Details of the Target

General Information of Target

Target ID LDTP00327
Target Name Peroxisomal targeting signal 2 receptor (PEX7)
Gene Name PEX7
Gene ID 5191
Synonyms
PTS2R; Peroxisomal targeting signal 2 receptor; PTS2 receptor; Peroxin-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL
FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS
QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL
RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG
HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT
QVADCSWDETIKIYDPACLTIPA
Target Bioclass
Transporter and channel
Family
WD repeat peroxin-7 family
Subcellular location
Cytoplasm, cytosol
Function
Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol. Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex.
Uniprot ID
O00628
Ensemble ID
ENST00000318471.5
HGNC ID
HGNC:8860

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.E309K .
HCT116 SNV: p.S160N .
MFE319 SNV: p.R13L .
OCIAML5 SNV: p.L238F .
SAOS2 SNV: p.L214Q .
SKMEL3 SNV: p.E237D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C207(0.96)  LDD0532  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
Lodoacetamide azide
 Probe Info  		C204(0.00); C207(0.00)  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C207(0.91)  LDD1507  [7]
 LDCM0215  AC10 HCT 116 C207(0.96)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C204(1.02); C207(1.06)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C204(1.23); C207(1.19)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C204(1.16); C207(1.18)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C204(1.07); C207(1.10)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C204(1.00); C207(1.28)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C204(1.24); C207(1.26)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C204(1.52); C207(1.37)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C204(1.04); C207(1.06)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C204(1.13); C207(1.14)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C204(1.01); C207(1.06)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C207(0.91)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C204(1.10); C207(1.20)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C204(1.00); C207(1.03)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C204(0.93); C207(1.00)  LDD0827  [1]
 LDCM0237  AC12 HCT 116 C207(1.00)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C207(0.85)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C207(1.00)  LDD0587  [1]
 LDCM0276  AC17 HEK-293T C207(0.91)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C207(0.88)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C45(0.82); C207(0.88)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C207(1.14)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C45(1.05); C207(0.92)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C207(0.99)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C207(1.15)  LDD1521  [7]
 LDCM0284  AC24 HEK-293T C207(0.91)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C207(0.89)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C207(0.88)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C45(1.26); C207(0.93)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C45(0.82); C207(0.88)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C207(1.01)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C45(1.00); C207(0.91)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C207(1.05)  LDD1530  [7]
 LDCM0293  AC32 HEK-293T C207(1.01)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C207(0.98)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C207(0.97)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C45(1.20); C207(0.97)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C45(0.88); C207(1.19)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C207(1.08)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C207(1.09)  LDD1538  [7]
 LDCM0301  AC4 HEK-293T C45(1.02); C207(1.00)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C207(1.02)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C207(0.95)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C207(0.79)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C45(1.00); C207(0.96)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C45(1.03); C207(1.02)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C207(0.91)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C204(0.83); C207(0.83)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C204(0.82); C207(0.82)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C204(0.83); C207(0.83)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C204(0.99); C207(0.99)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C207(0.87)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C204(0.74); C207(0.74)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C204(0.85); C207(0.85)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C204(0.89); C207(0.89)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C204(0.80); C207(0.80)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C204(0.86); C207(0.86)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C204(0.85); C207(0.85)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C204(1.02); C207(1.02)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C207(0.97)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C207(1.41)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C207(1.05)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C207(0.95)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C207(1.56)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C207(1.25)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C207(1.00)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C207(1.00)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C207(1.32)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C207(1.20)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C207(1.00)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C207(1.21)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C207(1.43)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C207(1.22)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C207(0.87)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C207(1.11)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C207(1.09)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C207(1.08)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C207(1.23)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C207(1.22)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C207(1.88)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C207(1.34)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C207(1.61)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C207(1.17)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C207(1.18)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C207(0.86)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C207(1.35)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C207(1.17)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C207(1.17)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C207(1.20)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C207(1.11)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C207(1.09)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C207(1.24)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C207(1.37)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C207(1.60)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C207(1.22)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C207(1.30)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C207(0.96)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C207(1.29)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C207(1.27)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C207(1.17)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C207(1.34)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C207(0.94)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C207(1.26)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C204(0.97); C207(1.04)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C204(0.93); C207(1.04)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C207(0.93)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C207(0.94)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C207(1.10)  LDD0592  [1]
