Details of the Target

General Information of Target

Target ID LDTP19506
Target Name PiggyBac transposable element-derived protein 2 (PGBD2)
Gene Name PGBD2
Gene ID 267002
Synonyms
PiggyBac transposable element-derived protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWTPELAILRGFPTEAERQQWKQEGVVGSESGSFLQLLLEGNYEAIFLNSMTQNIFNSTT
TAEEKIDSYLEKQVVTFLDYSTDLDTTERQQLIFLLGVSSLQLFVQSNWTGPPVDLHPQD
FLSSVLFQQFSEVKGLDAFVLSLLTLDGESIYSLTSKPILLLLARIILVNVRHKLTAIQS
LPWWTLRCVNIHQHLLEERSPLLFTLAENCIDQVMKLQNLFVDDSGRYLAIQFHLECAYV
FLYYYEYRKAKDQLDIAKDISQLQIDLTGALGKRTRFQENYVAQLILDVRREGDVLSNCE
FTPAPTPQEHLTKNLELNDDTILNDIKLADCEQFQMPDLCAEEIAIILGICTNFQKNNPV
HTLTEVELLAFTSCLLSQPKFWAIQTSALILRTKLEKGSTRRVERAMRQTQALADQFEDK
TTSVLERLKIFYCCQVPPHWAIQRQLASLLFELGCTSSALQIFEKLEMWEDVVICYERAG
QHGKAEEILRQELEKKETPSLYCLLGDVLGDHSCYDKAWELSRYRSARAQRSKALLHLRN
KEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDNAEAWNN
LSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRD
KYKDVQVLKILVRAVIDGMTDRSGDVATGLKGKLQELFGRVTSRVTNDGEIWRLYAHVYG
NGQSEKPDENEKAFQCLSKAYKCDTQSNCWEKDITSFKEVVQRALGLAHVAIKCSKNKSS
SQEAVQMLSSVRLNLRGLLSKAKQLFTDVATGEMSRELADDITAMDTLVTELQDLSNQFR
NQY
Target Bioclass
Other
Uniprot ID
Q6P3X8
Ensemble ID
ENST00000329291.6
HGNC ID
HGNC:19399

