Details of the Target

General Information of Target

Target ID LDTP19833
Target Name SPRY domain-containing protein 4 (SPRYD4)
Gene Name SPRYD4
Gene ID 283377
Synonyms
SPRY domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERKINRREKEKEYEGKHNSLEDTDQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLE
GIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLK
GLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRL
DGFPEEFSISSNIIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLT
SLDCSKGSIVHSDALHFIK
Target Bioclass
Other
Uniprot ID
Q8WW59
Ensemble ID
ENST00000338146.7
HGNC ID
HGNC:27468

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Probe 1
 Probe Info  		Y54(12.82)  LDD3495  [2]
DBIA
 Probe Info  		C114(1.61)  LDD3313  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
AOyne
 Probe Info  		11.50  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HEK-293T C114(0.83)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C114(0.86)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C114(0.83)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C114(6.39)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C114(0.83)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C114(0.83)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C114(1.03)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C114(0.93)  LDD1510  [9]
 LDCM0238  AC120 HEK-293T C114(0.82)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C114(0.71)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C114(0.87)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C114(0.84)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C114(0.83)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C114(0.91)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C114(1.27)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C114(1.30)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C114(0.72)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C114(0.64)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C114(0.62)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C114(0.82)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C114(0.73)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C114(0.61)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C114(0.72)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C114(0.75)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C114(0.70)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C114(0.81)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C114(1.11)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C114(0.89)  LDD0856  [8]
 LDCM0260  AC140 HEK-293T C114(0.73)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C114(0.85)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C114(0.73)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C114(1.14)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C114(1.26)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C114(1.26)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C114(1.44)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C114(1.32)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C114(1.36)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C114(1.09)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C114(0.89)  LDD1513  [9]
 LDCM0271  AC150 HEK-293T C114(1.13)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C114(1.11)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C114(1.09)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C114(1.31)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C114(1.29)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C114(1.06)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C114(1.44)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C114(1.83)  LDD2165  [8]
 LDCM0280  AC20 HEK-293T C114(0.92)  LDD1519  [9]
 LDCM0283  AC23 HEK-293T C114(0.87)  LDD1522  [9]
 LDCM0285  AC25 HEK-293T C114(0.92)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C114(0.90)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C114(0.90)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C114(1.07)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C114(0.76)  LDD0887  [8]
 LDCM0291  AC30 HEK-293T C114(0.74)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C114(0.86)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C114(0.88)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C114(0.81)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C114(0.92)  LDD0893  [8]
 LDCM0297  AC36 HEK-293T C114(1.03)  LDD1536  [9]
 LDCM0300  AC39 HEK-293T C114(0.97)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C114(1.03)  LDD1540  [9]
 LDCM0306  AC44 HEK-293T C114(0.94)  LDD1545  [9]
 LDCM0308  AC46 HEK-293T C114(1.21)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C114(0.96)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C114(1.13)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C114(0.94)  LDD0909  [8]
 LDCM0313  AC50 HEK-293T C114(1.00)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C114(1.23)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C114(1.19)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C114(1.66)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C114(1.15)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C114(1.14)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C114(0.96)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C114(1.08)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C114(0.89)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C114(0.93)  LDD0920  [8]
 LDCM0324  AC60 HEK-293T C114(2.49)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C114(0.86)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C114(0.74)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C114(0.75)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C114(0.75)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C114(0.72)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C114(0.76)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C114(0.70)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C114(1.50)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C114(1.03)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C114(0.88)  LDD1568  [9]
 LDCM0335  AC70 HEK-293T C114(0.85)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C114(0.91)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C114(0.99)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C114(0.89)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C114(1.02)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C114(0.91)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C114(1.03)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C114(0.98)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C114(0.92)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C114(1.10)  LDD0942  [8]
