Details of the Target

General Information of Target

Target ID LDTP12513
Target Name Disrupted in schizophrenia 1 protein (DISC1)
Gene Name DISC1
Gene ID 27185
Synonyms
KIAA0457; Disrupted in schizophrenia 1 protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDE
MDRSREVVQELIDEYHAATQPDYISWGTQEQ
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation.
Uniprot ID
Q9NRI5
Ensemble ID
ENST00000317586.8
HGNC ID
HGNC:2888

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.L829P .
HT115 SNV: p.A410T .
KYM1 SNV: p.S715Y .
MEWO SNV: p.F147I .
RL952 SNV: p.R455Ter .
SNU5 SNV: p.K482I .
TC71 SNV: p.G4W .
TE11 SNV: p.R289L .
TOV21G SNV: p.E739Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C684(1.02)  LDD2229  [2]
DBIA
 Probe Info  		C86(0.89)  LDD1507  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C86(0.89)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C86(1.03); C844(0.74)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C844(1.01)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C86(0.90); C844(1.04)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C844(1.00)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C86(1.01)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C86(0.87); C844(0.87)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C86(1.11); C844(0.93)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C844(0.99)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C844(1.47)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C86(0.83); C844(1.11)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C844(0.97)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C86(1.37); C844(1.08)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C86(0.94)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C86(1.06); C844(0.77)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C844(0.79)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C844(1.11)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C86(1.07); C844(1.12)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C844(1.16)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C86(1.26); C844(0.81)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C86(0.83)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C86(1.11); C844(0.96)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C844(0.96)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C844(1.22)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C86(1.05); C844(1.04)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C844(1.07)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C844(0.91)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C86(1.24); C844(0.91)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C86(0.82)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C86(1.01); C844(0.70)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C844(0.99)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C844(1.33)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C86(1.17); C844(1.08)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C844(0.98)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C86(1.02); C844(0.99)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C86(1.18)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C844(1.03)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C86(0.93); C844(0.70)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C844(1.06)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C844(2.11)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C86(0.74); C844(1.16)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C844(0.65)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C86(1.07); C844(0.99)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C86(1.10)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C86(0.95); C844(0.84)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C86(1.09); C844(1.00)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C844(1.04)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C844(1.39)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C86(1.23); C844(1.03)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C844(0.88)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C86(1.04); C844(0.90)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C844(0.91)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C86(1.20); C844(1.12)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C844(1.18)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C86(0.99)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C86(1.10); C844(0.92)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C86(1.20)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C86(1.84); C844(1.02)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C844(0.81)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C86(0.99)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C86(1.07); C844(0.83)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C844(0.88)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C86(1.61)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C86(1.00); C844(1.03)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C844(1.07)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C86(1.30)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C844(1.17)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C86(0.76); C844(0.99)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C844(0.99)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C86(1.21)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C86(1.07); C844(0.93)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C844(1.02)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C86(1.17)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C86(1.10); C844(1.09)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C86(1.16); C844(0.99)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C844(0.96)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C86(1.08)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C86(1.07); C844(0.95)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C844(0.97)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C86(1.27)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C86(1.03); C844(1.06)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C844(0.91)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C86(1.06)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C86(1.31); C844(1.04)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C844(0.94)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C86(0.98)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C86(0.85); C844(0.70)  LDD1609  [3]
 LDCM0408  CL20 HEK-293T C844(1.02)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C844(1.33)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C86(0.52); C844(1.06)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C844(1.05)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C86(1.21); C844(0.94)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C86(1.12)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C86(0.95); C844(1.03)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C844(0.93)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C86(1.39)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C86(0.96); C844(1.13)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C86(0.88); C844(0.81)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C844(1.03)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C844(1.39)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C86(1.10); C844(0.97)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C844(0.74)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C86(0.96); C844(0.91)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C86(0.84)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C86(0.92); C844(1.17)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C844(1.02)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C844(0.90)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C86(1.30)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C86(1.26); C844(1.04)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C844(0.91)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C844(0.81)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C86