Details of the Target

General Information of Target

Target ID LDTP00939
Target Name E3 ubiquitin-protein ligase MGRN1 (MGRN1)
Gene Name MGRN1
Gene ID 23295
Synonyms
KIAA0544; RNF156; E3 ubiquitin-protein ligase MGRN1; EC 2.3.2.27; Mahogunin RING finger protein 1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL
NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL
EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF
SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK
QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT
SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK
SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS
DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL
GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA
LGPDSCSVGIDE
Target Bioclass
Enzyme
Subcellular location
Cytoplasm, cytosol; Early endosome
Function
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling.
Uniprot ID
O60291
Ensemble ID
ENST00000262370.12
HGNC ID
HGNC:20254

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C428(2.07)  LDD0168  [1]
DBIA
 Probe Info  		C528(1.00)  LDD1492  [2]
IA-alkyne
 Probe Info  		C293(0.00); C428(0.00)  LDD0165  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		C356(0.00); C428(0.00)  LDD0018  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		12.30  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		8.06  LDD1850  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C428(2.07)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C528(2.38)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C297(1.07)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C528(0.85); C297(0.92); C299(0.94)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C297(0.87)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C297(0.93)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C528(1.04); C297(0.97)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C528(0.95); C297(0.92); C299(0.95)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C297(1.00)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C528(0.89); C297(0.95); C299(1.04)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C297(0.90)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C528(1.04); C297(0.87); C299(1.00)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C297(0.89)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C299(0.85)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C528(0.95); C297(0.85)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C528(0.91); C297(0.88); C299(1.04)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C356(1.20); C299(1.01)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C297(1.29)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C528(0.93); C297(0.90); C299(1.06)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C297(1.09)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C297(0.95)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C299(0.93)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C297(0.90)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C528(0.84); C297(0.99)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C528(1.01); C297(0.75); C299(0.99)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C356(1.14); C299(0.94)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C297(0.99)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C528(1.18); C297(0.81); C299(1.15)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C297(1.10)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C297(1.04)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C299(1.04)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C528(1.05); C297(1.04)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C528(1.18); C297(1.03); C299(1.11)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C297(1.05)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C356(1.11); C299(0.90)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C297(1.10)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C528(1.00); C297(0.87); C299(1.27)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C297(0.86)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C297(0.95)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C299(1.16)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C528(0.99); C297(1.07)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C528(1.09); C297(0.85); C299(1.02)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C356(1.25); C299(1.14)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C297(1.15)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C299(0.96)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C528(0.92); C297(0.74); C299(0.96)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C297(0.78)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C297(1.01)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C299(0.91)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C528(0.99); C297(0.98)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C528(0.95); C297(0.84); C299(1.07)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C356(1.07); C299(0.94)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C297(1.19)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C528(0.89); C297(1.05); C299(1.05)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C297(0.86)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C528(0.93); C297(1.00)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C297(1.04)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C299(0.91)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C528(0.99); C297(0.92)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C528(1.06); C297(0.88); C299(1.04)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C356(1.20); C299(0.95)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C528(1.11); C297(0.85); C299(1.12)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C356(1.13); C299(0.92)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C299(0.86)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C297(1.01)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C356(1.04); C299(0.97)  LDD1514  [2]
 LDCM0630  CCW28-3 231MFP C428(1.80)  LDD2214  [11]
 LDCM0367  CL1 HEK-293T C528(0.92); C356(1.11); C297(0.99); C299(0.93)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C528(1.07); C297(0.97)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C528(1.04); C356(1.06); C297(1.01); C299(1.15)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C299(0.97)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C297(1.10)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C528(1.08); C356(0.91); C297(1.10); C299(0.98)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C299(1.07)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C297(0.93)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C528(1.08); C356(1.08); C297(1.11); C299(0.99)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C528(1.16); C297(0.67); C299(1.34)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C299(1.16)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C297(0.83)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C528(1.05); C356(1.00); C297(1.12); C299(1.01)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C299(1.10)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C297(1.09)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C528(1.08); C356(1.06); C297(0.93); C299(1.19)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C299(0.96)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C297(1.15)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C356(1.01); C299(0.90)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C528(0.93); C356(1.03); C297(0.91); C299(1.11)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C299(0.89)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C297(1.10)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C528(0.92); C356(0.87); C297(1.03); C299(0.98)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C299(0.88)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C297(1.27)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C528(1.04); C356(1.00); C297(0.89); C299(1.05)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C299(1.15)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C297(0.89)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C297(1.12)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C528(1.03); C297(0.75); C299(1.33)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C297(0.97)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C299(1.03)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C297(1.12)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C299(0.82)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C528(1.07); C297(1.12)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C528(1.31); C297(0.76); C299(1.48)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C356(1.12); C299(0.90)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C528(0.99); C356(0.79); C297(0.98); C299(0.94)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C299(0.95)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C297(1.29)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C297(1.03)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C297(0.96)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C528(0.97); C297(0.98); C299(1.05)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C297(0.95)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C297(0.99)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C299(0.74)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C528(1.07); C297(1.04)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C528(1.08); C297(0.82); C299(1.21)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C356(1.04); C299(0.98)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C528(0.98); C356(0.89); C297(1.25); C299(0.97)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C297(1.09)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C297(1.04)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C528(0.85); C297(0.90); C299(1.07)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C297(0.82)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C297(0.94)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C299(0.82)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C528(0.97); C297(1.22)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C528(1.29); C297(0.80); C299(1.48)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C356(1.14); C299(0.73)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C528(0.99); C356(0.89); C297(1.01); C299(0.89)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C297(1.22)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C299(1.08)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C297(0.89)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C528(0.84); C297(0.77); C299(1.22)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C297(1.14)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C297(1.25)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C299(0.97)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C528(1.07); C297(1.09)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C528(1.05); C297(0.77); C299(1.18)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C528(0.86); C297(0.80); C299(1.09)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C356(1.14); C299(1.08)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C528(1.08); C356(0.95); C297(0.89); C299(1.07)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C299(1.19)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C297(1.06)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C297(1.00)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C528(0.99); C297(1.01); C299(1.19)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C297(0.96)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C297(0.99)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C299(0.88)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C297(1.02)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C528(1.09); C297(0.89)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C528(0.97); C297(0.88); C299(1.28)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C356(1.03); C299(1.27)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C528(0.85); C356(0.94); C297(0.99); C299(1.09)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C299(1.18)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C297(1.18)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C528(0.92); C297(1.06); C299(1.17)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C297(0.95)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C297(0.90)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C297(1.02)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C299(0.92)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C528(1.01); C297(1.01)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C528(1.14); C297(0.78); C299(1.48)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C356(1.08); C299(0.83)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C528(0.95); C356(0.82); C297(1.18); C299(1.03)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C299(0.99)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C297(1.17)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C297(1.01)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C299(1.00)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C528(0.77); C297(0.91); C299(1.12)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C297(0.89)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C297(1.05)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C299(0.97)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C528(1.13); C297(1.12)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C528(0.97); C297(0.75); C299(1.24)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C356(1.36); C299(1.13)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C528(1.04); C356(0.97); C297(0.92); C299(1.10)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C299(1.13)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C297(1.05)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C297(1.13)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C297(0.95)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C299(0.88)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C528(1.00)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C528(1.06)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C528(1.11)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.