Details of the Target

General Information of Target

Target ID LDTP16121
Target Name CXXC motif containing zinc binding protein (CZIB)
Gene Name CZIB
Gene ID 54987
Synonyms
C1orf123; CXXC motif containing zinc binding protein; UPF0587 protein C1orf123
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKVKALQCALALEISSVTCPGVVLKDKEDIYLSICVFGQYKKTQCVPATFPLVFNARMV
FEKVFPDAVDPGDVVTQLEYDTAVFELIQLVPPVGETLSTYDENTRDFMFPGPNQMSGHH
DSNRQVTMRRISGLRGNAPRLEFSTTSVITECLISSRKCHTQDKFIYHLAPVEKSHGRLQ
NRTSRSQKKKSKSPERSKYCINAKNYEQPTISSKSHSPSPYTKRRMCELSEDTRRRLAHL
NLGPYEFKKETDKPPFVIRHVDPPSPRADTLLGSSGRDCERDGWSRVHNDHSHLGCCRPK
DYKVIRTPHGRDFDDSLEKCEEYLSPRSCSKPRHSARTLLVHSAPSTMPKHSPSPVLNRA
SLRERFHSDWCSPSNCDEIHDRVKNVLKSHQAHQRHLYDERDLEKDDELELKRSLLCRDS
AYDSDPEYSSCQQPRGTFHLDDGEYWSNRAASYKGKSHRPIFENSMDKMYRNLYKKACSS
ASHTQESF
Target Bioclass
Other
Family
UPF0587 family
Uniprot ID
Q9NWV4
Ensemble ID
ENST00000294360.5
HGNC ID
HGNC:26059

