Details of the Target

General Information of Target

Target ID LDTP17389
Target Name UPF0547 protein C16orf87 (C16orf87)
Gene Name C16orf87
Gene ID 388272
Synonyms
UPF0547 protein C16orf87
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHLMMFRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSLGFCIYQPEAFSLLEKG
KEPWKILRDETRGPCPDMQSRCQTKKLLPKNGIFEREIAQLEIMRICKNHSLDCLCFRGD
WEGNTQFQTLQDNQEECFKQVIRTCEKRPTFNQHTVFNLHQRLNTGDKLNEFKELGKAFI
SGSDHTQHQLIHTSEKFCGDKECGNTFLPDSEVIQYQTVHTVKKTYECKECGKSFSLRSS
LTGHKRIHTGEKPFKCKDCGKAFRFHSQLSVHKRIHTGEKSYECKECGKAFSCGSDLTRH
QRIHTGEKPYECNECRKAFSQRSHLIKHQRIHTGEKPYECKECGKAFTRGSHLTQHQRIH
TGEKSHECKECGKAFIRGSNLAQHQNVHVGRKPYKCEKCGKAYIWSSHLARHQRIHTGRK
PYECKQCGKTFTWASYLAQHEKIHNERKSYECKECGKTFLHGSEFNRHQKIHTGERNYEC
KECGKTFFRGSELNRHQKIHTGKRPYECEECGKAFLWGSQLTRHQRMHTGEEPYVCKECG
KSFIWGSQLTRHKKIHTDAEPYGCKKSSHIFSHHSYFTEQKIHNSANLCEWTDYGNTFSH
ESNFAQHQNIYTFEKSYEFKDFEKAFSSSSHFISLL
Target Bioclass
Other
Family
UPF0547 family
Uniprot ID
Q6PH81
Ensemble ID
ENST00000285697.9
HGNC ID
HGNC:33754

