Details of the Target

General Information of Target

Target ID LDTP15569
Target Name F-box only protein 27 (FBXO27)
Gene Name FBXO27
Gene ID 126433
Synonyms
FBG5; FBX27; F-box only protein 27; F-box/G-domain protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGAASASVREPTPLPGRGAPRTKPRAGRGPTVGTPATLALPARGRPRSRNGLASKGQRG
AAPTGPGHRALPSRDTALPQERNKKLEAVGTGIEPKAMSQGLVTFGDVAVDFSQEEWEWL
NPIQRNLYRKVMLENYRNLASLGLCVSKPDVISSLEQGKEPWTVKRKMTRAWCPDLKAVW
KIKELPLKKDFCEGKLSQAVITERLTSYNLEYSLLGEHWDYDALFETQPGLVTIKNLAVD
FRQQLHPAQKNFCKNGIWENNSDLGSAGHCVAKPDLVSLLEQEKEPWMVKRELTGSLFSG
QRSVHETQELFPKQDSYAEGVTDRTSNTKLDCSSFRENWDSDYVFGRKLAVGQETQFRQE
PITHNKTLSKERERTYNKSGRWFYLDDSEEKVHNRDSIKNFQKSSVVIKQTGIYAGKKLF
KCNECKKTFTQSSSLTVHQRIHTGEKPYKCNECGKAFSDGSSFARHQRCHTGKKPYECIE
CGKAFIQNTSLIRHWRYYHTGEKPFDCIDCGKAFSDHIGLNQHRRIHTGEKPYKCDVCHK
SFRYGSSLTVHQRIHTGEKPYECDVCRKAFSHHASLTQHQRVHSGEKPFKCKECGKAFRQ
NIHLASHLRIHTGEKPFECAECGKSFSISSQLATHQRIHTGEKPYECKVCSKAFTQKAHL
AQHQKTHTGEKPYECKECGKAFSQTTHLIQHQRVHTGEKPYKCMECGKAFGDNSSCTQHQ
RLHTGQRPYECIECGKAFKTKSSLICHRRSHTGEKPYECSVCGKAFSHRQSLSVHQRIHS
GKKPYECKECRKTFIQIGHLNQHKRVHTGERSYNYKKSRKVFRQTAHLAHHQRIHTGESS
TCPSLPSTSNPVDLFPKFLWNPSSLPSP
Target Bioclass
Enzyme
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
Uniprot ID
Q8NI29
Ensemble ID
ENST00000292853.9
HGNC ID
HGNC:18753

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C99(3.08)  LDD2093  [1]
IPM
 Probe Info  		C99(5.95)  LDD1702  [1]
DBIA
 Probe Info  		C89(1.48)  LDD0532  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C89(1.23)  LDD1093  [2]
 LDCM0215  AC10 HCT 116 C89(1.48)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C89(1.33)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C89(1.42)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C89(1.53)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C89(0.94)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C89(0.88)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C89(1.21)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C89(0.85)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C89(1.04)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C89(0.94)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C89(0.95)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C89(1.56)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C89(0.97)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C89(0.99)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C89(0.78)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C89(1.13)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C89(0.79)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C89(1.06)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C89(1.04)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C89(0.97)  LDD2161  [2]
 LDCM0279  AC2 PaTu 8988t C89(0.98)  LDD1158  [2]
 LDCM0290  AC3 PaTu 8988t C89(1.07)  LDD1169  [2]
 LDCM0296  AC35 PaTu 8988t C89(1.05)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C89(1.47)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C89(0.98)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C89(1.23)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C89(1.06)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C89(1.34)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C89(1.03)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C89(1.15)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C89(1.36)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C89(1.88)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C89(1.51)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C89(1.76)  LDD1186  [2]
 LDCM0312  AC5 PaTu 8988t C89(1.39)  LDD1191  [2]
 LDCM0323  AC6 HCT 116 C89(1.66)  LDD0640  [2]
 LDCM0332  AC68 HCT 116 C89(1.19)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C89(0.93)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C89(1.27)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C89(1.60)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C89(0.65)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C89(1.10)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C89(1.06)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C89(0.86)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C89(1.02)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C89(1.12)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C89(1.28)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C89(1.11)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C89(1.44)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C89(1.66)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C89(1.06)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C89(0.76)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C89(1.07)  LDD0665  [2]
 LDCM0248  AKOS034007472 HCT 116 C89(1.08)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C89(1.55)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C89(1.73)  LDD0592  [2]
 LDCM0369  CL100 PaTu 8988t C89(1.26)  LDD1248  [2]
 LDCM0370  CL101 HCT 116 C89(1.80)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C89(1.28)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C89(1.83)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C89(1.17)  LDD0690  [2]
 LDCM0387  CL117 PaTu 8988t C89(1.01)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C89(0.82)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C89(1.29)  LDD1268  [2]
 LDCM0391  CL120 PaTu 8988t C89(1.36)  LDD1270  [2]
 LDCM0404  CL17 HCT 116 C89(1.17)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C89(0.79)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C89(1.06)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C89(1.29)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C89(1.80)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C89(0.78)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C89(0.81)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C89(1.01)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C89(0.61)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C89(0.86)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C89(1.08)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C89(1.38)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C89(1.12)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C89(1.05)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C89(1.04)  LDD0737  [2]
 LDCM0421  CL32 PaTu 8988t C89(1.87)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C89(1.77)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C89(1.78)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C89(1.52)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C89(1.78)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C89(2.05)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C89(1.38)  LDD1307  [2]
 LDCM0430  CL40 PaTu 8988t C89(1.05)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C89(1.49)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C89(1.30)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C89(1.48)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C89(1.57)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C89(2.32)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C89(1.93)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C89(1.13)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C89(1.21)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C89(1.14)  LDD1318  [2]
 LDCM0441  CL50 PaTu 8988t C89(1.28)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C89(1.43)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C89(1.66)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C89(1.88)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C89(1.81)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C89(1.17)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C89(1.96)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C89(1.61)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C89(1.42)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C89(1.23)  LDD1329  [2]
 LDCM0452  CL60 PaTu 8988t C89(1.38)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C89(0.97)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C89(1.71)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C89(1.66)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C89(2.94)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C89(1.43)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C89(1.40)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C89(1.24)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C89(1.77)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C89(7.64)  LDD1340  [2]
 LDCM0463  CL70 PaTu 8988t C89(1.43)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C89(1.73)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C89(1.51)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C89(2.27)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C89(1.55)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C89(1.23)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C89(1.06)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C89(1.18)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C89(1.19)  LDD1351  [2]
 LDCM0474  CL80 PaTu 8988t C89(1.89)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C89(1.33)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C89(1.14)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C89(0.95)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C89(1.67)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C89(1.30)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C89(1.36)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C89(1.70)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C89(1.50)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C89(1.14)  LDD1362  [2]
 LDCM0485  CL90 PaTu 8988t C89(1.42)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C89(0.97)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C89(5.37)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C89(2.57)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C89(1.02)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C89(1.77)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C89(1.72)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C89(1.64)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C89(2.88)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C89(1.15)  LDD1373  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C99(5.95)  LDD1702  [1]
 LDCM0468  Fragment33 PaTu 8988t C89(1.25)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C89(1.46)  LDD1306  [2]
 LDCM0022  KB02 A204 C89(5.56)  LDD2252  [3]
 LDCM0023  KB03 A204 C89(14.38)  LDD2669  [3]
 LDCM0024  KB05 MKN-1 C89(11.20)  LDD3331  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C99(3.08)  LDD2093  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C99(1.30)  LDD2129  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840