Details of the Target

General Information of Target

Target ID LDTP14182
Target Name Suppressor of tumorigenicity 14 protein (ST14)
Gene Name ST14
Gene ID 6768
Synonyms
PRSS14; SNC19; TADG15; Suppressor of tumorigenicity 14 protein; EC 3.4.21.109; Matriptase; Membrane-type serine protease 1; MT-SP1; Prostamin; Serine protease 14; Serine protease TADG-15; Tumor-associated differentially-expressed gene 15 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKLRLLGLRYQEYVTRHPAATAQLETAVRGFSYLLAGRFADSHELSELVYSASNLLVLL
NDGILRKELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALVQLAK
AVLRMLLLLWFKAGLQTSPPIVPLDRETQAQPPDGDHSPGNHEQSYVGKRSNRVVRTLQN
TPSLHSRHWGAPQQREGRQQQHHEELSATPTPLGLQETIAEFLYIARPLLHLLSLGLWGQ
RSWKPWLLAGVVDVTSLSLLSDRKGLTRRERRELRRRTILLLYYLLRSPFYDRFSEARIL
FLLQLLADHVPGVGLVTRPLMDYLPTWQKIYFYSWG
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Membrane
Function
Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. Proteolytically cleaves and therefore activates TMPRSS13.
TTD ID
T31543
Uniprot ID
Q9Y5Y6
DrugMap ID
TTPRO7W
Ensemble ID
ENST00000278742.6
HGNC ID
HGNC:11344
ChEMBL ID
CHEMBL3018

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C574(0.00); C587(0.00); C579(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C340(1.38)  LDD0532  [2]
IA-alkyne
 Probe Info  		C340(0.00); C567(0.00)  LDD0162  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C340(1.38)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C574(0.93); C579(0.93)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C574(0.98); C579(0.98)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C574(1.15); C579(1.15)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C574(1.15); C579(1.15)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C574(1.15); C579(1.15)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C574(1.03); C579(1.03)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C574(1.06); C579(1.06)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C574(1.16); C579(1.16)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C574(0.80); C579(0.80)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C574(0.95); C579(0.95)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C340(1.03)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C574(0.87); C579(0.87)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C574(0.97); C579(0.97)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C574(1.09); C579(1.09)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C340(1.36)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C340(1.21)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C340(0.83)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C340(0.86)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C340(1.02)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C340(1.08)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C340(1.13)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C340(0.74)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C340(1.31)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C340(0.79)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C340(1.07)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C340(1.06)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C340(1.15)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C340(1.15)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C340(1.35)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C340(1.02)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C574(0.50); C579(0.50)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C574(0.44); C579(0.44)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C574(0.44); C579(0.44)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C574(0.48); C579(0.48)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C574(0.48); C579(0.48)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C574(0.56); C579(0.56)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C574(0.54); C579(0.54)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C574(0.62); C579(0.62)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C574(0.59); C579(0.59)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C574(0.57); C579(0.57)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C574(0.60); C579(0.60)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C574(0.58); C579(0.58)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C340(1.19)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C574(0.60); C579(0.60)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C574(0.58); C579(0.58)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C574(0.49); C579(0.49)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C340(0.75); C574(0.81); C579(0.81)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C340(0.99); C574(1.50); C579(1.50)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C340(0.88); C574(1.08); C579(1.08)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C574(1.04); C579(1.04); C340(1.14)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C340(0.85); C574(1.33); C579(1.33)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C340(0.93); C574(1.56); C579(1.56)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C340(0.86); C574(1.15); C579(1.15)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C340(1.62)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C574(1.13); C579(1.13); C340(1.13)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C574(1.10); C579(1.10); C340(1.36)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C340(0.91); C574(1.45); C579(1.45)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C340(0.74); C574(1.35); C579(1.35)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C340(1.56); C574(1.46); C579(1.46)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C340(0.97); C574(1.44); C579(1.44)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C340(1.68); C574(1.02); C579(1.02)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C340(1.18); C574(0.86); C579(0.86)  LDD2161  [2]
 LDCM0285  AC25 HCT 116 C340(1.09)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C340(1.05)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C340(1.04)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C340(1.09)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C340(1.14)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C340(0.93)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C340(1.06)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C340(1.01)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C340(1.07)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C340(1.00)  LDD0612  [2]
 LDCM0323  AC6 HCT 116 C340(1.13)  LDD0640  [2]
 LDCM0332  AC68 HCT 116 C574(1.09); C579(1.09)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C574(1.03); C579(1.03)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C340(1.51)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C574(1.10); C579(1.10)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C574(1.03); C579(1.03)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C574(1.03); C579(1.03)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C574(0.93); C579(0.93)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C574(0.88); C579(0.88)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C574(1.04); C579(1.04)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C574(1.04); C579(1.04)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C574(0.99); C579(0.99)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C574(0.97); C579(0.97)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C574(0.87); C579(0.87)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C340(1.01)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C574(1.10); C579(1.10)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C574(0.81); C579(0.81)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C574(0.75); C579(0.75)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C340(1.73)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C340(1.87)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C340(1.42)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C340(2.05)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C340(1.10)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C340(1.55)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C340(1.80)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C340(1.14)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C340(1.79)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C340(1.57)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C340(1.28)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C340(1.26)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C340(1.77)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C340(1.32)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C340(1.72)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C574(0.98); C579(0.98)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C574(0.91); C579(0.91)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C340(1.25)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C340(1.23)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C340(1.02)  LDD0592  [2]
 LDCM0370  CL101 HCT 116 C340(1.13)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C340(1.15)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C340(0.98)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C340(1.11)  LDD0690  [2]
 LDCM0382  CL112 HCT 116 C340(1.20)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C340(0.95)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C340(0.98)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C340(1.02)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C340(1.08)  LDD0703  [2]
 LDCM0022  KB02 A3-KAW C340(1.46)  LDD2257  [5]
 LDCM0023  KB03 A431 C340(2.72)  LDD2675  [5]
 LDCM0024  KB05 G361 C244(3.57); C397(3.69); C587(1.68); C830(1.87)  LDD3311  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Urokinase BiotechDrug DB00013
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-nas-phe(3-am)-4-(2-guanidinoethyl)Piperidine Small molecular drug D0SP2I
3-tapap Small molecular drug D01TWD
Benzamidine Small molecular drug D07SFI
Camostat Small molecular drug DB13729
Inhibitor 1 [Colombo Et Al., 2012] Small molecular drug D0W2SV
Pmid23849879c3 Small molecular drug D00LOL
Pmid25489658c4d Small molecular drug D07OQF
Patented
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us8569313, Inhibitor 14 Small molecular drug D0PY4S
Us8569313, Inhibitor 15 Small molecular drug D0U4EO
Us8569313, Inhibitor 18 Small molecular drug D0CN2Q
Us8569313, Inhibitor 19 Small molecular drug D0RN9V

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840