 LDCM0632  CL-Sc Hep-G2 C5(0.92)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C207(1.30)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C207(0.97)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C207(0.90)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C207(1.02)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C207(1.04)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C207(0.99)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C207(0.94)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C207(1.14)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C207(1.00)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C45(1.31)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C207(1.04)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C207(1.14)  LDD1582  [7]
 LDCM0380  CL110 HEK-293T C207(0.90)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C45(0.83)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C207(0.87)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C207(1.07)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C207(0.89)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C45(0.93)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C207(0.98)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C207(1.02)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C207(1.01)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C45(1.00)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C207(1.13)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C207(0.89)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C204(0.80); C207(0.80)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C204(0.86); C207(0.86)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C204(1.19); C207(1.19)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C204(0.79); C207(0.79)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C207(1.23)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C207(1.13)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C207(1.04)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C207(1.20)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C207(1.10)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C207(1.73)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C45(0.95)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C207(1.04)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C207(0.94)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C207(1.11)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C45(1.15); C207(0.89)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C207(1.37)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C45(1.13); C207(1.13)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C207(0.87)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C207(1.68)  LDD1614  [7]
 LDCM0412  CL24 HEK-293T C207(1.11)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C207(0.99)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C207(1.04)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C45(0.87)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C207(0.95)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C207(1.05)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C45(1.09)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C207(1.02)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C204(0.58)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C204(0.68)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C204(0.27)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C204(0.76)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C204(1.34)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C204(0.77)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C204(0.81)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C204(0.80)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C207(1.11)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C204(0.47)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C204(1.38)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C204(0.70)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C204(1.70)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C204(0.85)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C204(0.75)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C207(0.97)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C207(0.93)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C207(0.82)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C207(0.86)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C207(1.10)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C207(0.90)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C207(0.84)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C207(0.84)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C207(0.90)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C207(0.96)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C207(0.74)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C207(0.91)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C207(1.08)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C207(0.82)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C207(0.85)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C207(0.99)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C207(0.88)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C204(0.94); C207(0.91)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C204(0.75); C207(0.92)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C204(0.89); C207(0.99)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C204(1.26); C207(1.18)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C204(0.92); C207(0.92)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C204(1.45); C207(1.42)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C204(1.09); C207(1.02)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C204(1.14); C207(1.16)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C204(1.13); C207(1.04)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C45(1.36); C207(0.95)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C204(1.08); C207(1.04)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C204(0.80); C207(1.03)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C204(1.09); C207(0.96)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C204(1.40); C207(1.31)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C204(0.94); C207(1.20)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C204(1.20); C207(1.23)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C204(1.77); C207(1.35)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C204(1.08); C207(1.30)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C204(1.05); C207(1.06)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C45(0.64); C207(0.80)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C204(1.18); C207(1.14)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C204(1.29); C207(1.09)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C204(1.06); C207(1.17)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C204(1.24); C207(1.16)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C204(1.33); C207(1.32)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C204(1.07); C207(1.12)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C204(1.23); C207(1.11)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C204(1.16); C207(1.15)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C204(1.08); C207(1.17)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C204(1.26); C207(1.09)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C207(1.05)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C204(2.02); C207(1.44)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C45(0.88); C207(1.26)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C45(1.16); C207(0.86)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C207(1.04)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C207(1.21)  LDD1692  [7]
 LDCM0491  CL96 HEK-293T C207(1.08)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C207(1.03)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C207(1.19)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C45(0.81)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C45(1.08)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C204(1.44); C207(1.52)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C204(0.97)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C207(1.05)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C207(1.05)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C207(1.01)  LDD1502  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C5(0.94)  LDD2207  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PAK4-inhibitor INKA1 (INKA1) INKA family Q96EL1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.