Details of the Target

General Information of Target

Target ID LDTP12174
Target Name Zinc finger FYVE domain-containing protein 1 (ZFYVE1)
Gene Name ZFYVE1
Gene ID 53349
Synonyms
DFCP1; KIAA1589; TAFF1; ZNFN2A1; Zinc finger FYVE domain-containing protein 1; Double FYVE-containing protein 1; SR3; Tandem FYVE fingers-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD
EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP
APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS
RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL
LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS
LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG
SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD
AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS
PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS
Target Bioclass
Other
Subcellular location
Golgi apparatus, Golgi stack
Function
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. Regulates the morphology, size and distribution of LDs. Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger.; (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication.
Uniprot ID
Q9HBF4
Ensemble ID
ENST00000318876.9
HGNC ID
HGNC:13180

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.V531A .
EFO27 SNV: p.D413N .
MOLT4 SNV: p.S419I IA-alkyne    Probe Info 
NCIH1793 SNV: p.D177N .
RKO SNV: p.C18Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K113(3.91); K360(1.02)  LDD0277  [1]
DBIA
 Probe Info  		C628(1.78); C631(1.78); C740(2.00); C748(2.00)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		C45(0.00); C459(0.00); C174(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C651(0.99); C654(0.99); C740(1.57)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C740(0.98)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C740(0.88)  LDD0824  [2]
 LDCM0230  AC113 HEK-293T C740(0.65)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C740(0.78)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C740(0.69)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C740(0.65)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C740(0.69)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C740(0.68)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C740(0.80)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C740(0.77)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C740(0.89)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C740(0.70)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C740(0.91)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C740(0.90)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C740(0.74)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C740(0.84)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C740(1.08)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C740(1.11)  LDD0843  [2]
 LDCM0259  AC14 HEK-293T C740(0.80)  LDD0857  [2]
 LDCM0270  AC15 HEK-293T C740(0.88)  LDD0868  [2]
 LDCM0276  AC17 HEK-293T C651(1.03); C654(1.03)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C651(0.86); C654(0.86)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C651(0.96); C654(0.96)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C651(0.83); C654(0.83); C740(1.07)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C651(1.10); C654(1.10)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C651(1.23); C654(1.23)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C651(1.24); C654(1.24)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C651(0.94); C654(0.94)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C651(0.91); C654(0.91)  LDD0882  [2]
 LDCM0285  AC25 PaTu 8988t C740(0.68); C745(0.68); C748(0.68)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C740(1.02); C745(1.02); C748(1.02)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C740(0.64); C745(0.64); C748(0.64)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C740(0.74); C745(0.74); C748(0.74)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C740(1.22); C745(1.22); C748(1.22)  LDD1168  [2]
 LDCM0290  AC3 HEK-293T C651(0.90); C654(0.90); C740(1.15)  LDD0888  [2]
 LDCM0291  AC30 PaTu 8988t C740(0.69); C745(0.69); C748(0.69)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C740(0.66); C745(0.66); C748(0.66)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C740(1.07); C745(1.07); C748(1.07)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C740(0.69); C745(0.69); C748(0.69)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C740(0.75); C745(0.75); C748(0.75)  LDD1174  [2]
 LDCM0296  AC35 HEK-293T C740(1.15)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C740(1.38)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C740(1.45)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C740(1.05)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C740(0.95)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C651(0.99); C654(0.99); C740(1.24)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C740(1.29)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C740(2.48)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C740(1.24)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C740(1.14)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C740(1.07)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C740(1.05)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C604(0.97); C217(1.08); C74(0.96); C651(1.01)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C604(1.04); C217(0.97); C767(1.05); C74(1.03)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C604(1.19); C217(1.06); C74(0.94); C651(1.03)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C604(1.03); C217(0.87)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C651(0.91); C654(0.91); C740(1.19)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C604(1.01); C217(0.97); C74(1.05); C651(1.16)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C604(1.08); C217(0.94); C767(0.94); C74(1.05)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C604(1.09); C217(0.93); C767(0.98); C74(1.01)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C604(0.97); C217(0.99); C651(1.19)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C604(1.04); C217(1.06); C74(1.06); C651(0.83)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C604(1.13); C217(0.95); C767(1.05); C74(1.06)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C604(1.09); C217(1.10); C74(0.96); C651(1.02)  LDD1558  [6]
