Details of the Target

General Information of Target

Target ID LDTP02090
Target Name Complement factor I (CFI)
Gene Name CFI
Gene ID 3426
Synonyms
IF; Complement factor I; EC 3.4.21.45; C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVT
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted, extracellular space
Function
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.
TTD ID
T92750
Uniprot ID
P05156
DrugMap ID
TT6ATLX
Ensemble ID
ENST00000394634.7
HGNC ID
HGNC:5394

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C67(1.18)  LDD0532  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C61(1.66); C67(1.66)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C67(1.18)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C67(1.79)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C67(1.67)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C67(1.37)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C67(0.93)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C67(1.04)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C67(1.10)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C67(1.19)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C67(0.78)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C67(1.17)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C67(0.88)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C67(1.63)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C67(0.91)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C67(0.93)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C67(0.90)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C67(1.19)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C67(1.04)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C67(0.95)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C67(0.92)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C67(1.01)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C61(1.18); C67(1.18)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C61(1.09); C67(1.09)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C61(1.09); C67(1.09)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C61(1.17); C67(1.17)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C61(1.19); C67(1.19)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C61(1.15); C67(1.15)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C61(1.35); C67(1.35)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C61(1.41); C67(1.41)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C61(1.07); C67(1.07)  LDD0882  [1]
 LDCM0290  AC3 HEK-293T C61(1.27); C67(1.27)  LDD0888  [1]
 LDCM0296  AC35 HCT 116 C67(0.48)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C67(0.57)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C67(0.47)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C67(0.88)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C67(0.66)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C61(1.21); C67(1.21)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C67(0.54)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C67(0.73)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C67(0.76)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C67(0.66)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C67(0.62)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C67(0.53)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C67(0.74)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C67(0.93)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C67(0.87)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C67(0.86)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C61(1.44); C67(1.44)  LDD0910  [1]
 LDCM0313  AC50 HCT 116 C67(0.99)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C67(1.01)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C67(0.92)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C67(1.17)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C67(0.92)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C67(1.84)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C67(1.22)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C61(0.94); C67(0.94)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C61(0.96); C67(0.96)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C61(0.92); C67(0.92)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C67(1.01)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C61(1.04); C67(1.04)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C61(1.18); C67(1.18)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C61(1.00); C67(1.00)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C61(1.15); C67(1.15)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C61(0.99); C67(0.99)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C61(1.17); C67(1.17)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C61(1.06); C67(1.06)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C61(1.11); C67(1.11)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C67(0.88)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C67(1.04)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C67(1.09)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C67(1.01)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C67(1.36)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C67(1.56)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C67(1.37)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C67(1.43)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C67(0.87)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C67(1.01)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C67(0.86)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C67(0.90)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C67(1.12)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C67(1.43)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C67(1.26)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C67(1.03)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C67(1.06)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C61(0.95); C67(0.95)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C61(1.03); C67(1.03)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C61(0.94); C67(0.94)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C61(1.08); C67(1.08)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C61(1.06); C67(1.06)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C61(1.00); C67(1.00)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C61(1.12); C67(1.12)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C61(1.08); C67(1.08)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C61(1.04); C67(1.04)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C61(1.02); C67(1.02)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C61(1.05); C67(1.05)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C61(1.05); C67(1.05)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C61(1.42); C67(1.42)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C61(1.33); C67(1.33)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C61(1.65); C67(1.65)  LDD0962  [1]
 LDCM0248  AKOS034007472 HCT 116 C67(1.59)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C67(1.05)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C67(1.38)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C67(0.99)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C67(0.64)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C61(1.16); C67(1.16)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C67(0.91)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C67(0.74)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C67(1.17)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C67(1.07)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C61(1.00); C67(1.00)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C61(1.07); C67(1.07)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C61(0.86); C67(0.86)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C61(0.99); C67(0.99)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C61(1.05); C67(1.05)  LDD0976  [1]
