Details of the Target

General Information of Target

Target ID LDTP13259
Target Name NADPH-dependent diflavin oxidoreductase 1 (NDOR1)
Gene Name NDOR1
Gene ID 27158
Synonyms
NR1; NADPH-dependent diflavin oxidoreductase 1; EC 1.18.1.-; NADPH-dependent FMN and FAD-containing oxidoreductase; Novel reductase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG
NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES
VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
Target Bioclass
Enzyme
Family
NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family
Subcellular location
Cytoplasm, perinuclear region
Function
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A. {|HAMAP-Rule:MF_03178}.
Uniprot ID
Q9UHB4
Ensemble ID
ENST00000371521.8
HGNC ID
HGNC:29838

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCLP1 SNV: p.L357F .
FTC133 SNV: p.R75M .
Ishikawa (Heraklio) 02 ER SNV: p.D246A DBIA    Probe Info 
KYM1 SNV: p.M275L DBIA    Probe Info 
LNCaP clone FGC SNV: p.L330V DBIA    Probe Info 
MCAS SNV: p.M564I .
MCC13 Substitution: p.R433W DBIA    Probe Info 
MONOMAC6 SNV: p.K504E .
NCIH23 SNV: p.V194I .
RH41 SNV: p.T60S DBIA    Probe Info 
RKO SNV: p.A86T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C507(0.49)  LDD2227  [1]
DBIA
 Probe Info  		C486(4.79)  LDD0209  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C358(0.00); C507(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C358(0.00); C486(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C263(0.00); C358(0.00); C486(0.00)  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C486(1.32); C507(1.06); C88(0.91); C574(1.08)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C486(1.01); C88(1.08); C574(0.96); C319(1.07)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C486(1.05); C507(0.97); C88(1.07); C574(0.62)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C486(0.95); C507(0.92); C88(1.16); C574(1.05)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C486(1.02); C507(1.31)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C293(1.13); C486(1.09); C507(0.99); C88(1.06)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C486(0.98); C507(1.04); C88(0.93); C574(1.08)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C486(0.94); C88(1.03); C574(0.90); C319(0.82)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C486(0.92); C507(0.79); C88(0.94); C574(0.91)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C486(1.00); C88(1.03); C574(1.07); C319(0.84)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C486(1.01); C507(0.84); C88(1.06); C574(1.01)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C486(0.96); C507(1.18); C88(0.92); C574(0.84)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C486(0.92); C507(1.32)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C293(0.94); C486(0.97); C507(1.17); C88(0.97)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C486(1.06); C507(1.09); C88(0.98); C574(1.00)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C486(1.07); C507(1.27); C88(0.98); C574(0.89)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C486(1.00); C88(0.99); C574(1.07); C319(0.95)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C486(0.99); C507(1.03); C88(1.03); C574(0.87)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C486(1.03); C507(1.00); C88(1.03); C574(0.99)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C486(0.95); C507(1.05); C88(1.04); C574(0.92)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C486(1.09); C507(0.88); C88(0.95); C574(1.13)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C486(1.08); C507(1.11)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C293(1.18); C486(0.91); C507(0.92); C88(1.08)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C486(0.96); C507(1.03); C88(1.08); C574(1.03)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C486(0.99); C507(0.86); C88(0.96); C574(1.07)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C486(1.13); C88(1.00); C574(1.04); C319(0.91)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C486(1.13); C507(1.01); C88(0.91); C574(0.73)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C486(1.10); C507(0.95); C88(1.13); C574(1.21)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C486(1.07); C507(1.18); C88(1.00); C574(0.87)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C486(1.15); C507(1.14)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C293(1.28); C486(0.98); C507(0.95); C88(1.02)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C486(1.20); C507(1.24); C88(1.10); C574(1.17)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C486(1.13); C507(1.10); C88(1.18); C574(1.30)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C486(1.00); C507(1.00); C88(1.12); C574(1.04)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C486(1.05); C88(1.04); C574(0.91); C319(1.21)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C486(0.97); C507(0.78); C88(1.05); C574(0.74)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C486(1.08); C507(1.05); C88(1.05); C574(1.06)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C486(0.92); C507(0.83); C88(1.04); C574(0.94)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C486(0.99); C507(1.29)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C293(1.14); C486(1.09); C507(1.05); C88(0.95)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C486(1.18); C507(1.14); C88(1