Details of the Target

General Information of Target

Target ID LDTP13386
Target Name N-acetylglucosamine-1-phosphotransferase subunit gamma (GNPTG)
Gene Name GNPTG
Gene ID 84572
Synonyms
C16orf27; GNPTAG; N-acetylglucosamine-1-phosphotransferase subunit gamma; GlcNAc-1-phosphotransferase subunit gamma; UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKL
DRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSI
LGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKD
LAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKK
KDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQ
YKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRC
GEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSEL
IDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLR
FLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHE
WGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVA
KLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHK
LKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQV
EHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLS
FQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQ
SEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSM
SVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTA
AWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQ
MQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQK
IIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
Target Bioclass
Other
Subcellular location
Secreted
Function
Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors.
Uniprot ID
Q9UJJ9
Ensemble ID
ENST00000204679.9
HGNC ID
HGNC:23026

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C142(0.31)  LDD2127  [1]
DBIA
 Probe Info  		C142(1.02)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C142(1.03)  LDD1507  [5]
 LDCM0237  AC12 HEK-293T C142(1.05)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C142(0.98)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C142(1.03)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C142(1.00)  LDD1515  [5]
 LDCM0280  AC20 HEK-293T C142(0.98)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C142(1.05)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C142(0.99)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C142(1.04)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C142(0.96)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C142(1.03)  LDD1524  [5]
 LDCM0288  AC28 HEK-293T C142(1.00)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C142(1.11)  LDD1528  [5]
 LDCM0291  AC30 HEK-293T C142(0.99)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C142(1.01)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C142(1.08)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C142(1.00)  LDD1533  [5]
 LDCM0297  AC36 HEK-293T C142(1.04)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C142(1.17)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C142(0.92)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C142(0.99)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C142(1.01)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C142(1.07)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C142(1.05)  LDD1542  [5]
 LDCM0306  AC44 HEK-293T C142(1.03)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C142(1.11)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C142(1.04)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C142(1.02)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C142(0.99)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C142(0.99)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C142(1.10)  LDD1551  [5]
 LDCM0315  AC52 HEK-293T C142(1.01)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C142(1.06)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C142(0.99)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C142(0.98)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C142(1.03)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C142(1.02)  LDD1559  [5]
 LDCM0323  AC6 HEK-293T C142(1.06)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C142(1.01)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C142(1.13)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C142(1.01)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C142(1.08)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C142(1.04)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C142(0.95)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C142(1.08)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C142(1.09)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C142(1.07)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C142(1.12)  LDD1514  [5]
 LDCM0020  ARS-1620 HCC44 C142(1.02)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C142(1.03)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C142(1.15)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C142(1.05)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C142(1.07)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C142(1.02)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C142(1.02)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C142(1.04)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C142(1.04)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C142(0.97)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C142(0.96)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C142(1.00)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C142(1.06)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C142(1.15)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C142(1.04)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C142(1.04)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C142(1.07)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C142(1.02)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C142(1.07)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C142(1.07)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C142(1.07)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C142(1.07)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C142(1.00)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C142(0.99)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C142(1.15)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C142(1.03)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C142(1.01)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C142(0.95)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C142(0.96)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C142(1.06)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C142(0.99)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C142(1.00)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C142(1.04)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C142(1.00)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C142(1.13)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C142(0.94)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C142(1.00)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C142(1.02)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C142(1.10)  LDD1608  [5]
 LDCM0407  CL2 HEK-293T C142(0.92)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C142(1.09)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C142(1.37)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C142(1.08)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C142(1.04)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C142(1.05)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C142(1.07)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C142(0.94)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C142(0.94)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C142(1.03)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C142(1.04)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C142(0.93)  LDD1622  [5]
 LDCM0421  CL32 HEK-293T C142(1.06)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C142(1.21)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C142(1.06)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C142(1.05)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C142(1.02)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C142(1.01)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C142(1.00)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C142(1.02)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C142(1.08)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C142(1.01)  LDD1635  [5]
 LDCM0434  CL44 HEK-293T C142(1.08)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C142(1.38)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C142(1.06)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C142(1.16)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C142(1.05)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C142(1.09)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C142(0.98)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C142(1.00)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C142(1.07)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C142(1.07)  LDD1647  [5]
 LDCM0447  CL56 HEK-293T C142(1.10)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C142(1.34)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C142(1.04)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C142(1.09)  LDD1653  [5]
 LDCM0452  CL60 HEK-293T C142(1.09)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C142(1.05)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C142(1.00)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C142(0.93)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C142(1.05)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C142(1.01)  LDD1660  [5]
 LDCM0460  CL68 HEK-293T C142(1.02)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C142(1.22)  LDD1664  [5]
 LDCM0463  CL70 HEK-293T C142(1.02)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C142(1.08)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C142(1.03)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C142(1.11)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C142(0.96)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C142(1.05)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C142(1.10)  LDD1673  [5]
 LDCM0473  CL8 HEK-293T C142(1.20)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C142(1.03)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C142(1.19)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C142(1.02)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C142(1.09)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C142(1.03)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C142(1.07)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C142(1.01)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C142(0.99)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C142(1.02)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C142(1.00)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C142(1.39)  LDD1687  [5]
 LDCM0487  CL92 HEK-293T C142(1.06)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C142(1.30)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C142(1.08)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C142(1.23)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C142(1.14)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C142(1.11)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C142(0.97)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C142(1.05)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C142(1.03)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C142(0.94)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C142(0.99)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C142(0.92)  LDD1492  [5]
 LDCM0023  KB03 Jurkat C142(11.73)  LDD0209  [6]
 LDCM0024  KB05 G361 C71(3.02)  LDD3311  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C142(0.31)  LDD2127  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) Stealth family Q3T906

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840