Details of the Target

General Information of Target

Target ID LDTP13547
Target Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1)
Gene Name ASAP1
Gene ID 50807
Synonyms
DDEF1; KIAA1249; PAG2; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; Development and differentiation-enhancing factor 1; DEF-1; Differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN
GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV
ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK
GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL
MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ
DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAK
VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT
QIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLE
DEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLALLYIFF
IVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFT
DYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSF
VIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQVLDSLLN
SQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACE
QDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHL
PVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNR
RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISF
NWDRLASWINLTEQWPYRTSWLILYLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLE
IDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISIGGLAYP
PLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPF
FAPYLYTPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPA
PGPVVLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQCNIDELKKEMN
MNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRASHNELPHTELSS
QTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQ
AEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGKDSE
PKPDDGRKSFLMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGKKSSERS
SLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVERVPKSPEHSA
EPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLHNEVADDSQLEKANLIELEDD
SHSGKRGIPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEENWPACQKAYNLNRTP
STVTLNNNSAPANRANQNFDEMEGIRETSQVILRPSSSPNPTTIQNENLKSMTHKRSQRS
SYTRLSKDPPELHAAASSESTGFGEERESIL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation.
Uniprot ID
Q9ULH1
Ensemble ID
ENST00000518721.6
HGNC ID
HGNC:2720
ChEMBL ID
CHEMBL2146311

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.A578V DBIA    Probe Info 
HCC1806 SNV: p.N378K DBIA    Probe Info 
HCT15 SNV: p.F166Y DBIA    Probe Info 
HT115 SNV: p.L709I DBIA    Probe Info 
IGROV1 Insertion: p.S384IfsTer3 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.V405A DBIA    Probe Info 
JURKAT SNV: p.G160Ter .
LNCaP clone FGC SNV: p.P918S DBIA    Probe Info 
MCC26 SNV: p.G310R .
RKO SNV: p.P727L .
SNGM SNV: p.R424C; p.K1116N DBIA    Probe Info 
SNU308 Deletion: p.L968_Q985del DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K189(0.28); K232(4.76)  LDD0277  [2]
DBIA
 Probe Info  		C560(3.94)  LDD3310  [3]
BTD
 Probe Info  		C557(0.79)  LDD2092  [4]
IPM
 Probe Info  		C557(1.48)  LDD1701  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
AOyne
 Probe Info  		12.80  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C557(0.96)  LDD2112  [4]
 LDCM0214  AC1 HEK-293T C557(0.92); C219(0.89)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C557(1.00); C219(1.03); C685(1.18)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C557(1.02); C219(1.07); C685(1.19)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C557(1.07); C219(1.31)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C557(1.01); C248(0.99)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C557(1.03); C219(0.94)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C557(0.91); C219(1.03)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C557(1.01); C219(1.06); C685(1.24)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C557(1.14); C219(0.93); C685(1.25)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C557(0.98); C219(0.93); C685(1.05)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C557(1.02); C219(1.03)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C557(0.97); C248(0.92)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C557(1.07); C248(0.90)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C557(1.05); C219(0.90)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C557(1.02); C373(1.04); C219(1.07); C248(0.91)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C557(0.95); C219(1.00)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C557(1.10); C219(0.91); C685(1.02)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C557(1.01); C219(0.93); C685(0.82)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C557(1.06); C219(1.17)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C557(0.97); C248(0.89)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C557(0.97); C219(1.05); C685(1.11)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C557(1.00); C248(0.96)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C557(1.01); C219(0.91)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C557(0.98); C373(1.15); C219(1.08); C248(0.99)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C557(0.89); C219(0.97)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C557(0.94); C219(0.98); C685(1.07)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C557(0.94); C219(1.11); C685(0.97)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C557(0.91); C219(1.10)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C557(0.91); C248(0.89)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C557(0.93); C248(0.92)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C557(0.96); C219(1.08)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C557(1.06); C219(1.12)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C557(0.92); C373(1.10); C219(1.16); C248(0.99)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C557(0.94); C219(1.02)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C557(1.06); C219(1.00); C685(0.99)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C557(1.03); C219(0.95); C685(0.97)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C557(0.97); C219(0.87)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C557(0.93); C248(1.00)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C557(0.95); C248(1.08)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C557(0.98); C219(1.02)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C557(1.05); C373(1.17); C219(1.25); C248(0.93)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C557(0.94); C219(0.91)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C557(0.95); C248(0.94)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C557(0.98); C219(0.97); C685(1.09)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