Details of the Target

General Information of Target

Target ID LDTP13942
Target Name Protein MEMO1 (MEMO1)
Gene Name MEMO1
Gene ID 51072
Synonyms
C2orf4; MEMO; NS5ATP7; Protein MEMO1; C21orf19-like protein; Hepatitis C virus NS5A-transactivated protein 7; HCV NS5A-transactivated protein 7; Mediator of ErbB2-driven cell motility 1; Mediator of cell motility 1; Memo-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAHNRGTELDLSWISKIQVNHPAVLRRAEQIQARRTVKKEWQAAWLLKAVTFIDLTTLS
GDDTSSNIQRLCYKAKYPIREDLLKALNMHDKGITTAAVCVYPARVCDAVKALKAAGCNI
PVASVAAGFPAGQTHLKTRLEEIRLAVEDGATEIDVVINRSLVLTGQWEALYDEIRQFRK
ACGEAHLKTILATGELGTLTNVYKASMIAMMAGSDFIKTSTGKETVNATFPVAIVMLRAI
RDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQ
IYHHVTGRYAAYHDLPMS
Target Bioclass
Other
Family
MEMO1 family
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Uniprot ID
Q9Y316
Ensemble ID
ENST00000295065.9
HGNC ID
HGNC:14014

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.G170R DBIA    Probe Info 
NCIH2172 SNV: p.M144I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y199(65.43); Y201(233.33); Y202(17.88)  LDD3495  [1]
DBIA
 Probe Info  		C91(1.58)  LDD3311  [2]
BTD
 Probe Info  		C244(2.23)  LDD1700  [3]
HHS-475
 Probe Info  		Y54(0.70)  LDD0264  [4]
HHS-465
 Probe Info  		Y54(9.44)  LDD2237  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C88(0.00); C244(0.00); C191(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C55(0.00); C58(0.00); C88(0.00); C244(0.00)  LDD0036  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
NAIA_5
 Probe Info  		C58(0.00); C88(0.00); C244(0.00); C279(0.00)  LDD2223  [10]
HHS-482
 Probe Info  		Y54(1.27)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C244(0.89)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C244(1.23)  LDD2152  [3]
 LDCM0214  AC1 HEK-293T C88(0.96)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C88(0.91); C191(1.17)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C88(0.92)  LDD1509  [11]
 LDCM0259  AC14 HEK-293T C191(1.27)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C88(0.95)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C88(1.02)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C88(0.91); C191(0.84)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C88(0.90)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C88(0.71); C191(1.03)  LDD1518  [11]
 LDCM0281  AC21 HEK-293T C191(1.07)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C191(1.01)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C88(0.94)  LDD1522  [11]
 LDCM0285  AC25 HEK-293T C88(0.99)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C88(0.88); C191(1.32)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C88(0.81)  LDD1526  [11]
 LDCM0289  AC29 HEK-293T C191(1.03)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C88(0.76)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C191(0.99)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C88(0.86)  LDD1531  [11]
 LDCM0294  AC33 HEK-293T C88(0.92)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C88(0.84); C191(1.04)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C88(1.02)  LDD1535  [11]
 LDCM0298  AC37 HEK-293T C191(1.15)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C191(1.36)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C88(0.96)  LDD1539  [11]
 LDCM0303  AC41 HEK-293T C88(0.95)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C88(0.85); C191(1.15)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C88(0.81)  LDD1544  [11]
 LDCM0307  AC45 HEK-293T C191(1.04)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C191(1.27)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C88(0.93)  LDD1548  [11]
 LDCM0311  AC49 HEK-293T C88(1.12)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C191(0.99)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C88(0.86); C191(0.96)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C88(1.04)  LDD1553  [11]
 LDCM0316  AC53 HEK-293T C191(1.17)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C191(1.43)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C88(0.92)  LDD1557  [11]
 LDCM0320  AC57 HEK-293T C88(1.05)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C88(0.86); C191(1.05)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C88(0.95)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C191(1.16)  LDD1562  [11]
 LDCM0325  AC61 HEK-293T C191(1.09)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C191(1.20)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C88(0.92)  LDD1566  [11]
 LDCM0334  AC7 HEK-293T C88(1.00)  LDD1568  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C244(0.67)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C191(1.09)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C88(1.04)  LDD1570  [11]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C88(0.83)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C191(1.20)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C88(0.92)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C88(0.93)  LDD1574  [11]
 LDCM0373  CL104 HEK-293T C88(1.11)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C88(0.88)  LDD1578  [11]
 LDCM0377  CL108 HEK-293T C88(1.36)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C88(0.91)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C88(1.00)  LDD1583  [11]
 LDCM0382  CL112 HEK-293T C88(0.88)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C88(0.87)  LDD1587  [11]
 LDCM0386  CL116 HEK-293T C88(1.08)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C88(0.99)  LDD1591  [11]
 LDCM0391  CL120 HEK-293T C88(1.18)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C88(0.89)  LDD1596  [11]
 LDCM0395  CL124 HEK-293T C88(0.91)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C88(0.79)  LDD1600  [11]
 LDCM0399  CL128 HEK-293T C88(0.86)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C88(0.82)  LDD1604  [11]
 LDCM0403  CL16 HEK-293T C88(1.14)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C88(1.03)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C88(0.85); C191(0.95)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C88(1.11)  LDD1610  [11]
 LDCM0409  CL21 HEK-293T C191(0.88)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C191(1.22)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C88(0.93)  LDD1615  [11]
 LDCM0413  CL25 HEK-293T C88(0.81)  LDD1617  [11]
 LDCM0416  CL28 HEK-293T C88(0.95)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C88(0.98)  LDD1621  [11]
 LDCM0419  CL30 HEK-293T C88(0.82); C191(1.24)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C88(0.96)  LDD1624  [11]
 LDCM0422  CL33 HEK-293T C191(1.09)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C191(0.89)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C88(0.98)  LDD1628  [11]
