Details of the Target

General Information of Target

Target ID LDTP13857
Target Name BTB/POZ domain-containing protein 3 (BTBD3)
Gene Name BTBD3
Gene ID 22903
Synonyms
KIAA0952; BTB/POZ domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMPGETHSAAPGTAADLSRCQGCASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDE
LQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYARVK
EECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKN
EKELRHIGTQISSDSYGSIDKRKVKLLLKELWLCVNTTHRLPGEGSRCVPEKPAKAITSS
RVPGEDGTLPPTQGSPLRTSNVQTCLTKLSMEIKEDFLCQNVEKQSSSGTNCSSDHVFNE
NGNLEVLVQSHRDGGSTEFVDHDHFFDEDLQAAIDFFKLPPPLLSPVPSPPPMSSPHPGS
LPSSFAPETYFGEYTDSSDNDSVQLRNSAECVSEDDTTESQNYFGSLRKNKGSGTWEEKP
KSHEAIQALNTWEVNKVTTSGLETFTATLRESSATHSLVGEKHWTTASRSMSDRKRDILH
ETKTQMEVREMDKSVQTEKTIHKLTRGLCIERLSASPAQEKEAAPGKSELCSSPLGKRPL
NELMESEGKTVLSKMMGSPKSEFTKWTRINEITSEPDRITVSGHFHRLSRELEKEKEDTQ
GFTLGESPESEDDDSGDGMDVAGLDIETSFSSSSTLVALSVGSNPQSSSGLDCGNDTDIT
TKVFSTEPHHSEHKLQTKTLNTLHLQSEPPECSIGGNNLENSLCALSPELGASNFNDQKS
SGIEYTKVVKGLTKIHSLPRSVFMKATKDGQCESQDPRIELTLNKPDFTSLIGSQAALIK
SGLGFVKSTSWHHSDLLRKGGEESLRAKSEHEQKTSHQLQKAMPFLQNRGPTPKPDLLRE
NNNPVEFKTTASVLPNQVSVITKQTRPEKVQSAKLEHLRPHRVEPTLVTENSGNKTGMST
VAKCDGERDDTTQNITEVAAVKSISPEVSASRRKLDFNSPGGSSPVENSDCSTNSRLSFS
PENILIQNQDIVREAAVQGDGQKQRQPQATDLDSSGTHGSEMLPATEVTVSGGFSVEETS
CGDTGRSGGEALAVANDSTSTPQNANGLWKLKSTTPGGALPECFGTTDTTFSSAFCRKHG
ETQDTSQSSLPGTLHCYTGIREGGDDTEVESEAFSCSEGSEQQDAPDDSQKNLGDTDAAV
AEVRPSLEVGYLTSALQDFNISTFSELDRLSTSEVVMFLESCQLGDYSSGDSVSECSSKG
TLSKEMNKELKASEIGEKYRKQPCEEETLGTCEEWIESEEDDYSLKNTSQLTQCSLETLS
EVLTKIRQELQTNSEDCNGKDTGSLLLLNVNNNMTTENLKEKSPFRETTGSSSHASEPTP
QAAALDTEGSSPISGMPQNENPQSRPEARSDAGRQTDGGEEDLPEPVEPSALCSDSVMEP
SIEQSSNCEAETTFQCQIATVTSEVINVLINKDQNLVIEKGDNWTIISGVAVLPHVDQVT
LCDIPGDIPISQDQGELEAGCIPVTSAEKSPEASHTGPAFQEAPCGNNLSCPQEDVSSSG
QSTNFDKSRLRNRPVKPSIWISSQIYDQNFETQIVASDHTYYNSKLEPSGKNKNRSKISN
KDQSNKPVKTSASSRVETHQSEVAQSFSGEKANTKTQRSQTQTILANADTSTPTDCSPDT
LSKIRQEVGPPLPPLLAPLIATPPRTSQPLSPLISSSSPSSPASPVGQVSPFRETPVPPA
MSPWPEDPRRASPPDPSPSPSAASASERVVPSPLQFCAATPKHALPVPGRLPPCASGHAA
VGGPQENSVKILDTMYPELSARARTLNILKGNIQLTRGPPADCKNLPGPASAMIGFKTIT
SAATAFVKTGSSSGGDCNQDKSRDLGTQQDSSGKRTLSTSTLRSAKRLRLDTGSPEPETR
GVTAEGIHKNLPGNLPPAEVATTNEERSCSSPAVSAVSQLPLSPKETVESHDKAIANALK
KIAEFSFDLLPVIRSHVYVGNISKKPVMRDQEKEVVYEFSTTKKHLAECLLHSILSELKI
QKISMDHNYIHALCRVYVGICRQLGDLERARLFCYSLLKEDFPESEKLTLFIANMWHDIF
LSQSVINKAMQLVARQRAKGEVLNCLRAFLNWEKNAPVDVGFMVSKLLLTIQLCPKTEFQ
PSEKFGEDLSDNTWEYIFAIDLLCCHQKWIWTHDNIISKELWPVMDKWIKYRKGHANIAY
TPDIIIASILRLIGRLGQLGLKEGFPSAVKNISSVIGMFIQHAHDEDIPWGIQLAAVYAL
CDLSPSNPAEISKILEAWRREASKSVPSAIVSCLEEVSALSTEELG
Target Bioclass
Enzyme
Subcellular location
Cytoplasm, cytosol
Function Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed.
