGIPAPSTETELDVLLPTATSLPIPRKSA
TVIPEIEGIKAEAKALDDMFESSTLSDGQAIADQSEIIPTLGQFERTQEEYEDKKHAGPS
FQPEFSSGAEEALVDHTPYLSIATTHLMDQSVTEVPDVMEGSNPPYYTDTTLAVSTFAKL
SSQTPSSPLTIYSGSEASGHTEIPQPSALPGIDVGSSVMSPQDSFKEIHVNIEATFKPSS
EEYLHITEPPSLSPDTKLEPSEDDGKPELLEEMEASPTELIAVEGTEILQDFQNKTDGQV
SGEAIKMFPTIKTPEAGTVITTADEIELEGATQWPHSTSASATYGVEAGVVPWLSPQTSE
RPTLSSSPEINPETQAALIRGQDSTIAASEQQVAARILDSNDQATVNPVEFNTEVATPPF
SLLETSNETDFLIGINEESVEGTAIYLPGPDRCKMNPCLNGGTCYPTETSYVCTCVPGYS
GDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC
YKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQWIGLNDKMFEHDFRWT
DGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPP
VVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPKITCMNPSAYQR
TYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR
Target Bioclass
Immunoglobulin
Family
Aggrecan/versican proteoglycan family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Uniprot ID
P13611
Ensemble ID
ENST00000265077.8
HGNC ID
HGNC:2464

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.H1873Q DBIA    Probe Info 
A549 SNV: p.H1160N .
AGS SNV: p.T2816P .
AN3CA SNV: p.C3325R .
CALU1 SNV: p.D2529H .
COLO678 SNV: p.S2856L .
COLO829 SNV: p.D203N .
DU145 SNV: p.L163M .
EFO21 SNV: p.E1545D DBIA    Probe Info 
HCC1806 SNV: p.S444Ter DBIA    Probe Info 
HCT116 SNV: p.T1503I .
HCT15 SNV: p.L1372I; p.G1632E; p.T2650I .
HEC1 SNV: p.L3038I DBIA    Probe Info 
HEL SNV: p.V955D .
HEL9217 SNV: p.V955D .
HSC4 SNV: p.I1194M .
HT Deletion: p.F1682LfsTer25 .
HT115 SNV: p.Q626H; p.E1621D .
HT1376 SNV: p.E2745K .
HUH1 SNV: p.I1194M DBIA    Probe Info 
IM95 SNV: p.L1854S .
IPC298 SNV: p.V3055A; p.P3106S; p.S3319F DBIA    Probe Info 
JEKO1 SNV: p.G1144C .
JURKAT Deletion: p.T2953HfsTer16
SNV: p.S2616N		 .
KYSE30 SNV: p.D2551E .
LN18 SNV: p.E1137D .
LNCaP clone FGC Deletion: p.Q2090KfsTer3
SNV: p.A953V;p.E2002G		 .
LS180 SNV: p.S1577R DBIA    Probe Info 
MCC13 SNV: p.S1925F
Substitution: p.P1544F		 DBIA    Probe Info 
MCC26 SNV: p.P1929S DBIA    Probe Info 
MELJUSO SNV: p.G99E; p.E853K; p.D3375N .
MEWO SNV: p.P2696S .
MFE296 SNV: p.V868D .
MKN45 SNV: p.E2637V DBIA    Probe Info 
NALM6 SNV: p.F1938L .
NCIH1155 SNV: p.A2757T DBIA    Probe Info 
NCIH1793 SNV: p.D2437Y; p.T2516K .
NCIH1993 SNV: p.P2954T .
NCIH2286 Deletion: p.A2690QfsTer20
SNV: p.P1502L;p.E2794Ter		 .
NCIH3122 SNV: p.I3207F DBIA    Probe Info 
NCIH358 SNV: p.P1828A; p.P1882Q .
OV90 SNV: p.Y2623D DBIA    Probe Info 
OVISE SNV: p.S1758G DBIA    Probe Info 
OVK18 Substitution: p.D2937Y DBIA    Probe Info 
PC14 SNV: p.S1315G DBIA    Probe Info 
PC3 SNV: p.F3308L .
PC9 SNV: p.S1315G .
PF382 SNV: p.E1739D .
RKO SNV: p.R630G DBIA    Probe Info 
SHP77 SNV: p.S618C .
SUDHL6 SNV: p.S1153Y .
SW403 SNV: p.G1768D DBIA    Probe Info 
SW620 Deletion: p.D661IfsTer4
SNV: p.D661G		 .
TE11 SNV: p.V3266A .
TE4 SNV: p.P1505T .