.12); C574(1.27)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C486(1.02); C507(1.04); C88(0.99); C574(1.11)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C486(1.03); C507(1.28); C88(1.08); C574(0.94)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C486(1.08); C88(1.03); C574(1.12); C319(1.04)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C486(1.13); C507(0.97); C88(0.94); C574(0.76)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C486(1.10); C507(0.99); C88(1.18); C574(1.20)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C486(1.05); C507(1.22); C88(1.02); C574(0.84)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C486(0.91); C507(1.01)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C293(1.25); C486(1.02); C507(0.87); C88(1.06)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C486(1.04); C507(1.34); C88(1.03); C574(1.32)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C486(1.13); C507(0.85); C88(0.96); C574(0.91)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C486(1.09); C88(0.99); C574(0.93); C319(1.39)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C486(1.16); C507(0.77); C88(0.88); C574(0.79)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C486(1.01); C507(1.31)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C486(0.96); C507(0.96); C88(1.04); C574(0.94)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C486(1.04); C507(1.10); C88(0.98); C574(0.84)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C486(0.94); C507(1.02)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C293(1.03); C486(0.99); C507(1.09); C88(1.00)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C486(1.09); C507(0.93); C88(1.02); C574(1.29)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C293(0.89); C486(1.02); C507(1.27); C88(1.09)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C486(1.04); C507(0.99); C88(1.02); C574(0.99)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C486(1.06); C507(1.05); C88(1.03); C574(0.84)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C486(1.04); C507(1.04); C88(1.01); C574(0.90)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C486(1.24); C507(1.01); C88(1.07); C574(1.32)  LDD1514  [6]
 LDCM0632  CL-Sc Hep-G2 C507(0.49)  LDD2227  [1]
 LDCM0367  CL1 HEK-293T C293(1.07); C486(1.14); C88(1.04); C574(0.97)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C486(1.62); C507(0.43)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C486(1.33); C507(0.98); C88(0.90)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C293(0.89); C486(1.17); C88(1.00); C574(1.01)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C486(1.54); C88(1.01); C574(0.75); C319(1.04)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C486(1.00); C507(0.87); C88(1.03); C574(1.14)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C486(0.99); C507(0.97); C88(1.17)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C293(1.02); C486(1.16); C88(1.00); C574(1.05)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C486(1.32); C88(0.99); C574(1.09); C319(0.86)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C486(0.88); C507(0.85); C88(1.12); C574(1.16)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C486(0.85); C507(0.81); C88(0.96)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C293(0.94); C486(1.13); C88(1.00); C574(0.93)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C293(0.79); C486(1.22); C507(0.92); C88(1.07)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C486(1.45); C88(0.99); C574(0.83); C319(0.75)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C486(1.04); C507(0.86); C88(0.98); C574(1.22)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C486(1.43); C507(0.74); C88(0.91)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C293(1.06); C486(1.01); C88(1.03); C574(1.09)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C486(1.18); C88(0.97); C574(1.45); C319(0.92)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C486(1.02); C507(1.13); C88(1.15); C574(1.24)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C486(0.98); C507(0.87); C88(1.03)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C293(1.00); C486(1.10); C88(1.08); C574(1.04)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C486(1.36); C88(1.06); C574(1.08); C319(1.01)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C486(0.99); C507(0.91); C88(1.18); C574(1.28)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C486(1.44); C507(1.00); C88(1.15); C574(1.59)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C486(0.84); C507(0.97); C88(1.15)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C293(0.95); C486(1.04); C88(1.00); C574(0.95)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C486(1.15); C88(1.07); C574(1.01); C319(1.01)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C486(1.31); C507(1.16); C88(0.97); C574(1.11)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C486(0.89); C507(0.95); C88(1.00)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C293(0.96); C486(0.98); C88(0.98); C574(0.96)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C486(1.18); C88(1.06); C574(1.12); C319(1.09)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C486(1.08); C507(0.85); C88(1.03); C574(1.04)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C486(1.05); C507(0.94); C88(1.04)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C293(1.01