 LDCM0320  AC57 PaTu 8988t C740(1.92); C745(1.92); C748(1.92)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C740(1.27); C745(1.27); C748(1.27)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C740(1.50); C745(1.50); C748(1.50)  LDD1201  [2]
 LDCM0323  AC6 HEK-293T C740(0.74)  LDD0921  [2]
 LDCM0324  AC60 PaTu 8988t C740(1.62); C745(1.62); C748(1.62)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C740(1.62); C745(1.62); C748(1.62)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C740(1.17); C745(1.17); C748(1.17)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C740(1.32); C745(1.32); C748(1.32)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C740(1.78); C745(1.78); C748(1.78)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C740(1.12); C745(1.12); C748(1.12)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C740(1.54); C745(1.54); C748(1.54)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C740(1.29); C745(1.29); C748(1.29)  LDD1210  [2]
 LDCM0334  AC7 HEK-293T C740(1.14)  LDD0932  [2]
 LDCM0345  AC8 HEK-293T C740(0.91)  LDD0943  [2]
 LDCM0248  AKOS034007472 HEK-293T C740(0.88)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C740(0.79)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C740(0.76)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C740(1.13)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C740(1.15)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C651(0.89); C654(0.89); C740(1.04)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C740(0.82)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C740(0.82)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C740(0.94)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C740(0.92)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C651(1.33); C654(1.33)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C651(1.06); C654(1.06)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C651(1.04); C654(1.04)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C651(0.89); C654(0.89)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C651(1.10); C654(1.10)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C740(1.09)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C651(1.09); C654(1.09)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C651(0.95); C654(0.95)  LDD0979  [2]
 LDCM0382  CL112 PaTu 8988t C740(0.92); C745(0.92); C748(0.92)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C740(0.79); C745(0.79); C748(0.79)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C740(0.72); C745(0.72); C748(0.72)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C740(0.65); C745(0.65); C748(0.65)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C740(0.95); C745(0.95); C748(0.95)  LDD1265  [2]
 LDCM0387  CL117 HEK-293T C740(1.49)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C740(1.43)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C740(1.05)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C740(0.98)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C740(1.00)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C604(1.07); C217(0.89); C74(1.14)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C604(1.05); C217(0.94); C74(1.03)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C604(0.92); C217(0.84); C74(0.79)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C604(0.98); C217(1.14); C74(1.02)  LDD1599  [6]
 LDCM0396  CL125 PaTu 8988t C740(0.96); C745(0.96); C748(0.96)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C740(1.70); C745(1.70); C748(1.70)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C740(1.19); C745(1.19); C748(1.19)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C740(1.04); C745(1.04); C748(1.04)  LDD1278  [2]
 LDCM0400  CL13 HEK-293T C740(1.00)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C740(0.89)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C740(1.34)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C651(0.98); C654(0.98)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C651(1.06); C654(1.06)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C651(1.05); C654(1.05)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C651(1.04); C654(1.04)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C740(1.00)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C651(1.08); C654(1.08)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C651(1.42); C654(1.42)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C651(1.56); C654(1.56)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C651(1.13); C654(1.13)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C651(1.14); C654(1.14)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C651(1.06); C654(1.06)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C651(0.93); C654(0.93)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C651(1.33); C654(1.33)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C651(1.88); C654(1.88)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C651(1.10); C654(1.10)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C740(0.85)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C651(1.50); C654(1.50)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C651(0.96); C654(0.96)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C651(0.98); C654(0.98)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C651(0.74); C654(0.74)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C651(0.93); C654(0.93)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C651(0.95); C654(0.95)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C651(1.10); C654(1.10)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C651(0.99); C654(0.99)