Details of the Target

General Information of Target

Target ID LDTP17203
Target Name Zinc finger protein 569 (ZNF569)
Gene Name ZNF569
Gene ID 148266
Synonyms
Zinc finger protein 569
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESKAWESNNEDLLSSSGVTSNGGSSSSFFVSSIRGTIIENTSSAGTLTQVPFFPKYEVE
LDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQ
EMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMML
SHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRI
FPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQ
MEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTE
ARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE
LDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKV
VEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG
DHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN
DRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLN
EVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEG
SDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELST
VATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ
HTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDP
TRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNN
SLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSP
VHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLV
EDLQLKNQAMSSMIRNQEKRIQKVKDQEKMLLK
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q5MCW4
Ensemble ID
ENST00000316950.11
HGNC ID
HGNC:24737

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L369R .
HT115 SNV: p.E110D; p.S340F; p.K430I .
LS180 Deletion: p.F130SfsTer17 .
REH SNV: p.S420N .
SW403 SNV: p.R203I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C152(0.71)  LDD0813  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C165(2.12)  LDD1093  [1]
 LDCM0215  AC10 HEK-293T C152(0.71)  LDD0813  [1]
 LDCM0216  AC100 PaTu 8988t C145(1.23); C152(1.23)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C145(1.03); C152(1.03)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C145(1.13); C152(1.13)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C145(1.23); C152(1.23)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C145(1.00); C152(1.00)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C145(1.07); C152(1.07)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C145(1.12); C152(1.12)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C145(1.09); C152(1.09)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C145(1.23); C152(1.23)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C145(1.24); C152(1.24)  LDD1104  [1]
 LDCM0226  AC11 HEK-293T C152(0.97)  LDD0824  [1]
 LDCM0227  AC110 PaTu 8988t C145(1.29); C152(1.29)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C145(1.41); C152(1.41)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C145(1.09); C152(1.09)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C145(0.90); C152(0.90)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C145(0.88); C152(0.88)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C145(1.01); C152(1.01)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C145(0.93); C152(0.93)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C145(1.01); C152(1.01)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C145(0.93); C152(0.93)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C145(0.94); C152(0.94)  LDD1115  [1]
 LDCM0237  AC12 HEK-293T C152(0.76)  LDD0835  [1]
 LDCM0238  AC120 PaTu 8988t C145(0.71); C152(0.71)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C145(0.87); C152(0.87)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C145(0.78); C152(0.78)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C145(0.75); C152(0.75)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C145(0.81); C152(0.81)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C145(0.94); C152(0.94)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C145(0.83); C152(0.83)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C145(0.77); C152(0.77)  LDD1124  [1]
 LDCM0246  AC128 HEK-293T C145(0.94); C152(0.94)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C145(1.05); C152(1.05)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C145(0.98); C152(0.98)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C145(1.03); C152(1.03)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C145(1.03); C152(1.03)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C145(0.95); C152(0.95)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C145(0.92); C152(0.92)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C145(0.97); C152(0.97)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C145(1.04); C152(1.04)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C145(1.11); C152(1.11)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C145(1.01); C152(1.01)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C145(1.17); C152(1.17)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C152(0.76)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C145(1.00); C152(1.00)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C145(1.06); C152(1.06)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C145(1.17); C152(1.17)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C145(0.92); C152(0.86)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C145(1.08); C152(0.76)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C145(1.03); C152(0.82)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C145(0.89); C152(0.83)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C145(1.18); C152(0.76)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C145(1.20); C152(0.70)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C145(1.27); C152(0.84)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C152(0.66)  LDD0868  [1]
 LDCM0271  AC150 HEK-293T C145(0.96); C152(0.78)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C145(0.91); C152(0.85)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C145(0.94); C152(0.80)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C145(0.97); C152(0.85)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C145(1.51); C152(0.89)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C145(1.11); C152(0.94)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C145(1.08); C152(0.81)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C145(1.16); C152(0.74)  LDD2165  [1]
 LDCM0276  AC17 PaTu 8988t C165(1.02); C145(1.20); C152(1.20)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C165(1.23); C145(1.34); C152(1.34)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C165(1.02); C145(1.01); C152(1.01)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C165(1.65)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C165(1.31); C145(1.05); C152(1.05)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C165(1.28); C145(1.05); C152(1.05)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C165(1.35); C145(1.09); C152(1.09)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C165(1.47); C145(1.16); C152(1.16)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C165(1.29); C145(1.46); C152(1.46)  LDD1163  [1]
 LDCM0290  AC3 PaTu 8988t C165(1.60)  LDD1169  [1]
 LDCM0301  AC4 PaTu 8988t C165(1.27)  LDD1180  [1]
 LDCM0312  AC5 PaTu 8988t C165(1.97)  LDD1191  [1]
 LDCM0320  AC57 HEK-293T C145(0.89); C152(0.84)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C145(0.77); C152(1.36)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C145(0.67); C152(1.22)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C152(0.89)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C145(1.07); C152(1.02)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C145(0.96); C152(0.87)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C145(0.69); C152(1.54)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C145(0.74); C152(1.00)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C145(1.14); C152(1.42)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C145(0.75); C152(1.07)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C145(0.85); C152(0.97)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C145(0.89); C152(1.37)  LDD0929  [1]
