Details of the Target

General Information of Target

Target ID LDTP17807
Target Name Zinc finger protein 680 (ZNF680)
Gene Name ZNF680
Gene ID 340252
Synonyms
Zinc finger protein 680
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLTEGRVVFEDVAIYFSQEEWGHLDEAQRLLYRDVMLENLALLSSLGSWHGAEDEEAPS
QQGFSVGVSEVTASKPCLSSQKVHPSETCGPPLKDILCLVEHNGIHPEQHIYICEAELFQ
HPKQQIGENLSRGDDWIPSFGKNHRVHMAEEIFTCMEGWKDLPATSCLLQHQGPQSEWKP
YRDTEDREAFQTGQNDYKCSECGKTFTCSYSFVEHQKIHTGERSYECNKCGKFFKYSANF
MKHQTVHTSERTYECRECGKSFMYNYRLMRHKRVHTGERPYECNTCGKFFRYSSTFVRHQ
RVHTGERPYECRECGKFFMDSSTLIKHQRVHTGERPYKCNDCGKFFRYISTLIRHQRIHT
GERPYECSVCGELFRYNSSLVKHWRNHTGERPYKCSECGKSFRYHCRLIRHQRVHTGERP
YECSECGKFFRYNSNLIKHWRNHTGERPYECRECGKAFSHKHILVEHQKIHSGERPYECS
ECQKAFIRKSHLVHHQKIHSEERLVCSMNVGNSLAKTPTSLNIRDFTMEKVYH
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8NEM1
Ensemble ID
ENST00000309683.11
HGNC ID
HGNC:26897

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.L477V .
CAL33 Deletion: p.K339_T366del .
HCT116 SNV: p.G216C .
HT115 SNV: p.R175I; p.L219R .
JURKAT SNV: p.M1? .
P31FUJ SNV: p.K481N .
SW756 SNV: p.S377Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C418(0.76)  LDD0613  [1]
HHS-465
 Probe Info  		K348(0.00); K351(0.00); Y350(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C418(1.19)  LDD1509  [3]
 LDCM0278  AC19 HEK-293T C418(1.31)  LDD1517  [3]
 LDCM0287  AC27 HEK-293T C418(1.16)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C418(1.22)  LDD1529  [3]
 LDCM0296  AC35 HCT 116 C418(0.76)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C418(0.73)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C418(0.69)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C418(0.91)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C418(1.07)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C418(1.14)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C418(0.88)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C418(1.42)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C418(1.45)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C418(1.14)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C418(0.93)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C418(0.80)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C418(0.70)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C418(0.86)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C418(0.99)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C418(1.03)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C418(0.63)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C418(0.74)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C418(1.30)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C418(0.82)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C418(0.96)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C418(1.10)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C418(1.87)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C418(5.05)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C418(3.97)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C418(2.06)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C418(2.23)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C418(3.32)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C418(1.69)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C418(2.20)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C418(1.71)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C418(1.81)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C418(3.11)  LDD0648  [1]
 LDCM0349  AC83 HCT 116 C418(1.31)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C418(1.53)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C418(1.40)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C418(1.17)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C418(1.77)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C418(1.22)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C418(1.25)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C418(0.63)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C418(1.83)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C418(1.29)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C418(0.96)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C418(1.58)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C418(1.02)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C418(1.30)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C418(1.35)  LDD0681  [1]
 LDCM0387  CL117 HCT 116 C418(1.33)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C418(1.13)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C418(1.34)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C418(1.35)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C418(0.66)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C418(1.14)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C418(0.99)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C418(1.21)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C418(0.64)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C418(1.61)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C418(1.43)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C418(1.21)  LDD0716  [1]
 LDCM0406  CL19 HEK-293T C418(1.34)  LDD1610  [3]
 LDCM0420  CL31 HEK-293T C418(0.96)  LDD1624  [3]
 LDCM0433  CL43 HEK-293T C418(1.07)  LDD1637  [3]
 LDCM0436  CL46 HCT 116 C418(1.67)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C418(1.12)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C418(1.67)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C418(1.28)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C418(1.85)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C418(1.16)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C418(1.25)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C418(1.92)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C418(1.43)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C418(1.24)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C418(1.09)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C418(1.11)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C418(1.10)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C418(1.38)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C418(1.77)  LDD0769  [1]
 LDCM0459  CL67 HEK-293T C418(1.34)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C418(1.13)  LDD1665  [3]
 LDCM0469  CL76 HCT 116 C418(1.65)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C418(2.36)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C418(1.60)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C418(1.72)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C418(1.42)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C418(1.90)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C418(1.35)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C418(1.55)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C418(1.74)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C418(1.70)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C418(1.41)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C418(2.09)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C418(1.63)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C418(1.68)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C418(1.70)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C418(1.08)  LDD1689  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402