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C16(0.95); C19(0.95); C27(0.95)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C19(1.07); C27(1.07)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C19(0.95); C27(0.95)  LDD0813  [1]
 LDCM0226  AC11 HEK-293T C19(1.08); C27(1.08)  LDD0824  [1]
 LDCM0237  AC12 HEK-293T C19(0.93); C27(0.93)  LDD0835  [1]
 LDCM0259  AC14 HEK-293T C19(1.57); C27(1.57)  LDD0857  [1]
 LDCM0270  AC15 HEK-293T C19(0.91); C27(0.91)  LDD0868  [1]
 LDCM0276  AC17 HEK-293T C27(1.01)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C27(1.12)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C27(1.07)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C19(1.10); C27(1.10)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C27(1.05)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C27(1.05)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C27(1.01)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C27(0.96)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C27(1.00)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C27(0.89)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C27(1.05)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C27(1.08)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C27(0.97)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C27(1.05)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C19(0.97); C27(0.97)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C27(0.95)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C27(1.02)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C27(1.04)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C27(1.08)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C27(0.94)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C27(1.00)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C27(1.15)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C27(0.96)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C27(1.00)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C27(0.92)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C19(1.07); C27(1.07)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C27(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C27(0.96)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C27(0.97)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C27(0.91)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C27(1.01)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C27(1.07)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C19(1.21); C27(1.21)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C19(1.10); C27(1.10)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C19(0.98); C27(0.98)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C19(1.10); C27(1.10)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C19(1.25); C27(1.25)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C19(0.98); C27(0.98)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C19(0.90); C27(0.90)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C19(0.88); C27(0.88)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C19(1.04); C27(1.04)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C19(1.19); C27(1.19)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C19(1.36); C27(1.36)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C19(1.44); C27(1.44)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C27(0.95)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C27(0.96)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C27(1.02)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C19(1.06); C27(1.06)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C27(0.98)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C27(1.14)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C27(1.04)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C27(0.99)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C27(1.02)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C19(0.82); C27(0.82)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C19(0.82); C27(0.82)  LDD0943  [1]
 LDCM0248  AKOS034007472 HEK-293T C19(1.21); C27(1.21)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C19(0.97); C27(0.97)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C19(1.47); C27(1.47)  LDD0873  [1]
 LDCM0020  ARS-1620 HCC44 C16(0.95); C19(0.95); C27(0.95)  LDD0078  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C19(0.87); C27(0.87)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C19(0.86); C27(0.86)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C19(0.71); C27(0.71)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C19(0.96); C27(0.96)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C19(1.07); C27(1.07)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C19(0.80); C27(0.80)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C19(0.90); C27(0.90)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C27(0.85)  LDD1578  [7]
 LDCM0376  CL107 HEK-293T C27(0.97)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C27(1.11)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C27(0.93)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C19(0.58); C27(0.58)  LDD0977  [1]
 LDCM0381  CL111 HEK-293T C27(0.94)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C27(1.17)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C27(1.12)  LDD1587  [7]
 LDCM0385  CL115 HEK-293T C27(0.99)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C27(1.01)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C27(0.90)  LDD1591  [7]
 LDCM0389  CL119 HEK-293T C27(0.95)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C19(0.92); C27(0.92)  LDD0988  [1]
 LDCM0391  CL120 HEK-293T C27(1.03)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C19(1.02); C27(1.02)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C19(0.85); C27(0.85)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C19(1.22); C27(1.22)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C19(1.28); C27(1.28)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C27(1.04)  LDD1600  [7]
 LDCM0398  CL127 HEK-293T C27(0.95)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C27(0.97)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C19(1.18); C27(1.18)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C19(0.86); C27(0.86)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C19(0.82); C27(0.82)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C27(1.07)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C27(1.01)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C27(1.17)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C27(0.97)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C19(0.92); C27(0.92)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C27(1.04)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C27(0.90)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C27(1.01)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C27(0.96)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C27(0.99)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C27(0.97)  LDD1617  [7]
 LDCM0415  CL27 HEK-293T C27(0.92)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C27(0.95)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C27(1.06)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C19(1.00); C27(1.00)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C27(1.10)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C27(0.99)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C27(1.01)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C27(0.95)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C27(0.95)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C27(1.17)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C27(0.94)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C27(1.01)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C27(0.94)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C19(0.95); C27(0.95)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C27(1.06)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C27(0.81)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C27(1.08)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C27(1.05)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C27(1.01)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C27(1.08)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C27(0.92)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C27(0.97)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C27(1.01)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C27(1.06)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C19(0.90); C27(0.90)  LDD1038  [1]
 LDCM0443  CL52 HEK-293T C27(1.19)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C27(0.87)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C27(1.05)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C27(0.96)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C27(0.96)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C27(0.92)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C27(0.95)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C27(0.93)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C19(0.75); C27(0.75)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C27(0.96)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C27(0.98)  LDD1656  [7]
 LDCM0455  CL63 HEK-293T C27(1.06)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C27(1.00)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C27(1.10)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C27(1.06)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C27(0.98)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C27(1.04)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C27(1.03)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C19(1.02); C27(1.02)  LDD1060  [1]
 LDCM0463  CL70 HEK-293T C27(1.04)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C27(1.16)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C27(1.01)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C27(1.00)  LDD1669  [7]
 LDCM0469  CL76 HEK-293T C27(1.02)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C27(0.78)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C27(1.12)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C27(0.88)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C19(0.71); C27(1.99)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C27(1.09)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C27(1.01)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C27(0.97)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C27(0.94)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C27(0.95)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C27(0.97)  LDD1682  [7]
 LDCM0481  CL87 HEK-293T C27(1.07)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C27(1.10)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C27(1.11)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C19(0.77); C27(1.40)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C27(0.94)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C19(0.97); C27(0.97)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C19(0.80); C27(0.80)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C19(0.99); C27(0.99)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C19(1.13); C27(1.13)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C19(0.99); C27(0.99)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C19(1.15); C27(1.15)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C19(1.11); C27(1.11)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C19(1.00); C27(1.00)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C19(0.86); C27(0.86)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C27(1.07)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C27(0.92)  LDD1671  [7]
 LDCM0022  KB02 HCT 116 C19(1.65); C27(1.65)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C19(1.43); C27(1.43)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C19(1.75); C27(1.75)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C16(1.38); C19(1.38); C27(1.38); C30(1.36)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Melanoma-associated antigen 12 (MAGEA12) . P43365

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402