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.Q507R .
AU565 SNV: p.E264Q .
CCK81 SNV: p.R587G .
DU145 SNV: p.R39S .
HGC27 SNV: p.E94Q .
HUH1 SNV: p.I157M .
IGROV1 Insertion: p.D150Ter .
LNCaP clone FGC Deletion: p.K366RfsTer3 .
MEWO SNV: p.G439E .
MFE319 Insertion: p.D351Ter
SNV: p.L93P;p.G143C		 .
NCIH1793 SNV: p.Q578H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C563(1.05); C566(1.05)  LDD0580  [1]
CY-1
 Probe Info  		H448(0.00); Q446(0.00)  LDD0246  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C506(1.24)  LDD1508  [3]
 LDCM0259  AC14 HEK-293T C254(1.08)  LDD1512  [3]
 LDCM0263  AC143 HCT 116 C563(1.05); C566(1.05)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C563(1.05); C566(1.05)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C563(1.10); C566(1.10)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C563(0.88); C566(0.88)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C563(0.99); C566(0.99)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C563(0.87); C566(0.87)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C563(0.97); C566(0.97)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C563(0.97); C566(0.97)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C563(0.98); C566(0.98)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C563(0.61); C566(0.61)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C563(0.81); C566(0.81)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C563(0.85); C566(0.85)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C563(0.88); C566(0.88)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C563(1.08); C566(1.08)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C563(1.22); C566(1.22)  LDD2161  [1]
 LDCM0277  AC18 HEK-293T C506(1.33)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C506(0.97)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C506(1.43)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C254(1.11)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C506(1.02)  LDD1523  [3]
 LDCM0285  AC25 HCT 116 C563(1.09); C566(1.09)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C563(0.82); C566(0.82)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C563(0.90); C566(0.90)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C563(0.69); C566(0.69)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C563(0.98); C566(0.98)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C563(0.74); C566(0.74)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C563(1.15); C566(1.15)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C563(0.73); C566(0.73)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C563(0.80); C566(0.80)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C563(0.61); C566(0.61)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C563(0.99); C566(0.99)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C563(1.33); C566(1.33)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C563(1.42); C566(1.42)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C563(1.80); C566(1.80)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C563(1.05); C566(1.05)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C563(0.98); C566(0.98)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C563(1.32); C566(1.32)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C563(1.17); C566(1.17)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C563(1.34); C566(1.34)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C563(1.10); C566(1.10)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C563(0.99); C566(0.99)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C563(1.16); C566(1.16)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C563(1.82); C566(1.82)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C563(1.33); C566(1.33)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C563(0.60); C566(0.60)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C506(1.26)  LDD1551  [3]
 LDCM0313  AC50 HCT 116 C563(0.76); C566(0.76)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C563(3.18); C566(3.18)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C563(0.99); C566(0.99)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C563(0.74); C566(0.74)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C563(0.69); C566(0.69)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C563(0.67); C566(0.67)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C563(0.70); C566(0.70)  LDD0636  [1]
 LDCM0321  AC58 HEK-293T C506(1.06)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C254(0.94)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C506(1.13)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C254(1.11)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C506(1.11)  LDD1567  [3]
 LDCM0332  AC68 HCT 116 C563(0.78); C566(0.78)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C563(0.74); C566(0.74)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C563(0.55); C566(0.55)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C563(1.18); C566(1.18)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C563(0.74); C566(0.74)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C563(0.85); C566(0.85)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C563(0.69); C566(0.69)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C563(0.73); C566(0.73)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C563(0.76); C566(0.76)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C563(1.08); C566(1.08)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C563(0.85); C566(0.85)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C563(0.79); C566(0.79)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C506(0.97)  LDD1569  [3]
 LDCM0346  AC80 HCT 116 C563(0.82); C566(0.82)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C563(1.15); C566(1.15)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C563(0.71); C566(0.71)  LDD0665  [1]
 LDCM0248  AKOS034007472 HEK-293T C506(1.22)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C506(0.88)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C506(0.74)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C254(1.42)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C506(0.74)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C298(1.22)  LDD1576  [3]
 LDCM0374  CL105 HEK-293T C506(0.83)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C298(1.08)  LDD1580  [3]
 LDCM0378  CL109 HEK-293T C506(0.84)  LDD1582  [3]
 LDCM0381  CL111 HEK-293T C298(1.02)  LDD1585  [3]
 LDCM0382  CL112 HCT 116 C563(0.74); C566(0.74)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C563(0.63); C566(0.63)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C563(0.83); C566(0.83)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C563(0.75); C566(0.75)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C563(0.84); C566(0.84)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C563(0.99); C566(0.99)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C563(1.32); C566(1.32)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C563(1.07); C566(1.07)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C506(0.91)  LDD1594  [3]
 LDCM0391  CL120 HCT 116 C563(1.25); C566(1.25)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C563(2.34); C566(2.34)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C563(1.15); C566(1.15)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C563(0.64); C566(0.64)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C563(0.57); C566(0.57)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C506(1.22)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C298(1.24)  LDD1602  [3]
 LDCM0400  CL13 HEK-293T C506(0.87)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C298(0.86)  LDD1606  [3]
 LDCM0405  CL18 HEK-293T C506(1.05)  LDD1609  [3]
 LDCM0409  CL21 HEK-293T C506(1.37)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C254(1.23)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C506(1.01)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C506(0.66)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C298(1.10)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C298(1.04)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C506(1.68)  LDD1623  [3]
 LDCM0422  CL33 HEK-293T C506(1.12)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C254(1.45)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C506(1.12)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C506(1.02)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C298(0.90)  LDD1632  [3]
 LDCM0432  CL42 HEK-293T C506(0.88)  LDD1636  [3]
 LDCM0435  CL45 HEK-293T C506(0.98)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C254(1.28)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C506(1.22)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C506(0.84)  LDD1643  [3]
 LDCM0445  CL54 HEK-293T C506(0.71)  LDD1648  [3]
 LDCM0448  CL57 HEK-293T C506(1.18)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C254(1.09)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C506(1.14)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C506(0.92)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C506(0.91)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C298(1.31)  LDD1658  [3]
 LDCM0458  CL66 HEK-293T C506(1.22)  LDD1661  [3]
 LDCM0461  CL69 HEK-293T C506(1.30)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C254(1.14)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C506(1.24)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C506(0.74)  LDD1669  [3]
 LDCM0471  CL78 HEK-293T C506(1.46)  LDD1674  [3]
 LDCM0475  CL81 HEK-293T C506(1.25)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C254(1.14)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C506(0.90)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C506(0.66)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C298(0.80)  LDD1684  [3]
 LDCM0484  CL9 HEK-293T C506(1.33)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C506(1.05)  LDD1688  [3]
 LDCM0488  CL93 HEK-293T C506(1.11)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C254(1.21)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C506(1.09)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C506(0.79)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C298(1.07)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C298(1.19)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C298(0.99)  LDD1671  [3]
 LDCM0022  KB02 MDST8 C3(1.72)  LDD2458  [4]
 LDCM0023  KB03 MDST8 C3(1.89)  LDD2875  [4]
 LDCM0024  KB05 RKO C3(1.83)  LDD3407  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840