Details of the Target

General Information of Target

Target ID LDTP13400
Target Name Probable E3 ubiquitin-protein ligase MID2 (MID2)
Gene Name MID2
Gene ID 11043
Synonyms
FXY2; RNF60; TRIM1; Probable E3 ubiquitin-protein ligase MID2; EC 2.3.2.27; Midin-2; Midline defect 2; Midline-2; RING finger protein 60; RING-type E3 ubiquitin transferase MID2; Tripartite motif-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ
QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE
PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI
DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM
FPANYVELIE
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Cytoplasm
Function
E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29.
Uniprot ID
Q9UJV3
Ensemble ID
ENST00000262843.11
HGNC ID
HGNC:7096

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.V251A .
CMK SNV: p.E557K .
EFO27 SNV: p.R522W .
HCT15 SNV: p.V151L .
HDQP1 SNV: p.P70A .
HT115 SNV: p.E284G; p.V656A .
IGROV1 SNV: p.A336T .
SW948 SNV: p.A378T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C720(0.97)  LDD2117  [1]
DBIA
 Probe Info  		C718(1.06); C720(1.06)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
AOyne
 Probe Info  		11.80  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C720(0.97)  LDD2117  [1]
 LDCM0214  AC1 HEK-293T C630(0.95)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C630(1.13); C195(1.09)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C630(1.08)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C630(1.00)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C630(1.04); C268(0.87)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C630(1.00)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C630(0.93)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C630(0.99); C195(0.99)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C630(0.96)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C630(1.08); C195(0.85)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C630(0.86)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C630(0.97); C195(0.95)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C630(0.97); C268(1.00)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C630(0.95)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C630(0.95); C195(1.00)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C630(0.91)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C630(1.07); C195(0.87)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C630(0.98)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C630(0.96)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C630(1.03); C195(1.11)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C630(1.08)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C630(1.04); C268(0.82)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C630(0.97)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C630(0.96); C195(1.03)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C630(0.98)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C630(1.10); C195(1.01)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C630(1.08)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C630(1.16)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C630(0.95); C195(1.02)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C630(1.05); C268(0.96)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C630(0.94)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C630(1.10)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C630(1.03); C195(0.97)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C630(1.01)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C630(1.12); C195(1.08)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C630(1.06)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C630(0.89)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C630(0.94); C195(1.08)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C630(1.00); C268(1.02)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C630(0.93)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C630(0.93); C195(1.00)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C630(0.96)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C630(0.91); C195(1.01)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C630(1.04); C195(0.93)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C630(1.05)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C630(0.85)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C630(0.97); C195(1.05)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C630(1.11); C268(1.09)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C630(0.93)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C630(1.02); C195(1.05)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C630(1.00)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C630(1.02); C195(1.09)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C630(1.00)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C630(1.07); C268(0.88)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C630(0.88)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C630(0.98); C195(1.04)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C630(1.05); C268(1.02)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C630(0.89)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C630(0.98); C195(1.05)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C630(0.92)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C630(0.97); C195(1.00)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C630(0.97); C195(1.04)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C630(1.00)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C630(0.93); C195(1.09)  LDD1514  [5]
 LDCM0020  ARS-1620 HCC44 C718(1.06); C720(1.06)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C630(0.99)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C630(0.94); C268(0.99)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C630(1.06)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C630(1.03)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C630(0.91); C195(0.99)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C630(0.95)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C630(1.03)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C630(0.97)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C630(1.00); C195(1.04)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C630(1.02)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C630(1.01)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C630(0.99)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C630(1.04)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C630(0.94); C195(0.83)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C630(1.03)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C630(0.98)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C630(1.01)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C630(0.85); C195(1.03)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C630(0.98)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C630(1.07)