Details of the Target

General Information of Target

Target ID LDTP00529
Target Name A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3)
Gene Name ADAMTS3
Gene ID 9508
Synonyms
KIAA0366; A disintegrin and metalloproteinase with thrombospondin motifs 3; ADAM-TS 3; ADAM-TS3; ADAMTS-3; EC 3.4.24.-; Procollagen II N-proteinase; PC II-NP; Procollagen II amino propeptide-processing enzyme
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHT
LSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNI
TDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYF
IEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQ
LNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVH
INVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQD
FGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA
MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDE
QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC
MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLC
NTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYM
KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT
RTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDL
GVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVI
QEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCN
IQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP
CNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPC
LGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLP
RSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSK
TVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRS
STLER
Target Bioclass
Enzyme
Subcellular location
Secreted
Function Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
Uniprot ID
O15072
Ensemble ID
ENST00000286657.10
HGNC ID
HGNC:219

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1047(0.92)  LDD0531  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1047(0.92)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C1047(0.51)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C1047(0.47)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C1047(1.00)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C1047(0.29)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C1047(0.70)  LDD0587  [2]
 LDCM0276  AC17 HEK-293T C415(0.90)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C415(0.76); C966(0.99)  LDD1517  [3]
 LDCM0279  AC2 HCT 116 C1047(1.34)  LDD0596  [2]
 LDCM0281  AC21 HEK-293T C1050(0.89)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C966(0.86)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C415(1.23)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C415(0.95); C966(1.04)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C1050(1.05)  LDD1528  [3]
 LDCM0290  AC3 HCT 116 C1047(1.60)  LDD0607  [2]
 LDCM0292  AC31 HEK-293T C966(0.99)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C415(0.95)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C415(0.90); C966(1.18)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C1050(1.21)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C966(1.05)  LDD1539  [3]
 LDCM0301  AC4 HCT 116 C1047(1.48)  LDD0618  [2]
 LDCM0303  AC41 HEK-293T C415(1.19)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C415(1.08); C966(1.22)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C1050(0.99)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C966(1.26)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C415(0.92)  LDD1550  [3]
 LDCM0312  AC5 HCT 116 C1047(1.50)  LDD0629  [2]
 LDCM0314  AC51 HEK-293T C415(0.89); C966(1.07)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C1050(1.20)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C966(1.13)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C415(0.85)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C415(0.78); C966(1.22)  LDD1561  [3]
 LDCM0323  AC6 HCT 116 C1047(0.61)  LDD0640  [2]
 LDCM0325  AC61 HEK-293T C1050(1.13)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C966(0.91)  LDD1566  [3]
 LDCM0332  AC68 HCT 116 C1047(0.67)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C1047(0.70)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C1047(0.55)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C1047(2.37)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C1047(0.88)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C1047(1.89)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C1047(1.69)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C1047(1.24)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C1047(1.27)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C1047(1.46)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C1047(0.58)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C1047(0.93)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C1047(1.44)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C1047(0.66)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C1047(1.17)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C1047(1.66)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C1047(1.44)  LDD0665  [2]
 LDCM0248  AKOS034007472 HCT 116 C1047(0.72)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C1047(1.18)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C1047(0.62)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C415(0.92)  LDD1571  [3]
 LDCM0369  CL100 HCT 116 C1047(1.30)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C1047(0.21)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C1047(0.27)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C1047(0.32)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C1047(0.45)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C415(1.01)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C415(0.78)  LDD1580  [3]
 LDCM0378  CL109 HEK-293T C415(1.06)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C966(0.98)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C415(0.83)  LDD1585  [3]
 LDCM0383  CL113 HEK-293T C415(1.08)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C415(0.81)  LDD1589  [3]
 LDCM0387  CL117 HEK-293T C415(1.02)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C415(1.01)  LDD1593  [3]
 LDCM0392  CL121 HEK-293T C415(1.05)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C415(0.97)  LDD1598  [3]
 LDCM0396  CL125 HEK-293T C415(0.88)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C415(1.03)  LDD1602  [3]
 LDCM0400  CL13 HEK-293T C415(1.00)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C415(1.09)  LDD1606  [3]
 LDCM0403  CL16 HCT 116 C1047(0.85)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C415(1.03)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C415(0.92); C966(1.15)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C1050(0.91)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C966(1.13)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C415(1.01)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C415(0.85)  LDD1619  [3]
 LDCM0417  CL29 HEK-293T C415(0.99)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C415(0.71)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C415(0.94); C966(1.24)  LDD1624  [3]
 LDCM0421  CL32 HCT 116 C1047(0.96)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C1047(0.78)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C1047(0.59)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C1047(2.97)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C1047(0.45)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C1047(1.64)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C1047(0.88)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C1047(1.01)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C1047(0.53)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C1047(1.24)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C1047(0.84)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C1047(2.07)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C1047(1.60)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C1047(1.08)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C1047(0.96)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C1047(0.82)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C1047(1.13)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C415(0.86)  LDD1644  [3]
 LDCM0441  CL50 HCT 116 C1047(0.69)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C1047(1.08)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C1047(0.78)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C1047(0.54)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C1047(0.65)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C1047(0.81)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C1047(0.62)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C1047(0.73)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C1047(0.81)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C1047(0.76)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C1047(0.81)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C415(0.96)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C415(0.88)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C415(1.01)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C415(1.16); C966(1.29)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C1050(0.84)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C415(1.02); C966(1.11)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C966(1.06)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C415(0.99)  LDD1669  [3]
 LDCM0470  CL77 HEK-293T C415(1.66)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C415(0.71); C966(1.14)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C1050(0.04)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C966(0.98)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C415(1.01)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C415(0.70)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C415(0.83)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C1050(0.76)  LDD1687  [3]
 LDCM0486  CL91 HCT 116 C1047(0.53)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C1047(0.58)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C1047(1.36)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C1047(1.12)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C1047(0.86)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C1047(1.00)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C1047(1.02)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C1047(1.30)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C1047(1.00)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C415(0.87)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C415(0.95)  LDD1671  [3]
 LDCM0427  Fragment51 HCT 116 C1047(0.60)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C333(0.93)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C333(0.93)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C333(0.87)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402