Details of the Target

General Information of Target

Target ID LDTP16954
Target Name Zinc finger protein 823 (ZNF823)
Gene Name ZNF823
Gene ID 55552
Synonyms
ZFP36; Zinc finger protein 823; Zinc finger protein ZFP-36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYGKIIFVLLLSGIVSISASSTTGVAMHTSTSSSVTKSYISSQTNGITLINWWAMARVIF
EVMLVVVGMIILISYCIR
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
P16415
Ensemble ID
ENST00000341191.11
HGNC ID
HGNC:30936

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.H123Y .
HCT15 SNV: p.H322Y .
HEC1B SNV: p.Q404R .
MCC13 SNV: p.P344S .
OVISE SNV: p.E105G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C222(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C399(81.02); C343(47.03)  LDD0209  [2]
IPM
 Probe Info  		C399(1.81)  LDD1701  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
HHS-465
 Probe Info  		K274(0.00); K277(0.00); Y276(0.00)  LDD2240  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C222(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C222(2.25)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C42(1.06)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C126(0.95); C343(1.06)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C343(1.14)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C126(1.08); C541(0.91)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C541(1.06)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C126(0.97); C541(0.92)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C42(0.89)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C126(0.87); C343(0.98)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C343(1.00)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C126(0.93); C343(1.05)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C126(1.15); C541(0.93)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C343(1.03)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C541(1.31)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C126(1.29); C541(0.89)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C541(0.92)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C42(0.98)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C126(0.97); C343(1.01)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C343(1.01)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C126(1.04); C541(0.90)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C343(1.16)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C343(1.03)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C541(0.91)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C126(0.92); C541(0.90)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C541(1.14)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C42(0.97)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C126(0.85); C343(1.18)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C343(1.09)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C126(1.12); C541(0.92)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C343(1.00)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C541(0.98)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C126(0.89); C541(0.91)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C126(1.03); C541(0.87)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C541(1.07)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C42(0.89)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C126(0.99); C343(1.08)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C343(1.02)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C126(1.08); C541(0.88)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C343(1.06)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C541(1.34)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C126(1.19); C541(0.84)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C541(0.98)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C42(1.04)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C343(1.06)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C126(0.95); C343(1.03)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C343(1.00)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C126(1.05); C541(0.91)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C343(0.99)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C541(1.00)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C126(1.12); C541(0.91)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C541(1.09)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C42(1.10)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C126(0.99); C343(1.10)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C343(1.04)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C541(1.13)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C126(0.98); C541(1.00)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C343(1.04)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C541(1.09)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C126(0.96); C541(0.97)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C541(0.96)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C126(1.19); C541(0.84)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C541(1.07)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C343(1.05)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C42(1.06)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C541(1.04)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C399(1.00)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C541(1.73)  LDD1572  [7]
 LDCM0370  CL101 HEK-293T C399(0.91)  LDD1574  [7]
 LDCM0374  CL105 HEK-293T C399(1.12)  LDD1578  [7]
 LDCM0378  CL109 HEK-293T C399(0.94)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C126(1.19); C541(1.04)  LDD1583  [7]
 LDCM0383  CL113 HEK-293T C399(0.94)  LDD1587  [7]
 LDCM0387  CL117 HEK-293T C399(1.00)  LDD1591  [7]
 LDCM0390  CL12 HEK-293T C541(1.14)  LDD1594  [7]
 LDCM0392  CL121 HEK-293T C399(0.96)  LDD1596  [7]
 LDCM0396  CL125 HEK-293T C399(0.99)  LDD1600  [7]
 LDCM0400  CL13 HEK-293T C399(0.95)  LDD1604  [7]
 LDCM0404  CL17 HEK-293T C42(1.23)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C126(0.96); C343(1.23)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C343(1.41)  LDD1610  [7]
 LDCM0408  CL20 HEK-293T C126(1.11); C541(0.90)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C343(1.45)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C541(1.11)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C126(1.11); C541(1.01)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C541(1.13)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C399(0.95)  LDD1617  [7]
 LDCM0417  CL29 HEK-293T C42(1.08)  LDD1621  [7]
 LDCM0419  CL30 HEK-293T C126(0.87); C343(1.09)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C343(1.24)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C126(1.06); C541(0.88)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C343(1.25)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C541(0.99)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C126(1.19); C541(1.04)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C541(1.14)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C399(1.10)  LDD1630  [7]
 LDCM0431  CL41 HEK-293T C42(1.03)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C126(0.90); C343(1.12)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C343(1.24)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C126(1.15); C541(1.11)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C343(1.37)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C541(1.07)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C126(1.03); C541(1.05)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C541(1.04)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C399(0.97)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C42(1.05)  LDD1644  [7]
 LDCM0444  CL53 HEK-293T C42(1.03)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C126(0.80); C343(1.26)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C343(1.20)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C126(1.03); C541(1.01)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C343(1.44)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C541(1.14)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C126(1.07); C541(1.02)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C126(0.83); C343(1.19)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C541(1.09)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C399(0.90)  LDD1656  [7]
 LDCM0457  CL65 HEK-293T C42(0.99)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C126(0.88); C343(1.26)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C343(1.12)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C126(1.15); C541(1.03)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C343(1.31)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C343(1.24)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C541(1.21)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C126(0.90); C541(1.14)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C541(1.12)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C399(0.98)  LDD1669  [7]
 LDCM0470  CL77 HEK-293T C42(1.06)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C126(0.84); C343(1.13)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C343(1.19)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C126(0.90); C541(0.91)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C126(1.02); C541(0.99)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C343(1.21)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C541(1.10)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C126(0.89); C541(0.92)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C541(0.95)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C399(0.99)  LDD1682  [7]
 LDCM0483  CL89 HEK-293T C42(1.06)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C343(1.44)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C126(0.72); C343(1.41)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C343(0.99)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C126(1.04); C541(0.96)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C343(1.24)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C541(1.19)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C126(1.09); C541(0.90)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C541(0.98)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C399(0.94)  LDD1695  [7]
 LDCM0022  KB02 T cell C399(5.82)  LDD1703  [8]
 LDCM0023  KB03 Jurkat C399(81.02); C343(47.03)  LDD0209  [2]
 LDCM0024  KB05 PC-3 C343(2.29)  LDD3395  [9]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840