); C486(0.90); C88(1.03); C574(0.94)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C486(1.09); C88(1.10); C574(1.43); C319(0.92)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C486(1.07); C507(1.10); C88(0.91); C574(1.09)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C486(0.89); C507(0.86); C88(1.07)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C486(1.34); C507(0.87); C88(1.02); C574(1.00)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C486(1.08); C88(1.04); C574(0.94); C319(0.79)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C486(1.06); C507(0.80); C88(1.08); C574(1.02)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C486(1.36); C88(1.01); C574(1.08); C319(0.94)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C486(0.97); C507(0.75); C88(1.18); C574(0.85)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C486(1.91); C507(0.92); C88(1.02); C574(0.84)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C486(1.17); C507(0.96)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C293(1.24); C486(1.13); C507(0.85); C88(1.20)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C486(1.67); C507(0.91); C88(1.28); C574(1.11)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C293(1.05); C486(1.56); C88(0.90); C574(0.90)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C486(1.28); C88(1.02); C574(1.05); C319(1.01)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C486(1.04); C507(1.04); C88(1.11); C574(1.07)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C486(0.95); C507(0.78); C88(1.00)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C486(0.98); C507(0.98); C88(1.03); C574(0.93)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C486(1.05); C507(1.03); C88(0.98); C574(1.25)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C486(1.02); C88(1.03); C574(0.78); C319(0.85)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C486(1.13); C507(0.88); C88(1.17); C574(0.90)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C486(1.28); C507(0.90); C88(1.15); C574(1.36)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C486(2.19); C507(0.86); C88(0.93); C574(0.77)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C486(1.14); C507(0.80)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C293(0.96); C486(1.05); C507(0.76); C88(1.09)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C486(1.25); C507(0.96); C88(1.04); C574(1.47)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C293(0.99); C486(1.26); C88(1.02); C574(0.98)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C486(1.35); C507(0.94); C88(1.25); C574(1.16)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C486(1.04); C507(0.97); C88(1.06)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C486(0.92); C507(0.85); C88(1.06)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C486(1.24); C507(1.24); C88(0.89); C574(0.86)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C486(1.02); C88(0.94); C574(0.87); C319(1.05)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C486(1.04); C507(0.85); C88(1.11); C574(0.64)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C486(0.96); C507(0.86); C88(1.16); C574(0.91)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C486(1.46); C507(0.80); C88(1.02); C574(1.00)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C486(1.09); C507(1.07)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C293(1.11); C486(1.10); C507(0.82); C88(1.08)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C486(1.43); C507(0.94); C88(1.02); C574(1.03)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C293(1.06); C486(1.03); C88(1.01); C574(0.88)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C486(1.21); C507(1.27); C88(1.14); C574(1.10)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C486(1.68); C88(0.99); C574(0.95); C319(0.85)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C486(0.99); C507(0.80); C88(0.98)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C486(1.17); C507(0.87); C88(0.96); C574(0.89)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C486(0.99); C88(1.12); C574(0.86); C319(0.71)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C486(1.06); C507(0.84); C88(1.03); C574(1.10)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C486(1.02); C507(0.83); C88(1.07); C574(1.12)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C486(1.69); C507(0.75); C88(0.97); C574(0.71)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C486(1.32); C507(1.26)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C293(0.93); C486(1.07); C507(0.80); C88(1.05)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C486(1.04); C88(1.08); C574(1.04); C319(0.56)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C486(1.70); C507(0.83); C88(1.19); C574(1.11)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C293(1.01); C486(1.00); C88(1.06); C574(1.10)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C486(1.57); C88(1.10); C574(1.25); C319(0.90)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C486(1.10); C507(1.14); C88(1.08); C574(1.10)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C486(1.19); C507(0.93); C88(0.96)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C486(1.01); C507(1.04); C88(0.99); C574(0.95)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C486(1.14); C88(1.04); C574(1.05); C319(0.86)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