Details of the Target

General Information of Target

Target ID LDTP02388
Target Name Complement C4-A (C4A)
Gene Name C4A
Gene ID 720
Synonyms
CO4; CPAMD2; Complement C4-A; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLWGLIWASSFFTLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRN
PSRNNVPCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDS
LSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVEN
SHGLRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPN
FEVKITPGKPYILTVPGHLDEMQLDIQARYIYGKPVQGVAYVRFGLLDEDGKKTFFRGLE
SQTKLVNGQSHISLSKAEFQDALEKLNMGITDLQGLRLYVAAAIIESPGGEMEEAELTSW
YFVSSPFSLDLSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQD
IQQNTDGSGQVSIPIIIPQTISELQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERPDS
RPPRVGDTLNLNLRAVGSGATFSHYYYMILSRGQIVFMNREPKRTLTSVSVFVDHHLAPS
FYFVAFYYHGDHPVANSLRVDVQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVA
LGALDTALYAAGSKSHKPLNMGKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQW
TLSRKRLSCPKEKTTRKKRNVNFQKAINEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRA
ARVQQPDCREPFLSCCQFAESLRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPE
NWLWRVETVDRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLP
MSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLCLAGGGGLAQQVLVPAGSARPVAFS
VVPTAAAAVSLKVVARGSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEI
PGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAP
TLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDSSTWLTA
FVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVA
LTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYAL
TLTKAPVDLLGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAPRNPSDPMPQAPAL
WIETTAYALLHLLLHEGKAEMADQASAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASH
TTEERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKV
LRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYEDYEYDELPAKDDPDAPLQPVTP
LQLFEGRRNRRRREAPKVVEEQESRVHYTVCIWRNGKVGLSGMAIADVTLLSGFHALRAD
LEKLTSLSDRYVSHFETEGPHVLLYFDSVPTSRECVGFEAVQEVPVGLVQPASATLYDYY
NPERRCSVFYGAPSKSRLLATLCSAEVCQCAEGKCPRQRRALERGLQDEDGYRMKFACYY
PRVEYGFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPG
KEYLIMGLDGATYDLEGHPQYLLDSNSWIEEMPSERLCRSTRQRAACAQLNDFLQEYGTQ
GCQV
Target Bioclass
Other
Subcellular location
Secreted
Function
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Uniprot ID
P0C0L4
Ensemble ID
ENST00000383325.8
HGNC ID
HGNC:1323

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K1503(1.22); K274(2.48)  LDD3494  [1]
DBIA
 Probe Info  		C736(0.31)  LDD0531  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C736(0.31)  LDD0531  [2]
 LDCM0263  AC143 HCT 116 C735(0.95); C736(1.00)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C735(0.82); C736(1.02)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C735(0.85); C736(1.05)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C736(0.92); C735(1.02)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C735(0.98); C736(1.06)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C735(1.02); C736(1.03)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C736(1.04); C735(1.10)  LDD0586  [2]
 LDCM0271  AC150 HCT 116 C736(0.83); C735(0.91)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C735(1.09); C736(1.09)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C735(1.05); C736(1.12)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C735(1.16); C736(1.20)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C735(1.14); C736(1.14)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C735(1.47); C736(1.41)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C735(0.96); C736(0.94)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C735(1.03); C736(1.17)  LDD2161  [2]
 LDCM0279  AC2 HCT 116 C736(1.28)  LDD0596  [2]
 LDCM0290  AC3 HCT 116 C736(1.33)  LDD0607  [2]
 LDCM0301  AC4 HCT 116 C736(1.19)  LDD0618  [2]
 LDCM0312  AC5 HCT 116 C736(1.20)  LDD0629  [2]
 LDCM0349  AC83 HCT 116 C735(1.42); C736(1.42)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C735(0.36); C736(0.36)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C735(0.97); C736(0.97)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C735(1.00); C736(1.00)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C735(0.92); C736(0.92)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C735(0.85); C736(0.85)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C735(1.17); C736(1.17)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C735(1.43); C736(1.43)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C735(1.12); C736(1.12)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C735(1.06); C736(1.06)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C735(1.05); C736(1.05)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C735(0.77); C736(0.77)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C735(0.96); C736(0.96)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C735(0.90); C736(0.90)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C735(1.16); C736(1.16)  LDD0681  [2]
 LDCM0367  CL1 HCT 116 C736(1.13); C735(1.23)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C736(1.63); C735(1.78)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C736(1.11)  LDD0686  [2]
 LDCM0379  CL11 HCT 116 C736(1.22); C735(1.35)  LDD0696  [2]
 LDCM0390  CL12 HCT 116 C736(1.23); C735(1.68)  LDD0707  [2]
 LDCM0400  CL13 HCT 116 C735(1.36); C736(1.49)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C735(1.54); C736(1.68)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C735(1.31); C736(1.40)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C735(1.02)  LDD0720  [2]
 LDCM0407  CL2 HCT 116 C736(1.13); C735(1.18)  LDD0724  [2]
 LDCM0418  CL3 HCT 116 C735(1.36); C736(1.29)  LDD0735  [2]
 LDCM0421  CL32 HCT 116 C735(1.15)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C735(0.45)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C735(1.30)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C735(1.21)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C735(1.20)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C735(0.65)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C735(0.47)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C735(1.03); C736(1.26)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C735(0.88)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C735(1.18)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C735(0.91)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C735(1.17)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C735(1.33)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C735(1.45)  LDD0752  [2]
 LDCM0440  CL5 HCT 116 C735(1.42); C736(1.40)  LDD0757  [2]
 LDCM0451  CL6 HCT 116 C735(1.55); C736(1.55)  LDD0768  [2]
 LDCM0462  CL7 HCT 116 C735(1.48); C736(1.48)  LDD0779  [2]
 LDCM0469  CL76 HCT 116 C735(0.50)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C735(0.58)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C735(0.32)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C735(0.34)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C735(1.16); C736(1.10)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C735(0.38)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C735(0.67)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C735(0.42)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C735(0.33)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C735(0.40)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C735(0.43)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C735(0.46)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C735(0.43)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C735(0.48)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C735(0.55)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C735(1.09); C736(1.37)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C735(0.42)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C736(0.47)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C736(0.88)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C736(1.12)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C736(1.15)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C736(0.99)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C736(1.30)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C736(1.41)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C736(0.85)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C736(1.19)  LDD0811  [2]
 LDCM0427  Fragment51 HCT 116 C735(1.05)  LDD0744  [2]
 LDCM0022  KB02 Hep 3B2.1-7 C1121(1.75)  LDD2353  [3]
 LDCM0023  KB03 Hep 3B2.1-7 C1121(1.74)  LDD2770  [3]
 LDCM0024  KB05 SK-HEP1 C1121(1.75)  LDD3424  [3]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840