Details of the Target

General Information of Target

Target ID LDTP11770
Target Name Rabenosyn-5 (RBSN)
Gene Name RBSN
Gene ID 64145
Synonyms
ZFYVE20; Rabenosyn-5; 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; Zinc finger FYVE domain-containing protein 20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSLLLLFTAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRK
LCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAV
SAAGVVNAISRACREGELSTCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDARE
REKNFAKGSEEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRK
VGDRLKEKYDSAAAMRVTRKGRLELVNSRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQ
GRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane.
Uniprot ID
Q9H1K0
Ensemble ID
ENST00000253699.7
HGNC ID
HGNC:20759

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.S582N DBIA    Probe Info 
HCT15 SNV: p.S350N .
LS123 SNV: p.A422S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C182(0.00); C187(0.00)  LDD0241  [1]
Probe 1
 Probe Info  		Y360(12.34); Y496(32.70)  LDD3495  [2]
DBIA
 Probe Info  		C182(0.92); C187(0.92)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C182(0.96); C187(0.96)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C190(1.04); C182(1.04)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C190(1.07); C182(0.94)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C190(1.02); C182(0.92)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C190(1.00); C182(0.94)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C190(1.07); C182(0.98)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C190(1.00); C182(1.07)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C190(1.01); C182(1.00)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C190(1.17); C182(0.72)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C182(1.07); C187(1.07)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C190(1.04); C182(0.97)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C190(0.91); C182(0.94)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C190(1.05); C182(1.02)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C190(1.13); C182(0.92)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C190(1.12); C182(0.96)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C182(0.83); C187(0.83)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C182(0.81); C187(0.81)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C182(0.77); C187(0.77)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C182(0.80); C187(0.80)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C182(0.71); C187(0.71)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C182(1.30); C187(1.30)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C182(0.86); C187(0.86)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C182(0.67); C187(0.67)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C182(0.77); C187(0.77)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C182(0.82); C187(0.82)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C182(0.73); C187(0.73)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C190(0.98); C182(0.98)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C190(1.13); C182(0.94)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C190(1.01); C182(0.95)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C190(1.03); C182(0.96)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C190(1.10); C182(0.95)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C182(1.18); C187(1.18)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C190(1.04); C182(0.97)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C190(1.08); C182(1.07)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C190(1.00); C182(1.08)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C190(1.04); C182(0.96)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C190(1.04); C182(0.93)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C190(0.93); C182(0.95)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C182(1.11); C187(1.11)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C182(1.11); C187(1.11)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C182(1.18); C187(1.18)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C182(1.29); C187(1.29)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C182(1.21); C187(1.21)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C182(1.02); C187(1.02)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C182(1.17); C187(1.17)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C182(1.10); C187(1.10)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C182(1.04); C187(1.04)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C182(1.32); C187(1.32)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C182(1.27); C187(1.27)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C182(1.01); C187(1.01)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C190(0.98); C182(1.10)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C190(1.02); C182(1.05)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C190(1.09); C182(0.95)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C190(0.97); C182(0.94)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C190(1.04); C182(1.00)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C190(0.95); C182(1.01)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C190(0.99); C182(1.04)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C190(1.10); C182(0.95)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C190(1.00); C182(1.05)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C190(1.04); C182(0.95)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C190(1.01); C182(0.96)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C190(0.98); C182(0.91)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C190(0.95); C182(1.03)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C190(1.08); C182(1.01)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C182(0.92); C187(0.92)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C182(0.81); C187(0.81)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C182(0.84); C187(0.84)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C182(0.95); C187(0.95)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C190(1.01); C182(0.96)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C190(0.94); C182(0.95)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C190(1.03); C182(0.97)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C190(0.94); C182(0.95)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C190(1.01); C182(0.92)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C190(1.00); C182(1.01)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C190(0.94); C182(0.86)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C190(1.01); C182(0.97)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C190(0.90); C182(0.92)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C182(0.89); C187(0.89)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C190(0.86); C182(0.93)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C190(0.92); C182(0.90)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C182(0.65); C187(0.65)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C182(0.84); C187(0.84)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C182(0.74); C187(0.74)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C182(0.73); C187(0.73)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C182(0.83); C187(0.83)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C190(1.07); C182(0.98)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C190(1.05); C182(0.91)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C190(0.97); C182(0.93)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C182(1.01); C187(1.01)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C190(0.90); C182(0.94)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C182(0.98); C187(0.98)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C182(1.07); C187(1.07)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C182(1.18); C187