Details of the Target

General Information of Target

Target ID LDTP15753
Target Name Unconventional myosin-XVB (MYO15B)
Gene Name MYO15B
Gene ID 80022
Synonyms
KIAA1783; MYO15BP; Unconventional myosin-XVB; Myosin XVBP; Unconventional myosin-15B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGSGGSGGSGGGPGPGPGGGGGPSGSGSGPGSNGGLGSGGELHPRTGRLVSLSACGRT
ARRQQPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSA
TGLKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLGEGDRVGVERTVAGELRLWVNGRDCGV
AATGLPPRVWAVVDLYGKCTQITVLPPEPGFSPPTPIPTPPLEPLAPTEDSALAEQGTSA
DEAFMVSPAQARPETFPNSLESHNDFANMELSEVVSNTILSAYNGGLLNVNLSSPPAGEG
LGSSGAATSPILTSNDALLFHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRDN
EMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNLQSGTIMMSGCGILTNGKGTRR
EYCEFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKVT
IVHNNNHSDRLRRNNAILRALSPEGALRRAAPAAQAEPERLLFHPNCGQKAAITHEGRTA
LRPHATDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMT
NLRSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPA
AWNVPPGVYAVVDLYGQAAQATIVDDVEVAPVPEPLPEGNNQVSPSSPSSGAGGSDLRFH
QLHGSNAVITNGGRTALRHNCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAG
VTAIRPEDLEFPNTMTDIDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTA
KGDLHYFINGQDQGAACSGLPPGKEVYAVVDLYGQCVQVSITNATGPMDNSLATSNTATE
KSFPLHSPVAGVAHRFHSTCGKNVTLEEDGTRAVRAAGYAHGLVFSTKELRAEEVFEVKV
EELDEKWAGSLRLGLTTLAPGEMGPGAGGGGPGLPPSLPELRTKTTWMVSSCEVRRDGQL
QRMNYGRNLERLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKNVWAVLDLYGPVRG
VSIVSSTRLEESEGTQPPSPSSDTGSEGEEDDEGEEHGLGGQNEVGIIPTTLEFLENHGK
NILLSNGNRTATRVASYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPER
LNFPASACALKRAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHV
NGVDQGVAVPDVPQPCHALVDLYGQCEQVTIVNPEPGAASGKSAGTQGDMEKADMVDGIK
ESVCWGPPPAASPLKSCEYHALCSRFQELLLLPEDYFMPPPKRSLCYCESCRKLRGDEAH
RRRGEPPREYALPFGWCRFNLRVNPRLEAGTLTKKWHMAYHGSNVAAVRRVLDRGELGAG
TASILSCRPLKGEPGVGFEEPGENCAPPREEQPPPVLLSPSLQYAGAETLASKVQFRDPK
SQRTHQAQVAFQVCVRPGSYTPGPPSAALGEPPDPHFSPAELEWVTKEKGATLLCALLVR
VE
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Subcellular location
Cytoplasm
Uniprot ID
Q96JP2
Ensemble ID
ENST00000584516.5
HGNC ID
HGNC:14083

