Details of the Target

General Information of Target

Target ID LDTP16119
Target Name Transmembrane protein 45A (TMEM45A)
Gene Name TMEM45A
Gene ID 55076
Synonyms
DERP7; DNAPTP4; Transmembrane protein 45A; DNA polymerase-transactivated protein 4; Dermal papilla-derived protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS
TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE
IEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR
QAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL
EQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
Target Bioclass
Other
Family
TMEM45 family
Subcellular location
Membrane
Uniprot ID
Q9NWC5
Ensemble ID
ENST00000323523.8
HGNC ID
HGNC:25480

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C255(8.22)  LDD3473  [1]
IA-alkyne
 Probe Info  		C31(2.78)  LDD0371  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C31(2.78)  LDD0371  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C31(2.91)  LDD0372  [2]
 LDCM0214  AC1 HEK-293T C255(0.90)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C255(1.00); C38(1.05)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C255(0.96); C38(1.07)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C255(1.01)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C255(1.01)  LDD1512  [4]
 LDCM0276  AC17 HEK-293T C255(0.90)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C255(0.97); C38(1.04)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C255(1.03); C38(1.41)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C255(0.97); C38(0.92)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C255(1.10)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C255(1.00)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C255(1.05)  LDD1521  [4]
 LDCM0284  AC24 HEK-293T C255(0.94)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C255(0.99)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C255(0.99); C38(1.09)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C255(0.96); C38(1.20)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C255(1.01)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C255(1.05)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C255(0.97); C38(1.08)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C255(1.01)  LDD1530  [4]
 LDCM0293  AC32 HEK-293T C255(0.96)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C255(1.00)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C255(0.99); C38(1.05)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C255(0.95); C38(1.18)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C255(1.03)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C255(0.99)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C255(1.00)  LDD1538  [4]
 LDCM0301  AC4 HEK-293T C255(1.05)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C255(1.00)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C255(0.96)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C255(1.03); C38(1.06)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C255(0.96); C38(1.00)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C255(1.03)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C255(1.03)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C255(1.02)  LDD1547  [4]
 LDCM0310  AC48 HEK-293T C255(0.98)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C255(0.93)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C255(1.01)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C255(0.97); C38(1.01)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C255(0.95); C38(0.89)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C255(1.04)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C255(0.99)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C255(0.95)  LDD1556  [4]
 LDCM0319  AC56 HEK-293T C255(1.03)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C255(0.96)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C255(1.04); C38(1.01)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C255(1.05); C38(1.11)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C255(1.03)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C255(1.06)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C255(1.02)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C255(1.04)  LDD1565  [4]
 LDCM0328  AC64 HEK-293T C255(1.01)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C255(1.01)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C255(0.99)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C255(0.98)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C255(1.02)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C255(0.92)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C255(1.35)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C255(1.00); C38(1.20)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C255(1.02)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C255(0.93)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C255(0.92)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C255(1.00); C38(1.11)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C255(1.01)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C255(0.96)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C255(0.93)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C255(1.04); C38(1.03)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C255(1.03)  LDD1582  [4]
 LDCM0380  CL110 HEK-293T C255(1.26)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C255(0.92)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C255(0.90); C38(1.28)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C255(1.05)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C255(1.18)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C255(0.97)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C255(1.04); C38(1.06)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C255(1.02)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C255(1.05)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C255(0.94)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C255(1.07)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C255(1.00); C38(1.12)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C255(1.00)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C255(1.05)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C255(1.06)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C255(0.98); C38(1.32)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C255(1.05)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C255(1.31)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C255(0.96)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C255(1.05); C38(0.96)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C255(1.11)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C255(0.98)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C255(1.14)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C255(1.00); C38(1.08)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C255(1.09)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C255(1.07); C38(1.14)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C255(1.06); C38(1.29)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C255(1.02)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C255(1.12)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C255(1.12)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C255(1.16)  LDD1614  [4]
 LDCM0412  CL24 HEK-293T C255(1.14)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C255(1.08)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C255(0.95)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C255(0.91)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C255(0.95); C38(1.26)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C255(0.92)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C255(1.04)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C255(1.03); C38(1.08)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C255(1.06); C38(1.32)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C255(1.13)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C255(1.24)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C255(1.08)  LDD1627  [4]
 LDCM0425  CL36 HEK-293T C255(1.19)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C255(0.96)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C255(0.91)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C255(1.08); C38(1.35)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C255(1.05); C38(1.09)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C255(1.04)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C255(1.00); C38(1.07)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C255(1.04); C38(1.33)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C255(1.09)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C255(1.08)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C255(1.12)  LDD1640  [4]
 LDCM0438  CL48 HEK-293T C255(1.05)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C255(1.06)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C255(1.05)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C255(1.12)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C255(1.05); C38(1.10)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C255(1.02)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C255(1.09); C38(2.16)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C255(0.98); C38(1.27)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C255(1.09)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C255(1.21)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C255(1.12)  LDD1652  [4]
 LDCM0451  CL6 HEK-293T C255(1.13); C38(1.96)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C255(1.19)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C255(1.09)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C255(0.96)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C255(0.91)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C255(1.09); C38(1.64)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C255(0.99)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C255(0.95); C38(1.09)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C255(1.04); C38(1.18)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C255(1.00)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C255(1.08)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C255(1.15); C38(1.22)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C255(1.19)  LDD1666  [4]
 LDCM0465  CL72 HEK-293T C255(1.15)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C255(1.07)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C255(0.93)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C255(1.00); C38(1.06)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C255(1.07)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C255(1.04); C38(1.02)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C255(0.94); C38(1.15)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C255(1.68)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C255(1.11)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C255(1.06)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C255(1.11)  LDD1679  [4]
 LDCM0478  CL84 HEK-293T C255(1.04)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C255(1.04)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C255(1.24)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C255(1.05)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C255(1.11); C38(1.10)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C255(1.02)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C255(1.12)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C255(1.38); C38(2.95)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C255(0.98); C38(1.21)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C255(1.13)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C255(1.14)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C255(1.11)  LDD1692  [4]
 LDCM0491  CL96 HEK-293T C255(1.22)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C255(0.97)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C255(1.12)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C255(0.87)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C255(0.94)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C255(0.92)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C255(0.93)  LDD1631  [4]
 LDCM0022  KB02 A431 C38(3.72)  LDD2258  [1]
 LDCM0023  KB03 A431 C38(6.84)  LDD2675  [1]
 LDCM0024  KB05 TGBC1TKB C255(8.22)  LDD3473  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum metallopeptidase 1 (ERMP1) Peptidase M28 family Q7Z2K6
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein A-II (APOA2) Apolipoprotein A2 family P02652
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Cardiac phospholamban (PLN) Phospholamban family P26678
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 19 (TMEM19) TMEM19 family Q96HH6
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402