Details of the Target

General Information of Target

Target ID LDTP12259
Target Name Post-GPI attachment to proteins factor 6 (PGAP6)
Gene Name PGAP6
Gene ID 58986
Synonyms
TMEM6; TMEM8; TMEM8A; Post-GPI attachment to proteins factor 6; EC 3.1.1.4; GPI processing phospholipase A2; GPI-PLA2; Protein M83; Transmembrane protein 6; Transmembrane protein 8; Transmembrane protein 8A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE
DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG
ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL
AHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCE
KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVK
FVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGEL
TPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHI
YTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
Target Bioclass
Enzyme
Family
TMEM8 family
Subcellular location
Cell membrane
Function
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane. In contrast to myomaker (TMEM8C), has no fusogenic activity.
Uniprot ID
Q9HCN3
Ensemble ID
ENST00000431232.7
HGNC ID
HGNC:17205

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C379(1.09)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C379(1.01)  LDD1507  [2]
 LDCM0237  AC12 HEK-293T C379(0.86)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C379(1.07)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C379(1.00)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C379(1.07)  LDD1515  [2]
 LDCM0280  AC20 HEK-293T C379(0.97)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C379(1.03)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C379(0.92)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C379(0.98)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C379(1.10)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C379(0.96)  LDD1524  [2]
 LDCM0288  AC28 HEK-293T C379(0.97)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C379(0.96)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C379(0.91)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C379(1.04)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C379(1.35)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C379(1.05)  LDD1533  [2]
 LDCM0297  AC36 HEK-293T C379(1.05)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C379(0.96)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C379(0.94)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C379(0.95)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C379(0.98)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C379(1.09)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C379(1.16)  LDD1542  [2]
 LDCM0306  AC44 HEK-293T C379(1.14)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C379(1.00)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C379(0.96)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C379(0.92)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C379(1.18)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C379(1.12)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C379(0.96)  LDD1551  [2]
 LDCM0315  AC52 HEK-293T C379(0.96)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C379(0.97)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C379(1.15)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C379(1.05)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C379(1.22)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C379(1.02)  LDD1559  [2]
 LDCM0323  AC6 HEK-293T C379(0.95)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C379(0.87)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C379(1.02)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C379(0.97)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C379(1.01)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C379(0.91)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C379(0.95)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C379(0.97)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C379(1.01)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C379(1.03)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C379(1.13)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C379(0.94)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C379(0.94)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C379(0.93)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C379(1.18)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C379(0.97); C760(0.85)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C379(1.15)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C379(0.87)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C379(1.06); C760(0.94)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C379(1.07)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C379(0.90)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C379(1.01)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C379(0.90); C760(0.94)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C379(1.04)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C379(0.94)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C379(0.86); C760(0.89)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C379(1.17)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C379(0.94)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C379(1.00); C760(1.05)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C379(1.04)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C379(0.98)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C379(0.93)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C379(0.85); C760(1.10)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C379(0.96)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C379(1.08)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C379(1.01); C760(1.05)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C379(1.04)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C379(1.05)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C379(0.97); C760(1.05)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C379(1.07)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C379(0.91)  LDD1608  [2]
 LDCM0408  CL20 HEK-293T C379(1.04)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C379(1.09)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C379(1.28)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C379(1.14)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C379(1.07)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C379(0.86)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C379(0.91); C760(0.94)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C379(0.96)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C379(1.20)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C379(0.84); C760(0.81)  LDD1622  [2]
 LDCM0421  CL32 HEK-293T C379(1.05)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C379(0.96)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C379(0.87)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C379(1.14)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C379(1.14)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C379(0.80)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C379(0.94); C760(1.21)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C379(0.99)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C379(1.16)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C379(1.02)  LDD1635  [2]
 LDCM0434  CL44 HEK-293T C379(1.07)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C379(0.92)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C379(1.05)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C379(1.09)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C379(1.30)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C379(0.99)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C379(1.02)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C379(1.14)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C379(1.00)  LDD1647  [2]
 LDCM0447  CL56 HEK-293T C379(1.04)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C379(0.99)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C379(1.03)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C379(1.00)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C379(1.30)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C379(0.88)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C379(1.07); C760(1.01)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C379(1.11)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C379(1.10)  LDD1660  [2]
 LDCM0460  CL68 HEK-293T C379(0.94)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C379(1.09)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C379(1.16)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C379(1.12)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C379(1.20)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C379(0.83)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C379(1.07)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C379(0.94)  LDD1673  [2]
 LDCM0473  CL8 HEK-293T C379(0.72)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C379(0.93)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C379(1.05)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C379(1.17)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C379(1.16)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C379(1.07)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C379(1.08)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C379(1.13); C760(0.91)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C379(1.15)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C379(1.04)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C379(1.16)  LDD1687  [2]
 LDCM0487  CL92 HEK-293T C379(1.09)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C379(0.98)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C379(0.98)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C379(0.87)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C379(1.04)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C379(0.93)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C379(0.90); C760(1.04)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C379(1.05); C760(1.11)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C379(0.92); C760(1.06)  LDD1671  [2]
 LDCM0022  KB02 A101D C379(1.01)  LDD2250  [1]
 LDCM0023  KB03 A204 C379(1.24)  LDD2669  [1]
 LDCM0024  KB05 IGR37 C379(1.09)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402