Details of the Target

General Information of Target

Target ID LDTP16560
Target Name Putative PIP5K1A and PSMD4-like protein (PIPSL)
Gene Name PIPSL
Synonyms
PSMD4P2; Putative PIP5K1A and PSMD4-like protein; PIP5K1A-PSMD4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQPENQGISLTGSVACGRPSMEGKI
LGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGLVNL
RVAGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVNLTS
ANCWATGWGLVSKQGETSDELQEMQLPLILEPWCHLLYGHMSYIMPDMLCAGDILNAKTV
CEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPTPAQ
PAPALSPALGPTLSVLMAMLAGWSVL
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.
Uniprot ID
A2A3N6
HGNC ID
HGNC:23733

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y293(7.51)  LDD3495  [1]
DBIA
 Probe Info  		C393(1.14)  LDD0593  [2]
ATP probe
 Probe Info  		K87(0.00); K223(0.00)  LDD0199  [3]
Acrolein
 Probe Info  		C393(0.00); H579(0.00); H561(0.00)  LDD0217  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 PaTu 8988t C393(1.07)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C393(0.96)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C393(1.02)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C393(1.06)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C393(1.02)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C393(1.02)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C393(1.03)  LDD1115  [2]
 LDCM0238  AC120 PaTu 8988t C393(1.11)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C393(1.06)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C393(0.91)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C393(0.96)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C393(1.05)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C393(0.98)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C393(1.04)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C393(1.08)  LDD1124  [2]
 LDCM0246  AC128 PaTu 8988t C393(0.80)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C393(1.12)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C393(0.97)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C393(0.65)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C393(0.69)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C393(0.93)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C393(0.68)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C393(0.70)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C393(0.96)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C393(0.76)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C393(1.01)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C393(0.90)  LDD1137  [2]
 LDCM0260  AC140 PaTu 8988t C393(0.92)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C393(0.83)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C393(1.64)  LDD1141  [2]
 LDCM0276  AC17 HCT 116 C393(1.14)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C393(1.40)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C393(1.36)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C393(1.13)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C393(1.15)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C393(1.19)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C393(1.32)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C393(0.98)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C393(1.14)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C393(1.16)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C393(1.05)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C393(1.36)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C393(1.10)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C393(1.24)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C393(1.16)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C393(1.06)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C393(1.00)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C393(1.08)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C393(1.16)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C393(1.27)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C393(1.12)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C393(1.07)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C393(1.08)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C393(0.95)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C393(1.20)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C393(0.99)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C393(1.27)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C393(1.11)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C393(0.93)  LDD0624  [2]
 LDCM0332  AC68 HCT 116 C393(0.89)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C393(0.83)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C393(0.87)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C393(1.03)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C393(0.79)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C393(0.74)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C393(0.78)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C393(0.84)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C393(0.93)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C393(0.86)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C393(0.90)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C393(0.96)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C393(0.82)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C393(0.91)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C393(0.97)  LDD0665  [2]
 LDCM0108  Chloroacetamide HeLa C393(0.00); H561(0.00)  LDD0222  [4]
 LDCM0367  CL1 PaTu 8988t C393(1.01)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C393(0.82)  LDD1247  [2]
 LDCM0374  CL105 HCT 116 C393(0.90)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C393(0.85)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C393(1.08)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C393(1.09)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C393(1.08)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C393(0.62)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C393(0.99)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C393(0.91)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C393(0.92)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C393(1.22)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C393(0.89)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C393(1.02)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C393(1.03)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C393(0.79)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C393(0.94)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C393(0.86)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C393(0.98)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C393(0.94)  LDD0708  [2]
 LDCM0400  CL13 PaTu 8988t C393(0.90)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C393(0.89)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C393(0.93)  LDD1281  [2]
 LDCM0403  CL16 PaTu 8988t C393(0.95)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C393(0.79)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C393(0.86)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C393(0.90)  LDD1285  [2]
 LDCM0407  CL2 PaTu 8988t C393(1.05)  LDD1286  [2]
 LDCM0408  CL20 PaTu 8988t C393(0.81)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C393(1.31)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C393(0.69)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C393(0.86)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C393(1.01)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C393(0.86)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C393(0.89)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C393(0.87)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C393(0.81)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C393(1.04)  LDD1296  [2]
 LDCM0418  CL3 PaTu 8988t C393(0.82)  LDD1297  [2]
 LDCM0419  CL30 PaTu 8988t C393(1.06)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C393(0.93)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C393(1.10)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C393(0.96)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C393(1.09)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C393(0.95)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C393(0.91)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C393(1.15)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C393(1.01)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C393(0.83)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C393(0.90)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C393(0.82)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C393(0.86)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C393(0.93)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C393(1.13)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C393(0.80)  LDD1314  [2]
 LDCM0436  CL46 HCT 116 C393(1.07)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C393(1.05)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C393(1.22)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C393(1.37)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C393(0.87)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C393(1.14)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C393(1.13)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C393(1.27)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C393(0.84)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C393(1.02)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C393(0.95)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C393(1.13)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C393(1.03)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C393(1.00)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C393(0.95)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C393(0.77)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C393(0.97)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C393(1.09)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C393(1.09)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C393(1.41)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C393(1.06)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C393(1.15)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C393(1.15)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C393(1.22)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C393(1.42)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C393(1.06)  LDD0778  [2]
 LDCM0462  CL7 PaTu 8988t C393(0.90)  LDD1341  [2]
 LDCM0463  CL70 HCT 116 C393(1.59)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C393(1.01)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C393(1.21)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C393(1.30)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C393(1.27)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C393(1.00)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C393(1.14)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C393(1.25)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C393(1.05)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C393(1.02)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C393(1.16)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C393(1.08)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C393(1.10)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C393(1.10)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C393(1.12)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C393(0.95)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C393(1.13)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C393(1.12)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C393(1.15)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C393(1.22)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C393(0.83)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C393(0.95)  LDD1364  [2]
 LDCM0468  Fragment33 HCT 116 C393(1.43)  LDD0785  [2]
 LDCM0427  Fragment51 PaTu 8988t C393(0.86)  LDD1306  [2]
 LDCM0107  IAA HeLa C393(0.00); H561(0.00)  LDD0221  [4]
 LDCM0022  KB02 42-MG-BA C446(1.24)  LDD2244  [5]
 LDCM0023  KB03 42-MG-BA C446(1.88)  LDD2661  [5]
 LDCM0024  KB05 SKMEL24 C312(2.89)  LDD3323  [5]
 LDCM0109  NEM HeLa H579(0.00); H561(0.00)  LDD0223  [4]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840