 LDCM0346  AC80 HEK-293T C114(1.06)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C114(1.16)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C114(0.98)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C114(2.12)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C114(0.65)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C114(1.15)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C114(0.83)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C114(0.73)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C114(0.98)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C114(0.76)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C114(0.82)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C114(1.35)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C114(1.45)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C114(0.98)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C114(0.79)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C114(1.32)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C114(1.09)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C114(1.35)  LDD0962  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C114(1.13)  LDD1571  [9]
 LDCM0370  CL101 HEK-293T C114(1.09)  LDD1574  [9]
 LDCM0372  CL103 HEK-293T C114(1.08)  LDD1576  [9]
 LDCM0374  CL105 HEK-293T C114(1.14)  LDD1578  [9]
 LDCM0376  CL107 HEK-293T C114(0.96)  LDD1580  [9]
 LDCM0378  CL109 HEK-293T C114(1.13)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C114(1.11)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C114(0.92)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C114(1.54)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C114(0.89)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C114(2.09)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C114(1.65)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C114(0.95)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C114(1.01)  LDD1591  [9]
 LDCM0389  CL119 HEK-293T C114(1.04)  LDD1593  [9]
 LDCM0392  CL121 HEK-293T C114(1.25)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C114(1.23)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C114(3.95)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C114(1.36)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C114(1.13)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C114(1.32)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C114(1.03)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C114(0.87)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C114(1.05)  LDD1604  [9]
 LDCM0402  CL15 HEK-293T C114(1.18)  LDD1606  [9]
 LDCM0408  CL20 HEK-293T C114(1.14)  LDD1612  [9]
 LDCM0411  CL23 HEK-293T C114(0.96)  LDD1615  [9]
 LDCM0413  CL25 HEK-293T C114(0.95)  LDD1617  [9]
 LDCM0415  CL27 HEK-293T C114(1.00)  LDD1619  [9]
 LDCM0418  CL3 HEK-293T C114(1.06)  LDD1622  [9]
 LDCM0420  CL31 HEK-293T C114(1.52)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C114(1.24)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C114(3.17)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C114(4.10)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C114(1.09)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C114(1.42)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C114(1.30)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C114(1.58)  LDD1026  [8]
 LDCM0430  CL40 HEK-293T C114(0.92)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C114(5.16)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C114(0.99)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C114(1.03)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C114(0.94)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C114(4.63)  LDD1033  [8]
 LDCM0437  CL47 HEK-293T C114(1.06)  LDD1641  [9]
 LDCM0439  CL49 HEK-293T C114(1.10)  LDD1643  [9]
 LDCM0447  CL56 HEK-293T C114(1.32)  LDD1650  [9]
 LDCM0450  CL59 HEK-293T C114(1.04)  LDD1653  [9]
 LDCM0453  CL61 HEK-293T C114(1.07)  LDD1656  [9]
 LDCM0455  CL63 HEK-293T C114(1.17)  LDD1658  [9]
 LDCM0460  CL68 HEK-293T C114(1.15)  LDD1663  [9]
 LDCM0464  CL71 HEK-293T C114(1.00)  LDD1667  [9]
 LDCM0466  CL73 HEK-293T C114(1.00)  LDD1669  [9]
 LDCM0473  CL8 HEK-293T C114(1.42)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C114(1.17)  LDD1677  [9]
 LDCM0477  CL83 HEK-293T C114(1.14)  LDD1680  [9]
 LDCM0479  CL85 HEK-293T C114(1.23)  LDD1682  [9]
 LDCM0481  CL87 HEK-293T C114(1.01)  LDD1684  [9]
 LDCM0487  CL92 HEK-293T C114(1.21)  LDD1690  [9]
 LDCM0490  CL95 HEK-293T C114(1.20)  LDD1693  [9]
 LDCM0492  CL97 HEK-293T C114(0.98)  LDD1695  [9]
 LDCM0494  CL99 HEK-293T C114(1.12)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C114(1.23)  LDD1698  [9]
 LDCM0625  F8 Ramos C114(0.61)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C114(0.69)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C114(0.44)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C114(0.81)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C114(0.78)  LDD2192  [10]
 LDCM0579  Fragment20 Ramos C114(0.79)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C114(1.10)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C114(0.88)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C114(0.72)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C114(1.76)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C114(1.00)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C114(0.82)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C114(0.69)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C114(1.03)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C114(0.85)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C114(0.67)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C114(0.84)  LDD1025  [8]
 LDCM0610  Fragment52 Ramos C114(0.96)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C114(0.90)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C114(0.54)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C114(0.43)  LDD2188  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 Ramos C114(0.41)  LDD2182  [10]
 LDCM0023  KB03 Ramos C114(0.58)  LDD2183  [10]
 LDCM0024  KB05 Hs 936.T C114(1.61)  LDD3313  [3]
 LDCM0131  RA190 MM1.R C114(1.07)  LDD0304  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit g, mitochondrial (ATP5MG) ATPase g subunit family O75964
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Elongation factor 1-beta (EEF1B2) EF-1-beta/EF-1-delta family P24534

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.