Details of the Target

General Information of Target

Target ID LDTP12152
Target Name Histone-lysine N-methyltransferase PRDM16 (PRDM16)
Gene Name PRDM16
Gene ID 63976
Synonyms
KIAA1675; MEL1; PFM13; Histone-lysine N-methyltransferase PRDM16; EC 2.1.1.367; PR domain zinc finger protein 16; PR domain-containing protein 16; Transcription factor MEL1; MDS1/EVI1-like gene 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
Target Bioclass
Enzyme
Family
PRDM16 family
Subcellular location
Nucleus
Function
Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions as a repressor of TGF-beta signaling.; [Isoform 4]: Binds DNA and functions as a transcriptional regulator. Functions as a repressor of TGF-beta signaling. May regulate granulocyte differentiation.
Uniprot ID
Q9HAZ2
Ensemble ID
ENST00000270722.10
HGNC ID
HGNC:14000
ChEMBL ID
CHEMBL5214855

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S1218Y DBIA    Probe Info 
CAL51 SNV: p.M863V DBIA    Probe Info 
COLO829 SNV: p.P851S .
DU145 SNV: p.Q712Ter .
EFO27 Insertion: p.A258GfsTer9 DBIA    Probe Info 
HCT15 SNV: p.G651C .
HDQP1 SNV: p.D1117H DBIA    Probe Info 
HS936T SNV: p.P495R .
IGR1 SNV: p.H854Y .
IGROV1 SNV: p.A7V .
LNCaP clone FGC SNV: p.G638C; p.K752E .
MFE319 SNV: p.P71L; p.T374I DBIA    Probe Info 
MOLT4 Deletion: p.P656RfsTer28 .
NB1 SNV: p.E1131Ter .
NCIH661 SNV: p.D985Y .
OCIAML5 SNV: p.S890Y .
REC1 SNV: p.D630G .
RKO SNV: p.D985G DBIA    Probe Info 
RL952 SNV: p.D1102Y DBIA    Probe Info 
SKMEL24 SNV: p.P531L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C176(1.93); C178(1.93); C410(1.68)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		C771(0.00); C843(0.00); C1107(0.00); C113(0.00)  LDD2156  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]
Phosphinate-6
 Probe Info  		C410(0.00); C771(0.00)  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C587(0.94); C157(1.10); C113(1.10)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C587(0.91); C157(0.99); C113(1.06); C1016(1.22)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C587(1.07); C113(1.14); C843(1.04); C1107(1.00)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C587(0.94); C410(1.07); C113(0.97); C1016(0.95)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C587(0.96); C157(1.00); C410(1.04); C1016(1.17)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C587(0.99); C1016(1.21); C843(0.89)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C587(1.10); C157(0.99); C113(1.15)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C587(0.95); C157(1.05); C113(1.13); C1016(1.24)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C587(1.17); C113(1.26); C843(1.23); C1107(1.00)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C587(1.00); C157(1.03); C113(1.08); C1016(1.11)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C587(0.94); C410(0.95); C113(0.74); C1016(0.91)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C157(1.25); C1016(0.96)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C587(0.96); C157(0.97); C410(0.91); C1016(1.03)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C587(0.99); C1016(1.14); C843(1.05)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C587(0.97); C113(0.99); C1016(1.27)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C587(0.87); C157(1.26); C113(1.05)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C587(1.00); C157(1.13); C113(0.98); C1016(1.13)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C587(1.04); C113(0.92); C843(0.99); C1107(1.16)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C587(0.99); C410(0.96); C113(0.94); C1016(0.79)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C157(1.16); C1016(0.86)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C587(1.15); C113(0.96); C843(1.05); C1107(0.98)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C587(0.90); C157(1.06); C410(0.91); C1016(1.05)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C587(0.94); C1016(1.12); C843(0.96)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C587(1.28); C113(0.96); C1016(1.31)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C587(0.99); C157(1.18); C113(1.02)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C587(1.06); C157(0.98); C113(1.09); C1016(1.14)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C587(0.98); C113(1.02); C843(1.37); C1107(1.10)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C587(0.95); C410(0.93); C113(0.97); C1016(0.99)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C157(1.19); C1016(0.97)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C587(0.91); C157(1.13); C410(0.87); C1016(0.86)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C587(1.08); C1016(1.16); C843(1.13)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C587(0.95); C410(1.06); C113(1.16); C1016(0.92)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C587(1.12); C113(1.66); C1016(1.15)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C587(1.27); C157(1.10); C113(1.14)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C587(1.01); C157(1.03); C113(0.97); C1016(1.44)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C587(1.06); C113(1.04); C843(1.12); C1107(1.09)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C587(0.95); C410(1.05); C113(1.60); C1016(1.08)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C157(1.18); C1016(0.80)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C587(0.98); C157(0.96); C410(0.89); C1016(1.18)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C587(1.05); C1016(1.15); C843(0.99)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C587(1.10); C113(0.92); C1016(1.28)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C587(0.97); C157(1.07); C113(0.95)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C157(1.18); C1016(0.97)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C587(0.98); C157(1.03); C113(1.33); C1016(1.21)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C587(1.04); C113(1.14); C843(1.20); C1107(0.96)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C587(1.02); C410(0.96); C113(1.33); C1016(0.94)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C157(1.10); C1016(0.91)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C587(0.96); C157(1.06); C410(0.95); C1016(1.18)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C587(1.00); C1016(1.35); C843(1.04)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C587(0.97); C113(1.10); C1016(1.07)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C587