Details of the Target

General Information of Target

Target ID LDTP16112
Target Name TBCC domain-containing protein 1 (TBCCD1)
Gene Name TBCCD1
Gene ID 55171
Synonyms
TBCC domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAG
RLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTE
QCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLP
LIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQIENQHQGAQDTSDLMSPSKRSSQKY
IIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDS
EAHAKYKNQVVYSTMLVFFKNAFQYVNSIQPSLFQGPNAPSQVPLVLLEDVSNVYGDVEI
DRNKHIHKKRKLAEGREKTMSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESW
ELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSIS
QPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKV
KPKFRKGSDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRG
ENLFLKAVNKICQQGNFQYENFFNYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKH
HTVTRGITKGVKEDFRLAMERQVSRCGENLMVVLHRFCINEKILLLQTLT
Target Bioclass
Other
Family
TBCC family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.
Uniprot ID
Q9NVR7
Ensemble ID
ENST00000338733.10
HGNC ID
HGNC:25546

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.W235Ter .
MOLT4 SNV: p.H197Y .
SKOV3 SNV: p.T415I DBIA    Probe Info 
TGBC52TKB SNV: p.L524V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C298(78.90)  LDD0209  [1]
IA-alkyne
 Probe Info  		C298(1.22)  LDD2186  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C298(0.99)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C298(1.05)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C298(1.12)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C449(0.98)  LDD1512  [6]
 LDCM0277  AC18 HEK-293T C298(0.74)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C298(1.22)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C298(0.83)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C298(1.04)  LDD1519  [6]
 LDCM0282  AC22 HEK-293T C449(0.95)  LDD1521  [6]
 LDCM0284  AC24 HEK-293T C298(0.89)  LDD1523  [6]
 LDCM0286  AC26 HEK-293T C298(0.91)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C298(0.94)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C298(1.11)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C298(1.00)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C449(1.10)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C298(0.91)  LDD1532  [6]
 LDCM0295  AC34 HEK-293T C298(0.73)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C298(0.92)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C298(0.84)  LDD1536  [6]
 LDCM0299  AC38 HEK-293T C449(1.10)  LDD1538  [6]
 LDCM0301  AC4 HEK-293T C298(0.96)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C298(1.07)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C298(0.85)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C298(0.89)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C298(1.05)  LDD1545  [6]
 LDCM0308  AC46 HEK-293T C449(1.10)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C298(0.94)  LDD1549  [6]
 LDCM0313  AC50 HEK-293T C298(1.02)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C298(0.99)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C298(1.26)  LDD1554  [6]
 LDCM0317  AC54 HEK-293T C449(1.19)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C298(0.93)  LDD1558  [6]
 LDCM0321  AC58 HEK-293T C298(0.96)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C298(0.96)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C449(0.95)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C298(0.96)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C449(0.98)  LDD1565  [6]
 LDCM0328  AC64 HEK-293T C298(0.97)  LDD1567  [6]
 LDCM0345  AC8 HEK-293T C298(0.95)  LDD1569  [6]
 LDCM0349  AC83 PaTu 8988t C263(0.84); C274(0.84)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C263(1.50); C274(1.50)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C263(1.03); C274(1.03)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C263(1.19); C274(1.19)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C263(1.14); C274(1.14)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C263(1.05); C274(1.05)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C263(1.23); C274(1.23)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C263(1.06); C274(1.06)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C263(1.32); C274(1.32)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C263(1.08); C274(1.08)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C263(1.27); C274(1.27)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C263(1.25); C274(1.25)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C263(1.19); C274(1.19)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C263(1.13); C274(1.13)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C263(1.25); C274(1.25)  LDD1243  [7]
 LDCM0275  AKOS034007705 HEK-293T C298(0.96)  LDD1514  [6]
 LDCM0367  CL1 PaTu 8988t C263(0.87); C274(0.87)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C263(0.52); C274(0.52)  LDD1247  [7]
 LDCM0379  CL11 PaTu 8988t C263(0.93); C274(0.93)  LDD1258  [7]
 LDCM0390  CL12 PaTu 8988t C263(0.97); C274(0.97)  LDD1269  [7]
