Details of the Target

General Information of Target

Target ID LDTP12809
Target Name Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8)
Gene Name SLC2A8
Gene ID 29988
Synonyms
GLUT8; GLUTX1; Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDFLVVGSIRKLA
SASLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGLGLEEYDED
DLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGM
EEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEG
RIKLQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLRSLVGLQEELLFQY
PDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFT
VYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVL
GKPEPAAQPVPESLPGEPEILPQAPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLD
PNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDAR
TELYRSLFGQLHPPDEGHGD
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
Subcellular location
Cell membrane
Function
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate.
Uniprot ID
Q9NY64
Ensemble ID
ENST00000373371.8
HGNC ID
HGNC:13812
ChEMBL ID
CHEMBL4295964

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C348
 Probe Info  		17.15  LDD2009  [1]
C349
 Probe Info  		9.06  LDD2010  [1]
C350
 Probe Info  		36.76  LDD2011  [1]
C390
 Probe Info  		34.30  LDD2049  [1]

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587