Details of the Target

General Information of Target

Target ID LDTP18568
Target Name Sorting nexin-24 (SNX24)
Gene Name SNX24
Gene ID 28966
Synonyms
Sorting nexin-24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVQMDPELAKRLFFEGATVVILNMPKGTEFGIDYNSWEVGPKFRGVKMIPPGIHFLHY
SSVDKANPKEVGPRMGFFLSLHQRGLTVLRWSTLREEVDLSPAPESEVEAMRANLQELDQ
FLGPYPYATLKKWISLTNFISEATVEKLQPENRQICAFSDVLPVLSMKHTKDRVGQNLPR
CGIECKSYQEGLARLPEMKPRAGTEIRFSELPTQMFPEGATPAEITKHSMDLSYALETVL
NKQFPSSPQDVLGELQFAFVCFLLGNVYEAFEHWKRLLNLLCRSEAAMMKHHTLYINLIS
ILYHQLGEIPADFFVDIVSQDNFLTSTLQVFFSSACSIAVDATLRKKAEKFQAHLTKKFR
WDFAAEPEDCAPVVVELPEGIEMG
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Cytoplasmic vesicle membrane
Function May be involved in several stages of intracellular trafficking.
Uniprot ID
Q9Y343
Ensemble ID
ENST00000261369.9
HGNC ID
HGNC:21533

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.P6L .
NCIH3122 SNV: p.Q73E .
PEO1 Deletion: p.L15RfsTer10 .
RPMI8226 SNV: p.G18E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K47(2.22); K61(10.00); K69(7.82)  LDD0277  [1]
DBIA
 Probe Info  		C114(1.12)  LDD1093  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C114(1.12)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C114(1.41)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C114(1.29)  LDD1105  [2]
 LDCM0237  AC12 PaTu 8988t C114(1.42)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C114(0.88)  LDD1138  [2]
 LDCM0270  AC15 PaTu 8988t C114(1.11)  LDD1149  [2]
 LDCM0276  AC17 PaTu 8988t C114(1.28)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C114(1.73)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C114(1.24)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C114(0.80)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C114(1.53)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C114(1.82)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C114(2.43)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C114(1.90)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C114(1.39)  LDD1163  [2]
 LDCM0285  AC25 HEK-293T C114(0.94)  LDD1524  [6]
 LDCM0287  AC27 HEK-293T C114(1.10)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C114(0.83)  LDD1527  [6]
 LDCM0290  AC3 PaTu 8988t C114(0.94)  LDD1169  [2]
 LDCM0291  AC30 HEK-293T C114(1.06)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C114(1.04)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C114(0.95)  LDD1533  [6]
 LDCM0296  AC35 PaTu 8988t C114(1.43)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C114(1.61)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C114(1.57)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C114(1.61)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C114(1.86)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C114(0.99)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C114(1.70)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C114(1.12)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C114(1.06)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C114(1.28)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C114(1.42)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C114(1.42)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C114(1.24)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C114(1.44)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C114(1.52)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C114(1.99)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C114(1.26)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C114(2.07)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C114(0.42)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C114(1.38)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C114(2.04)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C114(2.16)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C114(1.44)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C114(1.93)  LDD1198  [2]
 LDCM0320  AC57 HEK-293T C114(0.92)  LDD1559  [6]
 LDCM0322  AC59 HEK-293T C114(1.01)  LDD1561  [6]
 LDCM0323  AC6 PaTu 8988t C114(1.18)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C114(0.85)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C114(0.99)  LDD1565  [6]
 LDCM0328  AC64 HEK-293T C114(1.33)  LDD1567  [6]
 LDCM0334  AC7 PaTu 8988t C114(0.94)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C114(0.95)  LDD1224  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C114(1.04)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C114(1.73)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C114(1.24)  LDD1154  [2]
 LDCM0367  CL1 PaTu 8988t C114(1.06)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C114(1.41)  LDD1247  [2]
 LDCM0369  CL100 PaTu 8988t C114(1.05)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C114(1.06)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C114(1.14)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C114(1.41)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C114(1.11)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C114(1.30)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C114(1.21)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C114(1.08)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C114(1.20)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C114(1.20)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C114(1.19)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C114(1.36)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C114(2.06)  LDD1260  [2]
 LDCM0382  CL112 HEK-293T C114(0.98)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C114(0.81)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C114(1.03)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C114(1.14)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C114(1.03)  LDD1590  [6]
 LDCM0387  CL117 PaTu 8988t C114(1.05)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C114(0.97)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C114(1.32)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C114(1.21)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C114(1.38)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C114(1.15)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C114(1.38)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C114(1.77)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C114(1.99)  LDD1274  [2]
 LDCM0396  CL125 HEK-293T C114(1.01)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C114(1.01)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C114(0.80)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C114(0.90)  LDD1603  [6]
 LDCM0400  CL13 PaTu 8988t C114(1.58)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C114(1.57)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C114(1.22)  LDD1281  [2]
 LDCM0403  CL16 PaTu 8988t C114(1.67)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C114(1.92)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C114(1.70)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C114(1.37)  LDD1285  [2]
 LDCM0407  CL2 PaTu 8988t C114(1.25)  LDD1286  [2]
 LDCM0408  CL20 PaTu 8988t C114(1.97)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C114(1.94)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C114(1.69)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C114(2.57)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C114(2.00)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C114(1.27)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C114(1.71)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C114(1.55)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C114(2.28)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C114(2.13)  LDD1296  [2]
 LDCM0418  CL3 PaTu 8988t C114(1.31)  LDD1297  [2]
 LDCM0419  CL30 PaTu 8988t C114(1.72)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C114(1.28)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C114(1.32)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C114(1.30)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C114(1.34)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C114(1.41)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C114(1.11)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C114(1.75)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C114(1.38)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C114(1.11)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C114(1.19)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C114(1.30)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C114(1.48)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C114(1.91)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C114(1.56)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C114(1.41)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C114(1.09)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C114(1.08)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C114(1.06)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C114(1.19)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C114(1.50)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C114(1.12)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C114(1.11)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C114(1.13)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C114(1.44)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C114(1.25)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C114(1.24)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C114(0.73)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C114(1.57)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C114(1.14)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C114(1.71)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C114(1.23)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C114(1.40)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C114(0.89)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C114(0.97)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C114(1.06)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C114(1.31)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C114(1.02)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C114(1.49)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C114(1.21)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C114(1.55)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C114(1.59)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C114(1.29)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C114(1.32)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C114(0.96)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C114(0.86)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C114(1.38)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C114(1.19)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C114(1.19)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C114(1.36)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C114(1.51)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C114(1.42)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C114(1.46)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C114(1.42)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C114(1.56)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C114(1.59)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C114(1.55)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C114(1.57)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C114(1.29)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C114(1.41)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C114(1.62)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C114(1.80)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C114(1.41)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C114(1.37)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C114(1.66)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C114(0.58)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C114(0.70)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C114(0.91)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C114(1.24)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C114(1.62)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C114(0.70)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C114(0.81)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C114(1.18)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C114(0.90)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C114(0.94)  LDD1698  [6]
 LDCM0468  Fragment33 PaTu 8988t C114(1.32)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C114(1.67)  LDD1306  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402