Details of the Target

General Information of Target

Target ID LDTP02470
Target Name Telomere zinc finger-associated protein (ZBTB48)
Gene Name ZBTB48
Gene ID 3104
Synonyms
HKR3; TZAP; ZNF855; Telomere zinc finger-associated protein; TZAP; Krueppel-related zinc finger protein 3; hKR3; Zinc finger and BTB domain-containing protein 48; Zinc finger protein 855
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGSFVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSG
GSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKTSV
GQAAGGQSGLGPPASQNVNSHVKEPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSP
AQSEGPSSLCGKLKQALKPCPLEDKKPEDCKVPPRPLEAEGAQLQGGSNEWEVVVQVEDD
GDGDYMSEPEAVLTRRKSNVIRKPCAAEPALSAGSLAAEPAENRKGTAVPVECPTCHKKF
LSKYYLKVHNRKHTGEKPFECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFR
RRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRT
ELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPHVCEFCSHAFTQKANL
NMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHV
ASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIH
DRVENYNPRQRKLRNLIIEDEKMVVVALQPPAELEVGSAEVIVESLAQGGLASQLPGQRL
CAEESFTGPGVLEPSLIITAAVPEDCDT
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.
Uniprot ID
P10074
Ensemble ID
ENST00000377674.9
HGNC ID
HGNC:4930
ChEMBL ID
CHEMBL5069366

