Details of the Target

General Information of Target

Target ID LDTP13299
Target Name Ubiquitin carboxyl-terminal hydrolase 25 (USP25)
Gene Name USP25
Gene ID 29761
Synonyms
USP21; Ubiquitin carboxyl-terminal hydrolase 25; EC 3.4.19.12; Deubiquitinating enzyme 25; USP on chromosome 21; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATF
AFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRL
RNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYIL
IQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASW
TLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEF
LRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTS
CNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNL
LDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVD
MRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMG
QQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDT
LGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCM
AVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNR
VHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAF
KNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGF
QGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIG
FLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGY
KDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPM
VLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTS
FQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHG
HSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQV
VFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLT
EKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGS
TIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQAS
KAH
Target Bioclass
Enzyme
Family
Peptidase C19 family
Subcellular location
Cytoplasm
Function
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation, immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux. Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6. Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance.; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
Uniprot ID
Q9UHP3
Ensemble ID
ENST00000285679.10
HGNC ID
HGNC:12624
ChEMBL ID
CHEMBL4295975

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1085(2.30)  LDD3319  [1]
BTD
 Probe Info  		C931(0.61)  LDD2120  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1015(1.17)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C1037(0.79); C990(1.01); C1015(0.99)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C1037(0.99); C990(1.10); C1015(1.09)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C1015(1.03)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C1037(1.03); C990(0.89); C1015(1.05)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C1037(0.87); C990(1.34); C1015(0.98)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C1015(1.01)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C1037(0.66); C990(0.97); C1015(0.98)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C1037(0.71); C990(1.17); C1015(0.99)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C1037(0.82); C990(0.85); C1015(1.13)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C1015(1.07)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C1037(1.05); C990(0.81); C1015(0.95)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C1037(1.01); C990(0.98); C1015(1.02)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C1037(0.93); C990(0.99); C1015(1.02)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C1037(1.45); C990(1.50); C1015(1.07)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C1015(0.95)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C1037(0.80); C990(0.85); C1015(1.08)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C1037(1.03); C990(0.99); C1015(1.10)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C1015(0.98)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C1037(0.73); C990(0.88); C1015(1.00)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C1037(0.78); C990(1.69); C1015(1.11)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C1037(0.92); C990(0.95); C1015(0.92)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C1037(0.85); C990(1.13); C1015(0.98)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C1037(1.29); C990(1.00); C1015(1.16)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C1015(1.22)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C1037(0.67); C990(1.12); C1015(0.98)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C1037(0.84); C990(0.96); C1015(1.09)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C1015(1.11)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C1037(0.96); C990(1.16); C1015(1.12)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C1037(0.92); C990(1.10); C1015(1.08)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C1037(0.81); C990(1.25); C1015(1.07)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C1015(0.97)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C1037(0.96); C990(1.14); C1015(0.98)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C1015(1.27)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C1037(0.66); C990(1.25); C1015(1.05)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C1037(0.93); C990(1.21); C1015(1.06)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C1015(1.15)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C1037(0.75); C990(1.11); C1015(1.08)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C1037(0.99); C990(1.13); C1015(1.07)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C1037(0.89); C990(1.00); C1015(1.04)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C1037(1.02); C990(1.23); C1015(1.14)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C1015(1.11)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C1037(0.96); C990(0.88); C1015(1.06)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C1037(0.80); C990(0.92); C1015(1.06)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C1037(1.02); C990(1.32); C1015(1.28)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C1015(1.04)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C1037(0.87); C990(0.99); C1015(1.04)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C1037(0.84); C990(0.88); C1015(1.12)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C1037(1.07); C990(0.91); C1015(1.02)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C1037(1.16); C990(1.01); C1015(1.07)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C1015(1.03)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C1037(0.61); C990(0.79); C1015(1.03)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C1037(0.87); C990(0.93); C1015(1.02)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C1037(0.79); C990(0.91); C1015(1.07)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C1015(1.06)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C1037(0.77); C990(0.86); C1015(1.15)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C1037(0.78); C990(1.03); C1015(0.99)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C1037(0.93); C990(1.18); C1015(1.02)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C1037(0.92); C990(1.21); C1015(0.99)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C1037(1.10); C990(0.99); C1015(1.05)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C1037(0.87); C990(0.94); C1015(1.03)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C1037(0.65); C990(0.98); C1015(1.05)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C1015(1.03)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C1037(0.89); C990(1.06); C1015(1.09)  LDD1514  [6]
 LDCM0632  CL-Sc Hep-G2 C1015(0.65)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C1037(0.84); C990(0.97)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C1037(1.10); C990(0.94); C1015(0.86)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C1037(1.04)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C1037(1.10); C990(1.06)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C1037(0.94); C990(1.04)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C1037(1.20); C990(0.96)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C1037(1.17)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C1037(1.00); C990(1.07)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C1037(0.81); C990(0.91)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C1037(1.22); C990(0.73)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C1037(1.34)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C1037(1.06); C990(1.16)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C1037(1.52); C990(0.97); C1015(1.09)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C1037(0.78); C990(0.80)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C1037(1.94); C990(0.82)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C1037(1.31)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C1037(1.02); C990(1.05)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C1037(0.94); C990(1.23)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C1037(1.63); C990(0.79)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C1037(1.11)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C1037(1.00); C990(1.13)