Uniprot ID
Q9Y2F9
Ensemble ID
ENST00000254977.7
HGNC ID
HGNC:15854

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.K10T .
KMS27 SNV: p.E253K .
LNCaP clone FGC SNV: p.T450A .
NCIH1793 SNV: p.P19S .
SKMEL2 SNV: p.S447T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C381(1.60)  LDD3343  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C381(0.88)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C262(1.09)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C262(0.98); C212(1.11)  LDD1510  [3]
 LDCM0263  AC143 PaTu 8988t C226(1.14); C233(1.14); C381(0.81)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C226(1.35); C233(1.35); C381(0.95)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C226(1.08); C233(1.08); C381(0.92)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C226(0.94); C233(0.94); C381(0.83)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C226(1.15); C233(1.15); C381(0.78)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C226(1.09); C233(1.09); C381(1.00)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C226(1.29); C233(1.29); C381(1.04)  LDD1148  [2]
 LDCM0270  AC15 HEK-293T C212(1.05); C233(0.88)  LDD1513  [3]
 LDCM0271  AC150 PaTu 8988t C226(1.34); C233(1.34); C381(0.91)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C226(1.50); C233(1.50); C381(0.76)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C226(1.22); C233(1.22); C381(0.79)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C226(1.03); C233(1.03); C381(1.01)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C226(1.42); C233(1.42); C381(0.87)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C226(1.25); C233(1.25); C381(0.98)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C226(1.30); C233(1.30); C381(0.83)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C226(0.99); C233(0.99); C381(0.89)  LDD2169  [2]
 LDCM0276  AC17 PaTu 8988t C381(1.05)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C381(1.07)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C381(1.03)  LDD1157  [2]
 LDCM0279  AC2 HEK-293T C381(0.96)  LDD0877  [2]
 LDCM0280  AC20 PaTu 8988t C381(0.89)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C381(0.84)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C381(0.97)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C381(1.12)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C381(1.41)  LDD1163  [2]
 LDCM0285  AC25 HEK-293T C262(1.24)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C262(1.06)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C262(1.08); C212(1.07)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C262(0.91)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C381(0.96)  LDD0888  [2]
 LDCM0292  AC31 HEK-293T C212(1.05); C233(0.84)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C262(1.10)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C262(1.20)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C262(1.20)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C262(0.94); C212(0.88)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C262(1.21)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C212(1.21); C233(1.30)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C381(0.89)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C262(0.91)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C262(0.95)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C262(0.95)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C262(1.19); C212(1.13)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C262(1.16)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C381(0.80)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C381(0.82)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C381(0.89)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C381(0.88)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C381(0.85)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C381(0.85)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C381(0.78)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C381(0.88)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C381(0.81)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C381(0.89)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C381(0.87)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C381(0.83)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C262(0.97)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C262(0.97)  LDD1560  [3]
 LDCM0324  AC60 HEK-293T C262(0.89); C212(1.12)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C262(1.00)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C212(1.09); C233(1.23)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C262(1.05)  LDD1567  [3]
 LDCM0332  AC68 PaTu 8988t C381(0.95)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C381(0.89)  LDD1212  [2]
 LDCM0334  AC7 HEK-293T C212(0.98); C233(0.78)  LDD1568  [3]
 LDCM0335  AC70 PaTu 8988t C381(0.86)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C381(1.00)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C381(0.58)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C381(0.80)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C381(0.69)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C381(0.80)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C381(0.81)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C381(0.89)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C381(0.86)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C381(1.32)  LDD1223  [2]
 LDCM0345  AC8 HEK-293T C262(1.05)  LDD1569  [3]
 LDCM0346  AC80 PaTu 8988t C381(1.38)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C381(0.77)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C381(0.73)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C381(1.01)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C381(1.10)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C381(1.02)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C381(1.03)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C381(1.08)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C381(1.14)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C381(1.28)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C381(0.85)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C381(0.86)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C381(0.94)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C381(1.18)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C381(1.14)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C381(0.96)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C381(1.07)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C381(0.99)  LDD1243  [2]
 LDCM0248  AKOS034007472 HEK-293T C262(0.93)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C262(0.97)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C262(0.88)  LDD1514  [3]
 LDCM0367  CL1 PaTu 8988t C381(0.86)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C381(1.08)  LDD1247  [2]
 LDCM0369  CL100 HEK-293T C381(0.94)  LDD0967  [2]
 LDCM0372  CL103 HEK-293T C262(0.85)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C212(1.02); C244(0.93)  LDD1577  [3]
