Details of the Target

General Information of Target

Target ID LDTP17736
Target Name Zinc finger protein 525 (ZNF525)
Gene Name ZNF525
Gene ID 170958
Synonyms
KIAA1979; Zinc finger protein 525
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL
HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI
ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI
PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST
FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS
SNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHY
LYYWLKHHYNVHFNGLECKTPEEYKGWSVGKYIRSYYEECPKDKLPAYPESFDQDTEDDE
WEKKHRDHTAKKQSVIITIVG
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8N782
Ensemble ID
ENST00000474037.6
HGNC ID
HGNC:29423

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C62(1.05)  LDD0531  [1]
IA-alkyne
 Probe Info  		C264(0.00); C467(0.00)  LDD0167  [2]
HHS-465
 Probe Info  		I15(0.00); S18(0.00); F17(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C62(1.05)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C62(1.30)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C62(1.22)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C62(0.94)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C62(1.04)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C62(1.14)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C62(1.37)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C62(1.06)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C62(0.95)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C62(1.15)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C62(1.03)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C62(1.38)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C62(0.95)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C62(1.10)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C62(0.91)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C62(0.96)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C62(0.96)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C62(1.15)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C62(1.15)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C62(1.22)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C62(0.74)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C62(0.84)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C62(0.78)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C62(0.85)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C62(0.92)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C62(0.86)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C62(0.88)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C62(1.20)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C62(0.87)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C62(0.88)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C62(0.94)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C62(1.11)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C62(0.94)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C62(0.97)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C62(0.73)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C62(1.20)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C62(1.45)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C62(1.30)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C62(1.67)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C62(1.60)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C62(2.44)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C62(2.20)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C62(1.36)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C62(1.36)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C62(1.29)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C62(1.52)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C62(2.61)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C62(1.63)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C62(1.54)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C62(1.14)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C62(1.08)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C62(1.15)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C62(1.67)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C62(1.11)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C62(1.07)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C62(1.07)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C62(1.31)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C62(1.05)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C62(1.20)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C62(1.13)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C62(1.25)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C62(1.03)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C62(1.03)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C62(1.17)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C62(1.11)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C62(1.10)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C62(1.19)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C62(1.22)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C62(1.63)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C62(1.40)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C62(1.66)  LDD0612  [1]
 LDCM0301  AC4 HCT 116 C62(1.28)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C62(1.16)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C62(1.10)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C62(1.00)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C62(1.03)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C62(1.19)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C62(1.10)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C62(0.88)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C62(1.03)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C62(1.07)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C62(1.07)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C62(1.02)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C62(0.91)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C62(1.03)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C62(0.94)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C62(1.15)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C62(2.03)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C62(2.06)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C62(1.74)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C62(1.32)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C62(1.20)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C62(1.32)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C62(1.38)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C62(0.89)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C62(2.11)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C62(1.70)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C62(1.28)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C62(1.36)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C62(1.21)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C62(1.40)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C62(1.86)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C62(1.08)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C62(1.03)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C62(1.53)  LDD0592  [1]
 LDCM0369  CL100 HCT 116 C62(1.27)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C62(1.27)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C62(1.01)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C62(0.80)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C62(0.98)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C62(1.21)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C62(1.59)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C62(1.52)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C62(1.76)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C62(1.52)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C62(1.51)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C62(1.64)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C62(1.00)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C62(1.24)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C62(1.07)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C62(1.16)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C62(1.13)  LDD0703  [1]
 LDCM0396  CL125 HCT 116 C62(1.04)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C62(1.05)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C62(0.92)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C62(0.96)  LDD0716  [1]
 LDCM0486  CL91 HCT 116 C62(1.04)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C62(1.05)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C62(0.99)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C62(1.40)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C62(1.26)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C62(1.13)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C62(1.02)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C62(1.06)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C62(1.10)  LDD0811  [1]
 LDCM0022  KB02 ABC-1 C62(2.44)  LDD2262  [4]
 LDCM0023  KB03 ABC-1 C62(1.83)  LDD2679  [4]
 LDCM0024  KB05 OCUG-1 C62(2.45)  LDD3373  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840