Details of the Target

General Information of Target

Target ID LDTP14613
Target Name Glutathione S-transferase theta-2 (GSTT2)
Gene Name GSTT2
Gene ID 2953
Synonyms
Glutathione S-transferase theta-2; EC 2.5.1.18; GST class-theta-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGLEGPCWVGPGPDGGLAVSEEFGDVRLFGSARQPLGSLGGWTGHTFGCPAGICSNSEG
NVIVADEQRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDNSIKVYQGLK
ELA
Target Bioclass
Enzyme
Family
GST superfamily, Theta family
Subcellular location
Cytoplasm, cytosol
Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
Uniprot ID
P0CG29
Ensemble ID
ENST00000618279.2
HGNC ID
HGNC:4642
ChEMBL ID
CHEMBL2142

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C105(1.07)  LDD0531  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C105(1.07)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C105(1.08)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C105(1.23)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C105(1.26)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C105(1.24)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C105(1.29)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C105(1.17)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C105(1.17)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C105(1.43)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C105(1.24)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C105(1.16)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C105(1.00)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C105(1.22)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C105(1.47)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C105(1.26)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C105(1.35)  LDD0546  [1]
 LDCM0237  AC12 HCT 116 C105(1.20)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C105(1.36)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C105(1.29)  LDD0587  [1]
 LDCM0279  AC2 HCT 116 C105(1.20)  LDD0596  [1]
 LDCM0290  AC3 HCT 116 C105(1.52)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C105(1.27)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C105(1.19)  LDD0629  [1]
 LDCM0323  AC6 HCT 116 C105(1.16)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C105(1.15)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C105(1.10)  LDD0662  [1]
 LDCM0365  AC98 HCT 116 C105(1.53)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C105(1.18)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C105(1.36)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C105(1.24)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C105(1.08)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C105(1.01)  LDD2171  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0369  CL100 HCT 116 C105(0.96)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C105(1.23)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C105(1.24)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C105(1.11)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C105(1.36)  LDD0690  [1]
 LDCM0404  CL17 HCT 116 C105(1.42)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C105(1.15)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C105(1.16)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C105(1.22)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C105(1.39)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C105(1.01)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C105(1.14)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C105(1.15)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C105(1.09)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C105(1.01)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C105(1.11)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C105(1.37)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C105(1.26)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C105(0.89)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C105(1.15)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C105(0.89)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C105(1.01)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C105(1.41)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C105(0.90)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C105(0.93)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C105(0.91)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C105(1.01)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C105(0.95)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C105(1.06)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C105(1.13)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C105(0.93)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C105(1.01)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C105(1.36)  LDD0752  [1]
 LDCM0486  CL91 HCT 116 C105(1.27)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C105(1.03)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C105(0.92)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C105(0.99)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C105(1.30)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C105(1.23)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C105(1.31)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C105(1.19)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C105(1.88)  LDD0811  [1]
 LDCM0427  Fragment51 HCT 116 C105(0.89)  LDD0744  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0021  THZ1 HCT 116 C105(1.01)  LDD2173  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amitriptyline Small molecular drug DB00321
Deoxycholic Acid Small molecular drug DB03619
Glutathione Disulfide Small molecular drug DB03310
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-hexylglutathione Small molecular drug DB04132

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.