 LDCM0379  CL11 HCT 116 C67(0.67)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C61(1.18); C67(1.18)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C61(1.00); C67(1.00)  LDD0979  [1]
 LDCM0387  CL117 HCT 116 C67(0.45)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C67(0.71)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C67(0.58)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C67(0.69)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C67(0.58)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C67(1.68)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C67(1.26)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C67(0.99)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C67(1.17)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C61(1.02); C67(1.02)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C61(1.01); C67(1.01)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C61(0.81); C67(0.81)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C61(0.95); C67(0.95)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C67(0.79)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C67(0.73)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C67(0.67)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C61(0.99); C67(0.99)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C61(1.14); C67(1.14)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C61(1.19); C67(1.19)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C61(0.99); C67(0.99)  LDD1004  [1]
 LDCM0407  CL2 HCT 116 C67(0.76)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C61(0.99); C67(0.99)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C61(1.16); C67(1.16)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C61(1.12); C67(1.12)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C61(1.05); C67(1.05)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C61(0.93); C67(0.93)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C61(1.01); C67(1.01)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C61(1.05); C67(1.05)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C61(1.01); C67(1.01)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C61(1.03); C67(1.03)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C61(1.05); C67(1.05)  LDD1015  [1]
 LDCM0418  CL3 HCT 116 C67(0.67)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C61(1.31); C67(1.31)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C61(1.25); C67(1.25)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C61(1.12); C67(1.12)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C61(1.60); C67(1.60)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C61(1.23); C67(1.23)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C61(1.15); C67(1.15)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C61(1.11); C67(1.11)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C61(1.15); C67(1.15)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C61(1.44); C67(1.44)  LDD1026  [1]
 LDCM0429  CL4 HCT 116 C67(0.82)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C61(1.37); C67(1.37)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C61(1.39); C67(1.39)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C61(1.29); C67(1.29)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C61(1.39); C67(1.39)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C61(1.22); C67(1.22)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C61(1.66); C67(1.66)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C67(0.95)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C67(1.00)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C67(0.97)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C67(1.20)  LDD1037  [1]
 LDCM0440  CL5 HCT 116 C67(0.88)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C67(1.31)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C67(1.00)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C67(1.01)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C67(1.21)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C67(0.99)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C67(1.17)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C67(0.72)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C67(1.18)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C67(1.04)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C67(1.23)  LDD1048  [1]
 LDCM0451  CL6 HCT 116 C67(0.89)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C67(1.36)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C67(0.65)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C67(0.74)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C67(1.11)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C67(1.70)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C67(1.29)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C67(1.54)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C67(1.02)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C67(0.65)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C67(0.73)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C67(0.90)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C67(0.87)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C67(1.04)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C67(0.99)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C67(1.02)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C67(0.94)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C61(0.91); C67(0.91)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C61(0.94); C67(0.94)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C61(0.74); C67(0.74)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C61(0.83); C67(0.83)  LDD1070  [1]
 LDCM0473  CL8 HCT 116 C67(0.83)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C61(0.85); C67(0.85)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C61(0.84); C67(0.84)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C61(1.12); C67(1.12)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C61(1.21); C67(1.21)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C61(0.92); C67(0.92)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C61(0.74); C67(0.74)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C61(0.66); C67(0.66)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C61(0.78); C67(0.78)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C61(0.91); C67(0.91)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C61(0.86); C67(0.86)  LDD1081  [1]
 LDCM0484  CL9 HCT 116 C67(0.78)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C61(1.30); C67(1.30)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C61(1.09); C67(1.09)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C61(1.29); C67(1.29)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C61(0.98); C67(0.98)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C61(1.46); C67(1.46)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C61(1.56); C67(1.56)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C61(1.12); C67(1.12)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C61(1.07); C67(1.07)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C61(1.17); C67(1.17)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C61(0.98); C67(0.98)  LDD1092  [1]
 LDCM0468  Fragment33 HCT 116 C67(1.05)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C61(1.09); C67(1.09)  LDD1025  [1]
 LDCM0022  KB02 786-O C93(2.51)  LDD2247  [3]
 LDCM0023  KB03 786-O C93(3.49)  LDD2664  [3]
 LDCM0024  KB05 COLO792 C48(2.18)  LDD3310  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Zinc . DB01593
Zinc Acetate . DB14487
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tp-20 . D03QSR

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840