 LDCM0374  CL105 PaTu 8988t C381(0.87)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C381(1.06)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C381(1.27)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C381(1.02)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C381(1.12)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C381(1.10)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C381(0.94)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C381(1.16)  LDD1260  [2]
 LDCM0382  CL112 HEK-293T C212(1.01); C244(0.89)  LDD1586  [3]
 LDCM0385  CL115 HEK-293T C262(1.23)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C212(1.01); C244(1.19)  LDD1590  [3]
 LDCM0389  CL119 HEK-293T C262(0.92)  LDD1593  [3]
 LDCM0390  CL12 PaTu 8988t C381(1.49)  LDD1269  [2]
 LDCM0391  CL120 HEK-293T C212(1.10); C244(0.90)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C381(0.87)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C381(0.87)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C381(0.83)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C381(0.89)  LDD0993  [2]
 LDCM0398  CL127 HEK-293T C262(0.93)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C212(1.23); C244(0.86)  LDD1603  [3]
 LDCM0400  CL13 PaTu 8988t C381(1.88)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C381(1.39)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C381(1.02)  LDD1281  [2]
 LDCM0403  CL16 PaTu 8988t C226(1.06); C233(1.06)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C226(1.61); C233(1.61)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C226(0.99); C233(0.99)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C226(1.07); C233(1.07)  LDD1285  [2]
 LDCM0407  CL2 PaTu 8988t C381(1.09)  LDD1286  [2]
 LDCM0408  CL20 PaTu 8988t C226(1.16); C233(1.16)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C226(1.32); C233(1.32)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C226(1.19); C233(1.19)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C226(1.83); C233(1.83)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C226(1.09); C233(1.09)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C226(1.58); C233(1.58)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C226(1.01); C233(1.01)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C226(1.50); C233(1.50)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C226(1.46); C233(1.46)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C226(1.59); C233(1.59)  LDD1296  [2]
 LDCM0418  CL3 PaTu 8988t C381(1.03)  LDD1297  [2]
 LDCM0419  CL30 PaTu 8988t C226(1.20); C233(1.20)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C226(0.96); C233(0.96)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C226(1.03); C233(1.03)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C226(1.07); C233(1.07)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C226(1.09); C233(1.09)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C226(0.86); C233(0.86)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C226(0.78); C233(0.78)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C226(1.12); C233(1.12)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C226(1.04); C233(1.04)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C381(1.21)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C226(1.05); C233(1.05)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C226(1.20); C233(1.20)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C226(1.39); C233(1.39)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C226(1.53); C233(1.53)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C226(1.08); C233(1.08)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C226(0.89); C233(0.89)  LDD1314  [2]
 LDCM0436  CL46 HEK-293T C381(1.15)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C381(1.18)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C381(0.80)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C381(0.94)  LDD1037  [2]
 LDCM0440  CL5 PaTu 8988t C381(1.16)  LDD1319  [2]
 LDCM0441  CL50 HEK-293T C381(0.92)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C381(1.12)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C381(0.80)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C381(0.99)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C381(1.01)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C381(0.97)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C381(1.11)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C381(1.18)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C381(0.74)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C381(1.11)  LDD1048  [2]
 LDCM0451  CL6 PaTu 8988t C381(1.01)  LDD1330  [2]
 LDCM0452  CL60 HEK-293T C381(0.94)  LDD1050  [2]
 LDCM0455  CL63 HEK-293T C262(0.95)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C212(1.02); C244(0.75)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C262(1.08)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C262(1.03)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C262(0.93); C212(1.01)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C262(1.02)  LDD1664  [3]
 LDCM0462  CL7 PaTu 8988t C381(1.74)  LDD1341  [2]
 LDCM0464  CL71 HEK-293T C212(1.09); C233(1.41)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C262(1.22)  LDD1668  [3]
 LDCM0469  CL76 HEK-293T C381(1.00)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C381(0.89)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C381(1.28)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C381(1.21)  LDD1070  [2]
 LDCM0473  CL8 PaTu 8988t C381(1.73)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C381(1.19)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C381(0.98)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C381(0.89)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C381(0.92)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C381(1.17)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C381(1.14)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C381(1.79)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C381(1.11)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C381(1.03)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C381(1.16)  LDD1081  [2]
 LDCM0484  CL9 PaTu 8988t C381(1.04)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C381(0.93)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C381(0.97)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C381(0.87)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C381(0.96)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C381(1.04)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C381(0.94)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C381(0.96)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C381(0.94)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C381(0.99)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C381(0.93)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C262(1.07)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C262(0.90)  LDD1671  [3]
 LDCM0427  Fragment51 PaTu 8988t C226(1.19); C233(1.19)  LDD1306  [2]
 LDCM0022  KB02 HEK-293T C212(1.01)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C212(0.96)  LDD1497  [3]
 LDCM0024  KB05 NCI-H1299 C381(1.60)  LDD3343  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-3 (CUL3) Cullin family Q13618
BTB/POZ domain-containing protein 3 (BTBD3) . Q9Y2F9
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402