Details of the Target

General Information of Target

Target ID LDTP00789
Target Name Phospholipid-transporting ATPase IC (ATP8B1)
Gene Name ATP8B1
Gene ID 5205
Synonyms
ATPIC; FIC1; PFIC; Phospholipid-transporting ATPase IC; EC 7.6.2.1; ATPase class I type 8B member 1; Familial intrahepatic cholestasis type 1; P4-ATPase flippase complex alpha subunit ATP8B1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTERDSETTFDEDSQPNDEVVPYSDDETEDELDDQGSAVEPEQNRVNREAEENREPFRK
ECTWQVKANDRKYHEQPHFMNTKFLCIKESKYANNAIKTYKYNAFTFIPMNLFEQFKRAA
NLYFLALLILQAVPQISTLAWYTTLVPLLVVLGVTAIKDLVDDVARHKMDKEINNRTCEV
IKDGRFKVAKWKEIQVGDVIRLKKNDFVPADILLLSSSEPNSLCYVETAELDGETNLKFK
MSLEITDQYLQREDTLATFDGFIECEEPNNRLDKFTGTLFWRNTSFPLDADKILLRGCVI
RNTDFCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVYTIFVVLILLSAGLAIGHA
YWEAQVGNSSWYLYDGEDDTPSYRGFLIFWGYIIVLNTMVPISLYVSVEVIRLGQSHFIN
WDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCINGQIYGDHR
DASQHNHNKIEQVDFSWNTYADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLAVCHTVMVD
RTDGQLNYQAASPDEGALVNAARNFGFAFLARTQNTITISELGTERTYNVLAILDFNSDR
KRMSIIVRTPEGNIKLYCKGADTVIYERLHRMNPTKQETQDALDIFANETLRTLCLCYKE
IEEKEFTEWNKKFMAASVASTNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISK
LAKADIKIWVLTGDKKETAENIGFACELLTEDTTICYGEDINSLLHARMENQRNRGGVYA
KFAPPVQESFFPPGGNRALIITGSWLNEILLEKKTKRNKILKLKFPRTEEERRMRTQSKR
RLEAKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNM
IKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFA
FTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSLRFPGLYI
VGQRDLLFNYKRFFVSLLHGVLTSMILFFIPLGAYLQTVGQDGEAPSDYQSFAVTIASAL
VITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLFPSAFQFTGTASNAL
RQPYIWLTIILAVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKRLKAEEQWQRRQQVFRR
GVSTRRSAYAFSHQRGYADLISSGRSIRKKRSPLDAIVADGTAEYRRTGDS
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Subcellular location
Cell membrane
Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane. Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2. Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury.
Uniprot ID
O43520
Ensemble ID
ENST00000648908.2
HGNC ID
HGNC:3706

