Details of the Target

General Information of Target

Target ID LDTP12446
Target Name Putative histone-lysine N-methyltransferase PRDM6 (PRDM6)
Gene Name PRDM6
Gene ID 93166
Synonyms
PFM3; Putative histone-lysine N-methyltransferase PRDM6; EC 2.1.1.361; PR domain zinc finger protein 6; PR domain-containing protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPV
TSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPA
APVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKP
TEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRL
VFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKF
QLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYL
LFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEI
VFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVR
TWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRL
KSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG
GNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRK
DLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQ
KENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTS
RQSLIISMAPSAEGGEEVLTIEVKEKAKQ
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily
Subcellular location
Nucleus
Function
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.
Uniprot ID
Q9NQX0
Ensemble ID
ENST00000407847.5
HGNC ID
HGNC:9350
ChEMBL ID
CHEMBL5214858

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C426(1.05)  LDD1492  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		C138(0.00); C426(0.00); C150(0.00); C332(0.00)  LDD2156  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C332(1.00); C426(0.95)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C332(1.22)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C332(1.10); C426(0.94); C138(1.11)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C332(1.10); C426(0.80)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C332(0.73); C426(1.00)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C332(1.85); C426(1.00)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C332(0.99); C426(1.18)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C332(1.21)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C332(1.17); C426(1.13); C138(1.26)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C332(1.12)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C332(0.85); C426(0.80)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C332(1.07); C426(1.10)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C332(0.84); C426(1.09)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C332(1.24); C426(1.04)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C426(0.73)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C332(0.87); C426(1.16)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C332(1.19)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C332(1.10); C426(1.20); C138(1.18)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C332(0.77); C426(0.99)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C332(1.09); C426(0.99)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C332(1.04); C426(0.93); C138(1.09)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C332(0.74); C426(0.97)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C332(1.17); C426(0.87)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C426(0.86)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C332(1.13); C426(0.87)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C332(1.32)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C332(1.14); C426(0.94); C138(1.02)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C332(0.88); C426(0.86)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C332(1.21); C426(1.00)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C332(0.79); C426(1.05)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C332(0.98); C426(0.93)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C332(0.99); C426(0.72)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C426(0.65)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C332(0.88); C426(1.01)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C332(1.33)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C332(1.23); C426(0.95); C138(1.12)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C332(0.83); C426(0.87)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C332(1.11); C426(1.16)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C332(0.86); C426(1.06)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C332(1.75); C426(0.98)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C426(0.75)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C332(1.00); C426(1.01)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C332(0.95); C426(0.97)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C332(1.26)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C332(1.03); C426(1.17); C138(1.00)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C332(1.03); C426(0.89)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C332(1.05); C426(1.05)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C332(0.96); C426(1.08)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C332(1.04); C426(0.96)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C426(0.80)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C332(1.03); C426(1.05)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C332(1.20)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C332(1.11); C426(1.09); C138(1.16)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C332(0.81); C426(0.91)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C332(0.87); C426(0.84)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C332(1.11); C426(1.17)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C332(0.95); C426(0.97)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C332(0.93); C426(1.09)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C426(0.76)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C332(0.96); C426(0.88)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C426(0.63)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C332(1.08); C426(1.14)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C332(1.22); C426(1.06)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C426(0.72)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C332(1.66); C426(1.23)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C332(1.33); C426(1.16)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C332(1.17)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C332(1.22); C426(1.09)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C332(1.23); C426(1.17); C138(1.10)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C426(1.05); C138(0.77)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C332(0.97)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C332(1.17); C426(0.94)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C332(0.93); C426(0.89); C138(0.82)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C426(1.01); C138(0.70)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C332(1.21)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C332(1.62); C426(1.02)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C332(1.65); C426(1.13)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C332(0.98); C426(1.03); C138(0.94)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C426(1.34); C138(0.83)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C332(1.04)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C332(1.34); C426(1.25)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C332(1.20); C426(0.85); C138(1.06)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C426(0.86); C138(1.08)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C332(1.39)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C332(0.92); C426(1.27)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C332(1.01); C426(0.99); C138(1.12)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C426(1.07); C138(0.88)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C426(1.19)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C332(1.11)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C332(1.55); C426(1.23)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C332(1.05); C426(1.19); C138(0.92)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C426(0.95); C138(0.90)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C332(1.08)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C332(1.27); C426(1.39)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C332(1.27); C426(0.79); C138(0.95)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C426(1.26); C138(0.87)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C332(1.17)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C332(1.57); C426(1.75