 LDCM0334  AC7 HEK-293T C152(0.67)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C152(0.70)  LDD0943  [1]
 LDCM0349  AC83 HEK-293T C145(0.82); C152(0.82)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C145(1.18); C152(1.18)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C145(0.77); C152(0.77)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C145(1.01); C152(1.01)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C145(0.98); C152(0.98)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C145(0.94); C152(0.94)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C145(1.11); C152(1.11)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C145(0.96); C152(0.96)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C145(0.87); C152(0.87)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C145(0.90); C152(0.90)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C145(1.08); C152(1.08)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C145(1.08); C152(1.08)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C145(1.04); C152(1.04)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C145(0.84); C152(0.84)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C145(0.91); C152(0.91)  LDD0962  [1]
 LDCM0365  AC98 PaTu 8988t C145(1.25); C152(1.25)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C145(1.07); C152(1.07)  LDD1245  [1]
 LDCM0248  AKOS034007472 HEK-293T C152(1.07)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C152(0.61)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C152(0.74)  LDD0873  [1]
 LDCM0367  CL1 HEK-293T C145(1.22); C152(1.22)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C145(1.34); C152(1.34)  LDD0966  [1]
 LDCM0369  CL100 PaTu 8988t C165(1.46)  LDD1248  [1]
 LDCM0370  CL101 HEK-293T C152(0.83)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C152(0.72)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C152(0.92)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C152(0.63)  LDD0971  [1]
 LDCM0374  CL105 PaTu 8988t C165(1.16); C145(1.14); C152(1.14)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C165(1.02); C145(1.05); C152(1.05)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C165(0.93); C145(1.17); C152(1.17)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C165(1.03); C145(1.20); C152(1.20)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C165(1.19); C145(1.13); C152(1.13)  LDD1257  [1]
 LDCM0379  CL11 HEK-293T C145(0.88); C152(0.88)  LDD0977  [1]
 LDCM0380  CL110 PaTu 8988t C165(1.25); C145(1.35); C152(1.35)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C165(1.54); C145(1.56); C152(1.56)  LDD1260  [1]
 LDCM0390  CL12 HEK-293T C145(1.02); C152(1.02)  LDD0988  [1]
 LDCM0396  CL125 HEK-293T C145(0.81); C152(1.50)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C145(1.09); C152(1.01)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C145(0.69); C152(1.17)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C145(1.38); C152(1.24)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C145(0.92); C152(0.92)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C145(1.11); C152(1.11)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C145(1.59); C152(1.59)  LDD1000  [1]
 LDCM0403  CL16 PaTu 8988t C145(1.04); C152(1.04)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C145(1.00); C152(1.00)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C145(0.94); C152(0.94)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C145(0.80); C152(0.80)  LDD1285  [1]
 LDCM0407  CL2 HEK-293T C145(1.06); C152(1.06)  LDD1005  [1]
 LDCM0408  CL20 PaTu 8988t C145(0.86); C152(0.86)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C145(1.12); C152(1.12)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C145(0.86); C152(0.86)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C145(0.99); C152(0.99)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C145(0.99); C152(0.99)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C145(1.15); C152(1.15)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C145(0.94); C152(0.94)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C145(1.01); C152(1.01)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C145(0.91); C152(0.91)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C145(0.89); C152(0.89)  LDD1296  [1]
 LDCM0418  CL3 HEK-293T C145(0.88); C152(0.88)  LDD1016  [1]
 LDCM0419  CL30 PaTu 8988t C145(0.96); C152(0.96)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C165(1.13)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C165(1.15)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C165(1.39)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C165(1.45)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C165(1.41)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C165(1.28)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C165(1.66)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C165(1.37)  LDD1307  [1]
 LDCM0429  CL4 HEK-293T C145(1.09); C152(1.09)  LDD1027  [1]
 LDCM0430  CL40 PaTu 8988t C165(1.06)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C165(1.49)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C165(1.45)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C165(1.83)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C165(1.55)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C165(1.48)  LDD1314  [1]
 LDCM0440  CL5 HEK-293T C145(1.02); C152(1.02)  LDD1038  [1]
 LDCM0451  CL6 HEK-293T C145(1.18); C152(1.18)  LDD1049  [1]
 LDCM0453  CL61 HEK-293T C145(0.94); C152(0.94)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C145(0.94); C152(0.94)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C145(1.05); C152(1.05)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C145(1.44); C152(1.44)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C145(1.00); C152(1.00)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C145(1.16); C152(1.16)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C145(1.21); C152(1.21)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C145(0.83); C152(0.83)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C145(1.02); C152(1.02)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C145(0.99); C152(0.99)  LDD1060  [1]
 LDCM0463  CL70 HEK-293T C145(1.05); C152(1.05)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C145(0.98); C152(0.98)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C145(0.98); C152(0.98)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C145(1.21); C152(1.21)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C145(0.95); C152(0.95)  LDD1065  [1]
 LDCM0473  CL8 HEK-293T C145(1.03); C152(2.05)  LDD1071  [1]
 LDCM0484  CL9 HEK-293T C145(0.91); C152(1.23)  LDD1082  [1]
 LDCM0486  CL91 PaTu 8988t C165(1.44)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C165(1.73)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C165(1.70)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C165(1.59)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C165(2.70)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C165(1.54)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C165(1.92)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C165(2.10)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C165(1.40)  LDD1373  [1]
 LDCM0468  Fragment33 HEK-293T C145(1.26); C152(1.26)  LDD1066  [1]
 LDCM0427  Fragment51 PaTu 8988t C165(1.47)  LDD1306  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.