 LDCM0426  CL37 HEK-293T C88(0.89)  LDD1630  [11]
 LDCM0429  CL4 HEK-293T C88(0.97)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C88(1.03)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C88(1.06)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C88(0.95); C191(1.05)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C88(0.96)  LDD1637  [11]
 LDCM0435  CL45 HEK-293T C191(1.07)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C191(1.10)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C88(0.99)  LDD1641  [11]
 LDCM0439  CL49 HEK-293T C88(0.96)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C88(0.95)  LDD1644  [11]
 LDCM0443  CL52 HEK-293T C88(0.97)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C88(0.97)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C88(0.90); C191(0.93)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C88(0.88)  LDD1649  [11]
 LDCM0448  CL57 HEK-293T C191(1.11)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C191(1.22)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C88(0.94)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C88(0.95); C191(0.93)  LDD1654  [11]
 LDCM0453  CL61 HEK-293T C88(0.97)  LDD1656  [11]
 LDCM0456  CL64 HEK-293T C88(0.88)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C88(1.02)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C88(0.98); C191(0.98)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C88(0.98)  LDD1662  [11]
 LDCM0461  CL69 HEK-293T C191(1.01)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C88(0.93)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C191(1.08)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C88(0.96)  LDD1667  [11]
 LDCM0466  CL73 HEK-293T C88(0.79)  LDD1669  [11]
 LDCM0469  CL76 HEK-293T C88(0.83)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C88(1.11)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C88(0.90); C191(0.96)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C88(1.14)  LDD1675  [11]
 LDCM0475  CL81 HEK-293T C191(0.95)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C191(1.18)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C88(0.92)  LDD1680  [11]
 LDCM0479  CL85 HEK-293T C88(0.82)  LDD1682  [11]
 LDCM0482  CL88 HEK-293T C88(1.03)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C88(1.05)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C191(1.21)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C88(0.82); C191(0.65)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C88(1.01)  LDD1689  [11]
 LDCM0488  CL93 HEK-293T C191(0.94)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C191(1.58)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C88(0.87)  LDD1693  [11]
 LDCM0492  CL97 HEK-293T C88(0.88)  LDD1695  [11]
 LDCM0625  F8 Ramos C88(0.74)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C88(0.74)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C88(0.80)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C88(0.67)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C88(1.03)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C88(0.93)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C88(0.78)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C88(0.87)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C88(0.97)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C88(1.08)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C88(0.75)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C88(1.07)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C88(1.07)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C88(0.64)  LDD2201  [12]
 LDCM0468  Fragment33 Ramos C88(1.54)  LDD2202  [12]
 LDCM0596  Fragment38 Ramos C88(0.98)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C88(0.65)  LDD2184  [12]
 LDCM0614  Fragment56 Ramos C88(1.75)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C88(0.58)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C88(0.71)  LDD2188  [12]
 LDCM0116  HHS-0101 DM93 Y54(0.70)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y54(0.73)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y54(0.69)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y54(0.74)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y54(0.94)  LDD0268  [4]
 LDCM0107  IAA HeLa C244(0.00); C55(0.00)  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C244(0.99); C191(0.99)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C244(0.92); C191(0.86)  LDD1497  [11]
 LDCM0024  KB05 G361 C91(1.58)  LDD3311  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C244(0.50)  LDD2121  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C244(1.10)  LDD2093  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C244(0.87)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C244(0.73)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C244(1.27)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C244(0.83)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C244(0.97)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C244(0.53)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C244(1.37)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C244(0.51)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C244(1.84)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C244(0.99)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C244(0.96)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C244(1.03)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C244(1.24)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C244(0.57)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C244(0.51)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C244(1.41)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C244(1.07)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C244(0.97)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C244(2.23)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C244(0.80)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C244(0.39)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C244(1.99)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C244(0.86)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C244(0.56)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C244(0.86)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 22 (ZBTB22) Krueppel C2H2-type zinc-finger protein family O15209
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
ADP-ribosylation factor-binding protein GGA2 (GGA2) GGA protein family Q9UJY4
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Transforming acidic coiled-coil-containing protein 1 (TACC1) TACC family O75410
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Cancer/testis antigen 55 (CT55) . Q8WUE5
EMILIN-3 (EMILIN3) . Q9NT22
RNA-binding protein 45 (RBM45) . Q8IUH3

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578