Details of the Target

General Information of Target

Target ID LDTP01831
Target Name Protransforming growth factor alpha (TGFA)
Gene Name TGFA
Gene ID 7039
Synonyms
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha; TGF-alpha; EGF-like TGF; ETGF; TGF type 1)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC
RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL
IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Secreted, extracellular space; Cell membrane
Function TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
TTD ID
T00033
Uniprot ID
P01135
DrugMap ID
TT9AXQM
Ensemble ID
ENST00000295400.11
HGNC ID
HGNC:11765
ChEMBL ID
CHEMBL4662938

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FADU SNV: p.A37T .
MDST8 SNV: p.S94I .
SKMEL2 SNV: p.S26R .
SKMEL28 SNV: p.C153S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C153(0.92); C154(0.92)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C153(0.92); C154(0.92)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C153(0.86); C154(0.86)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C153(1.22); C154(1.22)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C153(0.88); C154(0.88)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C153(0.89); C154(0.89)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C153(0.95); C154(0.95)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C153(0.96); C154(1.05)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C154(0.98); C153(1.00)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C153(1.01); C154(1.18)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C153(1.07); C154(1.25)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C153(0.88); C154(0.92)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C153(0.91); C154(0.92)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C153(1.06); C154(1.06)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C153(1.00); C154(1.04)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C153(0.82); C154(1.20)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C153(0.91); C154(1.00)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C153(0.83); C154(0.90)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C153(0.83); C154(1.00)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C153(0.77); C154(1.05)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C153(0.92); C154(1.09)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C153(0.77); C154(0.86)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C154(0.92)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C154(0.92)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C154(0.84)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C153(1.13); C154(1.13)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C154(0.86)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C154(0.91)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C154(0.81)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C154(1.04)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C154(1.01)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C153(1.00); C154(1.00)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C153(0.96); C154(0.96)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C153(1.15); C154(1.15)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C153(2.11); C154(2.11)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C153(1.33); C154(1.33)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C153(1.02); C154(1.02)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C153(1.20); C154(1.20)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C153(1.09); C154(1.09)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C153(1.17); C154(1.17)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C153(1.02); C154(1.02)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C153(0.90); C154(0.90)  LDD0612  [1]
 LDCM0301  AC4 HCT 116 C153(0.98); C154(0.98)  LDD0618  [1]
 LDCM0308  AC46 HCT 116 C153(1.26); C154(1.26)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C153(1.08); C154(1.08)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C153(1.13); C154(1.13)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C153(1.18); C154(1.18)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C153(1.10); C154(1.10)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C153(1.20); C154(1.20)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C153(1.03); C154(1.03)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C153(1.14); C154(1.14)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C153(1.05); C154(1.05)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C153(1.08); C154(1.08)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C153(1.00); C154(1.00)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C153(0.98); C154(0.98)  LDD0636  [1]
 LDCM0323  AC6 HCT 116 C153(0.89); C154(0.89)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C153(0.93); C154(0.93)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C153(1.04); C154(1.04)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C153(1.21); C154(1.21)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C153(1.12); C154(1.12)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C153(1.04); C154(1.04)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C153(1.20); C154(1.20)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C153(1.08); C154(1.08)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C153(1.37); C154(1.37)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C153(1.20); C154(1.20)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C153(1.35); C154(1.35)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C153(1.22); C154(1.22)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C153(0.96); C154(0.96)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C153(1.20); C154(1.20)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C153(0.94); C154(0.94)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C153(1.38); C154(1.38)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C153(1.00); C154(1.00)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C153(1.80); C154(1.80)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C153(0.93); C154(0.93)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C153(0.96); C154(0.96)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C153(1.00); C154(1.00)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C153(1.16); C154(1.16)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C153(1.11); C154(1.11)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C153(1.10); C154(1.10)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C153(1.01); C154(1.01)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C153(1.12); C154(1.12)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C153(1.00); C154(1.00)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C153(1.09); C154(1.09)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C154(0.85)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C154(0.86)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C154(0.83)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C154(0.80)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C154(1.20)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C153(1.38); C154(1.38)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C154(0.94)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C154(1.04)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C153(0.99); C154(0.99)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C153(1.01); C154(1.01)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C153(1.50); C154(1.50)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C153(1.16); C154(1.16)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C153(0.98); C154(0.98)  LDD0703  [1]
 LDCM0390  CL12 HCT 116 C153(1.17); C154(1.17)  LDD0707  [1]
 LDCM0392  CL121 HCT 116 C153(1.29); C154(1.29)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C153(1.15); C154(1.15)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C153(1.75); C154(1.75)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C153(1.08); C154(1.08)  LDD0712  [1]
 LDCM0400  CL13 HCT 116 C153(1.14); C154(1.14)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C153(1.08); C154(1.08)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C153(1.32); C154(1.32)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C153(1.32); C154(1.32)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C153(1.20); C154(1.20)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C153(1.20); C154(1.20)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C153(1.21); C154(1.21)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C153(1.27); C154(1.27)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C153(1.12); C154(1.12)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C153(2.84); C154(2.84)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C153(1.01); C154(1.01)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C153(1.27); C154(1.27)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C153(1.26); C154(1.26)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C153(1.29); C154(1.29)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C153(1.27); C154(1.27)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C153(1.29); C154(1.29)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C153(1.30); C154(1.30)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C153(1.19); C154(1.19)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C153(1.16); C154(1.16)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C153(1.08); C154(1.08)  LDD0736  [1]
 LDCM0429  CL4 HCT 116 C153(6.65); C154(6.65)  LDD0746  [1]
 LDCM0436  CL46 HCT 116 C153(1.08); C154(1.08)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C153(1.05); C154(1.05)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C153(1.11); C154(1.11)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C153(1.00); C154(1.00)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C153(1.11); C154(1.11)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C153(1.02); C154(1.02)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C153(1.08); C154(1.08)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C153(1.35); C154(1.35)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C153(0.99); C154(0.99)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C153(1.43); C154(1.43)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C153(1.03); C154(1.03)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C153(0.91); C154(0.91)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C153(0.94); C154(0.94)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C153(1.05); C154(1.05)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C153(0.99); C154(0.99)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C153(1.18); C154(1.18)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C153(1.02); C154(1.02)  LDD0769  [1]
 LDCM0462  CL7 HCT 116 C153(1.26); C154(1.26)  LDD0779  [1]
 LDCM0469  CL76 HCT 116 C153(1.10); C154(1.10)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C153(1.15); C154(1.15)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C153(1.15); C154(1.15)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C153(1.13); C154(1.13)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C153(1.17); C154(1.17)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C153(1.18); C154(1.18)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C153(1.13); C154(1.13)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C153(1.29); C154(1.29)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C153(0.91); C154(0.91)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C153(0.96); C154(0.96)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C153(1.05); C154(1.05)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C153(1.08); C154(1.08)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C153(1.09); C154(1.09)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C153(1.13); C154(1.13)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C153(1.14); C154(1.14)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C153(1.34); C154(1.34)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C153(1.41); C154(1.41)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C153(1.04); C154(1.04)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C153(1.02); C154(1.02)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C153(1.05); C154(1.05)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C153(1.30); C154(1.30)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C153(1.36); C154(1.36)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C153(1.20); C154(1.20)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C153(1.13); C154(1.13)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C153(1.15); C154(1.15)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C153(0.97); C154(0.97)  LDD0811  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein naked cuticle homolog 2 (NKD2) NKD family Q969F2
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.