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C651(0.95); C654(0.95)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C740(0.75)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C651(0.89); C654(0.89)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C651(0.98); C654(0.98)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C651(1.05); C654(1.05)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C651(1.15); C654(1.15)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C651(0.92); C654(0.92)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C651(0.82); C654(0.82)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C604(0.84); C217(1.09); C74(1.05); C651(1.09)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C604(0.65); C217(1.06); C767(0.90); C74(0.85)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C604(0.54); C217(1.07); C74(0.83); C651(1.09)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C604(1.06); C217(1.04); C74(1.18)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C740(0.84)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C604(1.13); C217(0.97); C74(1.10)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C604(1.06); C217(1.19); C74(0.96)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C604(0.82); C217(0.90)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C604(0.90); C217(0.89); C74(1.00); C651(1.04)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C604(1.07); C217(1.01); C767(1.02); C74(0.93)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C604(0.91); C217(0.95); C767(0.96); C74(0.94)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C604(0.73); C217(0.84); C651(1.15)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C604(0.89); C217(1.13); C74(0.91); C651(1.07)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C604(0.70); C217(0.94); C767(0.76); C74(0.88)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C740(1.05)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C604(0.59); C217(0.95); C74(0.78); C651(0.86)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C651(1.08); C654(1.08); C740(0.88)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C651(1.01); C654(1.01); C740(0.84)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C651(0.89); C654(0.89); C740(0.89)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C651(0.68); C654(0.68); C740(0.82)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C651(0.84); C654(0.84); C740(0.89)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C651(0.92); C654(0.92); C740(0.80)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C651(0.91); C654(0.91); C740(0.83)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C651(1.08); C654(1.08); C740(0.76)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C651(0.83); C654(0.83); C740(0.89)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C740(0.88)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C651(1.01); C654(1.01); C740(0.93)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C651(0.88); C654(0.88); C740(0.82)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C651(0.94); C654(0.94); C740(0.86)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C651(0.93); C654(0.93); C740(0.79)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C651(0.72); C654(0.72); C740(0.96)  LDD1065  [2]
 LDCM0469  CL76 PaTu 8988t C740(0.76); C745(0.76); C748(0.76)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C740(0.65); C745(0.65); C748(0.65)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C740(0.96); C745(0.96); C748(0.96)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C740(0.83); C745(0.83); C748(0.83)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C740(0.88)  LDD1071  [2]
 LDCM0474  CL80 PaTu 8988t C740(0.87); C745(0.87); C748(0.87)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C740(0.82); C745(0.82); C748(0.82)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C740(0.88); C745(0.88); C748(0.88)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C740(0.98); C745(0.98); C748(0.98)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C740(0.72); C745(0.72); C748(0.72)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C740(0.80); C745(0.80); C748(0.80)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C740(0.75); C745(0.75); C748(0.75)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C740(0.76); C745(0.76); C748(0.76)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C740(0.85); C745(0.85); C748(0.85)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C740(0.86); C745(0.86); C748(0.86)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C740(0.94)  LDD1082  [2]
 LDCM0485  CL90 PaTu 8988t C740(0.67); C745(0.67); C748(0.67)  LDD1364  [2]
 LDCM0486  CL91 HEK-293T C651(0.92); C654(0.92); C740(0.95)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C651(0.77); C654(0.77); C740(1.21)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C651(0.96); C654(0.96); C740(0.82)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C651(0.92); C654(0.92); C740(1.09)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C651(0.89); C654(0.89); C740(0.99)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C651(0.72); C654(0.72); C740(0.92)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C651(0.96); C654(0.96); C740(0.99)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C651(0.81); C654(0.81); C740(1.18)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C651(0.91); C654(0.91); C740(1.11)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C604(0.92); C217(0.94); C74(1.02)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C651(0.92); C654(0.92); C740(0.80)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C651(0.89); C654(0.89)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C628(1.78); C631(1.78); C740(2.00); C748(2.00)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C628(1.96); C631(1.96); C740(1.90); C748(1.90)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C628(2.25); C631(2.25); C740(2.08); C748(2.08)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402