Details of the Target

General Information of Target

Target ID LDTP18732
Target Name Protein FAM234B (FAM234B)
Gene Name FAM234B
Gene ID 57613
Synonyms
KIAA1467; Protein FAM234B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MWSRRGLGVSRAPLHLLLGVWGPSGRTGGQRKGASLARPGRGGLASCSVGANGKRDVLFL
RKTLTNTVEDIQIDNFRRKSDLGVGSPDWKNLLIDVTREDHENSQNNSKRRCKVNCETDQ
R
Target Bioclass
Other
Family
FAM234 family
Subcellular location
Membrane
Uniprot ID
A2RU67
Ensemble ID
ENST00000197268.13
HGNC ID
HGNC:29288

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		4.20  LDD0043  [1]
DBIA
 Probe Info  		C475(1.03)  LDD3312  [2]
IPM
 Probe Info  		C475(1.15)  LDD1701  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		20.97  LDD1850  [5]
C310
 Probe Info  		12.38  LDD1977  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C211(1.31)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C397(1.05)  LDD1510  [6]
 LDCM0270  AC15 HEK-293T C397(1.04); C211(0.72)  LDD1513  [6]
 LDCM0278  AC19 HEK-293T C211(1.24)  LDD1517  [6]
 LDCM0280  AC20 HEK-293T C397(1.02)  LDD1519  [6]
 LDCM0283  AC23 HEK-293T C397(0.93); C211(1.04)  LDD1522  [6]
 LDCM0287  AC27 HEK-293T C211(0.96)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C397(1.11)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C211(0.93)  LDD1529  [6]
 LDCM0292  AC31 HEK-293T C397(0.94); C211(0.94)  LDD1531  [6]
 LDCM0296  AC35 HEK-293T C211(1.08)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C397(1.15)  LDD1536  [6]
 LDCM0300  AC39 HEK-293T C397(1.06); C211(0.69)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C397(1.07)  LDD1540  [6]
 LDCM0305  AC43 HEK-293T C211(0.83)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C397(1.25)  LDD1545  [6]
 LDCM0309  AC47 HEK-293T C397(1.03); C211(0.84)  LDD1548  [6]
 LDCM0314  AC51 HEK-293T C211(0.75)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C397(1.14)  LDD1554  [6]
 LDCM0318  AC55 HEK-293T C397(0.88); C211(0.89)  LDD1557  [6]
 LDCM0322  AC59 HEK-293T C211(1.17)  LDD1561  [6]
 LDCM0324  AC60 HEK-293T C397(1.00)  LDD1563  [6]
 LDCM0327  AC63 HEK-293T C397(0.97); C211(0.88)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C397(1.09); C211(0.92)  LDD1568  [6]
 LDCM0371  CL102 HEK-293T C397(0.85)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C188(1.17)  LDD1576  [6]
 LDCM0375  CL106 HEK-293T C397(0.93)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C188(0.82)  LDD1580  [6]
 LDCM0379  CL11 HEK-293T C397(1.00); C211(0.72)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C397(0.92)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C188(0.80)  LDD1585  [6]
 LDCM0384  CL114 HEK-293T C397(0.92)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C188(1.00)  LDD1589  [6]
 LDCM0388  CL118 HEK-293T C397(0.91)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C188(1.20)  LDD1593  [6]
 LDCM0393  CL122 HEK-293T C397(1.07)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C188(0.86)  LDD1598  [6]
 LDCM0397  CL126 HEK-293T C397(0.86)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C188(0.81)  LDD1602  [6]
 LDCM0401  CL14 HEK-293T C397(0.98)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C188(0.95)  LDD1606  [6]
 LDCM0406  CL19 HEK-293T C211(0.70)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C397(1.09)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C397(1.39)  LDD1612  [6]
 LDCM0411  CL23 HEK-293T C397(0.95); C211(0.92)  LDD1615  [6]
 LDCM0414  CL26 HEK-293T C397(1.06)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C188(0.87)  LDD1619  [6]
 LDCM0418  CL3 HEK-293T C188(1.28)  LDD1622  [6]
 LDCM0420  CL31 HEK-293T C211(1.22)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C397(1.23)  LDD1625  [6]
 LDCM0424  CL35 HEK-293T C397(0.91); C211(1.13)  LDD1628  [6]
 LDCM0428  CL39 HEK-293T C188(1.07)  LDD1632  [6]
 LDCM0433  CL43 HEK-293T C211(1.29)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C397(1.09)  LDD1638  [6]
 LDCM0437  CL47 HEK-293T C397(1.12); C211(1.21)  LDD1641  [6]
 LDCM0441  CL50 HEK-293T C397(1.03)  LDD1645  [6]
 LDCM0446  CL55 HEK-293T C211(0.97)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C397(1.03)  LDD1650  [6]
 LDCM0450  CL59 HEK-293T C397(1.05); C211(1.79)  LDD1653  [6]
 LDCM0454  CL62 HEK-293T C397(0.93)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C188(0.95)  LDD1658  [6]
 LDCM0459  CL67 HEK-293T C211(0.95)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C397(1.16)  LDD1663  [6]
 LDCM0462  CL7 HEK-293T C211(0.75)  LDD1665  [6]
 LDCM0464  CL71 HEK-293T C397(0.91); C211(0.85)  LDD1667  [6]
 LDCM0467  CL74 HEK-293T C397(1.01)  LDD1670  [6]
 LDCM0472  CL79 HEK-293T C211(0.95)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C397(1.08)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C397(1.34)  LDD1677  [6]
 LDCM0477  CL83 HEK-293T C397(0.96); C211(0.83)  LDD1680  [6]
 LDCM0480  CL86 HEK-293T C397(0.91)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C188(1.07)  LDD1684  [6]
 LDCM0486  CL91 HEK-293T C211(1.23)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C397(1.10)  LDD1690  [6]
 LDCM0490  CL95 HEK-293T C397(0.83); C211(0.60)  LDD1693  [6]
 LDCM0493  CL98 HEK-293T C397(0.94)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C188(0.92)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C188(1.05)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C475(0.68)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C188(1.06)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C397(1.03)  LDD1631  [6]
 LDCM0022  KB02 22RV1 C475(1.44)  LDD2243  [2]
 LDCM0023  KB03 MDA-MB-231 C475(1.15)  LDD1701  [3]
 LDCM0024  KB05 HMCB C475(1.03)  LDD3312  [2]

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402