 LDCM0400  CL13 PaTu 8988t C263(0.23); C274(0.23)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C263(0.22); C274(0.22)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C263(0.93); C274(0.93)  LDD1281  [7]
 LDCM0405  CL18 HEK-293T C298(0.78)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C298(0.84)  LDD1610  [6]
 LDCM0407  CL2 PaTu 8988t C263(0.57); C274(0.57)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C298(1.02)  LDD1612  [6]
 LDCM0410  CL22 HEK-293T C449(1.21)  LDD1614  [6]
 LDCM0412  CL24 HEK-293T C298(0.93)  LDD1616  [6]
 LDCM0418  CL3 PaTu 8988t C263(0.39); C274(0.39)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C298(0.65)  LDD1623  [6]
 LDCM0420  CL31 PaTu 8988t C263(0.91); C274(0.91)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C263(0.80); C274(0.80)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C263(0.82); C274(0.82)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C263(0.73); C274(0.73)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C263(0.69); C274(0.69)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C263(0.49); C274(0.49)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C263(0.68); C274(0.68)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C263(0.58); C274(0.58)  LDD1307  [7]
 LDCM0429  CL4 PaTu 8988t C263(0.35); C274(0.35)  LDD1308  [7]
 LDCM0430  CL40 PaTu 8988t C263(0.79); C274(0.79)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C263(0.58); C274(0.58)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C263(0.47); C274(0.47)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C263(0.34); C274(0.34)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C263(0.74); C274(0.74)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C263(0.66); C274(0.66)  LDD1314  [7]
 LDCM0436  CL46 HEK-293T C449(1.12)  LDD1640  [6]
 LDCM0438  CL48 HEK-293T C298(0.97)  LDD1642  [6]
 LDCM0440  CL5 PaTu 8988t C263(0.28); C274(0.28)  LDD1319  [7]
 LDCM0445  CL54 HEK-293T C298(0.86)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C298(0.93)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C298(1.46)  LDD1650  [6]
 LDCM0449  CL58 HEK-293T C449(1.23)  LDD1652  [6]
 LDCM0451  CL6 PaTu 8988t C263(0.74); C274(0.74)  LDD1330  [7]
 LDCM0452  CL60 HEK-293T C298(0.94)  LDD1655  [6]
 LDCM0458  CL66 HEK-293T C298(0.86)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C298(1.04)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C298(1.13)  LDD1663  [6]
 LDCM0462  CL7 PaTu 8988t C263(0.38); C274(0.38)  LDD1341  [7]
 LDCM0463  CL70 HEK-293T C449(1.08)  LDD1666  [6]
 LDCM0465  CL72 HEK-293T C298(0.96)  LDD1668  [6]
 LDCM0469  CL76 PaTu 8988t C263(0.70); C274(0.70)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C263(0.85); C274(0.85)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C263(0.71); C274(0.71)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C263(0.90); C274(0.90)  LDD1351  [7]
 LDCM0473  CL8 PaTu 8988t C263(0.58); C274(0.58)  LDD1352  [7]
 LDCM0474  CL80 PaTu 8988t C263(0.57); C274(0.57)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C263(0.74); C274(0.74)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C263(0.90); C274(0.90)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C263(0.74); C274(0.74)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C263(0.63); C274(0.63)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C263(0.80); C274(0.80)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C263(0.61); C274(0.61)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C263(0.62); C274(0.62)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C263(0.62); C274(0.62)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C263(0.71); C274(0.71)  LDD1362  [7]
 LDCM0484  CL9 PaTu 8988t C263(0.40); C274(0.40)  LDD1363  [7]
 LDCM0485  CL90 PaTu 8988t C263(1.02); C274(1.02)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C298(1.04)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C298(1.11)  LDD1690  [6]
 LDCM0489  CL94 HEK-293T C449(0.37)  LDD1692  [6]
 LDCM0491  CL96 HEK-293T C298(1.01)  LDD1694  [6]
 LDCM0625  F8 Ramos C298(1.14)  LDD2187  [2]
 LDCM0573  Fragment11 Ramos C298(1.82)  LDD2190  [2]
 LDCM0580  Fragment21 Ramos C298(1.37)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C298(1.16)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C298(1.14)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C298(1.06)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C298(1.03)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C298(0.89)  LDD2200  [2]
 LDCM0596  Fragment38 Ramos C298(1.05)  LDD2203  [2]
 LDCM0427  Fragment51 PaTu 8988t C263(0.43); C274(0.43)  LDD1306  [7]
 LDCM0610  Fragment52 Ramos C298(1.59)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C298(1.37)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C298(1.22)  LDD2186  [2]
 LDCM0022  KB02 42-MG-BA C62(1.38)  LDD2244  [8]
 LDCM0023  KB03 Jurkat C298(78.90)  LDD0209  [1]
 LDCM0024  KB05 G361 C62(1.18)  LDD3311  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine rich adaptor protein 1-like (LURAP1L) . Q8IV03

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840