(0.92); C157(1.13); C113(1.03)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C587(0.99); C157(1.08); C113(1.06); C1016(1.16)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C587(1.10); C113(1.14); C843(1.23); C1107(1.12)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C587(1.01); C157(1.23); C410(0.95); C1016(1.11)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C587(0.98); C410(0.99); C113(1.34); C1016(0.87)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C157(1.06); C1016(0.89)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C587(0.91); C157(1.08); C410(0.95); C1016(1.34)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C587(0.97); C1016(1.11); C843(1.07)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C587(0.89); C113(1.08); C1016(1.23)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C587(0.94); C1016(1.08); C843(1.18)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C587(0.93); C113(1.16); C1016(0.96)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C157(1.18); C1016(0.92)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C587(1.11); C157(1.18); C113(1.08)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C587(0.98); C113(1.16); C1016(1.17)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C587(0.96); C157(1.32)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C587(0.96); C157(1.60); C410(0.97); C1016(0.94)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C157(0.93); C410(1.04); C113(1.51); C1016(0.78)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C587(1.05); C157(1.23)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C587(0.96); C410(0.99)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C587(0.97); C157(1.58); C113(1.05); C1016(0.89)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C157(0.92); C410(1.06); C113(1.18); C1016(0.98)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C587(1.01); C157(1.02)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C587(0.97); C410(1.06)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C587(1.00); C157(1.11); C113(1.02); C1016(1.17)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C157(1.17); C410(1.00); C113(1.20); C1016(0.97)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C587(1.05); C157(0.93)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C587(1.00); C1016(1.16); C843(1.19)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C587(0.98); C410(1.00)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C587(0.96); C157(1.27); C113(1.08); C1016(1.00)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C157(0.91); C410(1.06); C113(1.12); C1016(1.09)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C587(0.97); C157(1.34)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C587(0.94); C410(0.99)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C587(1.03); C157(1.03); C113(1.05); C1016(0.98)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C157(0.90); C410(1.03); C113(1.24); C1016(0.84)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C587(0.98); C157(1.01)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C587(0.99); C410(1.16)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C587(0.98); C157(0.78); C113(0.86); C1016(1.07)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C587(1.32); C113(1.07); C1016(1.05)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C157(0.88); C410(1.07); C113(1.19); C1016(1.01)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C587(1.02); C157(1.09)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C587(1.06); C410(1.18)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C587(0.85); C157(0.91); C113(0.87); C1016(0.85)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C157(1.03); C410(1.02); C113(1.27); C1016(0.90)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C587(0.88); C157(1.23)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C587(0.93); C410(0.98)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C587(0.96); C157(1.26); C113(0.96); C1016(0.95)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C157(0.95); C410(1.03); C113(1.11); C1016(0.99)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C587(1.01); C157(1.14)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C587(1.34); C410(1.04)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C587(0.99); C157(1.11); C113(1.40); C1016(1.03)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C157(0.82); C410(1.07); C113(1.64); C1016(1.30)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C587(0.99); C157(1.37); C113(1.17)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C587(1.14); C157(1.16); C113(0.97); C1016(1.07)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C587(1.07); C113(0.78); C843(1.04); C1107(0.85)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C587(0.90); C410(1.22)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C587(1.17); C410(0.98); C113(1.09); C1016(0.86)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C157(1.13); C1016(0.82)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C587(1.03); C157(1.33); C410(0.89); C1016(1.17)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C587(1.09); C1016(1.12); C843(1.10)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C587(1.20); C113(1.04); C1016(1.14)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C587(1.10); C157(1.10)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C587(1.05); C410(0.95)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C587(0.99); C157(1.06); C113(0.84); C1016(0.91)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C157(0.91); C410(0.99); C113(1.55); C1016(1.35)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C587(1.05); C157(1.09); C113(1.22)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C587(0.92); C157(0.76); C113(1.23); C1016(0.95)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C587(1.08); C157(1.03); C113(1.14); C1016(1.31)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C587(1.25); C113(1.17); C843(1.19); C1107(0.82)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C587(1.07); C410(0.94); C113(0.73); C1016(0.99)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C157(1.03); C1016(0.87)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C587(1.16); C157(1.66); C410(0.88); C1016(1.05)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C587(1.14); C1016(1.17); C843(1.09)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C587(1.14); C113(1.14); C1016(1.32)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