TOV21G SNV: p.S2504N DBIA    Probe Info 
WM115 SNV: p.T1902A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C217(1.12)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [2]
PPMS
 Probe Info  		N.A.  LDD0008  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C217(1.12)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C217(0.71)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C217(0.68)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C217(0.77)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C217(0.64)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C217(0.64)  LDD0587  [1]
 LDCM0276  AC17 HEK-293T C3296(0.76); C315(1.10); C270(1.07)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C3296(1.24); C315(0.99)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C3296(1.12); C315(1.37); C217(1.29)  LDD1517  [4]
 LDCM0279  AC2 HCT 116 C217(0.97)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C3296(0.76); C315(0.95); C217(0.96); C270(1.06)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C3296(1.14); C315(1.06); C217(1.05); C270(1.03)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C3296(0.96); C315(1.07)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C3296(1.03); C315(1.07); C270(0.86)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C315(0.96); C217(0.90)  LDD1523  [4]
 LDCM0285  AC25 HCT 116 C217(1.04)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C217(1.64)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C217(1.51)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C217(1.56)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C217(1.65)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C217(0.96)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C217(1.32)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C217(1.58)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C217(1.50)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C217(1.64)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C217(1.61)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C3296(0.99); C315(1.14); C217(0.96)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C3296(0.86); C315(0.94); C217(1.06); C270(1.31)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C3296(1.08); C315(0.91); C217(1.02); C270(1.35)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C3296(1.12); C315(1.08)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C3296(0.92); C315(1.16); C270(0.84)  LDD1539  [4]
 LDCM0301  AC4 HCT 116 C217(1.03)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C315(0.96); C217(1.06)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C3296(0.88); C315(1.15); C270(1.20)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C3296(0.79); C315(1.16)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C3296(0.98); C315(1.08); C217(0.79)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C3296(1.06); C315(1.08); C217(1.01); C270(1.20)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C3296(1.20); C315(0.92); C217(1.03); C270(1.27)  LDD1546  [4]
 LDCM0308  AC46 HCT 116 C217(1.08)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C217(1.21)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C217(1.42)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C217(1.63)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C217(1.06)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C217(1.33)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C217(1.04)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C217(1.02)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C217(1.15)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C217(1.45)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C217(1.52)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C217(1.65)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C3296(1.10); C315(1.05); C270(1.54)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C3296(0.76); C315(1.08)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C3296(0.99); C315(1.01); C217(1.05)  LDD1561  [4]
 LDCM0323  AC6 HCT 116 C217(1.05)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C3296(1.20); C315(0.97); C217(1.03); C270(1.35)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C3296(1.05); C315(0.96); C217(1.07); C270(1.21)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C3296(0.78); C315(1.04)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C3296(1.01); C315(1.11); C270(0.84)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C315(0.92); C217(0.98)  LDD1567  [4]
 LDCM0332  AC68 HCT 116 C217(1.39)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C217(1.09)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C217(1.07)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C217(1.03)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C217(1.01)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C217(1.13)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C217(1.41)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C217(1.32)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C217(1.34)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C217(1.28)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C217(1.20)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C217(1.16)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C217(0.93)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C217(0.98)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C217(1.09)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C217(1.17)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C217(1.37)  LDD0665  [1]
 LDCM0248  AKOS034007472 HCT 116 C217(0.75)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C217(0.77)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C217(0.65)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C3296(0.86); C315(0.94)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C3296(1.37); C315(1.51)  LDD1572  [4]
 LDCM0369  CL100 HCT 116 C217(1.05)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C217(1.13)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C217(0.86)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C217(0.79)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C217(0.58)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C3296(0.87); C315(1.03)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C3296(0.95); C315(0.92); C217(0.95); C3180(1.03)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C3296(0.69); C315(0.93)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C3296(0.88); C315(0.91)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C3296(0.93); C315(1.07)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C3296(1.27); C315(1.26); C270(1.07)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C3296(1.10); C315(1.10); C217(0.86); C3180(1.09)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C3296(0.82); C315(1.03)  LDD1585  [4]
 LDCM0382  CL112 HCT 116 C217(1.35)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C217(1.58)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C217(1.25)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C217(1.53)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C217(1.39)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C3296(0.96); C315(0.95)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C3296(1.01); C315(0.87); C217(0.97); C3180(1.05)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C3296(1.06); C315(1.00)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C315(0.96); C217(1.05)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C3296(0.96); C315(0.80)  LDD1595  [4]
