Details of the Target

General Information of Target

Target ID LDTP01110
Target Name Auxilin (DNAJC6)
Gene Name DNAJC6
Gene ID 9829
Synonyms
KIAA0473; Auxilin; EC 3.1.3.-; DnaJ homolog subfamily C member 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYT
KGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAK
FHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFI
FCNLYSTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKSITVSP
IPFFNKQRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVVVSM
YHLRSTIGSRLQAKVTNTQIFQLQFHTGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVT
LDVELQPHDKVIDLTPPWEHYCTKDVNPSILFSSHQEHQDTLALGGQAPIDIPPDNPRHY
GQSGFFASLCWQDQKSEKSFCEEDHAALVNQESEQSDDELLTLSSPHGNANGDKPHGVKK
PSKKQQEPAAPPPPEDVDLLGLEGSAMSNSFSPPAAPPTNSELLSDLFGGGGAAGPTQAG
QSGVEDVFHPSGPASTQSTPRRSATSTSASPTLRVGEGATFDPFGAPSKPSGQDLLGSFL
NTSSASSDPFLQPTRSPSPTVHASSTPAVNIQPDVSGGWDWHAKPGGFGMGSKSAATSPT
GSSHGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGG
GWQQGGAYNWQQPQPKPQPSMPHSSPQNRPNYNVSFSAMPGGQNERGKGSSNLEGKQKAA
DFEDLLSGQGFNAHKDKKGPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTM
HTVLWAGETKWKPVGMADLVTPEQVKKVYRKAVLVVHPDKATGQPYEQYAKMIFMELNDA
WSEFENQGQKPLY
Target Bioclass
Enzyme
Function
May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking. Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1.
Uniprot ID
O75061
Ensemble ID
ENST00000263441.11
HGNC ID
HGNC:15469