C486(1.09); C507(0.93); C88(1.04); C574(0.93)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C486(0.93); C507(0.86); C88(0.92); C574(1.28)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C486(1.32); C507(0.99); C88(1.14); C574(0.90)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C486(1.03); C507(1.00); C88(0.98); C574(0.81)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C486(0.98); C507(0.92)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C293(1.08); C486(1.07); C507(1.13); C88(1.06)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C486(1.34); C507(0.89); C88(1.06); C574(1.18)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C293(0.91); C486(1.03); C88(1.03); C574(1.09)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C486(1.16); C88(1.01); C574(1.15); C319(0.94)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C486(0.98); C507(0.94); C88(1.09)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C486(1.20); C507(0.93); C88(0.96); C574(0.89)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C486(1.19); C88(1.09); C574(1.17); C319(0.84)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C486(1.05); C507(0.99); C88(0.95); C574(1.02)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C486(1.30); C507(0.89); C88(0.98); C574(0.93)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C486(0.98); C507(0.95); C88(1.15); C574(1.09)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C486(1.02); C507(1.00); C88(1.11); C574(0.90)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C486(0.94); C507(1.14)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C293(1.17); C486(0.98); C507(1.06); C88(1.18)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C486(1.21); C507(0.78); C88(0.97); C574(1.09)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C293(0.92); C486(1.03); C88(1.09); C574(1.04)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C486(1.33); C88(1.05); C574(1.05); C319(0.84)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C486(1.04); C507(1.10); C88(1.04); C574(1.38)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C486(0.91); C507(0.94); C88(1.06)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C486(1.30); C507(1.03); C88(1.02); C574(0.95)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C486(1.67); C507(1.45); C88(1.01); C574(0.95)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C486(1.47); C88(0.91); C574(0.39); C319(0.73)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C486(1.18); C507(1.05); C88(1.08); C574(0.82)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C486(1.16); C507(0.98); C88(0.97); C574(1.09)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C486(1.30); C507(0.94); C88(0.98); C574(0.75)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C486(1.09); C507(0.89)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C293(1.07); C486(1.61); C507(1.38); C88(1.04)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C486(1.66); C507(0.98); C88(1.15); C574(1.21)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C293(0.94); C486(1.15); C88(0.95); C574(0.95)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C486(1.52); C88(0.99); C574(0.81); C319(1.00)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C486(1.08); C507(1.01); C88(1.07); C574(1.18)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C486(1.12); C507(0.96); C88(1.11); C574(1.19)  LDD1698  [6]
 LDCM0625  F8 Ramos C486(0.68)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C507(9.81)  LDD2190  [7]
 LDCM0575  Fragment13 Ramos C507(0.44)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C507(1.62); C486(3.10)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C507(1.45)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C507(1.60)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C507(0.84); C486(0.99)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C507(0.96); C486(0.88)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C507(0.80); C486(1.55)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C507(1.13)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C507(1.40); C486(0.70)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C507(0.73)  LDD2201  [7]
 LDCM0468  Fragment33 HEK-293T C486(0.99); C507(1.18); C88(1.12); C574(1.12)  LDD1671  [6]
 LDCM0566  Fragment4 Ramos C507(0.71)  LDD2184  [7]
 LDCM0427  Fragment51 HEK-293T C486(1.15); C88(0.97); C574(1.28); C319(1.01)  LDD1631  [6]
 LDCM0614  Fragment56 Ramos C486(0.80)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C507(0.86)  LDD2186  [7]
 LDCM0022  KB02 HEK-293T C574(0.88)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C486(4.79)  LDD0209  [2]
 LDCM0024  KB05 MKN-1 C507(2.29)  LDD3331  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-6 (PSMB6) Peptidase T1B family P28072
Serine/threonine-protein kinase NLK (NLK) CMGC Ser/Thr protein kinase family Q9UBE8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B2 (HOXB2) Antp homeobox family P14652
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Homeobox protein MOX-1 (MEOX1) . P50221
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anamorsin (CIAPIN1) Anamorsin family Q6FI81
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
Centrosomal AT-AC splicing factor (CENATAC) . Q86UT8
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
G protein pathway suppressor 2 (GPS2) . Q13227
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840