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C630(1.03)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C630(0.94); C195(0.97)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C630(1.01)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C630(1.06); C195(1.06)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C630(1.07)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C630(0.98)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C630(1.01); C195(0.94)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C630(0.92)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C630(1.13)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C630(0.97)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C630(0.90); C195(0.94)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C630(0.96)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C630(0.95)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C630(0.98)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C630(0.92); C195(1.01)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C630(1.09)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C630(1.06)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C630(0.99)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C630(1.17); C195(1.01)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C630(1.16)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C630(0.92); C195(0.96)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C630(0.97)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C630(1.20); C195(1.05)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C630(1.15); C268(1.02)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C630(1.07)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C630(1.12); C195(1.05)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C630(0.94)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C630(0.95); C195(1.01)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C630(1.04)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C630(1.15)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C630(0.94)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C630(1.07)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C630(1.05); C195(0.99)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C630(1.17)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C630(1.11)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C630(1.07); C195(1.14)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C630(1.16); C268(1.06)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C630(1.15)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C630(0.98); C195(1.04)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C630(1.02)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C630(1.00)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C630(0.97)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C630(1.12)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C630(0.96)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C630(1.06); C195(1.17)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C630(1.08)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C630(0.90)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C630(0.96); C195(1.15)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C630(1.25); C268(1.15)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C630(1.11)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C630(1.13); C195(0.96)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C630(1.00)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C630(1.05)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C630(0.91); C195(1.13)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C630(1.08)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C630(0.98)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C630(1.15); C195(0.88)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C630(1.22)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C630(1.04)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C630(1.16); C195(0.95)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C630(1.19); C268(1.14)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C630(1.23)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C630(1.04); C195(1.21)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C630(1.13); C195(1.01)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C630(1.00)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C630(1.01); C195(0.94)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C630(1.06)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C630(1.13)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C630(0.98)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C630(1.03); C195(0.96)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C630(1.14)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C630(0.88)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C630(1.16); C195(1.02)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C630(1.03)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C630(1.21); C268(1.02)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C630(1.18)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C630(1.08); C195(1.06)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C630(0.92)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C630(0.93); C195(1.01)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C630(1.07)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C630(1.10)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C630(1.10); C195(1.08)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C630(1.07)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C630(0.79)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C630(1.02)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C630(1.14); C195(1.27)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C630(1.20); C268(0.93)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C630(1.16)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C630(1.08); C195(1.06)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C630(1.00)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C630(0.78); C195(1.06)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C630(0.88)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C630(1.11)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C630(0.90)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C630(1.08); C195(1.21)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C630(0.91); C195(1.10)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C630(1.10)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C630(1.03)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C630(1.10); C195(0.89)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C630(1.11); C268(1.01)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C630(0.95)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C630(1.05); C195(1.10)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C630(0.99)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C630(0.87); C195(1.17)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C630(0.96)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C630(1.02)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C630(0.92)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C630(0.91); C195(1.09)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C630(1.00)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C630(1.04)  LDD1497  [5]
