Details of the Target

General Information of Target

Target ID LDTP00627
Target Name Baculoviral IAP repeat-containing protein 5 (BIRC5)
Gene Name BIRC5
Gene ID 332
Synonyms
API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAKKVRRAIEQLAAMD
Target Type
Clinical trial
Target Bioclass
Other
Family
IAP family
Subcellular location
Cytoplasm
Function
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Essential for the maintenance of mitochondrial integrity and function. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
TTD ID
T02677
Uniprot ID
O15392
DrugMap ID
TTEWOHV
Ensemble ID
ENST00000374948.6
HGNC ID
HGNC:593
ChEMBL ID
CHEMBL5989

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C84(0.91)  LDD2093  [1]
NAIA_5
 Probe Info  		C31(20.00)  LDD2227  [2]
DBIA
 Probe Info  		C84(0.90); C60(1.03); C31(0.89)  LDD1492  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [4]
IPM
 Probe Info  		C84(0.00); C31(0.00)  LDD2156  [5]
Phosphinate-6
 Probe Info  		C84(0.00); C31(0.00)  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C84(1.13); C46(0.93); C60(0.98); C31(1.17)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C84(1.05); C46(0.96); C31(1.44)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C84(1.12); C46(0.95); C60(1.01); C31(1.32)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C84(1.07); C60(1.04); C31(1.12)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C84(0.99); C46(1.01); C60(1.11); C31(1.28)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C84(0.94); C60(1.01); C31(1.27); C33(1.08)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C84(1.13); C46(1.10); C60(1.04); C31(1.12)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C84(1.02); C46(0.95); C31(1.53)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C84(1.29); C46(0.89); C60(1.17); C31(1.39)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C84(1.05); C46(1.00); C31(1.30)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C84(1.11); C60(1.08); C31(1.27)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C84(0.99); C46(1.00); C31(1.33); C33(1.07)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C84(1.27); C46(0.82); C60(1.09); C31(1.24)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C84(1.06); C60(0.96); C31(1.17); C33(1.03)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C84(1.03); C46(1.02); C60(1.06); C31(1.16)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C84(1.10); C46(0.91); C60(1.04); C31(1.28)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C84(0.98); C46(0.93); C31(1.26)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C84(1.11); C46(0.98); C60(1.04); C31(1.19)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C84(1.06); C60(1.26); C31(1.16)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C84(0.94); C46(1.06); C31(1.25); C33(1.19)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C84(1.04); C46(0.92); C60(1.20); C31(1.05)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C84(1.06); C46(0.89); C60(1.03); C31(1.18)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C84(0.92); C60(1.06); C31(1.08); C33(0.96)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C84(1.03); C46(0.97); C60(0.99); C31(1.29)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C84(1.23); C46(1.01); C60(1.28); C31(1.35)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C84(1.11); C46(1.04); C31(0.99)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C84(1.20); C46(1.03); C60(1.10); C31(1.20)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C84(1.18); C60(1.15); C31(1.23)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C84(0.99); C46(0.97); C31(1.17); C33(1.25)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C84(1.04); C46(1.08); C60(1.10); C31(1.29)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C84(1.05); C60(1.12); C31(1.12); C33(0.99)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C84(1.08); C60(0.98); C31(1.06)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C84(1.12); C46(1.05); C60(1.22); C31(1.12)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C84(1.30); C46(1.05); C60(1.11); C31(1.30)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C84(1.11); C46(0.97); C31(1.17)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C84(1.27); C46(0.96); C60(1.23); C31(1.43)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C84(1.17); C60(1.13); C31(1.18)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C84(1.12); C46(0.95); C31(1.31); C33(1.10)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C84(1.23); C46(1.05); C60(1.01); C31(1.26)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C84(1.22); C60(1.03); C31(1.32); C33(1.04)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C84(1.13); C46(1.00); C60(1.01); C31(1.19)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C84(1.16); C46(1.00); C60(0.98); C31(1.30)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C84(0.98); C46(1.01); C31(1.28); C33(1.22)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C84(1.04); C46(0.98); C31(1.79)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C84(1.16); C46(0.94); C60(1.05); C31(1.35)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C84(1.16); C60(1.11); C31(1.17)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C84(0.95); C46(1.06); C31(1.11); C33(1.01)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C84(1.12); C46(0.88); C60(0.93); C31(1.24)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C84(0.99); C60(1.05); C31(1.13); C33(1.05)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C84(1.12); C46(0.96); C60(1.10); C31(1.22)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C84(1.11); C46(0.96); C60(1.23); C31(1.26)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C84(0.97); C46(0.99); C31(1.27)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C84(1.19); C46(0.99); C60(1.11); C31(1.21)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C84(0.90); C46(1.05); C60(1.06); C31(1.08)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C84(1.17); C60(1.16); C31(1.14)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C84(0.95); C46(1.10); C31(1.17); C33(0.99)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C84(0.95); C46(1.07); C60(1.17); C31(1.09)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C84(0.93); C60(1.01); C31(1.05); C33(0.91)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C84(1.03); C46(1.17); C60(1.07); C31(1.03)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C84(0.89); C60(1.09); C31(1.17); C33(1.04)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C84(1.09); C46(1.11); C60(1.00); C31(1.16)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C84(1.02); C46(1.14); C31(1.22); C33(1.42)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C84(1.18); C46(0.96); C60(1.15); C31(1.15)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C84(1.08); C46(1.14); C60(1.14); C31(1.18)  LDD1514  [3]
 LDCM0632  CL-Sc Hep-G2 C31(20.00)  LDD2227  [2]
 LDCM0367  CL1 HEK-293T C84(1.03); C46(0.89); C60(1.02); C31(1.09)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C84(1.25); C46(0.85); C60(1.06); C31(1.31)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C84(1.12); C60(1.00); C31(1.21)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C84(1.06); C46(1.03); C60(0.89); C31(1.17)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C84(1.11); C46(0.85); C31(1.22)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C84(1.21); C46(1.08); C60(1.09); C31(1.24)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C84(1.04); C60(0.97); C31(1.02)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C84(1.07); C46(1.17); C60(0.85); C31(1.24)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C84(1.08); C46(0.92); C31(1.04)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C84(1.10); C46(1.03); C60(0.99); C31(1.17)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C84(1.01); C60(1.02); C31(1.12)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C84(1.01); C46(0.99); C60(0.91); C31(1.08)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C84(0.84); C60(0.96); C31(1.27); C33(1.32)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C84(1.15); C46(1.14); C31(1.59)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C84(1.11); C46(0.93); C60(1.04); C31(1.05)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C84(1.12); C60(1.00); C31(1.11)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C84(1.10); C46(0.97); C60(1.12); C31(1.39)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C84(1.15); C46(0.90); C31(1.28)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C84(1.16); C46(1.02); C60(1.03); C31(1.25)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C84(1.16); C60(1.08); C31(1.20)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C84(1.04); C46(1.08); C60(1.07); C31(1.43)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C84(1.09); C46(1.04); C31(1.04)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C84(1.18); C46(0.97); C60(1.06); C31(1.15)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C84(0.99); C46(0.97); C60(1.11); C31(1.41)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C84(1.15); C60(1.02); C31(1.19)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C84(1.10); C46(1.11); C60(0.96); C31(1.13)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C84(1.15); C46(0.88); C31(1.06)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C84(1.23); C46(0.93); C60(0.99); C31(1.34)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C84(1.13); C60(0.92); C31(1.23)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C84(0.93); C46(1.16); C60(0.97); C31(1.17)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C84(1.04); C46(1.00); C31(1.25)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C84(1.09); C46(1.02); C60(1.17); C31(1.13)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C84(1.05); C60(1.05); C31(1.03)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C84(1.11); C46(1.06); C60(1.01); C31(1.24)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C84(1.11); C46(0.89); C31(0.98)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C84(1.50); C46(0.98); C60(1.17); C31(1.38)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C84(0.98); C60(1.00); C31(1.19)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C84(1.30); C46(0.88); C60(1.03); C31(1.23)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C84(0.99); C46(0.98); C31(1.13)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C84(1.22); C46(1.09); C60(1.06); C31(1.20)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C84(1.01); C46(0.97); C31(1.23)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C84(1.14); C60(1.34); C31(1.15)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C84(1.09); C46(0.93); C31(1.34); C33(1.31)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C84(1.22); C46(0.97); C60(0.98); C31(1.15)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C84(1.00); C60(1.09); C31(1.43); C33(0.99)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C84(1.01); C46(1.13); C60(1.06); C31(1.39)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C84(1.07); C46(1.05); C60(0.98); C31(1.41)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C84(1.13); C46(1.07); C31(1.14)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C84(1.15); C46(1.04); C60(1.18); C31(1.10)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C84(1.12); C60(0.96); C31(1.12)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C84(1.15); C46(0.96); C60(0.97); C31(1.11)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C84(1.10); C46(0.97); C60(1.10); C31(1.11)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C84(1.05); C46(0.99); C31(1.23)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C84(1.04); C46(1.10); C60(1.07); C31(1.24)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C84(1.07); C60(1.06); C31(1.18)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C84(1.38); C46(1.00); C31(1.41); C33(1.57)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C84(1.15); C46(0.91); C60(1.06); C31(1.56)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C84(1.30); C60(1.06); C31(1.29); C33(1.06)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C84(1.09); C46(1.01); C60(1.07); C31(1.41)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C84(1.04); C46(1.16); C60(1.04); C31(1.08)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C84(1.17); C46(1.08); C60(1.32); C31(1.35)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C84(1.07); C60(1.04); C31(1.19)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C84(1.09); C60(1.11); C31(1.33)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C84(1.23); C46(0.97); C60(1.20); C31(1.24)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C84(0.98); C46(0.91); C31(1.11)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C84(1.13); C46(1.03); C60(1.08); C31(1.20)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C84(1.04); C60(0.92); C31(1.22)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C84(1.15); C46(0.94); C31(1.35); C33(1.34)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C84(0.98); C46(0.92); C60(0.99); C31(1.15)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C84(1.28); C60(0.92); C31(1.38); C33(1.07)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C84(1.11); C46(1.08); C60(1.14); C31(1.48)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C84(0.97); C46(0.99); C60(0.97); C31(1.01)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C84(0.96); C46(1.01); C60(1.15); C31(1.43)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C84(1.13); C46(0.98); C31(1.02)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C84(1.09); C60(1.04); C31(1.25)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C84(1.41); C46(0.98); C60(0.95); C31(1.35)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C84(1.20); C46(0.75); C31(1.68)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C84(1.19); C46(1.03); C60(1.14); C31(1.15)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C84(1.12); C60(1.09); C31(1.09)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C84(1.43); C46(0.97); C31(1.09); C33(1.19)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C84(1.20); C46(0.70); C60(1.19); C31(1.33)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C84(0.99); C60(1.02); C31(1.55); C33(1.36)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C84(1.00); C46(0.94); C31(1.11)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C84(1.16); C46(1.34); C60(1.17); C31(1.37)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C84(1.02); C46(1.14); C60(1.03); C31(1.15)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C84(1.12); C46(0.95); C31(1.24)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C84(1.22); C46(1.04); C60(1.23); C31(1.21)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C84(1.28); C60(1.05); C31(1.24)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C84(1.20); C46(0.99); C60(1.07); C31(1.16)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C84(1.10); C46(1.05); C31(1.10)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C84(1.11); C46(1.04); C60(1.31); C31(1.31)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C84(1.21); C60(1.19); C31(1.06)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C84(1.03); C46(1.10); C31(1.23); C33(1.31)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C84(1.08); C46(1.01); C60(1.18); C31(1.17)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C84(1.09); C46(0.92); C60(1.03); C31(1.30)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C84(1.06); C60(1.00); C31(1.17); C33(1.06)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C84(1.14); C46(1.08); C60(1.25); C31(1.33)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C84(1.07); C46(0.98); C60(1.03); C31(1.16)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C84(1.03