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C185(1.85)  LDD3310  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
1d-yne
 Probe Info  		N.A.  LDD0356  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C268(0.94); C382(1.34); C128(0.95)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C268(1.11); C382(1.10); C128(0.89)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C268(0.97); C382(1.10); C128(1.09)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C268(0.91); C382(1.03); C128(0.90); C347(1.04)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C268(0.87)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C268(0.69); C382(0.84)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C268(0.90); C382(1.10); C128(0.87)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C268(1.12); C382(0.98); C128(1.03)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C268(0.82); C382(0.95); C128(0.91)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C268(1.10); C382(1.07); C128(1.02)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C268(1.19); C382(1.07); C128(0.88); C347(0.92)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C268(0.92); C382(0.93)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C268(0.82)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C268(0.78); C382(0.99)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C268(1.10); C128(0.89)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C268(0.77); C382(1.24); C128(0.93)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C268(1.04); C382(0.98); C128(0.93)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C268(0.77); C382(1.13); C128(0.95)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C268(0.99); C382(1.01); C128(0.91); C347(0.92)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C268(0.94); C382(0.97)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C268(1.11); C382(1.12); C128(1.03)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C268(0.76)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C268(0.95); C382(0.91)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C268(0.95); C128(0.93)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C268(0.99); C382(1.31); C128(0.86)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C268(1.15); C382(1.01); C128(0.91)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C268(0.78); C382(1.09); C128(0.98)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C268(0.99); C382(0.96); C128(0.86); C347(1.00)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C268(1.10); C382(0.94)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C268(0.73)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C268(0.84); C382(0.91)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C268(1.00); C382(0.98); C128(0.93); C347(1.04)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C268(1.12); C128(0.91)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C268(0.97); C382(1.03); C128(0.90)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C268(1.11); C382(1.16); C128(0.86)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C268(0.85); C382(1.02); C128(1.01)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C268(0.81); C382(0.99); C128(0.92); C347(1.02)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C268(1.06); C382(1.05)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C268(0.84)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C268(0.85); C382(0.83)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C268(1.20); C128(0.89)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C268(0.94); C382(1.62); C128(0.91)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C268(1.12); C382(0.98)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C268(1.05); C382(0.97); C128(0.93)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C268(0.77); C382(1.17); C128(1.04)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C268(0.98); C382(1.09); C128(0.93); C347(1.01)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C268(1.10); C382(0.96)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C268(0.83)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C268(0.74); C382(1.25)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C268(0.93); C128(1.05)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C268(0.94); C382(1.23); C128(1.01)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C268(1.18); C382(1.02); C128(1.05)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C268(0.86); C382(1.02); C128(0.97)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C268(0.91)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C268(1.07); C382(0.92); C128(1.01); C347(0.92)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C268(1.19); C382(1.05)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C268(0.91)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C268(0.76); C382(1.27)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C268(1.04); C128(0.94)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C268(0.71); C382(1.06)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C268(0.97); C128(0.93)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C268(1.25); C382(0.96)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C268(0.86); C382(1.08); C128(0.87)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C268(1.05); C128(0.86)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C268(0.95)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C268(0.71)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C382(1.21)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C268(0.96)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C268(0.65); C382(0.94)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C268(0.92); C382(1.06)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C382(0.77)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C268(0.88)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C268(1.01); C382(1.08)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C268(0.99); C382(1.05)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C382(1.00)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C268(0.87)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C268(1.12); C382(1.11)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C268(0.93); C382(1.20)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C268(0.97); C382(1.10)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C382(0.86)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C268(1.02)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C268(0.96); C382(0.81)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C268(0.99); C382(0.89)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C382(0.80)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C268(0.91)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C268(1.04); C382(0.80)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C268(1.09); C382(1.02)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C268(1.23); C128(0.93)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C382(1.19)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C268(1.00)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C268(1.05); C382(0.96)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C268(0.95); C382(0.95)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C382(0.94)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C268(1.16)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C268(1.06); C382(0.99)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C268(0.77); C382(1.05)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C382(1.07)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C268(1.04)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C268(1.02); C382(0.85)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C268(0.98); C382(0.94)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C382(1.01)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C268(0.90); C382(1.32); C128(0.88)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C268(1.22); C382(0.99); C128(1.03)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C268(0.97); C382(1.06); C128(0.99)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C268(1.13); C382(0.97)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C268(1.11); C382(0.96); C128(0.87); C347(1.06)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C268(1.20); C382(1.02)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C268(0.94)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C268(0.87); C382(0.97)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C268(1.18); C128(0.93)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C268(0.86)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C268(1.07); C382(0.78)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C268(0.97); C382(1.08)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C382(0.98)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C268(0.89); C382(1.13); C128(0.88)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C268(1.25); C382(1.06)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C268(1.17); C382(0.96); C128(0.94)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C268(1.06); C382(1.04); C128(0.97)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C268(1.50); C382(0.90); C128(0.82); C347(0.96)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C268(1.28); C382(0.94)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C268(0.97)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C268(0.81); C382(0.99)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C268(1.27); C128(0.92)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C268(0.99)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C268(1.06); C382(0.93)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C382(1.03)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C382(1.50)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C268(0.71); C382(1.19); C128(0.95)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C268(1.14); C382(1.11); C128(1.08)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C268(1.17); C382(1.04); C128(1.09)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C268(0.93); C382(1.02); C128(0.92); C347(0.96)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C268(1.50); C382(1.04)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C268(0.97)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C268(0.97); C382(0.98)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C268(1.12); C128(0.86)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C268(0.89)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C268(0.86); C382(1.22); C128(0.95)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C268(0.92); C382(0.93)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C382(0.83)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C268(0.80); C382(1.06); C128(1.02)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C268(1.08); C382(1.11); C128(0.86)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C268(0.98); C382(1.07); C128(1.09)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C268(1.01); C382(1.11); C128(0.94); C347(1.31)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C268(0.94); C382(0.97)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C268(0.84)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C268(1.11); C382(1.01)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C268(1.08); C382(1.10); C128(0.92)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C268(1.17); C128(0.91)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C268(1.10)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C268(1.06); C382(0.82)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C268(0.90); C382(0.94)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C382(1.07)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C268(0.94); C382(1.29); C128(0.94)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C268(1.46); C382(1.08); C128(1.03)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C268(0.80); C382(1.13); C128(1.00)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C268(1.05); C382(1.16); C128(0.93); C347(1.15)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C268(1.36); C382(1.00)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C268(0.84); C382(1.14); C128(1.21)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C268(0.90)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C268(0.89); C382(0.91)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C268(1.30); C128(0.98)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C268(1.01)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C268(1.06); C382(0.95)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C382(0.75)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C268(0.84); C382(1.56); C128(0.85)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C268(1.01); C382(1.16); C128(1.03)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C268(0.89); C382(1.04); C128(1.01)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C268(1.22); C382(0.96); C128(0.76); C347(0.97)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C268(1.14); C382(1.09); C128(0.79); C347(1.16)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C268(1.09); C382(0.96)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C268(0.80)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C268(0.80); C382(0.90)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C268(1.25); C128(1.09)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C268(0.90)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C268(1.12); C382(1.06)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C268(1.01); C382(1.17)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C382(0.95)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C268(0.74); C382(1.08); C128(0.90)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C268(1.15); C382(0.97)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C268(1.02); C382(0.97); C128(0.78)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C268(0.81); C382(1.05); C128(1.08)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C268(0.98); C382(1.02); C128(1.03); C347(0.96)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C268(1.02); C382(0.88)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C268(0.79)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C268(1.25); C382(1.19)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C268(1.11); C128(1.00)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C268(1.06)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C268(0.99); C382(0.95)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C268(1.05); C382(1.09)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C268(0.82); C382(1.09)  LDD1698  [6]
 LDCM0625  F8 Ramos C268(1.42)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C268(0.66)  LDD2189  [7]
 LDCM0574  Fragment12 Ramos C268(0.60)  LDD2191  [7]
 LDCM0576  Fragment14 Ramos C268(0.82)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C268(0.56)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C268(1.05)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C268(1.29)  LDD2196  [7]
 LDCM0588  Fragment30 Ramos C268(0.92)  LDD2199  [7]
 LDCM0590  Fragment32 Ramos C268(0.68)  LDD2201  [7]
 LDCM0468  Fragment33 HEK-293T C268(1.01); C382(1.05)  LDD1671  [6]
 LDCM0596  Fragment38 Ramos C268(0.81)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C268(0.95)  LDD2184  [7]
 LDCM0427  Fragment51 HEK-293T C268(1.00); C382(0.77)  LDD1631  [6]
 LDCM0614  Fragment56 Ramos C268(1.29)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C268(1.09)  LDD2186  [7]
 LDCM0571  Fragment9 Ramos C268(0.62)  LDD2188  [7]
 LDCM0022  KB02 HEK-293T C268(1.08)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C268(1.07)  LDD1497  [6]
 LDCM0024  KB05 COLO792 C185(1.85)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578