Details of the Target

General Information of Target

Target ID LDTP12337
Target Name Partitioning defective 6 homolog alpha (PARD6A)
Gene Name PARD6A
Gene ID 50855
Synonyms
PAR6A; Partitioning defective 6 homolog alpha; PAR-6; PAR-6 alpha; PAR-6A; PAR6C; Tax interaction protein 40; TIP-40
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MGNCAKRPWRRGPKDPLQWLGSPPRGSCPSPSSSPKEQGDPAPGVQGYSVLNSLVGPACI
FLRPSIAATQLDRELRPEEIEELQVAFQEFDRDRDGYIGCRELGACMRTLGYMPTEMELI
EISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGRISVGELRAA
LKALLGERLSQREVDEILQDVDLNGDGLVDFEEFVRMMSR
Target Bioclass
Other
Family
PAR6 family
Subcellular location
Cytoplasm
Function
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization.
Uniprot ID
Q9NPB6
Ensemble ID
ENST00000219255.3
HGNC ID
HGNC:15943

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C304(0.82); C311(0.82)  LDD1093  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C304(0.82); C311(0.82)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C304(1.42); C311(1.42)  LDD1094  [1]
 LDCM0216  AC100 PaTu 8988t C304(1.30); C311(1.30)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C304(1.06); C311(1.06)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C304(0.90); C311(0.90)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C304(1.01); C311(1.01)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C304(1.01); C311(1.01)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C304(1.61); C311(1.61)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C304(1.21); C311(1.21)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C304(0.92); C311(0.92)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C304(1.35); C311(1.35)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C304(1.35); C311(1.35)  LDD1104  [1]
 LDCM0226  AC11 PaTu 8988t C304(1.44); C311(1.44)  LDD1105  [1]
 LDCM0227  AC110 PaTu 8988t C304(1.49); C311(1.49)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C304(1.42); C311(1.42)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C304(1.10); C311(1.10)  LDD1108  [1]
 LDCM0237  AC12 PaTu 8988t C304(1.70); C311(1.70)  LDD1116  [1]
 LDCM0246  AC128 PaTu 8988t C304(0.97); C311(0.97)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C304(1.09); C311(1.09)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C304(1.02); C311(1.02)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C304(1.00); C311(1.00)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C304(1.11); C311(1.11)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C304(1.02); C311(1.02)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C304(1.06); C311(1.06)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C304(1.17); C311(1.17)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C304(1.20); C311(1.20)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C304(1.09); C311(1.09)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C304(1.29); C311(1.29)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C304(0.95); C311(0.95)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C304(1.27); C311(1.27)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C304(1.22); C311(1.22)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C304(0.97); C311(0.97)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C304(1.11); C311(1.11)  LDD1141  [1]
 LDCM0270  AC15 PaTu 8988t C304(1.39); C311(1.39)  LDD1149  [1]
 LDCM0276  AC17 PaTu 8988t C304(0.86); C311(0.86)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C304(1.15); C311(1.15)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C304(1.08); C311(1.08)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C304(0.86); C311(0.86)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C304(1.15); C311(1.15)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C304(1.07); C311(1.07)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C304(1.06); C311(1.06)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C304(1.04); C311(1.04)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C304(1.21); C311(1.21)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C304(1.04); C311(1.04)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C304(1.15); C311(1.15)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C304(1.11); C311(1.11)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C304(1.26); C311(1.26)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C304(1.16); C311(1.16)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C304(0.76); C311(0.76)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C304(1.25); C311(1.25)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C304(0.96); C311(0.96)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C304(1.49); C311(1.49)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C304(1.40); C311(1.40)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C304(1.31); C311(1.31)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C304(1.32); C311(1.32)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C304(1.97); C311(1.97)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C304(1.60); C311(1.60)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C304(1.42); C311(1.42)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C304(2.25); C311(2.25)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C304(0.82); C311(0.82)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C304(1.99); C311(1.99)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C304(1.69); C311(1.69)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C304(2.82); C311(2.82)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C304(1.70); C311(1.70)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C304(3.16); C311(3.16)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C304(1.43); C311(1.43)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C304(0.96); C311(0.96)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C304(1.01); C311(1.01)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C304(1.15); C311(1.15)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C304(1.38); C311(1.38)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C304(0.78); C311(0.78)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C304(1.46); C311(1.46)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C304(0.32); C311(0.32)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C304(1.18); C311(1.18)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C304(1.75); C311(1.75)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C304(1.49); C311(1.49)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C304(1.16); C311(1.16)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C304(1.46); C311(1.46)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C304(1.01); C311(1.01)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C304(0.92); C311(0.92)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C304(0.87); C311(0.87)  LDD1201  [1]
 LDCM0323  AC6 PaTu 8988t C304(1.33); C311(1.33)  LDD1202  [1]
 LDCM0324  AC60 PaTu 8988t C304(0.90); C311(0.90)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C304(0.86); C311(0.86)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C304(0.86); C311(0.86)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C304(0.93); C311(0.93)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C304(0.99); C311(0.99)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C304(0.96); C311(0.96)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C304(0.89); C311(0.89)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C304(0.91); C311(0.91)  LDD1210  [1]