C587(1.07); C157(1.03)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C587(0.95); C157(0.89); C113(1.28); C1016(0.95)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C157(1.04); C410(1.05); C113(1.18); C1016(0.80)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C157(0.94); C410(0.93); C113(1.03); C1016(1.17)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C587(0.93); C157(1.26); C113(0.96)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C587(1.10); C157(1.12); C113(1.07); C1016(1.01)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C587(1.13); C113(1.17); C843(1.12); C1107(0.76)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C587(1.02); C410(1.01); C113(0.90); C1016(0.93)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C157(1.08); C1016(1.03)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C587(1.19); C157(1.75); C410(0.85); C1016(1.64)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C587(0.98); C1016(1.08); C843(1.03)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C587(1.11); C113(1.05); C1016(1.31)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C587(0.96); C157(1.21)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C587(1.07); C157(1.35); C113(1.01)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C587(0.94); C410(1.05)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C157(0.94); C410(1.01); C113(1.21); C1016(0.84)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C587(1.08); C157(1.21); C113(0.92)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C587(1.33); C157(0.84); C113(1.29); C1016(1.08)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C587(1.01); C113(0.96); C843(1.12); C1107(0.87)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C587(1.05); C410(0.90); C113(1.30); C1016(0.80)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C157(1.28); C1016(0.90)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C587(1.10); C157(1.79); C410(0.91); C1016(1.07)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C587(1.07); C1016(1.08); C843(1.03)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C587(1.34); C157(1.10); C113(1.13); C1016(0.91)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C587(1.15); C113(1.17); C1016(1.23)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C587(1.01); C157(1.20)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C587(1.01); C410(0.95)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C587(1.03); C157(1.03); C113(1.23); C1016(1.07)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C157(0.97); C410(1.01); C113(1.36); C1016(1.07)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C587(1.04); C157(1.10); C113(1.10)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C587(1.28); C157(0.96); C113(1.02); C1016(1.21)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C587(1.08); C113(0.98); C843(1.04); C1107(0.93)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C587(1.08); C410(1.08); C113(1.28); C1016(1.25)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C157(1.25); C1016(0.94)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C587(0.98); C113(1.24); C843(1.01); C1107(0.93)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C587(1.10); C157(1.80); C410(0.76); C1016(0.99)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C587(0.95); C1016(1.22); C843(1.09)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C587(1.19); C113(1.03); C1016(1.21)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C587(0.97); C157(1.13)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C587(1.08); C410(1.09)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C157(0.97); C410(0.90); C113(1.33); C1016(0.94)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C587(0.90); C157(0.36); C113(0.97)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C587(1.05); C157(1.05); C113(0.94); C1016(1.44)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C587(0.96); C113(1.09); C843(1.13); C1107(0.76)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C587(1.03); C410(0.91); C113(1.03); C1016(0.58)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C587(1.00); C410(1.05); C113(1.20); C1016(1.03)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C157(1.17); C1016(0.95)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C587(0.99); C157(1.55); C410(1.01); C1016(0.95)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C587(0.97); C1016(1.27); C843(1.05)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C587(1.27); C113(0.98); C1016(1.18)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C587(1.03); C157(1.09)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C587(1.12); C410(0.96)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C587(0.99); C157(0.91); C113(1.19); C1016(1.03)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C157(0.81); C410(1.04); C113(1.40); C1016(0.72)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C587(0.96); C157(1.24); C113(1.11)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C157(1.24); C1016(0.87)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C587(1.47); C157(1.17); C113(1.12); C1016(0.86)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C587(1.08); C113(1.43); C843(1.13); C1107(0.87)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C587(1.09); C410(0.93); C113(1.02); C1016(0.79)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C157(1.12); C1016(0.78)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C587(1.05); C157(1.30); C410(0.93); C1016(1.08)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C587(1.01); C1016(0.89); C843(1.17)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C587(1.09); C113(1.07); C1016(0.92)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C587(1.10); C157(0.99)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C587(1.00); C410(1.00)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C587(1.04); C157(0.77); C113(0.99); C1016(0.73)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C587(1.07); C157(1.08); C113(1.12); C1016(0.88)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C587(0.94); C157(1.01); C113(1.15); C1016(1.07)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C587(0.89); C410(0.96)  LDD1631  [6]
 LDCM0022  KB02 HCT 116 C176(1.93); C178(1.93); C410(1.68)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C176(1.09); C178(1.09); C410(1.41)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C176(2.30); C178(2.30); C410(1.44)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402