)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C332(0.94); C426(0.94); C138(0.99)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C426(1.22); C138(0.89)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C332(1.10)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C332(1.07); C426(1.25)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C332(1.21)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C332(1.18); C426(1.21); C138(1.04)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C332(1.06); C426(0.94); C138(1.08)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C332(1.52); C426(1.04)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C332(1.26); C426(1.85)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C332(1.24); C426(1.02)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C332(1.32); C426(1.24)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C426(1.41)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C332(1.47); C426(1.35)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C332(1.01); C426(0.91); C138(1.05)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C426(1.23); C138(0.72)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C332(1.08)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C332(1.15); C426(1.20)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C426(1.15); C138(0.78)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C332(1.07)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C332(1.05); C426(1.17); C138(1.19)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C332(1.17); C426(0.88)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C332(1.43); C426(1.41)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C332(0.88); C426(1.23)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C332(1.44); C426(0.93)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C426(0.87)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C332(0.93); C426(1.23)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C426(1.16); C138(0.73)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C332(1.19)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C332(0.95)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C332(0.93); C426(1.03)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C332(1.30)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C332(1.10); C426(1.11); C138(1.00)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C332(1.17); C426(1.01)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C332(1.18); C426(1.27)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C332(0.91); C426(0.97)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C332(1.45); C426(0.95)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C426(0.76)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C332(1.15); C426(1.19)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C332(1.02); C426(1.37)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C332(0.96); C426(0.76); C138(0.88)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C332(1.27)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C332(0.91); C426(1.56)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C332(1.27)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C332(1.23); C426(1.24); C138(1.15)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C332(1.19); C426(1.17)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C332(1.47); C426(1.02)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C332(0.94); C426(1.01)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C332(1.46); C426(1.17)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C332(1.27)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C426(0.87)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C332(1.17); C426(1.63)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C332(1.14); C426(0.86); C138(1.04)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C426(1.12); C138(1.00)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C332(1.23)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C332(0.98); C426(1.16)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C332(1.31)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C332(1.09); C426(1.11); C138(1.25)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C332(1.28); C426(1.06)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C332(1.36); C426(0.99)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C332(1.13); C426(1.15); C138(1.21)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C332(0.99); C426(0.98)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C332(1.52); C426(1.58)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C426(1.19)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C332(1.23); C426(1.36)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C332(1.01); C426(1.25); C138(0.84)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C332(1.06)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C332(1.33); C426(1.08)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C332(1.41)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C332(0.97); C426(1.06); C138(1.10)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C332(1.54); C426(1.17)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C332(1.27); C426(0.94)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C332(1.29); C426(1.65)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C332(1.01); C426(0.89)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C332(2.06); C426(1.02)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C426(1.02)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C332(1.11); C426(1.15)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C332(0.97); C426(0.91); C138(0.87)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C426(0.94); C138(0.84)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C332(1.09)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C332(0.82); C426(1.04)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C332(1.23); C426(1.39)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C332(1.71)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C332(1.10); C426(1.09); C138(1.18)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C332(0.94); C426(0.86)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C332(1.33); C426(1.16)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C332(0.93); C426(1.29)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C332(1.13); C426(0.88)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C426(0.76)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C332(1.31); C426(1.06)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C332(1.28); C426(0.87); C138(1.07)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C426(1.03); C138(0.84)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C426(1.25); C138(1.01)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C426(1.08); C138(0.74)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C332(1.11); C426(0.81); C138(0.88)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C426(1.05)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C426(1.02)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C426(1.01)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) Adenosylhomocysteinase family O43865
tRNA wybutosine-synthesizing protein 2 homolog (TRMT12) TRM5/TYW2 family Q53H54
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Alanine--glyoxylate aminotransferase (AGXT) Class-V pyridoxal-phosphate-dependent aminotransferase family P21549
Glutaredoxin domain-containing cysteine-rich protein 1 (GRXCR1) GRXCR1 family A8MXD5
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Protein-tyrosine kinase 6 (PTK6) Tyr protein kinase family Q13882
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
GTP-binding protein GEM (GEM) RGK family P55040
Tripartite motif-containing protein 14 (TRIM14) TRIM/RBCC family Q14142
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Forkhead box protein D4-like 1 (FOXD4L1) . Q9NU39
Other
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cyclin-L1 (CCNL1) Cyclin family Q9UK58
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
Tektin-4 (TEKT4) Tektin family Q8WW24
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
BAG family molecular chaperone regulator 3 (BAG3) . O95817
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Chromobox protein homolog 8 (CBX8) . Q9HC52
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Cytoplasmic protein NCK2 (NCK2) . O43639
Elongin-A (ELOA) . Q14241
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Four and a half LIM domains protein 2 (FHL2) . Q14192
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Rhombotin-1 (LMO1) . P25800
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764