 LDCM0332  AC68 PaTu 8988t C304(0.90); C311(0.90)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C304(1.12); C311(1.12)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C304(1.13); C311(1.13)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C304(1.11); C311(1.11)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C304(0.91); C311(0.91)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C304(1.05); C311(1.05)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C304(0.99); C311(0.99)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C304(1.18); C311(1.18)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C304(1.03); C311(1.03)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C304(1.42); C311(1.42)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C304(1.14); C311(1.14)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C304(1.07); C311(1.07)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C304(1.17); C311(1.17)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C304(1.20); C311(1.20)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C304(1.00); C311(1.00)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C304(1.11); C311(1.11)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C304(1.31); C311(1.31)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C304(0.94); C311(0.94)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C304(0.85); C311(0.85)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C304(0.85); C311(0.85)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C304(0.94); C311(0.94)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C304(0.80); C311(0.80)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C304(0.89); C311(0.89)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C304(0.89); C311(0.89)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C304(0.79); C311(0.79)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C304(0.95); C311(0.95)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C304(0.88); C311(0.88)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C304(0.83); C311(0.83)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C304(1.00); C311(1.00)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C304(0.89); C311(0.89)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C304(0.79); C311(0.79)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C304(0.95); C311(0.95)  LDD1243  [1]
 LDCM0365  AC98 PaTu 8988t C304(1.30); C311(1.30)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C304(1.15); C311(1.15)  LDD1245  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C304(1.49); C311(1.49)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C304(1.33); C311(1.33)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C304(1.50); C311(1.50)  LDD1154  [1]
 LDCM0369  CL100 PaTu 8988t C304(0.85); C311(0.85)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C304(1.37); C311(1.37)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C304(1.65); C311(1.65)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C304(1.84); C311(1.84)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C304(1.47); C311(1.47)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C304(1.06); C311(1.06)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C304(1.17); C311(1.17)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C304(0.90); C311(0.90)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C304(1.42); C311(1.42)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C304(1.18); C311(1.18)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C304(1.35); C311(1.35)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C304(1.40); C311(1.40)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C304(1.20); C311(1.20)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C304(1.02); C311(1.02)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C304(1.26); C311(1.26)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C304(1.09); C311(1.09)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C304(1.14); C311(1.14)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C304(1.50); C311(1.50)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C304(3.48); C311(3.48)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C304(2.57); C311(2.57)  LDD1268  [1]
 LDCM0391  CL120 PaTu 8988t C304(1.68); C311(1.68)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C304(1.25); C311(1.25)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C304(1.15); C311(1.15)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C304(1.43); C311(1.43)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C304(1.40); C311(1.40)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C304(0.95); C311(0.95)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C304(0.91); C311(0.91)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C304(0.82); C311(0.82)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C304(0.94); C311(0.94)  LDD1278  [1]
 LDCM0420  CL31 PaTu 8988t C304(0.95); C311(0.95)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C304(1.17); C311(1.17)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C304(1.60); C311(1.60)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C304(1.41); C311(1.41)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C304(1.32); C311(1.32)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C304(1.18); C311(1.18)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C304(1.33); C311(1.33)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C304(1.42); C311(1.42)  LDD1307  [1]
 LDCM0430  CL40 PaTu 8988t C304(1.10); C311(1.10)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C304(1.35); C311(1.35)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C304(1.38); C311(1.38)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C304(1.55); C311(1.55)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C304(1.25); C311(1.25)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C304(1.43); C311(1.43)  LDD1314  [1]
 LDCM0453  CL61 PaTu 8988t C304(1.21); C311(1.21)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C304(1.20); C311(1.20)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C304(1.11); C311(1.11)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C304(1.43); C311(1.43)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C304(1.29); C311(1.29)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C304(1.46); C311(1.46)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C304(1.69); C311(1.69)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C304(1.10); C311(1.10)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C304(1.39); C311(1.39)  LDD1340  [1]
 LDCM0463  CL70 PaTu 8988t C304(0.99); C311(0.99)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C304(1.40); C311(1.40)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C304(1.56); C311(1.56)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C304(1.55); C311(1.55)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C304(1.44); C311(1.44)  LDD1346  [1]
 LDCM0486  CL91 PaTu 8988t C304(0.74); C311(0.74)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C304(0.73); C311(0.73)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C304(0.77); C311(0.77)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C304(0.81); C311(0.81)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C304(0.98); C311(0.98)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C304(0.83); C311(0.83)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C304(0.80); C311(0.80)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C304(0.87); C311(0.87)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C304(0.87); C311(0.87)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C304(1.61); C311(1.61)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C304(1.29); C311(1.29)  LDD1306  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein kinase C iota type (PRKCI) AGC Ser/Thr protein kinase family P41743
Protein kinase C zeta type (PRKCZ) AGC Ser/Thr protein kinase family Q05513
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) Protein-tyrosine phosphatase family Q16825
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Cell division control protein 42 homolog (CDC42) Rho family P60953
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein eta (YWHAH) 14-3-3 family Q04917
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Partitioning defective 3 homolog (PARD3) PAR3 family Q8TEW0
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Cadherin-5 (CDH5) . P33151

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.