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C1280(0.55)  LDD0531  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [3]
WYneO
 Probe Info  		N.A.  LDD0022  [3]
HHS-475
 Probe Info  		Y1095(1.22); Y962(1.93)  LDD2238  [4]
HHS-482
 Probe Info  		Y1095(0.76); Y962(0.85)  LDD2239  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1280(0.55)  LDD0531  [2]
 LDCM0276  AC17 HCT 116 C1280(1.27)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C1280(1.06)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C1280(1.37)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C1280(0.70)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C1280(2.31)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C1280(1.37)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C1280(0.97)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C1280(1.46)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C1280(1.72)  LDD0601  [2]
 LDCM0290  AC3 HCT 116 C1280(0.71)  LDD0607  [2]
 LDCM0301  AC4 HCT 116 C1280(0.71)  LDD0618  [2]
 LDCM0308  AC46 HCT 116 C1280(0.84)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C1280(1.16)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C1280(0.99)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C1280(1.31)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C1280(0.61)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C1280(1.14)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C1280(0.98)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C1280(1.29)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C1280(1.66)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C1280(1.01)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C1280(1.43)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C1280(1.81)  LDD0636  [2]
 LDCM0332  AC68 HCT 116 C1280(1.67)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C1280(1.44)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C1280(0.88)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C1280(1.61)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C1280(1.52)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C1280(1.37)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C1280(1.61)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C1280(1.55)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C1280(1.25)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C1280(1.71)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C1280(0.92)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C1280(0.96)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C1280(1.80)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C1280(1.06)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C1280(1.53)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C1280(1.68)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C1280(1.64)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C1280(2.11)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C1280(1.23)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C1280(0.80)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C1280(1.11)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C1280(1.58)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C1280(1.30)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C1280(2.36)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C1280(1.37)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C1280(1.20)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C1280(0.94)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C1280(1.36)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C1280(1.94)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C1280(2.08)  LDD0681  [2]
 LDCM0367  CL1 HCT 116 C1280(0.92)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C1280(2.17)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C1280(0.57)  LDD0686  [2]
 LDCM0374  CL105 HCT 116 C1280(1.09)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C1280(2.06)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C1280(1.01)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C1280(1.25)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C1280(1.59)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C1280(1.27)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C1280(0.93)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C1280(1.19)  LDD0698  [2]
 LDCM0390  CL12 HCT 116 C1280(1.55)  LDD0707  [2]
 LDCM0392  CL121 HCT 116 C1280(0.68)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C1280(1.34)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C1280(1.41)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C1280(1.26)  LDD0712  [2]
 LDCM0400  CL13 HCT 116 C1280(1.50)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C1280(1.53)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C1280(1.00)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C1280(0.88)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C1280(1.01)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C1280(1.19)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C1280(1.00)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C1280(0.86)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C1280(1.37)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C1280(1.26)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C1280(1.55)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C1280(1.12)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C1280(1.47)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C1280(1.16)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C1280(1.05)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C1280(1.48)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C1280(1.15)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C1280(1.36)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C1280(0.71)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C1280(1.30)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C1280(1.02)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C1280(1.06)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C1280(1.09)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C1280(1.25)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C1280(1.07)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C1280(1.09)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C1280(1.06)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C1280(1.09)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C1280(1.13)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C1280(0.93)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C1280(1.17)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C1280(1.38)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C1280(1.13)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C1280(1.05)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C1280(1.31)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C1280(1.17)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C1280(0.95)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C1280(0.87)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C1280(1.21)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C1280(1.03)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C1280(0.96)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C1280(1.17)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C1280(1.04)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C1280(0.92)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C1280(0.84)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C1280(0.67)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C1280(0.84)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C1280(0.87)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C1280(1.00)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C1280(1.00)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C1280(1.11)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C1280(1.16)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C1280(0.98)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C1280(1.34)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C1280(1.22)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C1280(1.33)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C1280(1.18)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C1280(1.49)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C1280(1.30)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C1280(1.45)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C1280(1.12)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C1280(1.56)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C1280(1.63)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C1280(1.25)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C1280(0.94)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C1280(1.10)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C1280(1.20)  LDD0784  [2]
 LDCM0473  CL8 HCT 116 C1280(1.76)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C1280(1.30)  LDD0801  [2]
 LDCM0486  CL91 HCT 116 C1280(0.78)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C1280(0.88)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C1280(0.57)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C1280(0.61)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C1280(0.57)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C1280(0.61)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C1280(0.66)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C1280(0.65)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C1280(0.58)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C1280(1.44)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C1280(1.20)  LDD0744  [2]
 LDCM0022  KB02 BT-549 C611(1.79)  LDD2279  [5]
 LDCM0023  KB03 BT-549 C949(2.37); C611(2.10)  LDD2696  [5]
 LDCM0024  KB05 OZ C1280(1.04)  LDD3389  [5]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840