 LDCM0392  CL121 HCT 116 C217(0.83)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C217(1.35)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C217(1.48)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C217(1.19)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C3296(0.93); C315(0.91)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C3296(1.08); C315(0.94); C217(0.96); C3180(1.05)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C3296(1.05); C315(0.88)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C3296(0.98); C315(0.88)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C3296(0.91); C315(1.03)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C3296(1.13); C315(1.16); C217(0.91); C3180(1.03)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C3296(0.71); C315(0.96)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C3296(1.02); C315(0.96)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C3296(1.01); C315(1.24); C270(1.28)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C3296(0.77); C315(1.02)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C3296(1.06); C315(1.08); C217(1.03)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C3296(1.08); C315(1.18); C217(0.94); C3180(1.13)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C3296(0.90); C315(1.04); C217(1.00); C270(1.17)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C3296(1.34); C315(1.12); C217(1.43); C270(1.07)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C3296(1.31); C315(1.12)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C3296(1.34); C315(1.22); C270(1.09)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C315(0.97); C217(0.98)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C3296(0.88); C315(1.03)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C3296(0.95); C315(1.07); C217(1.03); C3180(0.99)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C3296(0.57); C315(0.88)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C3296(0.96); C315(0.89)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C3296(0.97); C315(1.09); C270(1.32)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C3296(0.97); C315(0.91)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C3296(0.94); C315(0.99)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C3296(1.05); C315(1.02); C217(0.96)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C3296(1.37); C315(0.85); C217(1.04); C270(1.28)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C3296(1.47); C315(1.10); C217(1.30); C270(1.10)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C3296(1.09); C315(1.12)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C3296(1.20); C315(1.46); C270(0.93)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C315(1.03); C217(0.98)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C3296(0.91); C315(0.91)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C3296(0.98); C315(1.00)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C3296(1.02); C315(0.85)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C3296(1.00); C315(0.96)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C3296(1.07); C315(1.06); C270(1.18)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C3296(1.20); C315(1.03)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C3296(1.01); C315(0.97); C217(1.00)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C3296(1.40); C315(1.07); C217(1.01); C270(1.07)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C3296(1.32); C315(1.08); C217(1.21); C270(1.10)  LDD1639  [4]
 LDCM0436  CL46 HCT 116 C217(0.83)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C217(0.91)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C217(0.85)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C217(0.89)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C3296(1.01); C315(1.12); C270(0.92)  LDD1644  [4]
 LDCM0441  CL50 HCT 116 C217(0.79)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C217(1.25)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C217(1.29)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C217(0.80)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C217(0.99)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C217(0.96)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C217(0.92)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C217(0.97)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C217(0.86)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C217(0.84)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C3296(0.86); C315(1.11)  LDD1654  [4]
 LDCM0452  CL60 HCT 116 C217(0.92)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C3296(0.92); C315(0.96)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C3296(1.15); C315(1.07); C217(0.86); C3180(1.01)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C3296(0.71); C315(0.91)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C3296(0.98); C315(0.86)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C3296(0.72); C315(1.16); C270(1.22)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C3296(0.77); C315(1.15)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C3296(1.09); C315(1.01); C217(1.02)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C3296(0.93); C315(1.09); C217(0.97); C270(1.23)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C3296(1.20); C315(1.11); C217(1.31); C270(1.11)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C3296(1.06); C315(1.09); C217(0.93)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C3296(1.29); C315(1.25)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C3296(1.19); C315(1.22); C270(0.89)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C315(0.96); C217(1.01)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C3296(0.85); C315(0.79)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C3296(0.98); C315(0.86); C217(0.98); C3180(1.00)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C3296(0.97); C315(0.89)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C3296(0.94); C315(1.14); C270(1.41)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C3296(1.00); C315(1.01)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C3296(1.04); C315(0.98); C217(1.06)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C3296(0.98); C315(1.19); C217(1.24); C270(1.34)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C3296(1.04); C315(1.12); C217(1.13); C270(1.24)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C3296(1.19); C315(0.98); C217(1.24); C270(1.13)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C3296(1.04); C315(1.27)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C3296(1.19); C315(1.29); C270(0.97)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C315(1.19); C217(1.03)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C3296(0.93); C315(0.84)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C3296(1.00); C315(0.83); C217(0.94); C3180(1.05)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C3296(0.87); C315(0.87)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C3296(0.96); C315(0.88)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C3296(0.93); C315(1.16); C270(1.03)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C3296(1.25); C315(1.18); C217(1.41); C270(1.07)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C3296(1.48); C315(1.15)  LDD1688  [4]
 LDCM0486  CL91 HCT 116 C217(1.28)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C217(1.30)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C217(1.01)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C217(1.01)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C217(1.23)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C217(1.28)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C217(1.00)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C217(1.27)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C217(1.29)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C3296(0.98); C315(1.10)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C3296(1.39); C315(0.88)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C3296(0.96); C315(0.88); C217(0.95); C3180(1.01)  LDD1631  [4]
 LDCM0022  KB02 42-MG-BA C315(1.39)  LDD2244  [5]
 LDCM0023  KB03 42-MG-BA C315(1.54)  LDD2661  [5]
 LDCM0024  KB05 G361 C315(1.94)  LDD3311  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Matrix metalloproteinase-9 (MMP9) Peptidase M10A family P14780

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hyaluronic Acid Small molecular drug DB08818

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840