); C46(0.94); C31(1.06)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C84(1.06); C60(1.03); C31(1.23)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C84(1.17); C46(1.07); C60(1.08); C31(1.38)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C84(0.99); C46(1.05); C31(1.08)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C84(1.10); C46(1.01); C60(1.07); C31(1.40)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C84(1.74); C60(1.26); C31(1.06)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C84(1.01); C60(1.17); C31(1.21)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C84(0.93); C46(1.09); C31(1.24); C33(1.16)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C84(0.99); C46(0.93); C60(1.00); C31(1.16)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C84(1.00); C60(1.03); C31(1.33); C33(1.28)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C84(1.04); C46(1.08); C60(0.99); C31(1.20)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C84(0.96); C46(1.05); C60(1.11); C31(1.23)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C84(0.91); C46(1.09); C31(0.99)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C84(1.09); C46(1.00); C60(1.24); C31(1.21)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C84(0.96); C60(1.00); C31(1.19)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C84(1.05); C46(1.01); C60(1.12); C31(1.24)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C84(0.93); C46(0.95); C31(1.23); C33(1.15)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C84(1.42); C46(1.08); C31(1.27)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C84(1.23); C46(1.01); C60(1.31); C31(1.27)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C84(1.25); C60(1.20); C31(1.18)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C84(1.22); C46(1.15); C31(1.14); C33(1.18)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C84(0.88); C46(1.01); C60(1.04); C31(1.28)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C84(1.08); C60(1.11); C31(1.42); C33(1.89)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C84(0.92); C46(0.99); C60(1.05); C31(1.11)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C84(1.08); C46(1.21); C60(1.03); C31(1.14)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C84(1.07); C46(0.99); C31(1.16)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C84(0.98); C46(0.95); C60(1.09); C31(1.31)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C84(1.29); C46(1.00); C60(1.12); C31(1.27)  LDD1698  [3]
 LDCM0625  F8 Ramos C84(4.30); 0.62  LDD2187  [8]
 LDCM0572  Fragment10 Ramos 1.14  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C84(5.05); 2.05  LDD2190  [8]
 LDCM0574  Fragment12 Ramos 4.57  LDD2191  [8]
 LDCM0576  Fragment14 Ramos C84(6.71); 1.78  LDD2193  [8]
 LDCM0580  Fragment21 Ramos 2.05  LDD2195  [8]
 LDCM0582  Fragment23 Ramos 3.35  LDD2196  [8]
 LDCM0578  Fragment27 Ramos 1.60  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C84(1.08); 0.63  LDD2198  [8]
 LDCM0588  Fragment30 Ramos 3.19  LDD2199  [8]
 LDCM0468  Fragment33 HEK-293T C84(1.12); C46(1.07); C60(1.07); C31(1.13)  LDD1671  [3]
 LDCM0596  Fragment38 Ramos 2.72  LDD2203  [8]
 LDCM0427  Fragment51 HEK-293T C84(1.17); C46(1.07); C31(1.22)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C84(0.90); C60(1.03); C31(0.89)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C84(0.99); C60(0.94); C31(1.02)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C84(0.99); C60(1.08); C31(0.87)  LDD1502  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C84(0.91)  LDD2093  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C84(1.29)  LDD2094  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C84(0.43)  LDD2140  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
Cyclin-dependent kinase 1 (CDK1) CMGC Ser/Thr protein kinase family P06493
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) Ser/Thr protein kinase family Q9BXM7
Aurora kinase A (AURKA) Ser/Thr protein kinase family O14965
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
Aurora kinase C (AURKC) Ser/Thr protein kinase family Q9UQB9
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Beclin-1 (BECN1) Beclin family Q14457
Exportin-1 (XPO1) Exportin family O14980
Huntingtin (HTT) Huntingtin family P42858
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Alpha-synuclein (SNCA) Synuclein family P37840
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Borealin (CDCA8) Borealin family Q53HL2
Coiled-coil domain-containing protein 85B (CCDC85B) CCDC85 family Q15834
GAS2-like protein 3 (GAS2L3) GAS2 family Q86XJ1
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
Inner centromere protein (INCENP) INCENP family Q9NQS7
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
TAR DNA-binding protein 43 (TARDBP) . Q13148

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Berberine Small molecular drug DB04115
Reserpine Small molecular drug DB00206
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 23722 . D07TMR
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cv-9201 Vaccine D02DVK
Survaxm . D0KQ8W
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ezn-3042 . D01GQD
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ly2181308 . DB05141

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578