C557(1.04); C219(1.06); C685(0.91)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C557(0.83); C219(1.23)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C557(1.01); C248(1.02)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C557(0.86); C248(0.86)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C557(0.96); C219(0.90)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C557(0.99); C373(1.11); C219(0.91); C248(1.05)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C557(0.94); C219(0.97)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C557(0.94); C219(1.06); C685(0.92)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C557(1.01); C219(1.04); C685(0.94)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C557(0.93); C248(0.88)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C557(0.95); C219(1.13)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C557(0.97); C248(0.99)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C557(0.92); C248(0.80)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C557(0.97); C219(0.95)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C557(0.95); C373(0.98); C219(1.13); C248(0.97)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C557(0.96); C219(0.78)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C557(1.05); C373(1.12); C219(0.97); C248(0.95)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C557(1.01); C248(1.00)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C557(0.93); C219(0.99)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C557(1.04); C373(1.16); C219(1.23); C248(0.95)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 12.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C557(0.97); C219(1.01)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C557(0.90); C248(1.11)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C557(0.95); C373(0.99); C219(0.94)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C557(1.01); C219(1.01)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C557(0.98); C219(1.22); C248(1.18)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C557(0.98); C219(1.00)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C557(1.01); C373(0.90); C219(1.04)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C557(0.98); C219(1.02)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C557(0.95); C219(1.15); C248(1.13)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C557(0.97); C219(1.02)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C557(1.00); C373(0.90); C219(1.07)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C557(0.95); C219(1.01)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C557(0.90); C219(1.09)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C557(0.96); C219(1.35); C248(1.17)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C557(1.04); C219(1.02)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C557(1.16); C373(0.94); C219(1.02)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C557(1.05); C219(1.01)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C557(0.94); C219(1.24); C248(1.13)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C557(0.93); C219(1.01)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C557(0.96); C373(0.79); C219(1.06)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C557(1.06); C219(1.08)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C557(1.11); C219(1.02); C248(1.09)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C557(1.03); C219(0.96)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C557(0.98); C373(1.12); C219(0.98); C248(0.94)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C557(0.97); C373(0.97); C219(1.09)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C557(1.03); C219(0.94)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C557(1.03); C219(1.15); C248(1.06)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C557(0.87); C219(1.19)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C557(1.02); C373(0.98); C219(1.12)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C557(1.03); C219(0.99)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C557(1.03); C219(1.15); C248(1.15)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C557(0.89); C219(1.03)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C557(1.07); C373(0.96); C219(1.05)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C557(0.99); C219(0.98)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C557(0.97); C219(1.15); C248(1.00)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C557(0.87); C219(1.45)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C557(0.99); C373(1.00); C219(1.11)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C557(0.83); C219(1.35)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C557(0.95); C219(0.93); C685(1.46)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C557(1.00); C219(0.91); C685(0.98)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C557(0.94); C219(1.22); C248(1.10)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C557(1.21); C219(1.24)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C557(0.93); C248(1.64)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C557(0.89); C248(0.92)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C557(0.99); C219(0.92)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C557(1.06); C373(1.27); C219(1.28); C248(1.05)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C557(1.04); C219(0.95)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C557(1.00); C219(1.01); C248(1.02)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C557(1.11); C219(1.01)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C557(0.97); C373(0.86); C219(1.00)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C557(0.98); C219(0.99)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C557(0.84); C219(1.11)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C557(1.02); C219(0.96); C685(0.98)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C557(1.04); C219(1.25); C685(1.37)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C557(1.07); C219(1.11)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C557(0.93); C248(1.33)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C557(1.06); C248(0.83)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C557(1.13); C219(0.86)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C557(1.01); C373(1.23); C219(1.15); C248(1.10)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C557(0.98); C219(0.98)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C557(0.88); C219(0.96)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C557(1.06); C373(0.93); C219(1.14)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C557(1.04); C373(0.90); C219(1.00)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C557(0.90); C219(0.98)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C557(1.00); C219(0.97); C685(0.96)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C557(1.06); C219(0.97); C685(0.95)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C557(1.08); C219(1.10)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C557(0.97); C248(0.95)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C557(0.96); C248(1.10)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C557(1.09); C219(0.93)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C557(1.05); C373(1.09); C219(0.93); C248(1.07)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C557(1.05); C219(1.02)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C557(0.94); C219(0.92)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C557(1.02); C219(1.04); C248(1.09)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C557(0.99); C373(0.93); C219(1.12)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C557(0.86); C219(1.25)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C557(0.93); C219(1.20); C685(1.08)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C557(1.00); C219(1.07); C685(0.86)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C557(0.89); C219(1.10)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C557(0.89); C248(1.07)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C557(1.02); C248(1.10)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C557(1.06); C219(0.93)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C557(0.95); C219(1.27); C685(1.26)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C557(1.06); C373(1.14); C219(1.10); C248(1.18)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C557(1.07); C219(0.98)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C557(0.95); C219(1.12); C248(1.02)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C557(0.93); C219(1.01)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C557(0.95); C373(0.95); C219(1.27)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C557(0.92); C219(0.93)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C557(1.00); C219(1.02); C685(0.92)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C557(1.09); C219(1.03); C685(1.06)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C557(0.85); C219(1.09)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C557(0.95); C248(1.13)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C557(0.95); C219(1.13); C685(0.94)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C557(0.98); C248(1.04)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C557(1.12); C219(1.05)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C557(1.07); C373(1.14); C219(1.08); C248(1.01)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C557(1.01); C219(1.10)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C557(1.02); C219(1.08); C248(1.03)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C557(1.07); C373(0.91); C219(1.08)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C557(0.88); C219(1.11)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C557(1.02); C219(0.96); C685(1.07)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C557(1.00); C219(0.90); C685(0.90)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C557(0.85); C219(4.35)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C557(0.91); C219(1.12)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C557(1.02); C248(0.93)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C557(1.01); C248(0.94)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C557(1.05); C219(0.94)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C557(1.07); C373(1.14); C219(1.09); C248(1.08)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C557(1.08); C219(1.03)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C557(0.97); C219(1.14); C248(1.15)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C557(0.93); C219(1.16)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C557(1.06); C373(0.95); C219(1.14)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C557(0.90); C219(0.96)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C557(0.93); C248(1.02)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C557(0.94); C219(1.53); C685(0.95)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C557(0.99); C219(1.09); C685(0.88)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C557(1.07); C219(1.36)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C557(0.95); C248(1.13)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C557(1.20); C248(0.93)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C557(0.93); C219(1.13)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C557(1.03); C373(1.19); C219(1.11); C248(1.16)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C557(1.01); C219(0.99)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C557(0.99); C219(1.11); C248(1.12)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C557(0.89); C219(1.10)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C557(0.90); C219(1.00)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C557(0.94); C219(1.02)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C557(0.98); C219(1.10); C248(1.13)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C557(0.91); C373(0.97)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C557(1.01); C373(1.14)  LDD1497  [9]
 LDCM0024  KB05 COLO792 C560(3.94)  LDD3310  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C557(0.79)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C557(0.57)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C557(1.07)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C557(0.84)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C557(0.99)  LDD2099  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C557(0.73)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C557(1.35)  LDD2105  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C557(1.06)  LDD2116  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C557(1.13)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C557(1.34)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C557(0.88)  LDD2125  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C557(1.29)  LDD2136  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C557(0.47)  LDD2146  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Tyrosine-protein kinase HCK (HCK) Tyr protein kinase family P08631
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
SH2/SH3 adapter protein NCK1 (NCK1) . P16333
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97
Src substrate cortactin (CTTN) . Q14247

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402