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C62(1.00)  LDD3315  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C62(0.26)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C62(1.15)  LDD1094  [2]
 LDCM0216  AC100 PaTu 8988t C62(1.78)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C62(1.38)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C62(1.38)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C62(1.41)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C62(1.23)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C62(1.56)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C62(1.33)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C62(1.33)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C62(1.49)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C62(1.68)  LDD1104  [2]
 LDCM0226  AC11 PaTu 8988t C62(0.95)  LDD1105  [2]
 LDCM0227  AC110 PaTu 8988t C62(1.37)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C62(1.95)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C62(1.25)  LDD1108  [2]
 LDCM0230  AC113 PaTu 8988t C62(1.04)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C62(0.97)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C62(0.67)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C62(0.83)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C62(1.03)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C62(1.17)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C62(1.33)  LDD1115  [2]
 LDCM0237  AC12 PaTu 8988t C62(0.90)  LDD1116  [2]
 LDCM0238  AC120 PaTu 8988t C62(1.08)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C62(1.24)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C62(0.97)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C62(0.92)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C62(1.20)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C62(1.05)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C62(0.88)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C62(1.28)  LDD1124  [2]
 LDCM0259  AC14 PaTu 8988t C62(1.11)  LDD1138  [2]
 LDCM0263  AC143 PaTu 8988t C62(1.32)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C62(1.59)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C62(1.22)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C62(1.16)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C62(1.31)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C62(1.23)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C62(1.48)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C62(1.24)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C62(1.23)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C62(0.98)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C62(1.16)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C62(1.60)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C62(1.22)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C62(1.56)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C62(1.34)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C62(1.24)  LDD2169  [2]
 LDCM0279  AC2 PaTu 8988t C62(0.32)  LDD1158  [2]
 LDCM0290  AC3 PaTu 8988t C62(0.35)  LDD1169  [2]
 LDCM0301  AC4 PaTu 8988t C62(0.40)  LDD1180  [2]
 LDCM0312  AC5 PaTu 8988t C62(0.32)  LDD1191  [2]
 LDCM0320  AC57 PaTu 8988t C62(1.20)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C62(1.32)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C62(1.24)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C62(0.95)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C62(1.18)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C62(1.57)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C62(1.35)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C62(1.01)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C62(1.14)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C62(1.21)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C62(1.36)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C62(1.28)  LDD1210  [2]
 LDCM0334  AC7 PaTu 8988t C62(0.98)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C62(0.84)  LDD1224  [2]
 LDCM0365  AC98 PaTu 8988t C62(1.85)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C62(1.39)  LDD1245  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C62(1.09)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C62(1.16)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C62(1.06)  LDD1154  [2]
 LDCM0367  CL1 PaTu 8988t C62(1.02)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C62(1.15)  LDD1247  [2]
 LDCM0369  CL100 PaTu 8988t C62(0.29)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C62(0.98)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C62(0.93)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C62(1.00)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C62(1.01)  LDD1252  [2]
 LDCM0379  CL11 PaTu 8988t C62(1.18)  LDD1258  [2]
 LDCM0390  CL12 PaTu 8988t C62(1.17)  LDD1269  [2]
 LDCM0396  CL125 PaTu 8988t C62(1.23)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C62(1.30)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C62(1.26)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C62(1.12)  LDD1278  [2]
 LDCM0400  CL13 PaTu 8988t C62(1.27)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C62(1.23)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C62(1.05)  LDD1281  [2]
 LDCM0403  CL16 PaTu 8988t C62(1.29)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C62(1.23)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C62(1.25)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C62(1.20)  LDD1285  [2]
 LDCM0407  CL2 PaTu 8988t C62(1.03)  LDD1286  [2]
 LDCM0408  CL20 PaTu 8988t C62(1.24)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C62(1.16)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C62(1.17)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C62(1.26)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C62(1.24)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C62(1.26)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C62(1.31)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C62(1.22)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C62(1.28)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C62(1.16)  LDD1296  [2]
 LDCM0418  CL3 PaTu 8988t C62(1.10)  LDD1297  [2]
 LDCM0419  CL30 PaTu 8988t C62(1.15)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C62(1.13)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C62(1.34)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C62(1.08)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C62(1.31)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C62(1.45)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C62(0.49)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C62(1.13)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C62(1.33)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C62(1.05)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C62(1.04)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C62(1.02)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C62(1.17)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C62(1.30)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C62(1.38)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C62(1.26)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C62(1.11)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C62(0.99)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C62(0.99)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C62(1.30)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C62(1.12)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C62(1.13)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C62(1.24)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C62(1.14)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C62(1.35)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C62(1.11)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C62(1.09)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C62(1.04)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C62(1.05)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C62(1.04)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C62(1.03)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C62(1.08)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C62(1.10)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C62(0.74)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C62(0.62)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C62(0.71)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C62(0.83)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C62(0.81)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C62(0.92)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C62(1.03)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C62(0.97)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C62(1.02)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C62(1.13)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C62(0.95)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C62(0.66)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C62(0.69)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C62(0.97)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C62(0.87)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C62(1.10)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C62(1.11)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C62(1.25)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C62(1.27)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C62(0.97)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C62(1.11)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C62(1.27)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C62(1.48)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C62(1.52)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C62(1.04)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C62(1.23)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C62(1.16)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C62(1.18)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C62(1.32)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C62(0.99)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C62(1.25)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C62(1.23)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C62(0.24)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C62(0.21)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C62(0.28)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C62(0.25)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C62(0.29)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C62(0.23)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C62(0.30)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C62(0.28)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C62(0.25)  LDD1373  [2]
 LDCM0468  Fragment33 PaTu 8988t C62(0.75)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C62(1.33)  LDD1306  [2]
 LDCM0022  KB02 AU565 C62(1.24)  LDD2265  [1]
 LDCM0023  KB03 AU565 C62(1.15)  LDD2682  [1]
 LDCM0024  KB05 IGR39 C62(1.00)  LDD3315  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.