Details of the Target

General Information of Target

Target ID LDTP12668
Target Name Sodium-coupled neutral amino acid transporter 7 (SLC38A7)
Gene Name SLC38A7
Gene ID 55238
Synonyms
SNAT7; Sodium-coupled neutral amino acid transporter 7; Solute carrier family 38 member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDT
LFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEY
IDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIP
IIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGST
EEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRC
KLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAE
KELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAAQLLQSQAQQSGAQQTKKD
KDKKNASFT
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Amino acid/polyamine transporter 2 family
Subcellular location
Lysosome membrane
Function
Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.
TTD ID
T93337
Uniprot ID
Q9NVC3
DrugMap ID
TTEARWC
Ensemble ID
ENST00000219320.9
HGNC ID
HGNC:25582

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 Deletion: p.V357CfsTer38 DBIA    Probe Info 
HUCCT1 SNV: p.E40Q .
TOV21G SNV: p.S169G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C30(2.18)  LDD3312  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
AOyne
 Probe Info  		13.70  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C30(0.94); C123(0.96)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C30(0.93); C123(0.85)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C30(1.00); C123(1.17)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C30(0.91); C123(0.99)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C30(0.84); C123(1.07)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C30(0.96); C123(1.01)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C30(1.08); C123(0.99)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C30(0.90); C123(0.85)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C30(1.13); C123(0.97)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C30(0.89); C123(0.80)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C30(0.93); C123(0.94)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C30(0.98)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C30(0.87); C123(0.97)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C30(0.97); C123(0.98)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C30(0.97); C123(0.99)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C30(1.01); C123(1.02)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C30(0.98); C123(0.90)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C30(1.00); C123(0.93)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C30(1.01); C123(0.87)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C30(0.98)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C30(1.01); C123(0.96)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C30(0.94); C123(0.99)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C30(0.96); C123(0.97)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C30(0.99); C123(0.91)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C30(1.07); C123(1.03)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C30(0.91); C123(0.86)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C30(1.08); C123(1.03)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C30(0.85); C123(0.93)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C30(0.95)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C30(0.80); C123(1.09)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C30(0.94); C123(0.99)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C30(0.93); C123(0.98)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C30(0.98); C123(1.01)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C30(1.04); C123(1.10)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C30(0.92); C123(0.72)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C30(1.04); C123(1.14)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C30(0.94); C123(0.97)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C30(0.96)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C30(0.81); C123(1.08)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C30(0.85); C123(0.91)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C30(0.93); C123(1.10)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C30(1.05); C123(1.03)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C30(1.06)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C30(0.91); C123(0.78)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C30(1.02); C123(1.04)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C30(0.97); C123(0.86)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C30(0.99)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C30(0.86); C123(1.20)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C30(0.86); C123(1.01)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C30(0.99); C123(1.03)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C30(1.15); C123(0.93)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C30(0.91); C123(0.94)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C30(0.99); C123(1.11)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C30(0.83); C123(1.08)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C30(0.95); C123(0.92)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C30(1.05)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C30(0.92); C123(1.07)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C30(0.94); C123(1.04)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C30(1.01); C123(0.97)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C30(0.98); C123(0.98)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C30(0.97); C123(1.03)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C30(1.05)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C30(1.10); C123(1.19)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C30(1.00); C123(1.05)  LDD1514  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C30(1.00); C123(1.11)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C30(0.89); C123(1.41)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C30(0.97); C123(0.93)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C30(1.03); C123(1.08)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C30(0.92); C123(0.92)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C30(0.88); C123(0.96)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C30(0.94); C123(1.01)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C30(0.98); C123(0.98)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C30(0.93); C123(1.04)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C30(0.85); C123(0.96)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C30(0.97); C123(0.94)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C30(1.01); C123(1.11)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C30(0.98); C123(1.69)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C30(0.92); C123(1.02)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C30(0.93); C123(0.97)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C30(0.99); C123(0.94)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C30(1.03); C123(0.98)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C30(0.91); C123(1.07)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C30(0.88); C123(0.97)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C30(0.89); C123(0.93)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C30(0.96); C123(1.13)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C30(0.95); C123(1.10)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C30(1.00); C123(0.97)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C30(1.04); C123(1.44)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C30(0.93); C123(0.98)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C30(1.01); C123(1.12)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C30(0.91); C123(0.93)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C30(0.82); C123(0.96)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C30(0.91); C123(0.92)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C30(1.00); C123(1.21)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C30(0.91); C123(1.02)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C30(0.88); C123(0.99)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C30(1.00); C123(0.92)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C30(1.10); C123(1.20)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C30(0.93); C123(1.05)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C30(0.80); C123