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K55(10.00)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
Probe 1
 Probe Info  		Y140(25.87); Y151(12.12)  LDD3495  [3]
BTD
 Probe Info  		C33(0.59)  LDD2104  [4]
HHS-475
 Probe Info  		Y45(2.51)  LDD0264  [5]
DBIA
 Probe Info  		C33(1.89); C36(1.89)  LDD0080  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
NAIA_5
 Probe Info  		C160(0.00); C102(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C102(0.93); C33(1.03)  LDD1507  [10]
 LDCM0226  AC11 HEK-293T C36(1.26)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C102(1.06); C33(1.22)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C102(1.10); C36(1.20)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C102(0.95); C33(1.24); C36(1.10)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C102(1.01); C33(1.50)  LDD1515  [10]
 LDCM0278  AC19 HEK-293T C36(1.22)  LDD1517  [10]
 LDCM0280  AC20 HEK-293T C102(0.97); C33(0.98)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C102(1.08); C33(1.04)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C102(0.98); C36(1.01)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C102(1.07); C33(1.50); C36(1.06)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C102(1.14)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C102(1.04); C33(1.05)  LDD1524  [10]
 LDCM0287  AC27 HEK-293T C36(1.00)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C102(1.04); C33(0.97)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C102(1.06); C33(1.02)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C36(1.07)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C102(0.97); C36(1.18)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C102(1.12); C33(1.11); C36(1.07)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C102(1.11)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C102(1.03); C33(0.98)  LDD1533  [10]
 LDCM0296  AC35 HEK-293T C36(1.26)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C102(1.11); C33(1.20)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C102(1.09); C33(1.35)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C102(1.05); C36(1.00)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C102(0.95); C33(1.67); C36(0.93)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C102(1.04); C33(1.13)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C102(1.04)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C102(0.95); C33(1.42)  LDD1542  [10]
 LDCM0305  AC43 HEK-293T C36(1.22)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C102(1.10); C33(1.02)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C102(1.14); C33(1.27)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C102(1.03); C36(1.07)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C102(1.06); C33(1.13); C36(1.09)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C102(1.19)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C102(1.02); C33(1.39)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C102(1.05); C33(1.29)  LDD1551  [10]
 LDCM0314  AC51 HEK-293T C36(1.00)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C102(1.11); C33(0.94)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C102(1.04); C33(1.20)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C102(1.04); C36(1.21)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C102(1.03); C33(1.25); C36(0.96)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C102(1.08)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C102(1.06); C33(1.16)  LDD1559  [10]
 LDCM0322  AC59 HEK-293T C36(1.05)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C102(1.03); C36(0.97)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C102(1.10); C33(0.89)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C102(1.05); C33(1.14)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C102(1.05); C36(1.05)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C102(1.02); C33(1.09); C36(0.88)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C102(1.14)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C102(0.99); C33(1.47); C36(0.90)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C102(0.96)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C102(1.11); C33(1.13)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C102(0.94); C33(1.44)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C102(1.01)  LDD1514  [10]
 LDCM0632  CL-Sc Hep-G2 C160(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C102(0.94); C33(0.79)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C102(0.98); C36(0.83)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C102(1.01)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C102(0.98); C33(1.09)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C33(1.14)  LDD1575  [10]
 LDCM0373  CL104 HEK-293T C102(1.01)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C102(1.00); C33(0.96)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C33(0.83)  LDD1579  [10]
 LDCM0377  CL108 HEK-293T C102(0.93)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C102(0.97); C33(1.15)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C102(1.07); C33(1.27); C36(1.03)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C33(1.10)  LDD1584  [10]
 LDCM0382  CL112 HEK-293T C102(1.03)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C102(0.98); C33(0.92)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C33(1.26)  LDD1588  [10]
 LDCM0386  CL116 HEK-293T C102(0.99)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C102(0.93); C33(1.23)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C33(1.43)  LDD1592  [10]
 LDCM0390  CL12 HEK-293T C102(1.07)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C102(1.01)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C102(0.96); C33(1.02)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C33(1.09)  LDD1597  [10]
 LDCM0395  CL124 HEK-293T C102(1.08)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C102(0.98); C33(0.92)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C33(0.95)  LDD1601  [10]
 LDCM0399  CL128 HEK-293T C102(1.02)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C102(0.86); C33(0.78)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C33(0.97)  LDD1605  [10]
 LDCM0403  CL16 HEK-293T C102(1.04)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C102(0.99); C33(1.10)  LDD1608  [10]
 LDCM0406  CL19 HEK-293T C36(1.37)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C33(1.05)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C102(0.97); C33(0.96)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C102(1.09); C33(0.97)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C102(1.04); C36(1.06)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C102(1.09); C33(1.83); C36(0.99)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C102(1.01)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C102(1.00); C33(0.86)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C33(1.16)  LDD1618  [10]
 LDCM0416  CL28 HEK-293T C102(1.03)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C102(0.90); C33(1.19)  LDD1621  [10]
 LDCM0420  CL31 HEK-293T C36(1.10)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C102(1.08); C33(1.22)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C102(1.03); C33(1.36)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C102(1.05); C36(1.16)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C102(1.11); C33(1.14); C36(1.20)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C102(1.07)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C102(0.91); C33(0.87)  LDD1630  [10]
 LDCM0429  CL4 HEK-293T C102(0.95)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C102(1.03)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C102(0.98); C33(1.05)  LDD1635  [10]
 LDCM0433  CL43 HEK-293T C36(1.22)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C102(1.06); C33(0.87)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C102(1.11); C33(1.33)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C102(1.02); C36(1.08)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C102(1.07); C33(1.83); C36(0.98)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C102(1.14)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C102(1.07); C33(0.82)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C102(1.05); C33(1.16)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C33(1.41)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C102(1.03)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C102(1.04); C33(1.05)  LDD1647  [10]
 LDCM0446  CL55 HEK-293T C36(1.29)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C102(1.21); C33(1.01)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C102(1.10); C33(0.96)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C102(1.06); C36(1.25)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C102(1.08); C33(1.32); C36(1.14)  LDD1653  [10]
 LDCM0452  CL60 HEK-293T C102(1.14)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C102(1.03); C33(0.86)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C33(0.91)  LDD1657  [10]
 LDCM0456  CL64 HEK-293T C102(1.09)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C102(1.14); C33(1.17)  LDD1660  [10]
 LDCM0459  CL67 HEK-293T C36(1.39)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C102(1.15); C33(1.05)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C102(1.19); C33(1.07)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C36(1.30)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C102(1.07); C36(0.95)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C102(1.07); C33(1.39); C36(0.92)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C102(1.11)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C102(1.01); C33(1.04)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C33(1.17)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C102(1.07)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C102(1.09); C33(1.18)  LDD1673  [10]
 LDCM0472  CL79 HEK-293T C36(1.32)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C102(1.05); C33(0.78)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C102(1.09); C33(1.27)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C102(1.05); C33(1.60)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C102(1.05); C36(1.21)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C102(1.04); C33(1.49); C36(1.08)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C102(1.16)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C102(1.04); C33(0.89)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C33(1.14)  LDD1683  [10]
 LDCM0482  CL88 HEK-293T C102(1.03)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C102(0.96); C33(0.91)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C102(0.96); C33(1.08)  LDD1687  [10]
 LDCM0486  CL91 HEK-293T C36(1.00)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C102(1.08); C33(0.92)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C102(1.19); C33(1.40)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C102(1.03); C36(0.99)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C102(0.98); C33(1.03); C36(1.19)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C102(1.00)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C102(0.92); C33(0.89)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C33(1.08)  LDD1696  [10]
 LDCM0427  Fragment51 HEK-293T C33(0.81)  LDD1631  [10]
 LDCM0116  HHS-0101 DM93 Y45(2.51)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y45(2.79)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y45(3.20)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y45(1.64)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y45(2.96)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C33(1.89); C36(1.89)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C33(2.71); C36(2.71)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C33(3.29); C36(3.29)  LDD0082  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C33(0.59)  LDD2104  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C33(0.48)  LDD2109  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C33(0.28)  LDD2114  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C33(0.59)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C33(0.81)  LDD2127  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Copper chaperone for superoxide dismutase (CCS) Cu-Zn superoxide dismutase family O14618

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402