Details of the Target

General Information of Target

Target ID LDTP01082
Target Name F-box-like/WD repeat-containing protein TBL1X (TBL1X)
Gene Name TBL1X
Gene ID 6907
Synonyms
TBL1; F-box-like/WD repeat-containing protein TBL1X; SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN
FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED
GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA
GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW
NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG
TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT
GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW
DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS
ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV
HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Target Type
Clinical trial
Target Bioclass
Other
Family
WD repeat EBI family
Subcellular location
Nucleus
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
TTD ID
T63187
Uniprot ID
O60907
DrugMap ID
TTAL6S1
Ensemble ID
ENST00000380961.5
HGNC ID
HGNC:11585

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.T502M .
MCC13 SNV: p.D120N .
RBE SNV: p.D574Y .
RL952 SNV: p.R65Q; p.C528Y .
SG231 SNV: p.I81M DBIA    Probe Info 
SHSY5Y SNV: p.P242S .
U118MG SNV: p.N266T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y519(69.15)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C571(2.75)  LDD0170  [2]
DBIA
 Probe Info  		C571(18.86)  LDD0209  [3]
HHS-475
 Probe Info  		Y519(0.69)  LDD0264  [4]
5E-2FA
 Probe Info  		H283(0.00); H184(0.00); H359(0.00)  LDD2235  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
m-APA
 Probe Info  		H359(0.00); H184(0.00)  LDD2231  [5]
IA-alkyne
 Probe Info  		C238(0.00); C528(0.00); C497(0.00)  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
IPM
 Probe Info  		C571(0.00); C401(0.00)  LDD2156  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
AOyne
 Probe Info  		12.10  LDD0443  [12]
NAIA_5
 Probe Info  		C528(0.00); C571(0.00); C497(0.00)  LDD2223  [8]
HHS-465
 Probe Info  		N.A.  LDD2240  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C571(2.75)  LDD0170  [2]
 LDCM0214  AC1 HEK-293T C401(0.94)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C401(0.92)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C401(0.93); C553(1.17)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C401(0.85)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C401(0.87)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C401(0.91)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C401(0.90)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C401(0.99)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C401(0.85); C553(1.27)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C401(1.00)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C401(0.90)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C497(1.02); C401(1.01)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C401(0.93)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C401(0.98)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C401(0.96)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C401(0.92)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C401(0.97)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C401(0.93); C553(1.12)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C401(0.87)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C497(1.05); C401(0.97)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C401(0.94); C553(1.58)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C401(0.91)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C401(1.01)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C401(0.93)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C401(0.89)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C401(0.90)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C401(0.91); C553(1.40)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C401(0.87)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C497(1.03); C401(1.04)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C401(0.93)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C401(0.96)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C401(0.99)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C401(0.94)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C401(0.91)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C401(0.87)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C401(0.90); C553(1.05)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C401(0.86)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C497(1.13); C401(0.93)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C401(0.85)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C401(0.96)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C401(0.86)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C401(0.90)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C497(1.07); C401(1.07)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C401(0.95)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C401(1.00); C553(1.31)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C401(0.87)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C497(1.09); C401(1.03)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C401(0.92)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C401(0.93)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C401(0.96)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C401(0.95)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C401(0.97)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C401(1.00); C553(1.18)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C401(1.03)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C401(0.85)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C497(0.98); C401(1.05)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C401(0.96)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C401(0.99)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C401(0.99)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C401(0.99)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C401(0.94)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C497(1.08); C401(1.04)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C401(0.90)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C401(0.89)  LDD1514  [14]
 LDCM0367  CL1 HEK-293T C497(1.01); C401(0.97)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C401(0.70)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C401(0.92)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C497(0.99); C401(0.92)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C497(0.87); C401(0.94)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C401(0.86)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C401(0.92)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C497(1.02); C401(1.05)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C497(1.06); C401(0.95)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C401(0.95)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C401(0.98)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C497(0.95); C401(0.93)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C401(0.74)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C497(0.82); C401(0.88)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C401(0.89)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C401(0.92)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C497(1.14); C401(0.84)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C497(1.15); C401(0.91)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C401(0.88)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C401(0.92)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C497(1.00); C401(0.98)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C497(1.10); C401(0.94)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C401(0.95)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C401(0.83)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C401(0.92)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C497(1.08); C401(0.96)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C497(0.95); C401(0.95)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C401(0.85)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C401(0.90)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C497(0.94); C401(1.18)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C497(0.96); C401(1.02)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C401(1.01)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C401(1.01)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C497(1.02); C401(1.02)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C497(0.83); C401(0.91)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C401(0.70)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C401(0.84)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C401(0.71)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C401(0.78)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C401(0.82); C553(1.05)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C497(0.88); C401(0.86)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C401(0.71)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C497(0.94); C401(0.79)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C401(0.79)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C401(0.78)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C401(0.80)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C497(1.05); C401(0.92)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C497(1.00); C401(0.98)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C401(0.92)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C401(0.90)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C401(0.94)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C401(0.81)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C401(0.92)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C401(0.88); C553(1.17)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C401(0.83)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C497(0.94); C401(0.80)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C401(0.88)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C401(0.83)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C401(0.84)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C497(1.08); C401(0.90)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C401(0.88)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C401(0.89)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C401(0.93)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C401(0.86)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C401(0.96)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C401(0.92); C553(1.33)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C401(0.83)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C497(0.99); C401(0.86)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C401(0.90)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C401(0.85)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C401(0.88)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C497(0.98); C401(1.12)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C401(0.85)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C497(0.94); C401(0.93)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C401(0.91)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C401(0.77)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C401(0.77)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C401(0.84); C553(1.23)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C401(0.78)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C497(0.95); C401(0.86)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C401(0.81)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C401(0.82)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C401(0.78)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C401(0.90)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C497(1.00); C401(1.20)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C497(0.84); C401(0.94)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C401(0.89)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C401(0.85)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C401(0.88)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C401(0.89)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C401(0.87); C553(1.17)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C401(0.78)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C497(1.14); C401(0.89)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C401(0.85); C553(1.25)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C401(0.87)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C401(0.84)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C401(0.84)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C497(1.05); C401(1.11)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C497(1.01); C401(1.03)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C401(0.95)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C401(0.82)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C401(0.89)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C401(0.91); C553(1.01)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C401(0.58)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C401(0.85)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C497(1.11); C401(0.94)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C401(0.90)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C401(0.83)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C401(0.92)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C497(1.06); C401(1.36)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C497(0.88); C401(1.20)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C401(0.98)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C401(1.02)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C401(1.04)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C497(1.13); C401(0.85)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C401(0.76)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C401(1.02); C553(1.47)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C401(0.80)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C497(0.98); C401(0.89)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C401(0.85)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C401(0.76)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C401(0.94)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C497(0.91); C401(1.18)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C497(1.05); C401(0.94)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C401(1.01)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C401(0.87)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C401(0.92)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C497(1.23); C401(1.02)  LDD1631  [14]
 LDCM0116  HHS-0101 DM93 Y519(0.69)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y519(0.91)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y519(0.83)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y519(0.88)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y519(0.82)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C401(1.01)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C571(18.86)  LDD0209  [3]
 LDCM0024  KB05 IGR37 C446(1.45)  LDD3314  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 3 (ARL3) Arf family P36405
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DnaJ homolog subfamily B member 1 (DNAJB1) . P25685
G protein pathway suppressor 2 (GPS2) . Q13227
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840