(0.99)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C30(1.05); C123(1.03)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C30(1.04); C123(1.18)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C30(0.94); C123(0.91)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C30(1.03); C123(1.15)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C30(0.94); C123(1.16)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C30(0.95); C123(1.20)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C30(1.20)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C30(0.99); C123(1.49)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C30(1.01); C123(1.62)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C30(1.11); C123(1.48)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C30(1.02); C123(1.17)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C30(0.97); C123(0.98)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C30(0.87); C123(0.97)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C30(0.97); C123(0.97)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C30(1.00); C123(1.32)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C30(0.93); C123(1.02)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C30(0.91); C123(1.00)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C30(1.00); C123(1.31)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C30(0.93); C123(1.22)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C30(1.22)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C30(0.99); C123(1.49)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C30(0.99); C123(1.49)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C30(1.10); C123(1.39)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C30(0.91); C123(1.09)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C30(0.89); C123(0.93)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C30(1.00); C123(1.12)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C30(0.91); C123(0.98)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C30(1.00); C123(1.21)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C30(0.94); C123(0.92)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C30(1.01); C123(1.19)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C30(0.98); C123(1.05)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C30(1.20)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C30(0.95); C123(1.34)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C30(1.02); C123(1.51)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C30(1.10); C123(1.45)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C30(0.95); C123(1.13)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C30(1.17); C123(1.13)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C30(0.85); C123(1.02)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C30(0.97); C123(0.98)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C30(1.04); C123(1.04)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C30(0.87); C123(1.10)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C30(0.97); C123(1.04)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C30(0.95); C123(1.21)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C30(1.06)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C30(0.91); C123(1.41)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C30(0.96); C123(1.53)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C30(0.92); C123(0.97)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C30(0.95); C123(1.35)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C30(0.98); C123(1.09)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C30(0.91); C123(1.00)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C30(0.91); C123(0.93)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C30(0.99); C123(0.98)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C30(1.01); C123(0.98)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C30(0.97); C123(0.82)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C30(1.05); C123(1.03)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C30(0.87); C123(1.18)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C30(1.12)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C30(1.07); C123(1.45)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C30(0.86); C123(1.41)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C30(0.95); C123(1.62)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C30(1.02); C123(1.34)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C30(0.97); C123(1.08)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C30(0.95); C123(1.01)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C30(0.93); C123(0.98)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C30(1.06); C123(1.04)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C30(1.01); C123(1.05)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C30(0.99); C123(1.08)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C30(0.96); C123(1.43)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C30(0.92); C123(1.13)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C30(1.17)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C30(0.84); C123(1.38)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C30(0.93); C123(1.31)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C30(1.04); C123(1.25)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C30(1.02); C123(1.21)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C30(0.90); C123(1.09)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C30(0.88); C123(1.09)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C30(0.95); C123(1.07)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C30(1.02); C123(1.07)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C30(1.11)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C30(0.96); C123(1.13)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C30(1.06); C123(1.30)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C30(0.89); C123(1.16)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C30(1.20)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C30(0.93); C123(1.27)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C30(0.98); C123(1.43)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C30(0.96); C123(1.31)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C30(0.97); C123(1.12)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C30(0.94); C123(1.06)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C30(0.91); C123(0.97)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C30(0.91); C123(0.98)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C30(0.85); C123(0.95)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C30(0.90); C123(1.07)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C30(1.03)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C30(1.09)  LDD1497  [9]
 LDCM0024  KB05 HMCB C30(2.18)  LDD3312  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-secretase subunit APH-1A (APH1A) APH-1 family Q96BI3
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Proton-coupled zinc antiporter SLC30A2 (SLC30A2) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q9BRI3
H(+)/Cl(-) exchange transporter 7 (CLCN7) Chloride channel (TC 2.A.49) family P51798
Claudin-7 (CLDN7) Claudin family O95471
Gap junction alpha-8 protein (GJA8) Connexin family P48165
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
Aquaporin-9 (AQP9) MIP/aquaporin (TC 1.A.8) family O43315
Pannexin-1 (PANX1) Pannexin family Q96RD7
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family Q9H2J7
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) . Q9Y5Y7
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) BZIP family Q68CJ9
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Amphoterin-induced protein 1 (AMIGO1) AMIGO family Q86WK6
Programmed cell death 1 ligand 2 (PDCD1LG2) BTN/MOG family Q9BQ51
HERV-H LTR-associating protein 2 (HHLA2) . Q9UM44
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ectodysplasin-A (EDA) Tumor necrosis factor family Q92838
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Gap junction beta-5 protein (GJB5) Connexin family O95377
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Tetraspanin-8 (TSPAN8) Tetraspanin (TM4SF) family P19075
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
C-type lectin domain family 10 member A (CLEC10A) . Q8IUN9
Endoplasmic reticulum resident protein 29 (ERP29) . P30040
Lymphocyte antigen 6 complex locus protein G6c (LY6G6C) . O95867
Outer dense fiber protein 4 (ODF4) . Q2M2E3
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402