(0.85); C844(0.92)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C844(0.91)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C86(0.81); C844(0.96)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C86(1.53)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C86(1.06)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C844(1.14)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C86(1.15)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C86(1.12); C844(0.77)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C844(1.00)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C844(1.20)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C86(1.28); C844(1.07)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C844(0.94)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C86(1.03); C844(0.78)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C86(1.05); C844(0.86)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C86(1.38)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C86(1.17); C844(0.89)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C844(0.87)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C86(0.88)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C86(0.95); C844(0.77)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C844(0.92)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C844(1.26)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C86(1.33); C844(0.91)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C844(1.23)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C86(1.09); C844(1.08)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C86(1.04)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C844(0.89)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C86(1.47)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C86(0.93); C844(0.85)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C844(0.96)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C844(1.04)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C844(1.02)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C86(1.52); C844(0.78)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C844(0.98)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C86(1.10); C844(1.04)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C86(1.19)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C86(0.98); C844(0.95)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C844(0.96)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C86(1.26)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C844(1.16)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C86(1.45); C844(0.78)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C844(1.08)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C844(1.43)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C86(0.65); C844(0.90)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C844(0.92)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C86(1.23); C844(0.80)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C86(1.42)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C86(0.81); C844(0.95)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C86(0.93); C844(1.04)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C86(1.06); C844(0.93)  LDD1671  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 25 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-3' exoribonuclease 2 (XRN2) 5'-3' exonuclease family Q9H0D6
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
E3 ubiquitin-protein ligase BRE1B (RNF40) BRE1 family O75150
Histone-lysine N-methyltransferase SMYD1 (SMYD1) Class V-like SAM-binding methyltransferase superfamily Q8NB12
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Triple functional domain protein (TRIO) CAMK Ser/Thr protein kinase family O75962
Cyclin-dependent kinase-like 3 (CDKL3) CMGC Ser/Thr protein kinase family Q8IVW4
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) STE Ser/Thr protein kinase family O95819
TRAF2 and NCK-interacting protein kinase (TNIK) STE Ser/Thr protein kinase family Q9UKE5
GTP-binding protein GEM (GEM) RGK family P55040
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Kinesin-like protein KIF3A (KIF3A) Kinesin family Q9Y496
Kinesin-like protein KIF3C (KIF3C) Kinesin family O14782
E3 ubiquitin-protein ligase TRIM68 (TRIM68) TRIM/RBCC family Q6AZZ1
2-aminoethanethiol dioxygenase (ADO) . Q96SZ5
Tripartite motif-containing protein 29 (TRIM29) . Q14134
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Importin subunit beta-1 (KPNB1) Importin beta family Q14974
MICOS complex subunit MIC60 (IMMT) MICOS complex subunit Mic60 family Q16891
Nuclear pore membrane glycoprotein 210 (NUP210) NUP210 family Q8TEM1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1) Plakin or cytolinker family Q9UPN3
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) Spectrin family Q01082
N-terminal EF-hand calcium-binding protein 1 (NECAB1) . Q8N987
Nuclear pore complex protein Nup160 (NUP160) . Q12769
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) BZIP family Q9Y2D1
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
PHD finger protein 1 (PHF1) Polycomblike family O43189
Bromodomain-containing protein 1 (BRD1) . O95696
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Transcriptional repressor p66-beta (GATAD2B) . Q8WXI9
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
D(2) dopamine receptor (DRD2) G-protein coupled receptor 1 family P14416
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 141 (CCDC141) . Q6ZP82
Other
Click To Hide/Show 63 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Centrosomal protein of 170 kDa (CEP170) CEP170 family Q5SW79
Centrosomal protein of 63 kDa (CEP63) CEP63 family Q96MT8
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Clusterin (CLU) Clusterin family P10909
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
Eukaryotic translation initiation factor 3 subunit H (EIF3H) EIF-3 subunit H family O15372
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Phakinin (BFSP2) Intermediate filament family Q13515
Liprin-alpha-3 (PPFIA3) Liprin family O75145
Microtubule-associated protein 1A (MAP1A) MAP1 family P78559
Activating transcription factor 7-interacting protein 1 (ATF7IP) MCAF family Q6VMQ6
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
Nesprin-1 (SYNE1) Nesprin family Q8NF91
Nuclear distribution protein nudE homolog 1 (NDE1) NudE family Q9NXR1
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Ran-binding protein 9 (RANBP9) RANBP9/10 family Q96S59
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Structural maintenance of chromosomes protein 5 (SMC5) SMC family Q8IY18
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) Spectrin family Q13813
Spectrin beta chain, non-erythrocytic 4 (SPTBN4) Spectrin family Q9H254
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1
Syntaxin-11 (STX11) Syntaxin family O75558
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
TRAF3-interacting protein 1 (TRAF3IP1) TRAF3IP1 family Q8TDR0
Pre-rRNA-processing protein TSR2 homolog (TSR2) TSR2 family Q969E8
Collagen alpha-2(VI) chain (COL6A2) Type VI collagen family P12110
UPF0488 protein C8orf33 (C8orf33) UPF0488 family Q9H7E9
Gelsolin (GSN) Villin/gelsolin family P06396
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) WD repeat LIS1/nudF family P43034
A-kinase anchor protein 9 (AKAP9) . Q99996
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
BAG family molecular chaperone regulator 2 (BAG2) . O95816
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Coiled-coil domain-containing protein 92 (CCDC92) . Q53HC0
Cytoplasmic protein NCK2 (NCK2) . O43639
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
DnaJ homolog subfamily C member 7 (DNAJC7) . Q99615
Dystonin (DST) . Q03001
F-box only protein 34 (FBXO34) . Q9NWN3
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Intersectin-1 (ITSN1) . Q15811
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Matrin-3 (MATR3) . P43243
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Myomegalin (PDE4DIP) . Q5VU43
Noelin (OLFM1) . Q99784
Pericentrin (PCNT) . O95613
RNA-binding protein 41 (RBM41) . Q96IZ5
Uncharacterized protein CCDC197 (CCDC197) . Q8NCU1

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.