Details of the Target

General Information of Target

Target ID LDTP14169
Target Name Sorting nexin-13 (SNX13)
Gene Name SNX13
Gene ID 23161
Synonyms
KIAA0713; Sorting nexin-13; RGS domain- and PHOX domain-containing protein; RGS-PX1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVPWVRTMGQKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYIHILMIFWSFVA
GVVTFYCSLGPDSLLPNIFFTIKYKPKQLGLQELFPQGHSCAVCGKVKCKRHRPSLLLEN
YQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRITLRFFASVLIRR
IHKVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEFLQQAALEEYGPELHVALRSRRDE
LHYLRKLTELLFPYILPPKATDCRSLTLLIREILSGSVFLPSLDFLADPDTVNHLLIIFI
DDSPPEKATEPASPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAV
HVLQFCLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQ
RIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSK
LNRGSLSLDDFRNTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGVAEGEDDFIEEG
IVVMEDDSPVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERND
RRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEF
QEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQH
LEPFIMNFINSCESPKPKPSRPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNY
FMEVMTVEGVYDYLMYVGRVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLQCKLEQLFQ
EHRLVSLITLLRDAIFCENTEPRSLQDKQKGAKQTFEEMMNYIPDLLVKCIGEETKYESI
RLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWM
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Early endosome membrane
Function May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis. Acts as a GAP for Galphas.
Uniprot ID
Q9Y5W8
Ensemble ID
ENST00000428135.7
HGNC ID
HGNC:21335