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C265(3.40)  LDD3339  [1]
AHL-Pu-1
 Probe Info  		C265(4.22)  LDD0170  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C265(4.22)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C265(5.54); C200(2.81)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C200(1.14); C265(1.14); C111(1.07)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C200(1.03); C265(0.94)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C200(1.02); C265(0.91)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C200(1.11); C265(1.09)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C265(1.04); C111(0.99)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C200(1.10); C265(1.12); C111(1.07)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C200(1.20); C265(1.13); C111(1.03)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C200(1.05); C265(1.04)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C200(1.19); C265(1.06)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C200(1.20); C265(0.88)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C200(1.15); C265(1.18)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C265(1.20); C111(1.02)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C265(0.86); C111(1.05)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C200(1.01); C265(1.03); C111(1.08)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C200(0.93); C265(0.94); C111(1.01)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C200(1.14); C265(1.09); C111(0.96)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C200(1.06); C265(1.14)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C200(1.03); C265(1.07)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C200(1.08); C265(0.94)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C265(1.16); C111(0.99)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C200(1.02); C265(1.14)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C265(1.09); C111(1.07)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C200(1.04); C265(1.12); C111(1.00)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C200(0.94); C265(1.09); C111(1.03)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C200(1.06); C265(1.14); C111(1.19)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C200(1.15); C265(0.91)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C200(0.99); C265(0.91)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C200(1.16); C265(1.17)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C265(1.01); C111(0.98)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C265(1.10); C111(1.00)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C200(1.04); C265(0.91); C111(1.07)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C200(1.04); C265(0.96)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C200(0.94); C265(1.11); C111(0.92)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C200(1.18); C265(1.15); C111(1.28)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C200(1.19); C265(1.21)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C200(1.08); C265(1.00)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C200(1.12); C265(1.02)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C265(1.18); C111(1.11)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C265(1.09); C111(1.07)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C200(1.10); C265(1.47); C111(1.14)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C200(0.79); C265(1.02); C111(1.06)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C200(1.13); C265(1.08); C111(1.01)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C265(0.87); C111(0.96)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C200(1.17); C265(0.99)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C200(1.01); C265(0.97)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C200(1.17); C265(0.89)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C265(1.08); C111(0.95)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C265(1.27); C111(1.04)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C200(1.13); C265(0.98); C111(1.02)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C200(0.86); C265(1.00); C111(0.94)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C200(1.07); C265(1.21); C111(1.05)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C200(1.12); C265(1.29)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C200(1.00); C265(1.11)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C265(0.81); C111(1.06)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C200(1.13); C265(0.85)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C265(1.18); C111(1.02)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C265(0.95); C111(1.03)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C200(1.15); C265(1.24); C111(1.06)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C200(0.83); C265(0.98); C111(1.03)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C200(0.99); C265(1.20); C111(1.06)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C200(1.00); C265(1.10); C111(1.05)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C265(1.12); C111(0.93)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C200(1.13); C265(1.15); C111(1.08)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C200(0.97); C265(0.89); C111(1.06)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C200(1.01); C265(0.94); C111(1.03)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C265(0.89); C111(1.26)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C200(1.19); C265(1.18); C26(1.16)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C200(1.02); C265(0.78); C111(1.12)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C200(1.14); C265(1.08)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C200(1.05); C265(1.28); C111(1.17)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C200(1.12); C265(1.08); C26(0.86)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C200(1.06); C265(1.24); C111(1.03)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C200(1.07); C265(1.08)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C200(1.44); C265(1.10); C111(1.02)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C200(1.11); C265(1.01); C26(0.78)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C200(1.02); C265(1.23); C111(1.03)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C200(0.92); C265(1.02); C111(0.98)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C200(1.10); C265(1.13)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C200(1.08); C265(1.08); C111(1.00)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C200(1.32); C265(1.02); C26(1.13)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C200(1.04); C265(1.42); C111(1.04)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C200(1.08); C265(1.31)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C200(0.97); C265(1.19); C111(1.09)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C200(1.02); C265(1.19); C26(0.80)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C200(0.99); C265(1.21); C111(1.09)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C200(1.15); C265(1.19)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C200(1.03); C265(1.27); C111(1.18)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C200(0.73); C265(1.14); C111(1.03)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C200(1.15); C265(1.01); C26(0.97)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C200(1.08); C265(0.93); C111(1.10)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C200(1.09); C265(1.19)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C200(1.15); C265(0.94); C111(1.15)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C200(1.06); C265(0.96); C26(1.18)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C200(1.05); C265(0.91); C111(0.96)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C200(1.21); C265(0.97)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C200(1.19); C265(1.01); C111(1.22)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C200(1.20); C265(0.85); C26(1.03)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C200(1.07); C265(1.27); C111(1.06)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C200(1.13); C265(1.36)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C200(1.06); C265(1.09); C111(1.68)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C200(1.05); C265(1.13); C26(1.04)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C200(1.09); C265(1.35); C111(1.30)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C200(1.13); C265(1.64)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C200(0.95); C265(1.41)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C200(1.10); C265(1.34)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C200(1.03); C265(0.90)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C265(1.03); C111(1.03)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C265(1.37); C111(1.00)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C200(0.85); C265(0.78); C111(1.14)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C200(0.72); C265(1.02); C111(0.94)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C200(1.18); C265(0.87); C111(1.04)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C200(1.16); C265(1.08)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C200(1.13); C265(1.07); C111(1.17)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C200(1.18); C265(1.04); C26(0.94)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C200(1.08); C265(1.28); C111(1.09)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C200(0.93); C265(1.20); C111(1.07)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C200(1.18); C265(1.23)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C200(1.10); C265(0.95)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C200(1.05); C265(1.16)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C265(1.02); C111(1.00)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C265(1.29); C111(1.00)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C200(0.99); C265(1.40); C111(0.97)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C200(0.81); C265(0.92); C111(0.97)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C200(1.13); C265(1.29); C111(0.99)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C200(1.24); C265(1.30); C111(1.11)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C200(1.07); C265(0.85); C26(1.17)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C200(1.27); C265(0.91); C26(0.92)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C200(1.06); C265(1.19); C111(1.01)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C200(1.17); C265(1.13)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C200(0.87); C265(0.96)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C200(0.95); C265(1.32)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C265(1.26); C111(0.90)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C265(1.04); C111(0.94)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C200(1.02); C265(1.05); C111(0.99)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C200(0.85); C265(0.90); C111(0.97)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C200(1.04); C265(1.03); C111(1.03)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C200(0.99); C265(1.25); C111(1.10)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C200(1.24); C265(1.24)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C200(1.17); C265(1.02); C26(1.13)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C200(1.05); C265(1.16); C111(1.23)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C200(1.12); C265(1.09)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C200(0.99); C265(1.25)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C200(1.18); C265(1.07)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C265(0.92); C111(1.06)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C265(1.04); C111(0.95)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C200(0.88); C265(1.44); C111(0.99)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C200(1.05); C265(0.92)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C200(1.03); C265(1.00); C111(1.05)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C200(1.10); C265(0.85); C111(1.04)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C200(1.14); C265(0.95)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C200(1.23); C265(1.16); C111(1.13)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C200(1.16); C265(0.99); C26(1.09)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C200(1.10); C265(1.00); C111(1.06)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C200(1.20); C265(1.06)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C200(0.94); C265(1.04)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C200(1.07); C265(1.36)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C265(1.12); C111(0.90)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C200(0.95); C265(1.26)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C265(0.85); C111(1.00)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C200(0.95); C265(1.03); C111(1.02)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C200(0.89); C265(1.07); C111(0.88)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C200(1.12); C265(1.25); C111(1.12)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C200(1.07); C265(1.16)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C200(1.18); C265(0.98); C26(0.89)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C200(1.16); C265(1.15); C111(1.11)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C200(1.12); C265(1.38)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C200(0.90); C265(1.03)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C200(1.24); C265(0.92)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C200(0.88); C265(1.07)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C265(1.22); C111(0.89)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C265(1.01); C111(0.94)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C200(0.83); C265(0.93); C111(0.91)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C200(0.81); C265(1.00); C111(0.93)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C200(1.08); C265(0.79); C111(1.05)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C200(1.20); C265(0.99)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C200(1.16); C265(1.11); C111(1.33)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C200(1.20); C265(0.90); C26(1.00)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C200(1.16); C265(1.12); C111(1.06)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C265(1.07); C111(0.95)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C200(1.14); C265(0.89)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C200(1.03); C265(1.02)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C200(1.01); C265(1.00)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C265(1.04); C111(1.03)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C265(1.26); C111(1.00)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C200(1.03); C265(1.25); C111(1.06)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C200(0.79); C265(0.85); C111(0.90)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C200(1.07); C265(0.90); C111(1.10)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C200(0.94); C265(1.03)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C200(1.08); C265(1.13); C111(1.11)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C200(1.43); C265(1.27); C111(1.08)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C200(1.05); C265(0.97); C111(1.07)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C200(1.26); C265(1.16)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C200(1.06); C265(0.79); C111(1.20)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C200(1.02); C265(1.11); C111(1.24)  LDD1497  [4]
 LDCM0024  KB05 NALM-6 C265(3.40)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger protein 317 (ZNF317) Krueppel C2H2-type zinc-finger protein family Q96PQ6
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 6 (ZBTB6) . Q15916
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger and BTB domain-containing protein 9 (ZBTB9) . Q96C00
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Prelamin-A/C (LMNA) Intermediate filament family P02545
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Colorectal mutant cancer protein (MCC) MCC family P23508
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
G patch domain-containing protein 2-like (GPATCH2L) . Q9NWQ4
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402