Details of the Target

General Information of Target

Target ID LDTP01520
Target Name Netrin receptor UNC5C (UNC5C)
Gene Name UNC5C
Gene ID 8633
Synonyms
UNC5H3; Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEP
LPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR
EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL
EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV
AKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCE
GQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSK
NCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALN
GGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIK
VYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLG
GHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGAL
LTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHIL
TENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQ
MGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCT
FTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPS
AFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQN
FPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
Target Bioclass
Immunoglobulin
Family
Unc-5 family
Subcellular location
Cell membrane
Function
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Uniprot ID
O95185
Ensemble ID
ENST00000453304.6
HGNC ID
HGNC:12569

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R849W .
HELA SNV: p.P58R .
HT SNV: p.D434Y .
HUH28 SNV: p.G451R .
MDAMB436 Insertion: p.A926SfsTer38 .
MEWO SNV: p.R285K; p.S516N; p.R700Ter .
MFE319 SNV: p.S593R .
NCIH1666 SNV: p.W266L .
NCIH2172 SNV: p.T820N .
NCIH2286 SNV: p.W147L .
NCIH23 SNV: p.W269Ter .
RVH421 SNV: p.S751F .
SW1271 SNV: p.P452H .
TE8 SNV: p.D233H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.18  LDD0318  [1]
DBIA
 Probe Info  		C853(1.42)  LDD3340  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C853(0.94); C692(1.27)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C853(1.00)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C853(1.08); C691(0.90)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C853(1.00)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C853(0.84); C530(1.15)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C853(0.96); C692(1.17)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C853(1.05)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C853(1.04)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C853(0.89); C691(0.92)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C853(1.05)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C853(0.93)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C853(0.76); C530(1.29)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C853(0.88)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C853(0.98); C692(1.12)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C853(0.96)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C853(0.96); C691(1.00)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C853(0.98)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C853(1.14)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C853(1.05); C530(1.17)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C853(0.81)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C853(1.08); C692(1.05)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C853(0.86)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C853(1.15); C691(1.00)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C853(0.94)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C853(0.87)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C853(1.04); C530(1.05)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C853(1.03); C691(0.89)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C853(1.02)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C853(1.04); C692(0.94)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C853(0.88)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C853(0.99); C691(1.09)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C853(0.94)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C853(0.88)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C853(0.92); C530(1.51)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C853(1.00)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C853(1.09); C692(0.90)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C853(1.00)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C853(0.96)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C853(1.06); C691(0.93)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C853(1.04)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C853(0.92)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C853(0.96); C530(1.44)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C853(1.10)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C853(1.11); C692(1.08)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C853(0.92)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C853(0.86)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C853(1.03); C691(1.03)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C853(0.92)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C853(0.95)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C853(0.91); C530(1.37)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C853(1.04)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C853(0.85); C530(0.74)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C853(0.95)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C853(1.06)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C853(0.99); C692(1.27)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C853(0.93)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C853(0.99)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C853(1.10)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C853(1.04); C691(0.82)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C853(1.02)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C692(0.76)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C853(0.98); C691(0.71)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C853(0.95)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C692(0.75)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C853(0.95); C691(1.46)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C853(0.93)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C853(0.98); C530(1.28)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C692(0.93)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C853(0.90); C691(0.72)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C853(0.94)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C692(0.96)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C853(0.86); C691(0.90)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C853(1.11)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C692(0.99)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C853(0.97)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C853(1.15); C691(0.90)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C853(0.93)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C692(0.44)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C853(1.20); C691(0.70)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C853(1.10)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C692(0.80)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C853(0.99); C691(0.92)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C853(1.00)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C692(1.04)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C853(1.04); C691(0.75)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C853(1.32); C692(1.09)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C853(1.04)  LDD1609  [3]
 LDCM0408  CL20 HEK-293T C853(1.12); C691(1.11)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C853(1.36)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C853(1.01)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C853(0.86); C530(1.06)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C853(1.09)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C853(1.07)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C692(0.98)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C853(1.06); C691(0.88)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C853(0.99); C692(1.30)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C692(0.84)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C853(0.98)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C853(1.16); C691(0.91)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C853(1.39)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C853(1.11)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C853(0.88); C530(1.10)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C853(0.81)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C853(1.01)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C692(1.12)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C853(0.90); C691(0.80)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C853(0.85); C691(0.61)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C853(1.02); C692(1.32)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C853(0.99)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C853(1.07); C691(1.18)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C853(1.06)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C853(0.99)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C853(1.12); C530(1.13)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C853(1.14)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C853(1.07)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C853(1.11); C692(1.07)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C853(1.04); C691(0.93)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C853(1.25); C692(0.85)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C853(0.99)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C853(1.18); C691(0.95)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C853(1.22)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C853(0.99)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C853(0.81); C530(1.22)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C853(1.19)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C853(1.07)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C853(1.05)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C692(0.95)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C853(1.24); C691(0.91)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C853(1.08); C692(1.73)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C853(1.30)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C853(1.14); C691(0.92)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C853(1.12)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C853(1.19)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C853(1.06); C530(0.94)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C853(1.02)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C853(0.90)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C853(1.00); C691(0.95)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C853(1.14); C692(1.05)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C853(1.10)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C853(1.39); C691(0.62)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C853(1.09); C691(0.83)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C853(1.12)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C853(1.10)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C853(1.00); C530(0.98)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C853(1.06)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C853(0.91)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C692(0.98)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C853(0.91); C691(0.63)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C853(1.17); C692(0.97)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C853(1.15)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C853(1.40)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C853(1.26); C691(1.18)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C853(1.37)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C853(0.98)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C853(1.33); C530(1.56)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C853(1.16)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C853(1.04)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C692(0.99)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C692(1.18)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C692(0.73)  LDD1671  [3]
 LDCM0022  KB02 A204 C853(2.61); C703(2.00)  LDD2252  [2]
 LDCM0023  KB03 A204 C853(4.05); C703(4.18)  LDD2669  [2]
 LDCM0024  KB05 NB1 C853(1.42)  LDD3340  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tubulin beta-3 chain (TUBB3) Tubulin family Q13509

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402