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0223  [1]
DBIA
 Probe Info  		C864(1.00)  LDD1164  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C214(0.89); C285(1.06)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C285(1.07); C864(1.26)  LDD1508  [4]
 LDCM0259  AC14 HEK-293T C285(1.06)  LDD1512  [4]
 LDCM0276  AC17 HEK-293T C214(0.85); C285(1.16)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C285(0.98); C864(1.62)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C285(1.02); C864(0.99)  LDD1518  [4]
 LDCM0281  AC21 HEK-293T C285(0.96)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C285(0.98)  LDD1521  [4]
 LDCM0284  AC24 HEK-293T C285(0.89)  LDD1523  [4]
 LDCM0285  AC25 PaTu 8988t C864(1.00)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C864(1.05)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C864(1.24)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C864(1.37)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C864(1.07)  LDD1168  [2]
 LDCM0291  AC30 PaTu 8988t C864(1.15)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C864(1.04)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C864(1.08)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C864(1.49)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C864(1.07)  LDD1174  [2]
 LDCM0298  AC37 HEK-293T C285(1.06)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C285(0.91)  LDD1538  [4]
 LDCM0302  AC40 HEK-293T C285(0.83)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C214(0.91); C285(1.14)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C285(1.02); C864(1.12)  LDD1543  [4]
 LDCM0307  AC45 HEK-293T C285(1.08)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C285(1.00)  LDD1547  [4]
 LDCM0310  AC48 HEK-293T C285(0.91)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C214(1.05); C285(1.12)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C285(1.13)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C285(1.01); C864(1.26)  LDD1552  [4]
 LDCM0316  AC53 HEK-293T C285(1.06)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C285(0.96)  LDD1556  [4]
 LDCM0319  AC56 HEK-293T C285(0.91)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C214(0.99); C285(1.09)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C285(1.02); C864(1.12)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C285(0.95)  LDD1562  [4]
 LDCM0325  AC61 HEK-293T C285(1.11)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C285(1.03)  LDD1565  [4]
 LDCM0328  AC64 HEK-293T C285(0.83)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C285(0.96)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C285(1.07)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C214(0.81); C285(1.15)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C285(0.92)  LDD1514  [4]
 LDCM0367  CL1 PaTu 8988t C864(1.21)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C864(1.43)  LDD1247  [2]
 LDCM0369  CL100 HEK-293T C214(1.01); C285(1.00)  LDD1573  [4]
 LDCM0372  CL103 HEK-293T C214(0.98); C285(1.17)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C214(0.90); C285(0.98)  LDD1577  [4]
 LDCM0376  CL107 HEK-293T C214(1.03); C285(1.07)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C214(1.05); C285(1.00)  LDD1581  [4]
 LDCM0379  CL11 PaTu 8988t C864(1.22)  LDD1258  [2]
 LDCM0381  CL111 HEK-293T C214(0.89); C285(0.92)  LDD1585  [4]
 LDCM0382  CL112 PaTu 8988t C864(1.36)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C864(1.07)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C864(1.14)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C864(1.17)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C864(1.34)  LDD1265  [2]
 LDCM0389  CL119 HEK-293T C214(1.04); C285(0.92)  LDD1593  [4]
 LDCM0390  CL12 PaTu 8988t C864(1.22)  LDD1269  [2]
 LDCM0391  CL120 HEK-293T C214(1.11); C285(1.06)  LDD1595  [4]
 LDCM0394  CL123 HEK-293T C214(0.86); C285(1.06)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C214(1.21); C285(0.91)  LDD1599  [4]
 LDCM0398  CL127 HEK-293T C214(1.08); C285(1.20)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C214(1.35); C285(0.95)  LDD1603  [4]
 LDCM0400  CL13 PaTu 8988t C864(1.94)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C864(1.65)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C864(1.28)  LDD1281  [2]
 LDCM0403  CL16 HEK-293T C214(1.04); C285(1.11)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C214(1.08); C285(1.06)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C285(1.30); C864(1.26)  LDD1609  [4]
 LDCM0407  CL2 PaTu 8988t C864(1.22)  LDD1286  [2]
 LDCM0409  CL21 HEK-293T C285(1.27)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C285(0.82)  LDD1614  [4]
 LDCM0412  CL24 HEK-293T C285(1.01)  LDD1616  [4]
 LDCM0415  CL27 HEK-293T C214(0.78); C285(0.92)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C214(0.86); C285(0.88)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C214(1.00); C285(0.91)  LDD1621  [4]
 LDCM0418  CL3 PaTu 8988t C864(1.31)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C285(0.94); C864(0.85)  LDD1623  [4]
 LDCM0420  CL31 PaTu 8988t C864(0.82)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C864(1.06)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C864(1.09)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C864(1.23)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C864(1.13)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C864(0.60)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C864(1.07)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C864(1.15)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C864(1.34)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C864(1.17)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C864(0.93)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C864(1.19)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C864(1.19)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C864(1.28)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C864(1.35)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C864(0.79)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C864(0.90)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C864(1.16)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C864(1.04)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C864(1.55)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C864(1.36)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C864(1.07)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C864(1.09)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C864(0.98)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C864(1.10)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C864(1.30)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C864(0.19)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C864(1.53)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C864(1.11)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C864(1.91)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C864(1.26)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C864(1.59)  LDD1331  [2]
 LDCM0455  CL63 HEK-293T C214(0.87); C285(0.95)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C214(1.08); C285(1.08)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C214(0.93); C285(1.02)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C285(1.04); C864(1.15)  LDD1661  [4]
 LDCM0461  CL69 HEK-293T C285(1.17)  LDD1664  [4]
 LDCM0462  CL7 PaTu 8988t C864(1.67)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C285(0.86)  LDD1666  [4]
 LDCM0465  CL72 HEK-293T C285(0.87)  LDD1668  [4]
 LDCM0469  CL76 HEK-293T C214(0.87); C285(1.07)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C214(0.93); C285(1.19)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C285(1.02); C864(1.01)  LDD1674  [4]
 LDCM0473  CL8 PaTu 8988t C864(1.58)  LDD1352  [2]
 LDCM0475  CL81 HEK-293T C285(1.12)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C285(0.91)  LDD1679  [4]
 LDCM0478  CL84 HEK-293T C285(0.97)  LDD1681  [4]
 LDCM0481  CL87 HEK-293T C214(0.96); C285(0.99)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C214(0.92); C285(1.12)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C214(0.88); C285(1.25)  LDD1686  [4]
 LDCM0484  CL9 PaTu 8988t C864(1.53)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C285(1.30); C864(1.44)  LDD1688  [4]
 LDCM0488  CL93 HEK-293T C285(1.15)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C285(1.10)  LDD1692  [4]
 LDCM0491  CL96 HEK-293T C285(0.99)  LDD1694  [4]
 LDCM0494  CL99 HEK-293T C214(0.69); C285(1.04)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C214(0.85); C285(0.87)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C214(0.79); C285(1.03)  LDD1671  [4]
 LDCM0427  Fragment51 PaTu 8988t C864(1.32)  LDD1306  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402