 LDCM0024  KB05 OZ C630(1.38)  LDD3389  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C720(0.58)  LDD2135  [1]
 LDCM0021  THZ1 HCT 116 C718(0.97); C720(0.97)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) Aldehyde dehydrogenase family P43353
Ethanolamine kinase 2 (ETNK2) Choline/ethanolamine kinase family Q9NVF9
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) FAST kinase family Q7L8L6
Ribonuclease P protein subunit p25-like protein (RPP25L) Histone-like Alba family Q8N5L8
Methyltransferase-like protein 17, mitochondrial (METTL17) Rsm22 family Q9H7H0
Cathepsin Z (CTSZ) Peptidase C1 family Q9UBR2
Ubiquitin carboxyl-terminal hydrolase 25 (USP25) Peptidase C19 family Q9UHP3
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Protein tyrosine phosphatase domain-containing protein 1 (PTPDC1) Protein-tyrosine phosphatase family A2A3K4
GTP-binding protein GEM (GEM) RGK family P55040
Chromodomain-helicase-DNA-binding protein 2 (CHD2) SNF2/RAD54 helicase family O14647
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Ubiquitin-conjugating enzyme family P61077
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
Ubiquitin-conjugating enzyme E2 E2 (UBE2E2) Ubiquitin-conjugating enzyme family Q96LR5
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Josephin-1 (JOSD1) . Q15040
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Ubiquitin domain-containing protein 1 (UBTD1) . Q9HAC8
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Golgin subfamily A member 7 (GOLGA7) ERF4 family Q7Z5G4
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
ADP/ATP translocase 3 (SLC25A6) Mitochondrial carrier (TC 2.A.29) family P12236
Solute carrier family 25 member 48 (SLC25A48) Mitochondrial carrier (TC 2.A.29) family Q6ZT89
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 40 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B9 (HOXB9) Abd-B homeobox family P17482
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-B2 (HOXB2) Antp homeobox family P14652
CREB3 regulatory factor (CREBRF) BZIP family Q8IUR6
REST corepressor 3 (RCOR3) CoREST family Q9P2K3
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein 266 (ZNF266) Krueppel C2H2-type zinc-finger protein family Q14584
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 440 (ZNF440) Krueppel C2H2-type zinc-finger protein family Q8IYI8
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 669 (ZNF669) Krueppel C2H2-type zinc-finger protein family Q96BR6
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 784 (ZNF784) Krueppel C2H2-type zinc-finger protein family Q8NCA9
Zinc finger protein 785 (ZNF785) Krueppel C2H2-type zinc-finger protein family A8K8V0
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Forkhead box protein D4-like 3 (FOXD4L3) . Q6VB84
Golgin-45 (BLZF1) . Q9H2G9
Highly divergent homeobox (HDX) . Q7Z353
Homeobox protein MOX-1 (MEOX1) . P50221
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Zinc finger protein 408 (ZNF408) . Q9H9D4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hyaluronan and proteoglycan link protein 2 (HAPLN2) HAPLN family Q9GZV7
Other
Click To Hide/Show 88 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein A (ATOSA) ATOS family Q32MH5
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
ATR-interacting protein (ATRIP) ATRIP family Q8WXE1
Breast cancer metastasis-suppressor 1-like protein (BRMS1L) BRMS1 family Q5PSV4
Bystin (BYSL) Bystin family Q13895
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Coiled-coil domain-containing protein 42 (CCDC42) CFAP73 family Q96M95
EKC/KEOPS complex subunit LAGE3 (LAGE3) CTAG/PCC1 family Q14657
DPY30 domain-containing protein 1 (DYDC1) Dpy-30 family Q8WWB3
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
EF-hand calcium-binding domain-containing protein 4B (CRACR2A) EFCAB4 family Q9BSW2
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
F-box/WD repeat-containing protein 5 (FBXW5) FBXW5 family Q969U6
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein DGCR6L (DGCR6L) Gonadal family Q9BY27
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Prorelaxin H1 (RLN1) Insulin family P04808
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Iron-sulfur cluster assembly enzyme ISCU (ISCU) NifU family Q9H1K1
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Pentatricopeptide repeat-containing protein 2, mitochondrial (PTCD2) PTCD2 family Q8WV60
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) SHFL family Q9NUL5
Spermatogenesis-associated protein 24 (SPATA24) SPATA24 family Q86W54
Mid1-interacting protein 1 (MID1IP1) SPOT14 family Q9NPA3
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Synaptosomal-associated protein 47 (SNAP47) SVAP1 family Q5SQN1
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Syntaxin-11 (STX11) Syntaxin family O75558
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Tektin-1 (TEKT1) Tektin family Q969V4
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
rRNA-processing protein UTP23 homolog (UTP23) UTP23/FCF1 family Q9BRU9
U3 small nucleolar RNA-associated protein 25 homolog (UTP25) UTP25 family Q68CQ4
Zinc finger C2HC domain-containing protein 1C (ZC2HC1C) ZC2HC1 family Q53FD0
Axin-1 (AXIN1) . O15169
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Calcium-regulated heat-stable protein 1 (CARHSP1) . Q9Y2V2
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Elongin-A (ELOA) . Q14241
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Epidermal growth factor-like protein 7 (EGFL7) . Q9UHF1
FERM domain-containing protein 6 (FRMD6) . Q96NE9
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Galectin-8 (LGALS8) . O00214
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
INO80 complex subunit B (INO80B) . Q9C086
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
IQ domain-containing protein N (IQCN) . Q9H0B3
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Lamin tail domain-containing protein 2 (LMNTD2) . Q8IXW0
Leucine-rich repeat-containing protein 45 (LRRC45) . Q96CN5
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
LIM domain transcription factor LMO4 (LMO4) . P61968
Melanoma-associated antigen 6 (MAGEA6) . P43360
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Neuronal migration protein doublecortin (DCX) . O43602
Phostensin (PPP1R18) . Q6NYC8
Placental protein 13-like (LGALS14) . Q8TCE9
PRKCA-binding protein (PICK1) . Q9NRD5
Properdin (CFP) . P27918
Protein unc-45 homolog A (UNC45A) . Q9H3U1
Putative Wilms tumor upstream neighbor 1 gene protein (WT1-AS) . Q06250
Rab effector Noc2 (RPH3AL) . Q9UNE2
Ran-binding protein 3-like (RANBP3L) . Q86VV4
Ras/Rap GTPase-activating protein SynGAP (SYNGAP1) . Q96PV0
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840