(1.18)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C182(1.06); C187(1.06)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C190(0.92); C182(1.07)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C190(0.96); C182(1.06)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C190(0.93); C182(0.97)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C190(0.89); C182(0.98)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C182(0.98); C187(0.98)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C182(1.00); C187(1.00)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C182(1.02); C187(1.02)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C190(0.79); C182(0.90)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C190(1.09); C182(0.88)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C190(1.03); C182(0.91)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C190(1.09); C182(0.89)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C182(0.85); C187(0.85)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C190(1.20); C182(0.89)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C190(0.88); C182(0.78)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C190(1.02); C182(0.88)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C190(1.10); C182(0.84)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C190(0.96); C182(0.91)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C190(0.99); C182(0.88)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C190(1.04); C182(0.97)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C190(1.00); C182(0.89)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C190(1.01); C182(0.90)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C190(1.05); C182(0.95)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C182(0.93); C187(0.93)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C190(0.95); C182(0.88)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C182(1.17); C187(1.17)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C182(0.99); C187(0.99)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C182(0.83); C187(0.83)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C182(0.83); C187(0.83)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C182(0.81); C187(0.81)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C182(0.84); C187(0.84)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C182(0.82); C187(0.82)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C182(0.81); C187(0.81)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C182(1.04); C187(1.04)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C182(0.82); C187(0.82)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C182(0.53); C187(0.53)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C182(0.95); C187(0.95)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C182(0.94); C187(0.94)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C182(0.91); C187(0.91)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C182(0.98); C187(0.98)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C190(1.06); C182(0.92)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C190(1.02); C182(0.88)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C190(0.98); C182(0.88)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C190(0.87); C182(0.94)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C182(0.90); C187(0.90)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C190(0.93); C182(0.82)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C190(0.85); C182(0.95)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C190(1.04); C182(0.89)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C190(0.89); C182(0.80)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C190(1.00); C182(0.85)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C190(1.02); C182(0.82)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C190(0.87); C182(0.75)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C190(1.04); C182(0.84)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C190(1.12); C182(0.83)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C182(0.82); C187(0.82)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C190(1.08); C182(0.89)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C182(1.00); C187(1.00)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C182(0.96); C187(0.96)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C182(0.84); C187(0.84)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C182(0.83); C187(0.83)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C182(1.11); C187(1.11)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C182(0.86); C187(0.86)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C182(1.01); C187(1.01)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C182(1.34); C187(1.34)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C182(0.88); C187(0.88)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C182(0.85); C187(0.85)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C182(1.01); C187(1.01)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C182(0.96); C187(0.96)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C182(0.87); C187(0.87)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C182(0.82); C187(0.82)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C182(0.94); C187(0.94)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C182(0.88); C187(0.88)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C182(0.91); C187(0.91)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C182(1.07); C187(1.07)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C182(0.87); C187(0.87)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C182(1.17); C187(0.90)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C182(1.06); C187(1.06)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C182(1.06); C187(1.06)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C182(0.97); C187(0.97)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C182(0.97); C187(0.97)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C182(0.91); C187(0.91)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C182(1.12); C187(1.12)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C182(0.91); C187(0.91)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C182(1.01); C187(1.01)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C182(1.12); C187(1.12)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C182(1.02); C187(1.02)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C182(1.29); C187(0.94)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C182(0.83); C187(0.83)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C182(1.03); C187(1.03)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C182(1.21); C187(1.21)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C182(1.12); C187(1.12)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C182(1.43); C187(1.43)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C182(1.02); C187(1.02)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C182(1.19); C187(1.19)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C182(1.20); C187(1.20)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C182(1.27); C187(1.27)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C182(1.12); C187(1.12)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C190(0.93); C182(0.86)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C182(0.73); C187(0.73)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C182(0.98); C187(0.98)  LDD1025  [3]
 LDCM0022  KB02 HCT 116 C163(1.47); C166(1.47)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C163(1.85); C166(1.85)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C163(1.29); C166(1.29)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-4A (RAB4A) Rab family P20338
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EH domain-containing protein 1 (EHD1) Dynamin/Fzo/YdjA family Q9H4M9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 45 (VPS45) STXBP/unc-18/SEC1 family Q9NRW7

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402