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C1037(0.93); C990(0.94)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C1037(1.08); C990(0.78)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C1037(1.24); C990(1.26); C1015(1.13)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C1037(1.41)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C1037(0.76); C990(0.93)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C1037(0.84); C990(1.01)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C1037(1.38); C990(0.79)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C1037(1.15)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C1037(0.69); C990(1.06)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C1037(0.73); C990(1.08)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C1037(1.05); C990(0.98)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C1037(1.18)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C1037(0.88); C990(1.09)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C1037(0.87); C990(0.94)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C1037(1.14); C990(0.76)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C1037(1.11)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C1015(1.54)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C1037(0.68); C990(0.91); C1015(1.03)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C1037(0.82); C990(1.38); C1015(1.13)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C1037(0.96); C990(0.79)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C1015(1.29)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C1037(0.88); C990(1.13); C1015(1.00)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C1037(1.01); C990(1.01); C1015(1.05)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C1037(1.04); C990(1.07); C1015(1.10)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C1037(1.05); C990(1.30); C1015(1.46)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C1037(0.75); C990(1.09)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C1037(1.03); C990(0.95)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C1037(1.47); C990(1.09)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C1037(1.15)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C1015(1.09)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C1037(1.07); C990(0.86)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C1037(0.74); C990(1.04); C1015(1.05)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C1037(0.77); C990(1.17); C1015(1.14)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C1015(0.97)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C1037(0.73); C990(1.01); C1015(0.90)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C1037(0.92); C990(0.86); C1015(1.01)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C1037(1.12); C990(1.08); C1015(1.04)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C1037(1.16); C990(1.01); C1015(1.04)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C1037(0.81); C990(1.33)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C1037(1.11); C990(0.69)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C1037(1.27)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C1037(1.10)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C1015(1.36)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C1037(0.71); C990(0.78); C1015(1.03)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C1037(1.27); C990(0.95); C1015(1.09)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C1015(0.92)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C1037(1.52); C990(0.78); C1015(0.97)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C1037(1.02); C990(1.09); C1015(1.05)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C1037(1.07); C990(0.92); C1015(1.06)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C1037(1.02); C990(1.05); C1015(1.05)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C1037(0.83); C990(0.98)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C1015(1.25)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C1037(0.98); C990(0.94)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C1037(1.88)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C1015(1.32)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C1037(0.71); C990(0.88); C1015(0.97)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C1037(0.96); C990(0.93); C1015(1.20)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C1015(1.35)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C1037(1.50); C990(0.88); C1015(1.13)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C1037(0.92); C990(0.80); C1015(1.10)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C1037(1.09); C990(0.95); C1015(1.18)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C1037(1.02); C990(0.90); C1015(1.02)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C1037(1.15); C990(1.23); C1015(1.34)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C1037(0.95); C990(1.03)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C1037(0.97); C990(1.01)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C1037(1.79); C990(0.85)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C1037(1.54)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C1015(1.00)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C1037(0.84); C990(0.77); C1015(1.00)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C1037(1.00); C990(0.92); C1015(1.09)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C1015(1.11)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C1037(0.75); C990(1.00); C1015(1.17)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C1037(0.91); C990(0.86); C1015(1.07)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C1037(1.00); C990(1.15); C1015(1.06)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C1037(1.35); C990(1.19); C1015(1.02)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C1037(1.25); C990(1.12); C1015(1.02)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C1037(0.97); C990(1.03)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C1037(0.86); C990(0.86)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C1037(1.09)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C1015(0.96)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C1037(0.84); C990(0.92); C1015(1.08)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C1037(0.95); C990(1.52); C1015(1.18)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C1015(0.90)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C1015(1.13)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C1037(0.73); C990(0.99); C1015(1.12)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C1037(0.76); C990(1.26); C1015(1.13)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C1037(1.11); C990(1.07); C1015(1.01)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C1037(1.06); C990(0.86); C1015(1.37)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C1037(0.72); C990(1.12)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C1037(0.65); C990(0.99)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C1037(0.93); C990(0.88)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C1037(1.00)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C1015(1.05)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C1037(1.00); C990(0.93); C1015(1.10)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C1037(0.71); C990(1.06); C1015(0.96)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C1037(0.62); C990(1.31); C1015(1.09)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C1015(1.10)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C1037(1.17); C990(0.92); C1015(1.10)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C1037(0.91); C990(0.80); C1015(1.04)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C1037(0.87); C990(1.01); C1015(1.01)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C1037(0.76); C990(1.00); C1015(1.34)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C1037(1.01); C990(1.01)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C1037(1.09); C990(0.99)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C1037(1.01); C990(0.84)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C1037(0.88); C990(0.87)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C1037(1.35); C990(0.83)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C1037(0.95); C990(0.92)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C1037(0.99)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C1037(0.88)  LDD1497  [6]
 LDCM0024  KB05 MEWO C1085(2.30)  LDD3319  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C931(0.61)  LDD2120  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
tRNA pseudouridine synthase Pus10 (PUS10) Pseudouridine synthase Pus10 family Q3MIT2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 426 (ZNF426) . Q9BUY5
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
UV excision repair protein RAD23 homolog B (RAD23B) RAD23 family P54727
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
Melanoma-associated antigen B4 (MAGEB4) . O15481

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402